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Items: 45

1.

Structural basis for dual-mode inhibition of the ABC transporter MsbA.

Ho H, Miu A, Alexander MK, Garcia NK, Oh A, Zilberleyb I, Reichelt M, Austin CD, Tam C, Shriver S, Hu H, Labadie SS, Liang J, Wang L, Wang J, Lu Y, Purkey HE, Quinn J, Franke Y, Clark K, Beresini MH, Tan MW, Sellers BD, Maurer T, Koehler MFT, Wecksler AT, Kiefer JR, Verma V, Xu Y, Nishiyama M, Payandeh J, Koth CM.

Nature. 2018 May;557(7704):196-201. doi: 10.1038/s41586-018-0083-5. Epub 2018 May 2.

PMID:
29720648
2.

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham-Anderson J, Hargadon B, Arron JR, Wardlaw A, Brightling CE, Heaney LG, Bradding P.

J Allergy Clin Immunol. 2018 Nov;142(5):1457-1468. doi: 10.1016/j.jaci.2017.12.982. Epub 2018 Mar 14.

PMID:
29550052
3.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus.

Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, Lesch J, Bents K, Everett C, Kohli PB, Linge S, Christian L, Barrett K, Jaochico A, Berezhkovskiy LM, Fan PW, Modrusan Z, Veliz K, Townsend MJ, DeVoss J, Johnson AR, Godemann R, Lee WP, Austin CD, McKenzie BS, Hackney JA, Crawford JJ, Staben ST, Alaoui Ismaili MH, Wu LC, Ghilardi N.

Nat Commun. 2018 Jan 12;9(1):179. doi: 10.1038/s41467-017-02672-0.

4.

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus.

Lopez MS, Tan IS, Yan D, Kang J, McCreary M, Modrusan Z, Austin CD, Xu M, Brown EJ.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11223-11228. doi: 10.1073/pnas.1700627114. Epub 2017 Oct 2.

5.

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Sitrin J, Suto E, Wuster A, Eastham-Anderson J, Kim JM, Austin CD, Lee WP, Behrens TW.

J Immunol. 2017 Aug 15;199(4):1238-1249. doi: 10.4049/jimmunol.1700608. Epub 2017 Jul 10.

6.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

Katewa A, Wang Y, Hackney JA, Huang T, Suto E, Ramamoorthi N, Austin CD, Bremer M, Chen JZ, Crawford JJ, Currie KS, Blomgren P, DeVoss J, DiPaolo JA, Hau J, Johnson A, Lesch J, DeForge LE, Lin Z, Liimatta M, Lubach JW, McVay S, Modrusan Z, Nguyen A, Poon C, Wang J, Liu L, Lee WP, Wong H, Young WB, Townsend MJ, Reif K.

JCI Insight. 2017 Apr 6;2(7):e90111. doi: 10.1172/jci.insight.90111.

7.

Depletion of major pathogenic cells in asthma by targeting CRTh2.

Huang T, Hazen M, Shang Y, Zhou M, Wu X, Yan D, Lin Z, Solon M, Luis E, Ngu H, Shi Y, Katewa A, Choy DF, Ramamoorthi N, Castellanos ER, Balazs M, Xu M, Lee WP, Matsumoto ML, Payandeh J, Arron JR, Hongo JA, Wang J, Hötzel I, Austin CD, Reif K.

JCI Insight. 2016 May 19;1(7):e86689. doi: 10.1172/jci.insight.86689.

8.

De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo.

Kofoed EM, Yan D, Katakam AK, Reichelt M, Lin B, Kim J, Park S, Date SV, Monk IR, Xu M, Austin CD, Maurer T, Tan MW.

J Bacteriol. 2016 Jun 27;198(14):2001-2015. doi: 10.1128/JB.00051-16. Print 2016 Jul 15.

9.

Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD.

Toxicol Sci. 2016 Jul;152(1):72-84. doi: 10.1093/toxsci/kfw067. Epub 2016 Apr 21.

PMID:
27103662
10.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.

Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949.

PMID:
26628680
11.

Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells.

Katakam AK, Brightbill H, Franci C, Kung C, Nunez V, Jones C 3rd, Peng I, Jeet S, Wu LC, Mellman I, Delamarre L, Austin CD.

Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14664-9. doi: 10.1073/pnas.1520627112. Epub 2015 Nov 11.

12.

Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation.

Brightbill HD, Jackman JK, Suto E, Kennedy H, Jones C 3rd, Chalasani S, Lin Z, Tam L, Roose-Girma M, Balazs M, Austin CD, Lee WP, Wu LC.

J Immunol. 2015 Aug 1;195(3):953-64. doi: 10.4049/jimmunol.1401514. Epub 2015 Jun 26.

13.

Addendum: IgE+ memory B cells and plasma cells generated through a germinal-center pathway.

Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC.

Nat Immunol. 2013 Dec;14(12):1302-4. doi: 10.1038/ni.2770. No abstract available.

PMID:
24240161
14.

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.

Misaghi S, Senger K, Sai T, Qu Y, Sun Y, Hamidzadeh K, Nguyen A, Jin Z, Zhou M, Yan D, Lin WY, Lin Z, Lorenzo MN, Sebrell A, Ding J, Xu M, Caplazi P, Austin CD, Balazs M, Roose-Girma M, DeForge L, Warming S, Lee WP, Dixit VM, Zarrin AA.

Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15770-5. doi: 10.1073/pnas.1221661110. Epub 2013 Sep 9.

15.

Characterization of the guinea pig CMV gH/gL/GP129/GP131/GP133 complex in infection and spread.

Auerbach M, Yan D, Fouts A, Xu M, Estevez A, Austin CD, Bazan F, Feierbach B.

Virology. 2013 Jun 20;441(1):75-84. doi: 10.1016/j.virol.2013.03.008. Epub 2013 Apr 4.

16.

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.

Lo B, Strasser G, Sagolla M, Austin CD, Junttila M, Mellman I.

J Cell Biol. 2012 Dec 24;199(7):1117-30. doi: 10.1083/jcb.201208080.

17.

Mycobacterium marinum SecA2 promotes stable granulomas and induces tumor necrosis factor alpha in vivo.

Watkins BY, Joshi SA, Ball DA, Leggett H, Park S, Kim J, Austin CD, Paler-Martinez A, Xu M, Downing KH, Brown EJ.

Infect Immun. 2012 Oct;80(10):3512-20. doi: 10.1128/IAI.00686-12. Epub 2012 Jul 30.

18.

IgE⁺ memory B cells and plasma cells generated through a germinal-center pathway.

Talay O, Yan D, Brightbill HD, Straney EE, Zhou M, Ladi E, Lee WP, Egen JG, Austin CD, Xu M, Wu LC.

Nat Immunol. 2012 Feb 26;13(4):396-404. doi: 10.1038/ni.2256.

PMID:
22366892
19.

Collective action of hematopoietic cell subsets mediates anti-IL10R1 and CpG tumor immunity.

Chou MY, Austin CD, Kim JM.

Cancer Immunol Immunother. 2012 Jul;61(7):1055-64. doi: 10.1007/s00262-011-1175-3. Epub 2011 Dec 11.

PMID:
22159473
20.

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.

Shikotra A, Choy DF, Ohri CM, Doran E, Butler C, Hargadon B, Shelley M, Abbas AR, Austin CD, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P.

J Allergy Clin Immunol. 2012 Jan;129(1):104-11.e1-9. doi: 10.1016/j.jaci.2011.08.031. Epub 2011 Oct 5.

PMID:
21975173
21.

In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.

Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F.

J Clin Invest. 2007 Dec;117(12):3868-78.

22.

Linking case management and community development.

Austin CD, McClelland RW, Gursansky D.

Care Manag J. 2006 Winter;7(4):162-8.

PMID:
17194052
23.

Death-receptor activation halts clathrin-dependent endocytosis.

Austin CD, Lawrence DA, Peden AA, Varfolomeev EE, Totpal K, De Mazière AM, Klumperman J, Arnott D, Pham V, Scheller RH, Ashkenazi A.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10283-10288. doi: 10.1073/pnas.0604044103. Epub 2006 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13560.

24.

Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates.

Austin CD, Wen X, Gazzard L, Nelson C, Scheller RH, Scales SJ.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17987-92. Epub 2005 Dec 1.

25.

Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin.

Austin CD, De Mazière AM, Pisacane PI, van Dijk SM, Eigenbrot C, Sliwkowski MX, Klumperman J, Scheller RH.

Mol Biol Cell. 2004 Dec;15(12):5268-82. Epub 2004 Sep 22.

26.

Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins.

Peden AA, Oorschot V, Hesser BA, Austin CD, Scheller RH, Klumperman J.

J Cell Biol. 2004 Mar 29;164(7):1065-76.

27.

Case management: who needs it? Does it work?

Austin CD.

Care Manag J. 2002 Summer;3(4):178-84.

PMID:
12847934
28.

Spindle cell lipoma of the foot and the application of CD34 immunohistochemistry to atypical lipomatous tumors in unusual locations.

Austin CD, Tiessen JR, Gopalan A, Williams JM Jr, Bangs CD, Cherry AM, Lehnert BA, Rouse RV.

Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):222-7.

PMID:
10981875
29.

Case management in the human services. Reflections of public policy.

Austin CD, McClelland RW.

J Case Manag. 1997 Fall;6(3):119-26. Review.

PMID:
9573971
30.

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network.

Chen YG, Siddhanta A, Austin CD, Hammond SM, Sung TC, Frohman MA, Morris AJ, Shields D.

J Cell Biol. 1997 Aug 11;138(3):495-504.

33.

Care planning in home care: an exploratory study.

Lemire AM, Austin CD.

J Case Manag. 1996 Spring;5(1):32-40.

PMID:
8715699
35.
38.
39.

Reactor panel discussion: commitment to integration.

Austin CD.

Spec Care Dentist. 1989 Jul-Aug;9(4):106-7. No abstract available.

PMID:
2623461
40.

Phosphorus and proton magnetic resonance spectroscopic studies on the relationship between transparency and glucose metabolism in the rabbit lens.

Williams WF, Austin CD, Farnsworth PN, Groth-Vasselli B, Willis JA, Schleich T.

Exp Eye Res. 1988 Jul;47(1):97-112.

PMID:
2842177
41.

The Veterans Administration Northwest Regional Health Services Research and Development Field Program: organization, activities, and early outcomes.

Austin CD, Carter WB, Durham ML, Hedrick SC, Hickam DH, Inui TS, Koepsell TD, Pearlman RA, Petersen MD, Rothman ML, et al.

Health Serv Res. 1986 Feb;20(6 Pt 2):825-39.

42.

Case management in long-term care: options and opportunities.

Austin CD.

Health Soc Work. 1983 Winter;8(1):16-30.

PMID:
6404716
43.

Validating professional judgment in a home care agency.

Austin CD, Seidl FW.

Health Soc Work. 1981 Feb;6(1):50-6.

PMID:
6783487
44.

The Wisconsin community care organization: preliminary findings from the Milwaukee experiment.

Applebaum R, Seidl FW, Austin CD.

Gerontologist. 1980 Jun;20(3 Pt 1):350-5. No abstract available.

PMID:
7390209
45.

Is home health care less expensive?

Seidl FW, Austin CD, Greene DR.

Health Soc Work. 1977 May;2(2):5-19. No abstract available.

PMID:
873381

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