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Items: 1 to 50 of 124

1.

Computationally Assisted Discovery and Assignment of a Highly Strained and PANC-1 Selective Alkaloid from Alaska's Deep Ocean.

Zou Y, Wang X, Sims J, Wang B, Pandey P, Welsh CL, Stone RP, Avery MA, Doerksen RJ, Ferreira D, Anklin C, Valeriote FA, Kelly M, Hamann MT.

J Am Chem Soc. 2019 Mar 13;141(10):4338-4344. doi: 10.1021/jacs.8b11403. Epub 2019 Mar 5.

PMID:
30758203
2.

Design, Synthesis, and Biological Evaluation of Peptidomimetic N-Substituted Cbz-4-Hyp-Hpa-Amides as Novel Inhibitors of Plasmodium falciparum.

Bacherikov VA, Chittiboyina AG, Avery MA.

Chem Biodivers. 2017 Aug;14(8). doi: 10.1002/cbdv.201700037. Epub 2017 Aug 1.

PMID:
28498611
3.

Total synthesis of macrodiolide ionophores aplasmomycin A and boromycin via double ring contraction.

Avery MA, Choudhry SC, Dhingra OP, Gray BD, Kang MC, Kuo SC, Vedananda TR, White JD, Whittle AJ.

Org Biomol Chem. 2014 Dec 7;12(45):9116-32. doi: 10.1039/c4ob01017e.

PMID:
25096282
4.

UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.

Yang J, Liang Q, Wang M, Jeffries C, Smithson D, Tu Y, Boulos N, Jacob MR, Shelat AA, Wu Y, Ravu RR, Gilbertson R, Avery MA, Khan IA, Walker LA, Guy RK, Li XC.

J Nat Prod. 2014 Apr 25;77(4):902-9. doi: 10.1021/np4009706. Epub 2014 Mar 11.

5.

Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.

Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J, Rosenthal PJ, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1274-9. doi: 10.1016/j.bmcl.2014.01.062. Epub 2014 Jan 31.

PMID:
24507921
6.

Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs.

Porta EO, Carvalho PB, Avery MA, Tekwani BL, Labadie GR.

Steroids. 2014 Jan;79:28-36. doi: 10.1016/j.steroids.2013.10.010. Epub 2013 Nov 4.

PMID:
24200958
7.

Directed hydrogenation of acyclic homoallylic alcohols: enantioselective syntheses of (+)- and (-)-laurenditerpenol.

Chittiboyina AG, Peddikotla P, Avery MA, Khan IA.

J Org Chem. 2013 Sep 20;78(18):9223-32. doi: 10.1021/jo401461x. Epub 2013 Sep 11.

PMID:
23985032
8.

Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes.

Pulcini S, Staines HM, Pittman JK, Slavic K, Doerig C, Halbert J, Tewari R, Shah F, Avery MA, Haynes RK, Krishna S.

J Infect Dis. 2013 Aug 1;208(3):468-78. doi: 10.1093/infdis/jit171. Epub 2013 Apr 18.

PMID:
23599312
9.

Stevioside methanol tetra-solvate.

Wu Y, Rodenburg DL, Ibrahim MA, McChesney JD, Avery MA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 1;69(Pt 3):o410-1. doi: 10.1107/S1600536813003954. Epub 2013 Feb 20.

10.

Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide-endoperoxides to PfATP6.

Helal MA, Avery MA.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5410-4. doi: 10.1016/j.bmcl.2012.07.053. Epub 2012 Jul 20.

PMID:
22877631
11.

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.

Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, Ding A, Brown RH Jr, Conforti L, Coleman M, Tessier-Lavigne M, Züchner S, Freeman MR.

Science. 2012 Jul 27;337(6093):481-4. doi: 10.1126/science.1223899. Epub 2012 Jun 7.

12.

WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.

Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR.

Curr Biol. 2012 Apr 10;22(7):596-600. doi: 10.1016/j.cub.2012.02.043. Epub 2012 Mar 15.

13.

Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics.

Pabbisetty D, Illendula A, Muraleedharan KM, Chittiboyina AG, Williamson JS, Avery MA, Avery BA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:123-9. doi: 10.1016/j.jchromb.2012.02.007. Epub 2012 Feb 13.

PMID:
22365535
14.

Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis.

Shah F, Gut J, Legac J, Shivakumar D, Sherman W, Rosenthal PJ, Avery MA.

J Chem Inf Model. 2012 Mar 26;52(3):696-710. doi: 10.1021/ci2005516. Epub 2012 Feb 28.

PMID:
22332946
15.

Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library.

Shah F, Mukherjee P, Gut J, Legac J, Rosenthal PJ, Tekwani BL, Avery MA.

J Chem Inf Model. 2011 Apr 25;51(4):852-64. doi: 10.1021/ci200029y. Epub 2011 Mar 23.

PMID:
21428453
16.

New insights into the binding mode of melanin concentrating hormone receptor-1 antagonists: homology modeling and explicit membrane molecular dynamics simulation study.

Helal MA, Chittiboyina AG, Avery MA.

J Chem Inf Model. 2011 Mar 28;51(3):635-46. doi: 10.1021/ci100355c. Epub 2011 Mar 3.

17.

Chemical characterization of a commercial Commiphora wightii resin sample and chemical profiling to assess for authenticity.

Ahmed R, Ali Z, Wu Y, Kulkarni S, Avery MA, Choudhary MI, Khan IA.

Planta Med. 2011 Jun;77(9):945-50. doi: 10.1055/s-0030-1250674. Epub 2011 Jan 14.

PMID:
21240842
18.

Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.

Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y.

PLoS Negl Trop Dis. 2010 Oct 12;4(10):e849. doi: 10.1371/journal.pntd.0000849.

19.

Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents.

Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J, Rosenthal PJ, Avery MA.

J Med Chem. 2010 Nov 11;53(21):7864-8. doi: 10.1021/jm1006462.

PMID:
20945914
20.

Physicochemical characterization of berberine chloride: a perspective in the development of a solution dosage form for oral delivery.

Battu SK, Repka MA, Maddineni S, Chittiboyina AG, Avery MA, Majumdar S.

AAPS PharmSciTech. 2010 Sep;11(3):1466-75. doi: 10.1208/s12249-010-9520-y. Epub 2010 Sep 15.

21.

Asymmetric total synthesis of the caspase-1 inhibitor (-)-berkeleyamide A.

Kulkarni SJ, Pedduri Y, Chittiboyina AG, Avery MA.

J Org Chem. 2010 May 7;75(9):3113-6. doi: 10.1021/jo1001033.

PMID:
20356061
22.

Preparation and characterization of inclusion complexes of a hemisuccinate ester prodrug of delta9-tetrahydrocannabinol with modified beta-cyclodextrins.

Upadhye SB, Kulkarni SJ, Majumdar S, Avery MA, Gul W, ElSohly MA, Repka MA.

AAPS PharmSciTech. 2010 Jun;11(2):509-17. doi: 10.1208/s12249-010-9401-4. Epub 2010 Mar 24.

23.

Two prenylated and C-methylated flavonoids from Tripterygium wilfordii.

Zeng F, Wang W, Wu Y, Dey M, Ye M, Avery MA, Khan IA, Guo DA.

Planta Med. 2010 Oct;76(14):1596-9. doi: 10.1055/s-0029-1241017. Epub 2010 Mar 22.

PMID:
20309799
24.

Increasing springtime ozone mixing ratios in the free troposphere over western North America.

Cooper OR, Parrish DD, Stohl A, Trainer M, Nédélec P, Thouret V, Cammas JP, Oltmans SJ, Johnson BJ, Tarasick D, Leblanc T, McDermid IS, Jaffe D, Gao R, Stith J, Ryerson T, Aikin K, Campos T, Weinheimer A, Avery MA.

Nature. 2010 Jan 21;463(7279):344-8. doi: 10.1038/nature08708.

PMID:
20090751
25.

Design, synthesis, and docking studies of novel benzimidazoles for the treatment of metabolic syndrome.

Mizuno CS, Chittiboyina AG, Shah FH, Patny A, Kurtz TW, Pershadsingh HA, Speth RC, Karamyan VT, Carvalho PB, Avery MA.

J Med Chem. 2010 Feb 11;53(3):1076-85. doi: 10.1021/jm901272d.

PMID:
20073471
26.

Structure and function of Plasmodium falciparum malate dehydrogenase: role of critical amino acids in co-substrate binding pocket.

Pradhan A, Tripathi AK, Desai PV, Mukherjee PK, Avery MA, Walker LA, Tekwani BL.

Biochimie. 2009 Nov-Dec;91(11-12):1509-17. doi: 10.1016/j.biochi.2009.09.005. Epub 2009 Sep 20.

PMID:
19772885
27.

Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling.

Jain S, Abraham I, Carvalho P, Kuang YH, Shaala LA, Youssef DT, Avery MA, Chen ZS, El Sayed KA.

J Nat Prod. 2009 Jul;72(7):1291-8. doi: 10.1021/np900091y.

PMID:
19534474
28.

In vitro erythrocytic uptake studies of artemisinin and selected derivatives using LC-MS and 2D-QSAR analysis of uptake in parasitized erythrocytes.

Shah F, Zhang SQ, Kandhari SP, Mukherjee P, Chittiboyina A, Avery MA, Avery BA.

Bioorg Med Chem. 2009 Jul 15;17(14):5325-31. doi: 10.1016/j.bmc.2009.05.026. Epub 2009 May 18.

PMID:
19497754
29.

Progress in the development of peroxide-based anti-parasitic agents.

Muraleedharan KM, Avery MA.

Drug Discov Today. 2009 Aug;14(15-16):793-803. doi: 10.1016/j.drudis.2009.05.008. Epub 2009 May 27. Review.

PMID:
19477287
30.

Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.

Avery MA, Sheehan AE, Kerr KS, Wang J, Freeman MR.

J Cell Biol. 2009 Feb 23;184(4):501-13. doi: 10.1083/jcb.200808042.

31.

Analysis of quaternary structure of a [LDH-like] malate dehydrogenase of Plasmodium falciparum with oligomeric mutants.

Pradhan A, Mukherjee P, Tripathi AK, Avery MA, Walker LA, Tekwani BL.

Mol Cell Biochem. 2009 May;325(1-2):141-8. doi: 10.1007/s11010-009-0028-2. Epub 2009 Jan 29.

PMID:
19184366
32.

3,3',5,5'-Tetra-nitro-biphen-yl.

Hammond N, Carvalho P, Wu Y, Avery MA.

Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 18;65(Pt 5):o1052-3. doi: 10.1107/S1600536809011088.

33.

(2S,4aR,6aR,7R,9S,10aS,10bR)-7-Carb-oxy-2-(3-fur-yl)-6a,10b-dimethyl-4,10-dioxoperhydro-benzo[f]isochromen-9-yl acetate.

Carvalho P, Kutrzeba LM, Zjawiony JK, Avery MA.

Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 6;65(Pt 3):o471-2. doi: 10.1107/S1600536809002074.

34.

5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-perhydro-3,12-ep-oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth-yl}benzene-1,3-diol.

Gul W, Carvalho P, Galal A, Avery MA, El Sohly MA.

Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 23;65(Pt 2):o358-9. doi: 10.1107/S1600536809002050.

35.

Cycloartane glycosides from Sutherlandia frutescens.

Fu X, Li XC, Smillie TJ, Carvalho P, Mabusela W, Syce J, Johnson Q, Folk W, Avery MA, Khan IA.

J Nat Prod. 2008 Oct;71(10):1749-53. doi: 10.1021/np800328r. Epub 2008 Sep 23.

36.

Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry.

Zhang SQ, Vinnakota H, Jung JC, Carvalho P, Chittiboyina AG, Avery MA, Avery BA.

Biomed Chromatogr. 2009 Mar;23(3):302-7. doi: 10.1002/bmc.1114.

PMID:
18800336
37.

1,3-Diaxially substituted trans-decalins: potential nonsteroidal human progesterone receptor inhibitors.

Li Z, Watkins EB, Liu H, Chittiboyina AG, Carvalho PB, Avery MA.

J Org Chem. 2008 Oct 3;73(19):7764-7. doi: 10.1021/jo800947m. Epub 2008 Sep 5.

PMID:
18771323
38.

Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides.

Rando DG, Avery MA, Tekwani BL, Khan SI, Ferreira EI.

Bioorg Med Chem. 2008 Jul 15;16(14):6724-31. doi: 10.1016/j.bmc.2008.05.076. Epub 2008 Jun 5.

PMID:
18571927
39.

QM/QM studies for Michael reaction in coronavirus main protease (3CL Pro).

Taranto AG, Carvalho P, Avery MA.

J Mol Graph Model. 2008 Oct;27(3):275-85. doi: 10.1016/j.jmgm.2008.05.002. Epub 2008 May 9.

PMID:
18567519
40.

Structural analysis of farnesyl pyrophosphate synthase from parasitic protozoa, a potential chemotherapeutic target.

Srivastava A, Mukherjee P, Desai PV, Avery MA, Tekwani BL.

Infect Disord Drug Targets. 2008 Mar;8(1):16-30. Review.

PMID:
18473904
41.

Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa.

Ali Z, Ferreira D, Carvalho P, Avery MA, Khan IA.

J Nat Prod. 2008 Jun;71(6):1111-2. doi: 10.1021/np800172x. Epub 2008 May 10.

PMID:
18471018
42.

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.

Ziegenfuss JS, Biswas R, Avery MA, Hong K, Sheehan AE, Yeung YG, Stanley ER, Freeman MR.

Nature. 2008 Jun 12;453(7197):935-9. doi: 10.1038/nature06901. Epub 2008 Apr 23.

43.

Probing the structures of leishmanial farnesyl pyrophosphate synthases: homology modeling and docking studies.

Mukherjee P, Desai PV, Srivastava A, Tekwani BL, Avery MA.

J Chem Inf Model. 2008 May;48(5):1026-40. doi: 10.1021/ci700355z. Epub 2008 Apr 18.

PMID:
18419114
44.

Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.

Mukherjee P, Pradhan A, Shah F, Tekwani BL, Avery MA.

Bioorg Med Chem. 2008 May 1;16(9):5254-65. doi: 10.1016/j.bmc.2008.03.005. Epub 2008 Mar 6.

PMID:
18362073
45.

Ultra-performance liquid chromatography-tandem mass spectrometric method for the determination of Artemisinin in rat serum and its application in pharmacokinetics.

Li L, Pabbisetty D, Carvalho P, Avery MA, Williamson JS, Avery BA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):131-7. doi: 10.1016/j.jchromb.2008.01.057. Epub 2008 Feb 20.

PMID:
18353736
46.

Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits.

Mukherjee P, Desai P, Ross L, White EL, Avery MA.

Bioorg Med Chem. 2008 Apr 1;16(7):4138-49. doi: 10.1016/j.bmc.2008.01.011. Epub 2008 Jan 11.

PMID:
18343121
47.

Urinary excretion study of coenzyme Q10 in rats by ultra-performance liquid chromatography-mass spectrometry.

Li L, Pabbisetty D, Zhu S, Avery MA, Avery BA.

J Chromatogr Sci. 2008 Mar;46(3):215-9.

PMID:
18334087
48.

Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.

Mizuno CS, Ma G, Khan S, Patny A, Avery MA, Rimando AM.

Bioorg Med Chem. 2008 Apr 1;16(7):3800-8. doi: 10.1016/j.bmc.2008.01.051. Epub 2008 Jan 31.

PMID:
18272370
49.

The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs.

Choi SR, Mukherjee P, Avery MA.

Curr Med Chem. 2008;15(2):161-71. Review.

PMID:
18220771
50.

Type 2 diabetes and oral antihyperglycemic drugs.

Mizuno CS, Chittiboyina AG, Kurtz TW, Pershadsingh HA, Avery MA.

Curr Med Chem. 2008;15(1):61-74. Review.

PMID:
18220763

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