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Items: 1 to 50 of 178

1.

Cigarette Smoke Toxins-induced mitochondrial dysfunction and pancreatitis involves Aryl hydrocarbon receptor mediated Cyp1 gene expression: protective effects of resveratrol.

Ghosh J, Roy Chowdhury A, Srinivasan S, Chattopadhyay M, Bose M, Bhattacharya S, Raza H, Fuchs SY, Rustgi AK, Gonzalez FJ, Avadhani NG.

Toxicol Sci. 2018 Aug 25. doi: 10.1093/toxsci/kfy206. [Epub ahead of print]

PMID:
30165701
2.

Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects.

Guha M, Srinivasan S, Raman P, Jiang Y, Kaufman BA, Taylor D, Dong D, Chakrabarti R, Picard M, Carstens RP, Kijima Y, Feldman M, Avadhani NG.

Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):1060-1071. doi: 10.1016/j.bbadis.2018.01.002. Epub 2018 Jan 5.

PMID:
29309924
3.

β-Naphthoflavone-Induced Mitochondrial Respiratory Damage in Cyp1 Knockout Mouse and in Cell Culture Systems: Attenuation by Resveratrol Treatment.

Anandasadagopan SK, Singh NM, Raza H, Bansal S, Selvaraj V, Singh S, Chowdhury AR, Leu NA, Avadhani NG.

Oxid Med Cell Longev. 2017;2017:5213186. doi: 10.1155/2017/5213186. Epub 2017 Sep 14.

4.

Blocking FSH induces thermogenic adipose tissue and reduces body fat.

Liu P, Ji Y, Yuen T, Rendina-Ruedy E, DeMambro VE, Dhawan S, Abu-Amer W, Izadmehr S, Zhou B, Shin AC, Latif R, Thangeswaran P, Gupta A, Li J, Shnayder V, Robinson ST, Yu YE, Zhang X, Yang F, Lu P, Zhou Y, Zhu LL, Oberlin DJ, Davies TF, Reagan MR, Brown A, Kumar TR, Epstein S, Iqbal J, Avadhani NG, New MI, Molina H, van Klinken JB, Guo EX, Buettner C, Haider S, Bian Z, Sun L, Rosen CJ, Zaidi M.

Nature. 2017 Jun 1;546(7656):107-112. doi: 10.1038/nature22342. Epub 2017 May 24.

5.

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Sepuri NBV, Angireddy R, Srinivasan S, Guha M, Spear J, Lu B, Anandatheerthavarada HK, Suzuki CK, Avadhani NG.

Biochim Biophys Acta Bioenerg. 2017 Jul;1858(7):519-528. doi: 10.1016/j.bbabio.2017.04.003. Epub 2017 Apr 23.

6.

Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance.

Whelan KA, Chandramouleeswaran PM, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, Darling DS, Kita Y, Natsugoe S, Winkler JD, Klein-Szanto AJ, Amaravadi RK, Avadhani NG, Rustgi AK, Nakagawa H.

Oncogene. 2017 Aug 24;36(34):4843-4858. doi: 10.1038/onc.2017.102. Epub 2017 Apr 17.

7.

Mitochondrial dysfunction and mitochondrial dynamics-The cancer connection.

Srinivasan S, Guha M, Kashina A, Avadhani NG.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):602-614. doi: 10.1016/j.bbabio.2017.01.004. Epub 2017 Jan 16. Review.

8.

HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression.

Guha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang JK, Klein Szanto A, Nakagawa H, Basha J, Kundu T, Avadhani NG.

Cell Discov. 2016 Dec 6;2:16045. eCollection 2016.

9.

Mitochondrial stress-induced p53 attenuates HIF-1α activity by physical association and enhanced ubiquitination.

Chowdhury AR, Long A, Fuchs SY, Rustgi A, Avadhani NG.

Oncogene. 2017 Jan 19;36(3):397-409. doi: 10.1038/onc.2016.211. Epub 2016 Jun 27.

10.

Mitochondrial respiratory defects promote the Warburg effect and cancer progression.

Srinivasan S, Guha M, Avadhani NG.

Mol Cell Oncol. 2015 Dec 10;3(2):e1085120. doi: 10.1080/23723556.2015.1085120. eCollection 2016 Mar.

11.

ALDH2 modulates autophagy flux to regulate acetaldehyde-mediated toxicity thresholds.

Tanaka K, Whelan KA, Chandramouleeswaran PM, Kagawa S, Rustgi SL, Noguchi C, Guha M, Srinivasan S, Amanuma Y, Ohashi S, Muto M, Klein-Szanto AJ, Noguchi E, Avadhani NG, Nakagawa H.

Am J Cancer Res. 2016 Mar 15;6(4):781-96. eCollection 2016.

12.

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.

Zhang G, Frederick DT, Wu L, Wei Z, Krepler C, Srinivasan S, Chae YC, Xu X, Choi H, Dimwamwa E, Ope O, Shannan B, Basu D, Zhang D, Guha M, Xiao M, Randell S, Sproesser K, Xu W, Liu J, Karakousis GC, Schuchter LM, Gangadhar TC, Amaravadi RK, Gu M, Xu C, Ghosh A, Xu W, Tian T, Zhang J, Zha S, Liu Q, Brafford P, Weeraratna A, Davies MA, Wargo JA, Avadhani NG, Lu Y, Mills GB, Altieri DC, Flaherty KT, Herlyn M.

J Clin Invest. 2016 May 2;126(5):1834-56. doi: 10.1172/JCI82661. Epub 2016 Apr 4.

13.

Defects in cytochrome c oxidase expression induce a metabolic shift to glycolysis and carcinogenesis.

Dong DW, Srinivasan S, Guha M, Avadhani NG.

Genom Data. 2015 Aug 14;6:99-107. doi: 10.1016/j.gdata.2015.07.031. eCollection 2015 Dec.

14.

Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.

Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG.

Oncogene. 2016 Mar 24;35(12):1585-95. doi: 10.1038/onc.2015.227. Epub 2015 Jul 6.

15.

Enhanced osteoclastogenesis by mitochondrial retrograde signaling through transcriptional activation of the cathepsin K gene.

Guha M, Srinivasan S, Koenigstein A, Zaidi M, Avadhani NG.

Ann N Y Acad Sci. 2016 Jan;1364:52-61. doi: 10.1111/nyas.12709. Epub 2015 Mar 18.

16.

Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression.

Kinugasa H, Whelan KA, Tanaka K, Natsuizaka M, Long A, Guo A, Chang S, Kagawa S, Srinivasan S, Guha M, Yamamoto K, St Clair DK, Avadhani NG, Diehl JA, Nakagawa H.

Oncogene. 2015 Oct 8;34(41):5229-39. doi: 10.1038/onc.2014.449. Epub 2015 Feb 9.

17.

Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.

Bajpai P, Srinivasan S, Ghosh J, Nagy LD, Wei S, Guengerich FP, Avadhani NG.

J Biol Chem. 2014 Oct 24;289(43):29614-30. doi: 10.1074/jbc.M114.583062. Epub 2014 Aug 26.

18.

Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction.

Bansal S, Leu AN, Gonzalez FJ, Guengerich FP, Chowdhury AR, Anandatheerthavarada HK, Avadhani NG.

J Biol Chem. 2014 Apr 4;289(14):9936-51. doi: 10.1074/jbc.M113.525659. Epub 2014 Feb 4.

19.

Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity.

Bansal S, Biswas G, Avadhani NG.

Redox Biol. 2013 Jul 23;2:273-83. doi: 10.1016/j.redox.2013.07.004. eCollection 2014.

20.

Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury.

Bhattacharya S, Katlinski KV, Reichert M, Takano S, Brice A, Zhao B, Yu Q, Zheng H, Carbone CJ, Katlinskaya YV, Leu NA, McCorkell KA, Srinivasan S, Girondo M, Rui H, May MJ, Avadhani NG, Rustgi AK, Fuchs SY.

EMBO Mol Med. 2014 Mar;6(3):384-97. doi: 10.1002/emmm.201303236. Epub 2014 Jan 30.

21.

Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.

Guha M, Srinivasan S, Ruthel G, Kashina AK, Carstens RP, Mendoza A, Khanna C, Van Winkle T, Avadhani NG.

Oncogene. 2014 Nov 6;33(45):5238-50. doi: 10.1038/onc.2013.467. Epub 2013 Nov 4.

22.

Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction.

Srinivasan S, Spear J, Chandran K, Joseph J, Kalyanaraman B, Avadhani NG.

PLoS One. 2013 Oct 10;8(10):e77129. doi: 10.1371/journal.pone.0077129. eCollection 2013.

23.

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics.

Guha M, Avadhani NG.

Mitochondrion. 2013 Nov;13(6):577-91. doi: 10.1016/j.mito.2013.08.007. Epub 2013 Sep 1. Review.

24.

Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.

Iqbal J, Sun L, Cao J, Yuen T, Lu P, Bab I, Leu NA, Srinivasan S, Wagage S, Hunter CA, Nebert DW, Zaidi M, Avadhani NG.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11115-20. doi: 10.1073/pnas.1220919110. Epub 2013 Jun 17.

25.

Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

Bansal S, Anandatheerthavarada HK, Prabu GK, Milne GL, Martin MV, Guengerich FP, Avadhani NG.

J Biol Chem. 2013 May 3;288(18):12627-44. doi: 10.1074/jbc.M113.452367. Epub 2013 Mar 7.

26.

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.

Bajpai P, Sangar MC, Singh S, Tang W, Bansal S, Chowdhury G, Cheng Q, Fang JK, Martin MV, Guengerich FP, Avadhani NG.

J Biol Chem. 2013 Feb 8;288(6):4436-51. doi: 10.1074/jbc.M112.402123. Epub 2012 Dec 20.

27.

Mitochondrial dysfunction in myocardium obtained from clinically normal dogs, clinically normal anesthetized dogs, and dogs with dilated cardiomyopathy.

Sleeper MM, Rosato BP, Bansal S, Avadhani NG.

Am J Vet Res. 2012 Nov;73(11):1759-64. doi: 10.2460/ajvr.73.11.1759.

PMID:
23106461
28.

Cytochrome c oxidase dysfunction in oxidative stress.

Srinivasan S, Avadhani NG.

Free Radic Biol Med. 2012 Sep 15;53(6):1252-63. doi: 10.1016/j.freeradbiomed.2012.07.021. Epub 2012 Jul 25. Review.

29.

Silencing of IkBβ mRNA causes disruption of mitochondrial retrograde signaling and suppression of tumor growth in vivo.

Tang W, Chowdhury AR, Guha M, Huang L, Van Winkle T, Rustgi AK, Avadhani NG.

Carcinogenesis. 2012 Sep;33(9):1762-8. doi: 10.1093/carcin/bgs190. Epub 2012 May 27.

30.

Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.

Bansal S, Srinivasan S, Anandasadagopan S, Chowdhury AR, Selvaraj V, Kalyanaraman B, Joseph J, Avadhani NG.

J Biol Chem. 2012 May 4;287(19):15284-97. doi: 10.1074/jbc.M111.314062. Epub 2012 Mar 6.

31.

Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.

Ren L, Hong SH, Chen QR, Briggs J, Cassavaugh J, Srinivasan S, Lizardo MM, Mendoza A, Xia AY, Avadhani N, Khan J, Khanna C.

Cancer Res. 2012 Feb 15;72(4):1001-12. doi: 10.1158/0008-5472.CAN-11-0210. Epub 2011 Dec 6.

32.

Targeting of the same proteins to multiple subcellular destinations: mechanisms and physiological implications.

Avadhani NG.

FEBS J. 2011 Nov;278(22):4217. doi: 10.1111/j.1742-4658.2011.08355.x. Epub 2011 Oct 24. No abstract available.

33.

Bimodal targeting of cytochrome P450s to endoplasmic reticulum and mitochondria: the concept of chimeric signals.

Avadhani NG, Sangar MC, Bansal S, Bajpai P.

FEBS J. 2011 Nov;278(22):4218-29. doi: 10.1111/j.1742-4658.2011.08356.x. Epub 2011 Oct 24. Review.

34.

The effects of smoke carcinogens on bone.

Yan C, Avadhani NG, Iqbal J.

Curr Osteoporos Rep. 2011 Dec;9(4):202-9. doi: 10.1007/s11914-011-0068-x. Review.

PMID:
21874290
35.

Impaired mitochondrial respiratory functions and oxidative stress in streptozotocin-induced diabetic rats.

Raza H, Prabu SK, John A, Avadhani NG.

Int J Mol Sci. 2011;12(5):3133-47. doi: 10.3390/ijms12053133. Epub 2011 May 13.

36.

Cell signaling.

Iqbal J, Zaidi M, Avadhani NG.

Ann N Y Acad Sci. 2010 Nov;1211:3-8. doi: 10.1111/j.1749-6632.2010.05811.x. Review.

PMID:
21062291
37.

Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2.

Guha M, Fang JK, Monks R, Birnbaum MJ, Avadhani NG.

Mol Biol Cell. 2010 Oct 15;21(20):3578-89. doi: 10.1091/mbc.E10-03-0192. Epub 2010 Aug 18.

38.

Leucine-rich pentatricopeptide-repeat containing protein regulates mitochondrial transcription.

Sondheimer N, Fang JK, Polyak E, Falk MJ, Avadhani NG.

Biochemistry. 2010 Sep 7;49(35):7467-73. doi: 10.1021/bi1008479.

39.

Bimodal targeting of microsomal cytochrome P450s to mitochondria: implications in drug metabolism and toxicity.

Sangar MC, Bansal S, Avadhani NG.

Expert Opin Drug Metab Toxicol. 2010 Oct;6(10):1231-51. doi: 10.1517/17425255.2010.503955. Review.

40.

Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.

Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG.

J Biol Chem. 2010 Aug 6;285(32):24609-19. doi: 10.1074/jbc.M110.121822. Epub 2010 Jun 7.

41.

Role of mitochondrial reactive oxygen species in osteoclast differentiation.

Srinivasan S, Koenigstein A, Joseph J, Sun L, Kalyanaraman B, Zaidi M, Avadhani NG.

Ann N Y Acad Sci. 2010 Mar;1192:245-52. doi: 10.1111/j.1749-6632.2009.05377.x.

42.

Role of calcineurin, hnRNPA2 and Akt in mitochondrial respiratory stress-mediated transcription activation of nuclear gene targets.

Guha M, Tang W, Sondheimer N, Avadhani NG.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1055-65. doi: 10.1016/j.bbabio.2010.02.008. Epub 2010 Feb 11.

43.

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting.

Sangar MC, Anandatheerthavarada HK, Martin MV, Guengerich FP, Avadhani NG.

Mol Genet Metab. 2010 Jan;99(1):90-7. doi: 10.1016/j.ymgme.2009.08.009.

44.

Heterogeneous nuclear ribonucleoprotein A2 is a common transcriptional coactivator in the nuclear transcription response to mitochondrial respiratory stress.

Guha M, Pan H, Fang JK, Avadhani NG.

Mol Biol Cell. 2009 Sep;20(18):4107-19. doi: 10.1091/mbc.E09-04-0296. Epub 2009 Jul 29.

45.

Human liver mitochondrial cytochrome P450 2D6--individual variations and implications in drug metabolism.

Sangar MC, Anandatheerthavarada HK, Tang W, Prabu SK, Martin MV, Dostalek M, Guengerich FP, Avadhani NG.

FEBS J. 2009 Jul;276(13):3440-53. doi: 10.1111/j.1742-4658.2009.07067.x. Epub 2009 May 11.

46.

Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism.

Anandatheerthavarada HK, Sepuri NB, Avadhani NG.

J Biol Chem. 2009 Jun 19;284(25):17352-63. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28.

47.

Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: implications in mitochondrial dysfunction and ROS production.

Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, Kalyanaraman B, Avadhani NG.

Biochem J. 2009 May 27;420(3):439-49. doi: 10.1042/BJ20090214.

48.

Doxorubicin inactivates myocardial cytochrome c oxidase in rats: cardioprotection by Mito-Q.

Chandran K, Aggarwal D, Migrino RQ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, Kalyanaraman B.

Biophys J. 2009 Feb 18;96(4):1388-98. doi: 10.1016/j.bpj.2008.10.042.

49.

An unusual TOM20/TOM22 bypass mechanism for the mitochondrial targeting of cytochrome P450 proteins containing N-terminal chimeric signals.

Anandatheerthavarada HK, Sepuri NB, Biswas G, Avadhani NG.

J Biol Chem. 2008 Dec 19;283(51):36060. No abstract available.

50.

Function of mitochondrial Stat3 in cellular respiration.

Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC.

Science. 2009 Feb 6;323(5915):793-7. doi: 10.1126/science.1164551. Epub 2009 Jan 8.

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