Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 522

1.

Nuclear receptor corepressor 1 represses cardiac hypertrophy.

Li C, Sun XN, Chen BY, Zeng MR, Du LJ, Liu T, Gu HH, Liu Y, Li YL, Zhou LJ, Zheng XJ, Zhang YY, Zhang WC, Liu Y, Shi C, Shao S, Shi XR, Yi Y, Liu X, Wang J, Auwerx J, Wang ZV, Jia F, Li RG, Duan SZ.

EMBO Mol Med. 2019 Sep 18:e9127. doi: 10.15252/emmm.201809127. [Epub ahead of print]

2.

Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity.

Zhu X, Shen W, Yao K, Wang H, Liu B, Li T, Song L, Diao D, Mao G, Huang P, Li C, Zhang H, Zou Y, Qiu Y, Zhao Y, Wang W, Yang Y, Hu Z, Auwerx J, Loscalzo J, Zhou Y, Ju Z.

Circ Res. 2019 Sep 13;125(7):707-719. doi: 10.1161/CIRCRESAHA.119.315529. Epub 2019 Aug 15.

PMID:
31412728
3.

Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis.

Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR.

Free Radic Biol Med. 2019 Aug 10;143:203-208. doi: 10.1016/j.freeradbiomed.2019.08.006. [Epub ahead of print]

PMID:
31408725
4.

The gut microbiota influences skeletal muscle mass and function in mice.

Lahiri S, Kim H, Garcia-Perez I, Reza MM, Martin KA, Kundu P, Cox LM, Selkrig J, Posma JM, Zhang H, Padmanabhan P, Moret C, Gulyás B, Blaser MJ, Auwerx J, Holmes E, Nicholson J, Wahli W, Pettersson S.

Sci Transl Med. 2019 Jul 24;11(502). pii: eaan5662. doi: 10.1126/scitranslmed.aan5662.

5.

Cross-species functional modules link proteostasis to human normal aging.

Komljenovic A, Li H, Sorrentino V, Kutalik Z, Auwerx J, Robinson-Rechavi M.

PLoS Comput Biol. 2019 Jul 3;15(7):e1007162. doi: 10.1371/journal.pcbi.1007162. eCollection 2019 Jul.

6.

Microfluidics-enabled phenotyping of a whole population of C. elegans worms over their embryonic and post-embryonic development at single-organism resolution.

Letizia MC, Cornaglia M, Trouillon R, Sorrentino V, Mouchiroud L, Bou Sleiman MS, Auwerx J, Gijs MAM.

Microsyst Nanoeng. 2018 May 7;4:6. doi: 10.1038/s41378-018-0003-8. eCollection 2018.

7.

Autophagy regulates lipid metabolism through selective turnover of NCoR1.

Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M.

Nat Commun. 2019 Apr 5;10(1):1567. doi: 10.1038/s41467-019-08829-3.

8.

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance.

Vannini N, Campos V, Girotra M, Trachsel V, Rojas-Sutterlin S, Tratwal J, Ragusa S, Stefanidis E, Ryu D, Rainer PY, Nikitin G, Giger S, Li TY, Semilietof A, Oggier A, Yersin Y, Tauzin L, Pirinen E, Cheng WC, Ratajczak J, Canto C, Ehrbar M, Sizzano F, Petrova TV, Vanhecke D, Zhang L, Romero P, Nahimana A, Cherix S, Duchosal MA, Ho PC, Deplancke B, Coukos G, Auwerx J, Lutolf MP, Naveiras O.

Cell Stem Cell. 2019 Mar 7;24(3):405-418.e7. doi: 10.1016/j.stem.2019.02.012.

PMID:
30849366
9.

The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo.

Wan X, Liu L, Zhou P, Hui X, He Q, Yu F, Zhang W, Ding X, Yuan X, Zhang N, Zhao Y, Zhu R, Liu Y, Hao P, Auwerx J, Song X, Leng Q, Zhang Y.

Blood Adv. 2019 Feb 26;3(4):644-657. doi: 10.1182/bloodadvances.2018022756.

10.

Niacin: an old lipid drug in a new NAD+ dress.

Romani M, Hofer DC, Katsyuba E, Auwerx J.

J Lipid Res. 2019 Apr;60(4):741-746. doi: 10.1194/jlr.S092007. Epub 2019 Feb 19.

PMID:
30782960
11.

Mild inborn errors of metabolism in commonly used inbred mouse strains.

Leandro J, Violante S, Argmann CA, Hagen J, Dodatko T, Bender A, Zhang W, Williams EG, Bachmann AM, Auwerx J, Yu C, Houten SM.

Mol Genet Metab. 2019 Apr;126(4):388-396. doi: 10.1016/j.ymgme.2019.01.021. Epub 2019 Jan 24.

PMID:
30709776
12.

The virtuous cycle of human genetics and mouse models in drug discovery.

Nadeau JH, Auwerx J.

Nat Rev Drug Discov. 2019 Apr;18(4):255-272. doi: 10.1038/s41573-018-0009-9. Review.

PMID:
30679805
13.

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J.

Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11.

PMID:
30642763
14.

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.

Atakan HB, Cornaglia M, Mouchiroud L, Auwerx J, Gijs MAM.

Lab Chip. 2018 Dec 18;19(1):120-135. doi: 10.1039/c8lc00863a.

PMID:
30484462
15.

Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip.

Migliozzi D, Cornaglia M, Mouchiroud L, Uhlmann V, Unser MA, Auwerx J, Gijs MAM.

J Biomed Opt. 2018 Nov;24(2):1-9. doi: 10.1117/1.JBO.24.2.021205.

16.

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells.

Dahlmans D, Houzelle A, Andreux P, Wang X, Jörgensen JA, Moullan N, Daemen S, Kersten S, Auwerx J, Hoeks J.

J Cell Physiol. 2019 May;234(5):6601-6610. doi: 10.1002/jcp.27401. Epub 2018 Nov 11.

17.

De novo NAD+ synthesis enhances mitochondrial function and improves health.

Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J.

Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24.

18.

Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.

Williams EG, Wu Y, Wolski W, Kim JY, Lan J, Hasan M, Halter C, Jha P, Ryu D, Auwerx J, Aebersold R.

Mol Cell Proteomics. 2018 Sep;17(9):1766-1777. doi: 10.1074/mcp.RA118.000554. Epub 2018 Jun 26.

19.

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.

Jha P, McDevitt MT, Gupta R, Quiros PM, Williams EG, Gariani K, Sleiman MB, Diserens L, Jochem A, Ulbrich A, Coon JJ, Auwerx J, Pagliarini DJ.

Cell Syst. 2018 Jun 27;6(6):722-733.e6. doi: 10.1016/j.cels.2018.05.016. Epub 2018 Jun 13.

20.

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.

Jha P, McDevitt MT, Halilbasic E, Williams EG, Quiros PM, Gariani K, Sleiman MB, Gupta R, Ulbrich A, Jochem A, Coon JJ, Trauner M, Pagliarini DJ, Auwerx J.

Cell Syst. 2018 Jun 27;6(6):709-721.e6. doi: 10.1016/j.cels.2018.05.009. Epub 2018 Jun 13.

21.

Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly.

Andreux PA, van Diemen MPJ, Heezen MR, Auwerx J, Rinsch C, Jan Groeneveld G, Singh A.

Sci Rep. 2018 Jun 4;8(1):8548. doi: 10.1038/s41598-018-26944-x.

22.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.

Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, Bricambert J, Saussenthaler S, Anthony E, Jha P, Derop J, Sand O, Rabearivelo I, Leloire A, Pigeyre M, Daujat-Chavanieu M, Gerbal-Chaloin S, Dayeh T, Lassailly G, Mathurin P, Staels B, Auwerx J, Schürmann A, Postic C, Schafmayer C, Hampe J, Bonnefond A, Pattou F, Froguel P.

Diabetes. 2018 Jul;67(7):1310-1321. doi: 10.2337/db17-1539. Epub 2018 May 4.

23.

Reduced oxidative capacity in macrophages results in systemic insulin resistance.

Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, Kim KS, Kim HJ, Kim CS, Lee CH, Williams RW, Kim H, Lee HK, Auwerx J, Shong M.

Nat Commun. 2018 Apr 19;9(1):1551. doi: 10.1038/s41467-018-03998-z.

24.

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.

Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF.

Aging Cell. 2018 Aug;17(4):e12751. doi: 10.1111/acel.12751. Epub 2018 Apr 14.

25.

The role of mitochondria in stem cell fate and aging.

Zhang H, Menzies KJ, Auwerx J.

Development. 2018 Apr 13;145(8). pii: dev143420. doi: 10.1242/dev.143420. Review.

26.

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM.

Cardiovasc Res. 2018 Aug 1;114(10):1324-1334. doi: 10.1093/cvr/cvy089.

PMID:
29635338
27.

ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.

28.

Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

Dong L, Cornaglia M, Krishnamani G, Zhang J, Mouchiroud L, Lehnert T, Auwerx J, Gijs MAM.

PLoS One. 2018 Mar 6;13(3):e0193989. doi: 10.1371/journal.pone.0193989. eCollection 2018.

29.

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.

Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J.

Elife. 2018 Feb 22;7. pii: e31019. doi: 10.7554/eLife.31019.

30.

Loss of Sirt3 accelerates arterial thrombosis by increasing formation of neutrophil extracellular traps and plasma tissue factor activity.

Gaul DS, Weber J, van Tits LJ, Sluka S, Pasterk L, Reiner MF, Calatayud N, Lohmann C, Klingenberg R, Pahla J, Vdovenko D, Tanner FC, Camici GG, Eriksson U, Auwerx J, Mach F, Windecker S, Rodondi N, Lüscher TF, Winnik S, Matter CM.

Cardiovasc Res. 2018 Jul 1;114(8):1178-1188. doi: 10.1093/cvr/cvy036.

31.

Genetic cartography of longevity in humans and mice: Current landscape and horizons.

Hook M, Roy S, Williams EG, Bou Sleiman M, Mozhui K, Nelson JF, Lu L, Auwerx J, Williams RW.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2718-2732. doi: 10.1016/j.bbadis.2018.01.026. Epub 2018 Feb 2. Review.

32.

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.

Pellicciari R, Liscio P, Giacchè N, De Franco F, Carotti A, Robertson J, Cialabrini L, Katsyuba E, Raffaelli N, Auwerx J.

J Med Chem. 2018 Feb 8;61(3):745-759. doi: 10.1021/acs.jmedchem.7b01254. Epub 2018 Jan 26.

PMID:
29345930
33.

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J.

Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6.

34.

An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function.

Li H, Wang X, Rukina D, Huang Q, Lin T, Sorrentino V, Zhang H, Bou Sleiman M, Arends D, McDaid A, Luan P, Ziari N, Velázquez-Villegas LA, Gariani K, Kutalik Z, Schoonjans K, Radcliffe RA, Prins P, Morgenthaler S, Williams RW, Auwerx J.

Cell Syst. 2018 Jan 24;6(1):90-102.e4. doi: 10.1016/j.cels.2017.10.016. Epub 2017 Nov 30.

35.

The chromatin remodeling factor ISW-1 integrates organismal responses against nuclear and mitochondrial stress.

Matilainen O, Sleiman MSB, Quiros PM, Garcia SMDA, Auwerx J.

Nat Commun. 2017 Nov 28;8(1):1818. doi: 10.1038/s41467-017-01903-8.

36.

The corepressor NCOR1 regulates the survival of single-positive thymocytes.

Müller L, Hainberger D, Stolz V, Hamminger P, Hassan H, Preglej T, Boucheron N, Sakaguchi S, Wiegers GJ, Villunger A, Auwerx J, Ellmeier W.

Sci Rep. 2017 Nov 21;7(1):15928. doi: 10.1038/s41598-017-15918-0.

37.

An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism.

Dahlmans D, Houzelle A, Andreux P, Jörgensen JA, Wang X, de Windt LJ, Schrauwen P, Auwerx J, Hoeks J.

Mol Metab. 2017 Nov;6(11):1429-1442. doi: 10.1016/j.molmet.2017.08.007. Epub 2017 Aug 31.

38.

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress.

Wang X, Auwerx J.

Mol Cell. 2017 Nov 2;68(3):540-551.e5. doi: 10.1016/j.molcel.2017.10.006.

39.

NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection.

Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q.

Nat Commun. 2017 Oct 16;8(1):959. doi: 10.1038/s41467-017-00931-8.

40.

Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.

Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A.

Brain Pathol. 2018 Sep;28(5):611-630. doi: 10.1111/bpa.12571. Epub 2017 Dec 26.

PMID:
29027761
41.

Repairing Mitochondrial Dysfunction in Disease.

Sorrentino V, Menzies KJ, Auwerx J.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:353-389. doi: 10.1146/annurev-pharmtox-010716-104908. Epub 2017 Sep 27. Review.

PMID:
28961065
42.

Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection.

Ciarlo E, Heinonen T, Théroude C, Herderschee J, Mombelli M, Lugrin J, Pfefferlé M, Tyrrell B, Lensch S, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Front Immunol. 2017 Aug 28;8:1037. doi: 10.3389/fimmu.2017.01037. eCollection 2017.

43.

Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function.

Item F, Wueest S, Lemos V, Stein S, Lucchini FC, Denzler R, Fisser MC, Challa TD, Pirinen E, Kim Y, Hemmi S, Gulbins E, Gross A, O'Reilly LA, Stoffel M, Auwerx J, Konrad D.

Nat Commun. 2017 Sep 7;8(1):480. doi: 10.1038/s41467-017-00566-9.

44.

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis.

Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB.

Gastroenterology. 2017 Dec;153(6):1568-1580.e10. doi: 10.1053/j.gastro.2017.08.039. Epub 2017 Aug 30.

45.

A multiscale study of the role of dynamin in the regulation of glucose uptake.

Trouillon R, Letizia MC, Menzies KJ, Mouchiroud L, Auwerx J, Schoonjans K, Gijs MAM.

Integr Biol (Camb). 2017 Oct 16;9(10):810-819. doi: 10.1039/c7ib00015d.

PMID:
28853753
46.

Modulating NAD+ metabolism, from bench to bedside.

Katsyuba E, Auwerx J.

EMBO J. 2017 Sep 15;36(18):2670-2683. doi: 10.15252/embj.201797135. Epub 2017 Aug 7. Review.

47.

Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.

McDaid AF, Joshi PK, Porcu E, Komljenovic A, Li H, Sorrentino V, Litovchenko M, Bevers RPJ, Rüeger S, Reymond A, Bochud M, Deplancke B, Williams RW, Robinson-Rechavi M, Paccaud F, Rousson V, Auwerx J, Wilson JF, Kutalik Z.

Nat Commun. 2017 Jul 27;8:15842. doi: 10.1038/ncomms15842.

48.

Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy.

Coquoz S, Marchand PJ, Bouwens A, Mouchiroud L, Sorrentino V, Szlag D, Auwerx J, Lasser T.

PLoS One. 2017 Jul 20;12(7):e0181676. doi: 10.1371/journal.pone.0181676. eCollection 2017.

49.

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain.

Preston S, Korhonen PK, Mouchiroud L, Cornaglia M, McGee SL, Young ND, Davis RA, Crawford S, Nowell C, Ansell BRE, Fisher GM, Andrews KT, Chang BCH, Gijs MAM, Sternberg PW, Auwerx J, Baell J, Hofmann A, Jabbar A, Gasser RB.

FASEB J. 2017 Oct;31(10):4515-4532. doi: 10.1096/fj.201700288R. Epub 2017 Jul 7.

PMID:
28687609
50.

Sirtuin 3 deficiency does not alter host defenses against bacterial and fungal infections.

Ciarlo E, Heinonen T, Lugrin J, Acha-Orbea H, Le Roy D, Auwerx J, Roger T.

Sci Rep. 2017 Jun 20;7(1):3853. doi: 10.1038/s41598-017-04263-x.

Supplemental Content

Loading ...
Support Center