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Items: 1 to 50 of 103

1.

Phase separation and clustering of an ABC transporter in Mycobacterium tuberculosis.

Heinkel F, Abraham L, Ko M, Chao J, Bach H, Hui LT, Li H, Zhu M, Ling YM, Rogalski JC, Scurll J, Bui JM, Mayor T, Gold MR, Chou KC, Av-Gay Y, McIntosh LP, Gsponer J.

Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16326-16331. doi: 10.1073/pnas.1820683116. Epub 2019 Jul 31.

PMID:
31366629
2.

S-Nitrosylation of α1-Antitrypsin Triggers Macrophages Toward Inflammatory Phenotype and Enhances Intra-Cellular Bacteria Elimination.

Kaner Z, Engelman R, Schuster R, Rider P, Greenberg D, Av-Gay Y, Benhar M, Lewis EC.

Front Immunol. 2019 Apr 2;10:590. doi: 10.3389/fimmu.2019.00590. eCollection 2019.

3.

Screening of Preselected Libraries Targeting Mycobacterium abscessus for Drug Discovery.

Richter A, Strauch A, Chao J, Ko M, Av-Gay Y.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00828-18. doi: 10.1128/AAC.00828-18. Print 2018 Sep.

4.

Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747.

Heinkel F, Shen L, Richard-Greenblatt M, Okon M, Bui JM, Gee CL, Gay LM, Alber T, Av-Gay Y, Gsponer J, McIntosh LP.

Structure. 2018 Jul 3;26(7):972-986.e6. doi: 10.1016/j.str.2018.04.018. Epub 2018 May 31.

5.

Synthesis, antimycobacterial activity and influence on mycobacterial InhA and PknB of 12-membered cyclodepsipeptides.

Laqua K, Klemm M, Richard-Greenblatt M, Richter A, Liebe L, Huang T, Lin S, Guardia A, Pérez-Herran E, Ballell L, Av-Gay Y, Imming P.

Bioorg Med Chem. 2018 Jul 23;26(12):3166-3190. doi: 10.1016/j.bmc.2018.04.045. Epub 2018 Apr 22.

PMID:
29706526
6.

Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages.

Wong D, Li W, Chao JD, Zhou P, Narula G, Tsui C, Ko M, Xie J, Martinez-Frailes C, Av-Gay Y.

Sci Rep. 2018 Jan 9;8(1):155. doi: 10.1038/s41598-017-18547-9.

7.

Nitric oxide inhalations in bronchiolitis: A pilot, randomized, double-blinded, controlled trial.

Tal A, Greenberg D, Av-Gay Y, Golan-Tripto I, Feinstein Y, Ben-Shimol S, Dagan R, Goldbart AD.

Pediatr Pulmonol. 2018 Jan;53(1):95-102. doi: 10.1002/ppul.23905. Epub 2017 Nov 27.

PMID:
29178284
8.

Genome Sequences of the Mycobacterium tuberculosis H37Rv-ptkA Deletion Mutant and Its Parental Strain.

Tsui CKM, Wong D, Narula G, Gardy JL, Hsiao WWH, Av-Gay Y.

Genome Announc. 2017 Nov 2;5(44). pii: e01156-17. doi: 10.1128/genomeA.01156-17.

9.
10.

Nitric oxide charged catheters as a potential strategy for prevention of hospital acquired infections.

Margel D, Mizrahi M, Regev-Shoshani G, Ko M, Moshe M, Ozalvo R, Shavit-Grievink L, Baniel J, Kedar D, Yossepowitch O, Lifshitz D, Nadu A, Greenberg D, Av-Gay Y.

PLoS One. 2017 Apr 14;12(4):e0174443. doi: 10.1371/journal.pone.0174443. eCollection 2017.

11.

Epigenetic Phosphorylation Control of Mycobacterium tuberculosis Infection and Persistence.

Richard-Greenblatt M, Av-Gay Y.

Microbiol Spectr. 2017 Mar;5(2). doi: 10.1128/microbiolspec.TBTB2-0005-2015. Review.

PMID:
28281439
12.

Aminorifamycins and Sporalactams Produced in Culture by a Micromonospora sp. Isolated from a Northeastern-Pacific Marine Sediment Are Potent Antibiotics.

Williams DE, Dalisay DS, Chen J, Polishchuck EA, Patrick BO, Narula G, Ko M, Av-Gay Y, Li H, Magarvey N, Andersen RJ.

Org Lett. 2017 Feb 17;19(4):766-769. doi: 10.1021/acs.orglett.6b03619. Epub 2017 Feb 6.

PMID:
28164711
13.

Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms.

Poirier V, Av-Gay Y.

Microbiol Spectr. 2015 Dec;3(6). doi: 10.1128/microbiolspec.VMBF-0003-2014. Review.

PMID:
27337278
14.

Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis.

Saini V, Cumming BM, Guidry L, Lamprecht DA, Adamson JH, Reddy VP, Chinta KC, Mazorodze JH, Glasgow JN, Richard-Greenblatt M, Gomez-Velasco A, Bach H, Av-Gay Y, Eoh H, Rhee K, Steyn AJC.

Cell Rep. 2016 Jan 26;14(3):572-585. doi: 10.1016/j.celrep.2015.12.056. Epub 2016 Jan 7.

15.

Development of an Intracellular Screen for New Compounds Able To Inhibit Mycobacterium tuberculosis Growth in Human Macrophages.

Sorrentino F, Gonzalez del Rio R, Zheng X, Presa Matilla J, Torres Gomez P, Martinez Hoyos M, Perez Herran ME, Mendoza Losana A, Av-Gay Y.

Antimicrob Agents Chemother. 2015 Oct 26;60(1):640-5. doi: 10.1128/AAC.01920-15. Print 2016 Jan.

16.

Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases.

Zhou P, Wong D, Li W, Xie J, Av-Gay Y.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):421-6. doi: 10.1016/j.bbrc.2015.09.124. Epub 2015 Sep 26.

PMID:
26417687
17.

Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.

Richard-Greenblatt M, Bach H, Adamson J, Peña-Diaz S, Li W, Steyn AJ, Av-Gay Y.

J Biol Chem. 2015 Sep 18;290(38):23064-76. doi: 10.1074/jbc.M115.648642. Epub 2015 Jul 30.

18.

Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis.

Hmama Z, Peña-Díaz S, Joseph S, Av-Gay Y.

Immunol Rev. 2015 Mar;264(1):220-32. doi: 10.1111/imr.12268. Review.

PMID:
25703562
19.

Phosphorylation control of protein tyrosine phosphatase A activity in Mycobacterium tuberculosis.

Zhou P, Li W, Wong D, Xie J, Av-Gay Y.

FEBS Lett. 2015 Jan 30;589(3):326-31. doi: 10.1016/j.febslet.2014.12.015. Epub 2014 Dec 20.

20.

Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α.

Poirier V, Bach H, Av-Gay Y.

J Biol Chem. 2014 Oct 17;289(42):29376-85. doi: 10.1074/jbc.M114.582502. Epub 2014 Sep 3.

21.

Microbial protein-tyrosine kinases.

Chao JD, Wong D, Av-Gay Y.

J Biol Chem. 2014 Apr 4;289(14):9463-72. doi: 10.1074/jbc.R113.520015. Epub 2014 Feb 19. Review.

22.

Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.

Sun J, Singh V, Lau A, Stokes RW, Obregón-Henao A, Orme IM, Wong D, Av-Gay Y, Hmama Z.

PLoS Pathog. 2013;9(7):e1003499. doi: 10.1371/journal.ppat.1003499. Epub 2013 Jul 18.

23.

Gaseous nitric oxide reduces influenza infectivity in vitro.

Regev-Shoshani G, Vimalanathan S, McMullin B, Road J, Av-Gay Y, Miller C.

Nitric Oxide. 2013 May 31;31:48-53. doi: 10.1016/j.niox.2013.03.007. Epub 2013 Apr 2.

PMID:
23562771
24.

Antimicrobial activity, cytotoxicity and inflammatory response of novel plastics embedded with silver nanoparticles.

Martínez-Gutiérrez F, Guajardo-Pacheco JM, Noriega-Trevino ME, Thi EP, Reiner N, Orrantia E, Av-Gay Y, Ruiz F, Bach H.

Future Microbiol. 2013 Mar;8(3):403-11. doi: 10.2217/fmb.13.5.

PMID:
23464375
25.

Disruption of the serine/threonine protein kinase H affects phthiocerol dimycocerosates synthesis in Mycobacterium tuberculosis.

Gómez-Velasco A, Bach H, Rana AK, Cox LR, Bhatt A, Besra GS, Av-Gay Y.

Microbiology. 2013 Apr;159(Pt 4):726-36. doi: 10.1099/mic.0.062067-0. Epub 2013 Feb 14.

26.

Mycobacterium tuberculosis-secreted phosphatases: from pathogenesis to targets for TB drug development.

Wong D, Chao JD, Av-Gay Y.

Trends Microbiol. 2013 Feb;21(2):100-9. doi: 10.1016/j.tim.2012.09.002. Epub 2012 Oct 16. Review.

PMID:
23084287
27.

Chemical constituents, anti-inflammatory and antioxidant activities of bark extracts from Prunus tucumanensis Lillo.

Bach SM, Perotti ME, Merep AP, Marcial GE, Grau A, Attarian R, Av-Gay Y, Bach H, Catalán CA.

Nat Prod Res. 2013;27(10):916-9. doi: 10.1080/14786419.2012.668693. Epub 2012 Mar 9.

PMID:
22889184
28.

Mycobacterium tuberculosis modulators of the macrophage's cellular events.

Poirier V, Av-Gay Y.

Microbes Infect. 2012 Nov;14(13):1211-9. doi: 10.1016/j.micinf.2012.07.001. Epub 2012 Jul 25. Review.

PMID:
22841679
29.

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Laennecia confusa.

Martínez Ruiz MG, Richard-Greenblatt M, Juárez ZN, Av-Gay Y, Bach H, Hernández LR.

ScientificWorldJournal. 2012;2012:263572. doi: 10.1100/2012/263572. Epub 2012 Apr 30.

30.

Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

Lam KK, Zheng X, Forestieri R, Balgi AD, Nodwell M, Vollett S, Anderson HJ, Andersen RJ, Av-Gay Y, Roberge M.

PLoS Pathog. 2012;8(5):e1002691. doi: 10.1371/journal.ppat.1002691. Epub 2012 May 10.

31.

A phase I clinical study of inhaled nitric oxide in healthy adults.

Miller C, Miller M, McMullin B, Regev G, Serghides L, Kain K, Road J, Av-Gay Y.

J Cyst Fibros. 2012 Jul;11(4):324-31. doi: 10.1016/j.jcf.2012.01.003. Epub 2012 Apr 18.

32.

Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+-ATPase to inhibit phagosome acidification.

Wong D, Bach H, Sun J, Hmama Z, Av-Gay Y.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19371-6. doi: 10.1073/pnas.1109201108. Epub 2011 Nov 15.

33.

The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance.

Burian J, Ramón-García S, Sweet G, Gómez-Velasco A, Av-Gay Y, Thompson CJ.

J Biol Chem. 2012 Jan 2;287(1):299-310. doi: 10.1074/jbc.M111.302588. Epub 2011 Nov 8.

34.

Antimicrobial activities of sesquiterpene lactones and inositol derivatives from Hymenoxys robusta.

Fortuna AM, Juárez ZN, Bach H, Nematallah A, Av-Gay Y, Sánchez-Arreola E, Catalán CA, Turbay S, Hernández LR.

Phytochemistry. 2011 Dec;72(18):2413-8. doi: 10.1016/j.phytochem.2011.09.001. Epub 2011 Sep 28.

PMID:
21963130
35.

Comparative efficacy of commercially available and emerging antimicrobial urinary catheters against bacteriuria caused by E. coli in vitro.

Regev-Shoshani G, Ko M, Crowe A, Av-Gay Y.

Urology. 2011 Aug;78(2):334-9. doi: 10.1016/j.urology.2011.02.063.

PMID:
21820571
36.

Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.

Martínez-Gutierrez F, Thi EP, Silverman JM, de Oliveira CC, Svensson SL, Vanden Hoek A, Sánchez EM, Reiner NE, Gaynor EC, Pryzdial EL, Conway EM, Orrantia E, Ruiz F, Av-Gay Y, Bach H.

Nanomedicine. 2012 Apr;8(3):328-36. doi: 10.1016/j.nano.2011.06.014. Epub 2011 Jun 28.

PMID:
21718674
37.

Coresistance to isoniazid and ethionamide maps to mycothiol biosynthetic genes in Mycobacterium bovis.

Vilchèze C, Av-Gay Y, Barnes SW, Larsen MH, Walker JR, Glynne RJ, Jacobs WR Jr.

Antimicrob Agents Chemother. 2011 Sep;55(9):4422-3. doi: 10.1128/AAC.00564-11. Epub 2011 Jun 27.

38.

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum.

Bolivar P, Cruz-Paredes C, Hernández LR, Juárez ZN, Sánchez-Arreola E, Av-Gay Y, Bach H.

J Ethnopharmacol. 2011 Sep 1;137(1):141-7. doi: 10.1016/j.jep.2011.04.069. Epub 2011 May 6.

PMID:
21586319
39.

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.

Ramón-García S, Ng C, Anderson H, Chao JD, Zheng X, Pfeifer T, Av-Gay Y, Roberge M, Thompson CJ.

Antimicrob Agents Chemother. 2011 Aug;55(8):3861-9. doi: 10.1128/AAC.00474-11. Epub 2011 May 16.

40.

Precise null deletion mutations of the mycothiol synthesis genes reveal their role in isoniazid and ethionamide resistance in Mycobacterium smegmatis.

Xu X, Vilchèze C, Av-Gay Y, Gómez-Velasco A, Jacobs WR Jr.

Antimicrob Agents Chemother. 2011 Jul;55(7):3133-9. doi: 10.1128/AAC.00020-11. Epub 2011 Apr 18.

41.

Antibacterial and cytotoxic activities of the sesquiterpene lactones cnicin and onopordopicrin.

Bach SM, Fortuna MA, Attarian R, de Trimarco JT, Catalán CA, Av-Gay Y, Bach H.

Nat Prod Commun. 2011 Feb;6(2):163-6.

PMID:
21425665
42.

MmpS4 promotes glycopeptidolipids biosynthesis and export in Mycobacterium smegmatis.

Deshayes C, Bach H, Euphrasie D, Attarian R, Coureuil M, Sougakoff W, Laval F, Av-Gay Y, Daffé M, Etienne G, Reyrat JM.

Mol Microbiol. 2010 Nov;78(4):989-1003. doi: 10.1111/j.1365-2958.2010.07385.x. Epub 2010 Sep 29.

43.

Antimycobacterial activity of UDP-galactopyranose mutase inhibitors.

Borrelli S, Zandberg WF, Mohan S, Ko M, Martinez-Gutierrez F, Partha SK, Sanders DA, Av-Gay Y, Pinto BM.

Int J Antimicrob Agents. 2010 Oct;36(4):364-8. doi: 10.1016/j.ijantimicag.2010.06.030. Epub 2010 Aug 3.

PMID:
20678902
44.

Convergence of Ser/Thr and two-component signaling to coordinate expression of the dormancy regulon in Mycobacterium tuberculosis.

Chao JD, Papavinasasundaram KG, Zheng X, Chávez-Steenbock A, Wang X, Lee GQ, Av-Gay Y.

J Biol Chem. 2010 Sep 17;285(38):29239-46. doi: 10.1074/jbc.M110.132894. Epub 2010 Jul 14.

45.

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: kinetics, molecular modeling, toxicity and effect on growth.

Mascarello A, Chiaradia LD, Vernal J, Villarino A, Guido RV, Perizzolo P, Poirier V, Wong D, Martins PG, Nunes RJ, Yunes RA, Andricopulo AD, Av-Gay Y, Terenzi H.

Bioorg Med Chem. 2010 Jun 1;18(11):3783-9. doi: 10.1016/j.bmc.2010.04.051. Epub 2010 Apr 21.

PMID:
20462762
46.

Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles.

Martinez-Gutierrez F, Olive PL, Banuelos A, Orrantia E, Nino N, Sanchez EM, Ruiz F, Bach H, Av-Gay Y.

Nanomedicine. 2010 Oct;6(5):681-8. doi: 10.1016/j.nano.2010.02.001. Epub 2010 Mar 6.

PMID:
20215045
47.

Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis.

Movahedzadeh F, Wheeler PR, Dinadayala P, Av-Gay Y, Parish T, Daffé M, Stoker NG.

BMC Microbiol. 2010 Feb 18;10:50. doi: 10.1186/1471-2180-10-50.

48.

Slow release of nitric oxide from charged catheters and its effect on biofilm formation by Escherichia coli.

Regev-Shoshani G, Ko M, Miller C, Av-Gay Y.

Antimicrob Agents Chemother. 2010 Jan;54(1):273-9. doi: 10.1128/AAC.00511-09. Epub 2009 Nov 2.

49.

Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis.

Chao J, Wong D, Zheng X, Poirier V, Bach H, Hmama Z, Av-Gay Y.

Biochim Biophys Acta. 2010 Mar;1804(3):620-7. doi: 10.1016/j.bbapap.2009.09.008. Epub 2009 Sep 18. Review.

PMID:
19766738
50.

Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system.

Attarian R, Bennie C, Bach H, Av-Gay Y.

FEBS Lett. 2009 Oct 6;583(19):3215-20. doi: 10.1016/j.febslet.2009.09.007. Epub 2009 Sep 6.

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