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Items: 34

1.

Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo.

Avizienyte E, Cole CL, Rushton G, Miller GJ, Bugatti A, Presta M, Gardiner JM, Jayson GC.

PLoS One. 2016 Aug 4;11(8):e0159739. doi: 10.1371/journal.pone.0159739. eCollection 2016.

2.

Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology.

Jayson GC, Hansen SU, Miller GJ, Cole CL, Rushton G, Avizienyte E, Gardiner JM.

Chem Commun (Camb). 2015 Sep 18;51(72):13846-9. doi: 10.1039/c5cc05222j. Epub 2015 Aug 3.

3.

The development of anti-angiogenic heparan sulfate oligosaccharides.

Jayson GC, Miller GJ, Hansen SU, Barath M, Gardiner JM, Avizienyte E.

Biochem Soc Trans. 2014 Dec;42(6):1596-600. doi: 10.1042/BST20140229.

PMID:
25399576
4.

Segregation of late outgrowth endothelial cells into functional endothelial CD34- and progenitor-like CD34+ cell populations.

Ferreras C, Cole CL, Urban K, Jayson GC, Avizienyte E.

Angiogenesis. 2015 Jan;18(1):47-68. doi: 10.1007/s10456-014-9446-1. Epub 2014 Oct 1.

PMID:
25269667
5.

Ovarian cancer cell heparan sulfate 6-O-sulfotransferases regulate an angiogenic program induced by heparin-binding epidermal growth factor (EGF)-like growth factor/EGF receptor signaling.

Cole CL, Rushton G, Jayson GC, Avizienyte E.

J Biol Chem. 2014 Apr 11;289(15):10488-501. doi: 10.1074/jbc.M113.534263. Epub 2014 Feb 22.

6.

Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies.

Hansen SU, Miller GJ, Cole C, Rushton G, Avizienyte E, Jayson GC, Gardiner JM.

Nat Commun. 2013;4:2016. doi: 10.1038/ncomms3016.

7.

Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor.

Ferreras C, Rushton G, Cole CL, Babur M, Telfer BA, van Kuppevelt TH, Gardiner JM, Williams KJ, Jayson GC, Avizienyte E.

J Biol Chem. 2012 Oct 19;287(43):36132-46. doi: 10.1074/jbc.M112.384875. Epub 2012 Aug 27.

8.

Synthesis and scalable conversion of L-iduronamides to heparin-related di- and tetrasaccharides.

Hansen SU, Miller GJ, Baráth M, Broberg KR, Avizienyte E, Helliwell M, Raftery J, Jayson GC, Gardiner JM.

J Org Chem. 2012 Sep 21;77(18):7823-43. Epub 2012 Sep 4.

PMID:
22900939
9.

Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.

Cole CL, Hansen SU, Baráth M, Rushton G, Gardiner JM, Avizienyte E, Jayson GC.

PLoS One. 2010 Jul 21;5(7):e11644. doi: 10.1371/journal.pone.0011644.

10.

Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations.

Avizienyte E, Ward RA, Garner AP.

Biochem J. 2008 Oct 15;415(2):197-206. doi: 10.1042/BJ20080728.

PMID:
18588508
11.

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.

Vitale S, Avizienyte E, Brunton VG, Frame MC.

Eur J Cell Biol. 2008 Sep;87(8-9):569-79. doi: 10.1016/j.ejcb.2008.04.002. Epub 2008 Jun 17.

PMID:
18562041
12.

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.

Avizienyte E, Keppler M, Sandilands E, Brunton VG, Winder SJ, Ng T, Frame MC.

Exp Cell Res. 2007 Sep 10;313(15):3175-88. Epub 2007 May 24.

PMID:
17651734
13.

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.

Avizienyte E, Frame MC.

Curr Opin Cell Biol. 2005 Oct;17(5):542-7.

PMID:
16099634
14.

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

McLean GW, Carragher NO, Avizienyte E, Evans J, Brunton VG, Frame MC.

Nat Rev Cancer. 2005 Jul;5(7):505-15. Review.

PMID:
16069815
15.

The SRC-induced mesenchymal state in late-stage colon cancer cells.

Avizienyte E, Brunton VG, Fincham VJ, Frame MC.

Cells Tissues Organs. 2005;179(1-2):73-80. Review.

PMID:
15942195
16.
17.
18.

Focal adhesion kinase as a potential target in oncology.

McLean GW, Avizienyte E, Frame MC.

Expert Opin Pharmacother. 2003 Feb;4(2):227-34. Review.

PMID:
12562313
19.

Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells.

Jones RJ, Avizienyte E, Wyke AW, Owens DW, Brunton VG, Frame MC.

Br J Cancer. 2002 Nov 4;87(10):1128-35.

20.

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Avizienyte E, Wyke AW, Jones RJ, McLean GW, Westhoff MA, Brunton VG, Frame MC.

Nat Cell Biol. 2002 Aug;4(8):632-8.

PMID:
12134161
21.

Frequent loss of SMAD4/DPC4 protein in colorectal cancers.

Salovaara R, Roth S, Loukola A, Launonen V, Sistonen P, Avizienyte E, Kristo P, Järvinen H, Souchelnytskyi S, Sarlomo-Rikala M, Aaltonen LA.

Gut. 2002 Jul;51(1):56-9.

22.

[A serine/threonine kinase gene defective in Peutz-Jeghers syndrome].

Hemminki A, Avizienyte E, Roth S, Loukola A, Aaltonen LA, Järvinen H, de la Chapelle A.

Duodecim. 1998;114(7):667-8. Finnish. No abstract available.

PMID:
11524750
23.

E-cadherin is not frequently mutated in hereditary gastric cancer.

Avizienyte E, Launonen V, Salovaara R, Kiviluoto T, Aaltonen LA.

J Med Genet. 2001 Jan;38(1):49-52. No abstract available.

24.

17 Direct Sequencing for Peutz-Jeghers Gene LKB1 (STK11) Mutations.

Aaltonen LA, Avizienyte E.

Methods Mol Med. 2001;50:175-83. doi: 10.1385/1-59259-084-5:175.

PMID:
21318826
25.

No evidence of Peutz-Jeghers syndrome gene LKB1 involvement in left-sided colorectal carcinomas.

Launonen V, Avizienyte E, Loukola A, Laiho P, Salovaara R, Järvinen H, Mecklin JP, Oku A, Shimane M, Kim HC, Kim JC, Nezu J, Aaltonen LA.

Cancer Res. 2000 Feb 1;60(3):546-8.

26.

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome.

Esteller M, Avizienyte E, Corn PG, Lothe RA, Baylin SB, Aaltonen LA, Herman JG.

Oncogene. 2000 Jan 6;19(1):164-8.

27.

PTEN and LKB1 genes in laryngeal tumours.

Chen RW, Avizienyte E, Roth S, Elivo I, Mäkitie AA, Aaltonen LM, Aaltonen LA.

J Med Genet. 1999 Dec;36(12):943-4. No abstract available.

28.

SMAD genes in juvenile polyposis.

Roth S, Sistonen P, Salovaara R, Hemminki A, Loukola A, Johansson M, Avizienyte E, Cleary KA, Lynch P, Amos CI, Kristo P, Mecklin JP, Kellokumpu I, Järvinen H, Aaltonen LA.

Genes Chromosomes Cancer. 1999 Sep;26(1):54-61.

PMID:
10441006
29.

Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients.

Wang ZJ, Churchman M, Avizienyte E, McKeown C, Davies S, Evans DG, Ferguson A, Ellis I, Xu WH, Yan ZY, Aaltonen LA, Tomlinson IP.

J Med Genet. 1999 May;36(5):365-8.

30.

LKB1 somatic mutations in sporadic tumors.

Avizienyte E, Loukola A, Roth S, Hemminki A, Tarkkanen M, Salovaara R, Arola J, Bützow R, Husgafvel-Pursiainen K, Kokkola A, Järvinen H, Aaltonen LA.

Am J Pathol. 1999 Mar;154(3):677-81.

31.

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

Ylikorkala A, Avizienyte E, Tomlinson IP, Tiainen M, Roth S, Loukola A, Hemminki A, Johansson M, Sistonen P, Markie D, Neale K, Phillips R, Zauber P, Twama T, Sampson J, Järvinen H, Mäkelä TP, Aaltonen LA.

Hum Mol Genet. 1999 Jan;8(1):45-51.

PMID:
9887330
32.

Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.

Avizienyte E, Roth S, Loukola A, Hemminki A, Lothe RA, Stenwig AE, Fosså SD, Salovaara R, Aaltonen LA.

Cancer Res. 1998 May 15;58(10):2087-90.

33.

Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3.

Olschwang S, Markie D, Seal S, Neale K, Phillips R, Cottrell S, Ellis I, Hodgson S, Zauber P, Spigelman A, Iwama T, Loff S, McKeown C, Marchese C, Sampson J, Davies S, Talbot I, Wyke J, Thomas G, Bodmer W, Hemminki A, Avizienyte E, de la Chapelle A, Aaltonen L, Tomlinson I, et al.

J Med Genet. 1998 Jan;35(1):42-4.

34.

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Höglund P, Järvinen H, Kristo P, Pelin K, Ridanpää M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA.

Nature. 1998 Jan 8;391(6663):184-7.

PMID:
9428765

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