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Items: 1 to 50 of 64

1.

N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.

MacNeil DE, Lambert-Lanteigne P, Autexier C.

Nucleic Acids Res. 2019 Jun 4;47(10):5368-5380. doi: 10.1093/nar/gkz233.

2.

Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells.

Dan J, Rousseau P, Hardikar S, Veland N, Wong J, Autexier C, Chen T.

Cell Rep. 2017 Aug 22;20(8):1936-1949. doi: 10.1016/j.celrep.2017.07.070.

3.

Telomerase Regulation from Beginning to the End.

MacNeil DE, Bensoussan HJ, Autexier C.

Genes (Basel). 2016 Sep 14;7(9). pii: E64. doi: 10.3390/genes7090064. Review.

4.

Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases.

Chu TW, MacNeil DE, Autexier C.

J Biol Chem. 2016 Apr 15;291(16):8374-86. doi: 10.1074/jbc.M116.714782. Epub 2016 Feb 17.

5.

An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.

Rousseau P, Khondaker S, Zhu S, Lauzon C, Mai S, Autexier C.

Biol Cell. 2016 Apr;108(4):96-112. doi: 10.1111/boc.201500089. Epub 2016 Feb 18.

PMID:
26787169
6.

Platinum(II) phenanthroimidazole G-quadruplex ligand induces selective telomere shortening in A549 cancer cells.

Mancini J, Rousseau P, Castor KJ, Sleiman HF, Autexier C.

Biochimie. 2016 Feb;121:287-97. doi: 10.1016/j.biochi.2015.12.015. Epub 2015 Dec 25.

PMID:
26724375
7.

The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.

Chu TW, D'Souza Y, Autexier C.

Mol Cell Biol. 2015 Oct 26;36(1):210-22. doi: 10.1128/MCB.00746-15. Print 2016 Jan 1.

8.

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells.

Spinella JF, Cassart P, Garnier N, Rousseau P, Drullion C, Richer C, Ouimet M, Saillour V, Healy J, Autexier C, Sinnett D.

BMC Cancer. 2015 Sep 7;15:621. doi: 10.1186/s12885-015-1639-5.

9.

Telomere biology: Rationale for diagnostics and therapeutics in cancer.

Rousseau P, Autexier C.

RNA Biol. 2015;12(10):1078-82. doi: 10.1080/15476286.2015.1081329. Epub 2015 Aug 20. Review. Erratum in: RNA Biol. 2016 Aug 17;13(8):740.

10.

Telomere length and the clinical phenotype of frailty in older adults undergoing cardiac surgery.

Brault ME, Ohayon SM, Kwan R, Bergman H, Eisenberg MJ, Boivin JF, Morin JF, Langlois Y, Autexier C, Afilalo J.

J Am Geriatr Soc. 2014 Nov;62(11):2205-7. doi: 10.1111/jgs.13076. No abstract available.

PMID:
25413191
11.

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase.

Zhu S, Rousseau P, Lauzon C, Gandin V, Topisirovic I, Autexier C.

Biochimie. 2014 Jun;101:93-103. doi: 10.1016/j.biochi.2013.12.023. Epub 2014 Jan 9.

PMID:
24412622
12.

Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.

Shawi M, Chu TW, Martinez-Marignac V, Yu Y, Gryaznov SM, Johnston JB, Lees-Miller SP, Assouline SE, Autexier C, Aloyz R.

PLoS One. 2013 Jul 29;8(7):e70428. doi: 10.1371/journal.pone.0070428. Print 2013.

13.

Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects.

Brault ME, Lauzon C, Autexier C.

Hum Mol Genet. 2013 Sep 1;22(17):3498-507. doi: 10.1093/hmg/ddt204. Epub 2013 May 8. Erratum in: Hum Mol Genet. 2014 Jan 1;23(1):279-80.

PMID:
23660516
14.

A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.

D'Souza Y, Chu TW, Autexier C.

Mol Biol Cell. 2013 May;24(9):1469-79. doi: 10.1091/mbc.E12-12-0889. Epub 2013 Feb 27.

15.

Regulation of telomere length and homeostasis by telomerase enzyme processivity.

D'Souza Y, Lauzon C, Chu TW, Autexier C.

J Cell Sci. 2013 Jan 15;126(Pt 2):676-87. doi: 10.1242/jcs.119297. Epub 2012 Nov 23.

16.

The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells.

Trapp-Fragnet L, Marie-Egyptienne DT, Fakhoury J, Rasschaert D, Autexier C.

Cell Mol Biol Lett. 2012 Dec;17(4):598-615. Epub 2012 Sep 1.

17.

ALTered telomeres in response to telomere dysfunction.

Brault ME, Autexier C.

Cell Cycle. 2011 Nov 15;10(22):3807-9. doi: 10.4161/cc.10.22.18188. Epub 2011 Nov 15. No abstract available.

PMID:
22064443
18.

Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes.

Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF.

ChemMedChem. 2012 Jan 2;7(1):85-94. doi: 10.1002/cmdc.201100453. Epub 2011 Nov 3.

PMID:
22052801
19.

Telomeric recombination induced by dysfunctional telomeres.

Brault ME, Autexier C.

Mol Biol Cell. 2011 Jan 15;22(2):179-88. doi: 10.1091/mbc.E10-02-0173. Epub 2010 Nov 30.

20.

Telomeric function of mammalian telomerases at short telomeres.

Fakhoury J, Marie-Egyptienne DT, Londoño-Vallejo JA, Autexier C.

J Cell Sci. 2010 May 15;123(Pt 10):1693-704. doi: 10.1242/jcs.063636. Epub 2010 Apr 27.

21.

Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA.

Marie-Egyptienne DT, Brault ME, Nimmo GA, Londoño-Vallejo JA, Autexier C.

Cancer Lett. 2009 Mar 18;275(2):266-76. doi: 10.1016/j.canlet.2008.10.027. Epub 2008 Dec 3.

PMID:
19056167
22.

A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor.

Kieltyka R, Englebienne P, Fakhoury J, Autexier C, Moitessier N, Sleiman HF.

J Am Chem Soc. 2008 Aug 6;130(31):10040-1. doi: 10.1021/ja8014023. Epub 2008 Jul 11.

PMID:
18616250
23.

POT of gold: modeling dyskeratosis congenita in the mouse.

Autexier C.

Genes Dev. 2008 Jul 1;22(13):1731-6. doi: 10.1101/gad.1695808.

24.

Telomerase, senescence and ageing.

Shawi M, Autexier C.

Mech Ageing Dev. 2008 Jan-Feb;129(1-2):3-10. doi: 10.1016/j.mad.2007.11.007. Epub 2007 Dec 14. Review.

PMID:
18215413
25.

Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.

Marie-Egyptienne DT, Brault ME, Zhu S, Autexier C.

Exp Cell Res. 2008 Feb 1;314(3):668-75. Epub 2007 Nov 7.

PMID:
18067891
26.

Harnessing telomerase in cancer therapeutics.

Fakhoury J, Nimmo GA, Autexier C.

Anticancer Agents Med Chem. 2007 Jul;7(4):475-83. Review.

PMID:
17630922
27.

Telomerase and neuronal marker status of differentiated NT2 and SK-N-SH human neuronal cells and primary human neurons.

Jain P, Cerone MA, Leblanc AC, Autexier C.

J Neurosci Res. 2007 Jan;85(1):83-9.

PMID:
17075923
28.

Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells.

Cerone MA, Londoño-Vallejo JA, Autexier C.

Mol Cancer Ther. 2006 Jul;5(7):1669-75.

29.

Mutated telomeres sensitize tumor cells to anticancer drugs independently of telomere shortening and mechanisms of telomere maintenance.

Cerone MA, Londoño-Vallejo JA, Autexier C.

Oncogene. 2006 Nov 30;25(56):7411-20. Epub 2006 Jun 12. Erratum in: Oncogene. 2007 Mar 22;26(13):1983.

PMID:
16767163
30.

The structure and function of telomerase reverse transcriptase.

Autexier C, Lue NF.

Annu Rev Biochem. 2006;75:493-517. Review.

PMID:
16756500
31.

A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation.

Marie-Egyptienne DT, Cerone MA, Londoño-Vallejo JA, Autexier C.

Nucleic Acids Res. 2005 Sep 28;33(17):5446-57. Print 2005.

32.

Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase.

Moriarty TJ, Marie-Egyptienne DT, Autexier C.

RNA. 2005 Sep;11(9):1448-60.

33.

A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT.

Cerone MA, Autexier C, Londoño-Vallejo JA, Bacchetti S.

Oncogene. 2005 Nov 24;24(53):7893-901.

PMID:
16116482
34.

Telomerase can act as a template- and RNA-independent terminal transferase.

Lue NF, Bosoy D, Moriarty TJ, Autexier C, Altman B, Leng S.

Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9778-83. Epub 2005 Jun 30.

35.
36.

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.

Moriarty TJ, Ward RJ, Taboski MA, Autexier C.

Mol Biol Cell. 2005 Jul;16(7):3152-61. Epub 2005 Apr 27.

37.

Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation.

Cerone MA, Ward RJ, Londoño-Vallejo JA, Autexier C.

Cell Cycle. 2005 Apr;4(4):585-9. Epub 2005 Apr 3.

PMID:
15753647
38.

Human telomerase catalyzes nucleolytic primer cleavage.

Huard S, Autexier C.

Nucleic Acids Res. 2004 Apr 19;32(7):2171-80. Print 2004.

39.
40.

Humanized telomeres and an attempt to express a functional human telomerase in yeast.

Bah A, Bachand F, Clair E, Autexier C, Wellinger RJ.

Nucleic Acids Res. 2004 Mar 26;32(6):1917-27. Print 2004.

41.

The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity.

Huard S, Moriarty TJ, Autexier C.

Nucleic Acids Res. 2003 Jul 15;31(14):4059-70.

42.

Targeting human telomerase in cancer therapy.

Huard S, Autexier C.

Curr Med Chem Anticancer Agents. 2002 Sep;2(5):577-87. Review.

PMID:
12678725
43.

Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.

Boisvert FM, Cote J, Boulanger MC, Cleroux P, Bachand F, Autexier C, Richard S.

J Cell Biol. 2002 Dec 23;159(6):957-69. Epub 2002 Dec 16.

44.

The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein.

Bachand F, Boisvert FM, Côté J, Richard S, Autexier C.

Mol Biol Cell. 2002 Sep;13(9):3192-202.

46.
47.

Tetrahymena proteins p80 and p95 are not core telomerase components.

Mason DX, Autexier C, Greider CW.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12368-73. Epub 2001 Oct 9.

48.

Human telomerase RNA-protein interactions.

Bachand F, Triki I, Autexier C.

Nucleic Acids Res. 2001 Aug 15;29(16):3385-93.

50.

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