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Items: 1 to 50 of 126

1.

Investigation of modified nanopore arrays using FIB/SEM tomography.

Holzinger A, Neusser G, Austen BJJ, Gamero-Quijano A, Herzog G, Arrigan DWM, Ziegler A, Walther P, Kranz C.

Faraday Discuss. 2018 Oct 1;210(0):113-130. doi: 10.1039/c8fd00019k.

PMID:
29974089
2.

Can MRI T1 be used to detect early changes in 5xFAD Alzheimer's mouse brain?

Spencer NG, Lovell DP, Elderfield K, Austen B, Howe FA.

MAGMA. 2017 Apr;30(2):153-163. doi: 10.1007/s10334-016-0593-9. Epub 2016 Oct 26.

3.

Calreticulin mutations and their importance in splanchnic vein thrombosis.

Sekhar M, Patch D, Austen B, Howard J, Hart S.

Br J Haematol. 2016 Jul;174(1):158-60. doi: 10.1111/bjh.13756. Epub 2015 Sep 11. No abstract available.

PMID:
26358155
4.

Gadolinium-complexed Aβ-binding contrast agents for MRI diagnosis of Alzheimer's Disease.

Matharu B, Spencer N, Howe F, Austen B.

Neuropeptides. 2015 Oct;53:63-70. doi: 10.1016/j.npep.2015.07.001. Epub 2015 Jul 20.

PMID:
26234669
5.

The elusive nature and diagnostics of misfolded Aβ oligomers.

Cerasoli E, Ryadnov MG, Austen BM.

Front Chem. 2015 Mar 19;3:17. doi: 10.3389/fchem.2015.00017. eCollection 2015. Review.

6.

Quantitative evaluation of MRI and histological characteristics of the 5xFAD Alzheimer mouse brain.

Spencer NG, Bridges LR, Elderfield K, Amir K, Austen B, Howe FA.

Neuroimage. 2013 Aug 1;76:108-15. doi: 10.1016/j.neuroimage.2013.02.071. Epub 2013 Mar 15.

PMID:
23507393
7.

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2.

Russell CL, Semerdjieva S, Empson RM, Austen BM, Beesley PW, Alifragis P.

PLoS One. 2012;7(8):e43201. doi: 10.1371/journal.pone.0043201. Epub 2012 Aug 15.

8.

ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele.

Skowronska A, Austen B, Powell JE, Weston V, Oscier DG, Dyer MJ, Matutes E, Pratt G, Fegan C, Moss P, Taylor MA, Stankovic T.

Haematologica. 2012 Jan;97(1):142-6. doi: 10.3324/haematol.2011.048827. Epub 2011 Sep 20.

9.

The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.

Parsons RB, Aravindan S, Kadampeswaran A, Evans EA, Sandhu KK, Levy ER, Thomas MG, Austen BM, Ramsden DB.

Biochem J. 2011 May 15;436(1):145-55. doi: 10.1042/BJ20101685.

PMID:
21352099
10.

Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease.

Matharu B, El-Agnaf O, Razvi A, Austen BM.

Peptides. 2010 Oct;31(10):1866-72. doi: 10.1016/j.peptides.2010.06.033. Epub 2010 Jul 13.

PMID:
20633587
11.

Frequent epigenetic inactivation of the SLIT2 gene in chronic and acute lymphocytic leukemia.

Dunwell TL, Dickinson RE, Stankovic T, Dallol A, Weston V, Austen B, Catchpoole D, Maher ER, Latif F.

Epigenetics. 2009 May 16;4(4):265-9. Epub 2009 May 1.

PMID:
19550140
13.

Intestinal perforation secondary to haematopoietic stem cell transplant associated thrombotic microangiopathy.

Hewamana S, Austen B, Murray J, Johnson S, Wilson K.

Eur J Haematol. 2009 Sep;83(3):277. doi: 10.1111/j.1600-0609.2009.01267.x. Epub 2009 Apr 13. No abstract available.

PMID:
19467016
14.

Molecular interactions of the plasma membrane calcium ATPase 2 at pre- and post-synaptic sites in rat cerebellum.

Garside ML, Turner PR, Austen B, Strehler EE, Beesley PW, Empson RM.

Neuroscience. 2009 Aug 18;162(2):383-95. doi: 10.1016/j.neuroscience.2009.04.059. Epub 2009 May 3.

15.

Galantamine inhibits beta-amyloid aggregation and cytotoxicity.

Matharu B, Gibson G, Parsons R, Huckerby TN, Moore SA, Cooper LJ, Millichamp R, Allsop D, Austen B.

J Neurol Sci. 2009 May 15;280(1-2):49-58. doi: 10.1016/j.jns.2009.01.024. Epub 2009 Feb 26.

PMID:
19249060
16.

A case of lymphoma presenting as splenic infarction.

Boddana PV, Tomson CR, Austen B, Davies S, Francis N, White H, Rooney N.

BMJ Case Rep. 2009;2009. pii: bcr09.2008.0849. doi: 10.1136/bcr.09.2008.0849. Epub 2009 Apr 20. No abstract available.

17.

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

Pepper C, Lin TT, Pratt G, Hewamana S, Brennan P, Hiller L, Hills R, Ward R, Starczynski J, Austen B, Hooper L, Stankovic T, Fegan C.

Blood. 2008 Nov 1;112(9):3807-17. doi: 10.1182/blood-2008-05-157131. Epub 2008 Jul 3.

18.

Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients.

Austen B, Barone G, Reiman A, Byrd PJ, Baker C, Starczynski J, Nobbs MC, Murphy RP, Enright H, Chaila E, Quinn J, Stankovic T, Pratt G, Taylor AM.

Br J Haematol. 2008 Sep;142(6):925-33. doi: 10.1111/j.1365-2141.2008.07281.x. Epub 2008 Jun 28.

PMID:
18573109
19.

HLA homology within the C5 domain promotes peptide binding by HIV type 1 gp120.

Cadogan M, Austen B, Heeney JL, Dalgleish AG.

AIDS Res Hum Retroviruses. 2008 Jun;24(6):845-55. doi: 10.1089/aid.2007.0194.

PMID:
18544021
20.

South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients.

Gunawardana C, Austen B, Powell JE, Fegan C, Wandroo F, Jacobs A, Pratt G, Moss P.

Br J Haematol. 2008 Aug;142(4):606-9. doi: 10.1111/j.1365-2141.2008.07226.x. Epub 2008 May 22.

PMID:
18503582
21.

A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL.

Best OG, Gardiner AC, Majid A, Walewska R, Austen B, Skowronska A, Ibbotson R, Stankovic T, Dyer MJ, Oscier DG.

Leukemia. 2008 Jul;22(7):1456-9. doi: 10.1038/sj.leu.2405092. Epub 2008 Jan 17. No abstract available.

PMID:
18200038
22.

Designing peptide inhibitors for oligomerization and toxicity of Alzheimer's beta-amyloid peptide.

Austen BM, Paleologou KE, Ali SA, Qureshi MM, Allsop D, El-Agnaf OM.

Biochemistry. 2008 Feb 19;47(7):1984-92. doi: 10.1021/bi701415b. Epub 2008 Jan 12.

PMID:
18189413
23.

Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

Austen B, Skowronska A, Baker C, Powell JE, Gardiner A, Oscier D, Majid A, Dyer M, Siebert R, Taylor AM, Moss PA, Stankovic T.

J Clin Oncol. 2007 Dec 1;25(34):5448-57. Epub 2007 Oct 29.

PMID:
17968022
25.

Regulation of the lipidation of beta-secretase by statins.

Parsons RB, Farrant JK, Price GC, Subramaniam D, Austen BM.

Biochem Soc Trans. 2007 Jun;35(Pt 3):577-82. Review.

PMID:
17511656
26.
27.
28.

Statins inhibit the dimerization of beta-secretase via both isoprenoid- and cholesterol-mediated mechanisms.

Parsons RB, Price GC, Farrant JK, Subramaniam D, Adeagbo-Sheikh J, Austen BM.

Biochem J. 2006 Oct 15;399(2):205-14.

29.

Structure and neurotoxicity of novel amyloids derived from the BRI gene.

Gibson G, El-Agnaf OM, Anwar Z, Sidera C, Isbister A, Austen BM.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1111-2.

PMID:
16246057
30.

Protein lipidation of BACE.

Parsons RB, Austen BM.

Biochem Soc Trans. 2005 Nov;33(Pt 5):1091-3.

PMID:
16246052
31.

Mutations in the ATM gene lead to impaired overall and treatment-free survival that is independent of IGVH mutation status in patients with B-CLL.

Austen B, Powell JE, Alvi A, Edwards I, Hooper L, Starczynski J, Taylor AM, Fegan C, Moss P, Stankovic T.

Blood. 2005 Nov 1;106(9):3175-82. Epub 2005 Jul 12.

32.

Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas.

Schmitz R, Renné C, Rosenquist R, Tinguely M, Distler V, Menestrina F, Lestani M, Stankovic T, Austen B, Bräuninger A, Hansmann ML, Küppers R.

Leukemia. 2005 Aug;19(8):1452-8.

PMID:
15973455
33.

Post-translational processing of beta-secretase in Alzheimer's disease.

Sidera C, Parsons R, Austen B.

Proteomics. 2005 Apr;5(6):1533-43.

PMID:
15789346
34.

The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease.

Sidera C, Parsons R, Austen B.

J Neurol Sci. 2005 Mar 15;229-230:269-73. Epub 2004 Dec 21.

PMID:
15760650
35.

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

Alvi AJ, Austen B, Weston VJ, Fegan C, MacCallum D, Gianella-Borradori A, Lane DP, Hubank M, Powell JE, Wei W, Taylor AM, Moss PA, Stankovic T.

Blood. 2005 Jun 1;105(11):4484-91. Epub 2005 Feb 3.

36.

Induction of cellular oxidative stress by the beta-amyloid peptide involved in Alzheimer's disease.

Gibson GL, Allsop D, Austen BM.

Protein Pept Lett. 2004 Jun;11(3):257-70.

PMID:
15182227
37.

Properties of neurotoxic peptides related to the Bri gene.

El-Agnaf O, Gibson G, Lee M, Wright A, Austen BM.

Protein Pept Lett. 2004 Jun;11(3):207-12.

PMID:
15182222
38.

Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.

Weston VJ, Austen B, Wei W, Marston E, Alvi A, Lawson S, Darbyshire PJ, Griffiths M, Hill F, Mann JR, Moss PA, Taylor AM, Stankovic T.

Blood. 2004 Sep 1;104(5):1465-73. Epub 2004 May 13.

39.

Proteolytic cascade in the amyloidogenesis of Alzheimer's disease.

Sidera C, Parsons R, Austen B.

Biochem Soc Trans. 2004 Feb;32(Pt 1):33-6.

PMID:
14748707
40.

Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia.

Gibson G, Gunasekera N, Lee M, Lelyveld V, El-Agnaf OM, Wright A, Austen B.

J Neurochem. 2004 Jan;88(2):281-90.

41.

Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

Stankovic T, Hubank M, Cronin D, Stewart GS, Fletcher D, Bignell CR, Alvi AJ, Austen B, Weston VJ, Fegan C, Byrd PJ, Moss PA, Taylor AM.

Blood. 2004 Jan 1;103(1):291-300. Epub 2003 Sep 4.

42.

The role of intracellular cholesterol on the processing of the beta-amyloid precursor protein.

Austen BM, Sidera C, Liu C, Frears E.

J Nutr Health Aging. 2003;7(1):31-6.

PMID:
12679838
43.

Emerging techniques in biomedical research and their application to alcohol toxicity.

Patel VB, Chaurand P, Caprioli RM, Austen BM, Frears ER, Manca F, Davies H, Vrana KE, Wheeler M, Preedy VR.

Alcohol Clin Exp Res. 2003 Feb;27(2):348-53.

PMID:
12605084
44.

Relation between cholesterol levels, statins and Alzheimer's disease in the human population.

Austen B, Christodoulou G, Terry JE.

J Nutr Health Aging. 2002;6(6):377-82. Review.

PMID:
12459888
45.
46.

Properties of neurotoxic peptides related to the BRI gene.

Austen B, el-Agnaf O, Nagala S, Patel B, Gunasekera N, Lee M, Lelyveld V.

Biochem Soc Trans. 2002 Aug;30(4):557-9.

PMID:
12196136
48.

Fatal disseminated fusarium infection in acute lymphoblastic leukaemia in complete remission.

Austen B, McCarthy H, Wilkins B, Smith A, Duncombe A.

J Clin Pathol. 2001 Jun;54(6):488-90.

49.

Effect of the disulfide bridge and the C-terminal extension on the oligomerization of the amyloid peptide ABri implicated in familial British dementia.

El-Agnaf OM, Sheridan JM, Sidera C, Siligardi G, Hussain R, Haris PI, Austen BM.

Biochemistry. 2001 Mar 27;40(12):3449-57.

PMID:
11297410
50.

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