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Items: 1 to 50 of 160

1.

Mechanistic study on the use of the L-type amino acid transporter 1 for brain intracellular delivery of ketoprofen via prodrug: a novel approach supporting the development of prodrugs for intracellular targets.

Puris E, Gynther M, de Lange EC, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.

Mol Pharm. 2019 Jun 10. doi: 10.1021/acs.molpharmaceut.9b00502. [Epub ahead of print]

PMID:
31180686
2.

Metabolic signature of extracellular vesicles depends on the cell culture conditions.

Palviainen M, Saari H, Kärkkäinen O, Pekkinen J, Auriola S, Yliperttula M, Puhka M, Hanhineva K, Siljander PR.

J Extracell Vesicles. 2019 Apr 4;8(1):1596669. doi: 10.1080/20013078.2019.1596669. eCollection 2019.

3.

Gender- and dose-related metabolome alterations in rat offspring after in utero and lactational exposure to PCB 180.

Pikkarainen A, Lehtonen M, Håkansson H, Auriola S, Viluksela M.

Toxicol Appl Pharmacol. 2019 May 1;370:56-64. doi: 10.1016/j.taap.2019.03.013. Epub 2019 Mar 14.

4.

Metabolism of Scoparone in Experimental Animals and Humans.

Juvonen RO, Novák F, Emmanouilidou E, Auriola S, Timonen J, Heikkinen AT, Küblbeck J, Finel M, Raunio H.

Planta Med. 2019 Apr;85(6):453-464. doi: 10.1055/a-0835-2301. Epub 2019 Feb 8.

PMID:
30736072
5.

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.

Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.

Eur J Pharm Sci. 2019 Mar 1;129:99-109. doi: 10.1016/j.ejps.2019.01.002. Epub 2019 Jan 6.

PMID:
30625368
6.

Blood steroids are associated with prognosis and fat distribution in endometrial cancer.

Tangen IL, Fasmer KE, Konings GF, Jochems A, Delvoux B, Xanthoulea S, Stokowy T, Strand E, Berg HF, Auriola S, Trovik J, Häkkinen MR, Haldorsen IS; ENITEC. Electronic address: https://www.esgo.org, Krakstad C, Romano A.

Gynecol Oncol. 2019 Jan;152(1):46-52. doi: 10.1016/j.ygyno.2018.10.024. Epub 2018 Oct 26.

PMID:
30554934
7.

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes.

Gynther M, Puris E, Peltokangas S, Auriola S, Kanninen KM, Koistinaho J, Huttunen KM, Ruponen M, Vellonen KS.

Pharm Res. 2018 Nov 28;36(1):17. doi: 10.1007/s11095-018-2546-7.

8.

Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue.

Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S.

J Pharm Biomed Anal. 2019 Feb 5;164:642-652. doi: 10.1016/j.jpba.2018.11.035. Epub 2018 Nov 16.

PMID:
30472582
9.

High-Fat Diet, Betaine, and Polydextrose Induce Changes in Adipose Tissue Inflammation and Metabolism in C57BL/6J Mice.

Airaksinen K, Jokkala J, Ahonen I, Auriola S, Kolehmainen M, Hanhineva K, Tiihonen K.

Mol Nutr Food Res. 2018 Dec;62(23):e1800455. doi: 10.1002/mnfr.201800455. Epub 2018 Oct 21.

PMID:
30290084
10.

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants.

Jääskeläinen T, Kärkkäinen O, Jokkala J, Litonius K, Heinonen S, Auriola S, Lehtonen M, Hanhineva K, Laivuori H; FINNPEC.

Sci Rep. 2018 Oct 2;8(1):14616. doi: 10.1038/s41598-018-32804-5.

11.

Diets rich in whole grains increase betainized compounds associated with glucose metabolism.

Kärkkäinen O, Lankinen MA, Vitale M, Jokkala J, Leppänen J, Koistinen V, Lehtonen M, Giacco R, Rosa-Sibakov N, Micard V, Rivellese AAA, Schwab U, Mykkänen H, Uusitupa M, Kolehmainen M, Riccardi G, Poutanen K, Auriola S, Hanhineva K.

Am J Clin Nutr. 2018 Nov 1;108(5):971-979. doi: 10.1093/ajcn/nqy169.

PMID:
30256894
12.

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes.

Kärkkäinen O, Tuomainen T, Koistinen V, Tuomainen M, Leppänen J, Laitinen T, Lehtonen M, Rysä J, Auriola S, Poso A, Tavi P, Hanhineva K.

Sci Rep. 2018 Aug 29;8(1):13036. doi: 10.1038/s41598-018-31484-5.

13.

Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure.

Konings GF, Saarinen N, Delvoux B, Kooreman L, Koskimies P, Krakstad C, Fasmer KE, Haldorsen IS, Zaffagnini A, Häkkinen MR, Auriola S, Dubois L, Lieuwes N, Verhaegen F, Schyns LE, Kruitwagen RF; ENITEC Consortium, Xanthoulea S, Romano A.

Int J Mol Sci. 2018 Aug 28;19(9). pii: E2547. doi: 10.3390/ijms19092547.

14.

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.

Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T.

Brain Behav Immun. 2018 Oct;73:670-681. doi: 10.1016/j.bbi.2018.07.021. Epub 2018 Jul 29.

PMID:
30063972
15.

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.

Lukin A, Kramer J, Hartmann M, Weizel L, Hernandez-Olmos V, Falahati K, Burghardt I, Kalinchenkova N, Bagnyukova D, Zhurilo N, Rautio J, Forsberg M, Ihalainen J, Auriola S, Leppänen J, Konstantinov I, Pogoryelov D, Proschak E, Dar'in D, Krasavin M.

Bioorg Chem. 2018 Oct;80:655-667. doi: 10.1016/j.bioorg.2018.07.014. Epub 2018 Jul 17.

PMID:
30059891
16.

Transplacental transfer and metabolism of diuron in human placenta.

Mohammed AM, Karttunen V, Huuskonen P, Huovinen M, Auriola S, Vähäkangas K.

Toxicol Lett. 2018 Oct 1;295:307-313. doi: 10.1016/j.toxlet.2018.07.012. Epub 2018 Jul 20.

PMID:
30010034
17.

Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals.

Tuomainen M, Lindström J, Lehtonen M, Auriola S, Pihlajamäki J, Peltonen M, Tuomilehto J, Uusitupa M, de Mello VD, Hanhineva K.

Nutr Diabetes. 2018 May 25;8(1):35. doi: 10.1038/s41387-018-0046-9.

18.

Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake.

Kärkkäinen J, Gynther M, Kokkola T, Petsalo A, Auriola S, Lahtela-Kakkonen M, Laine K, Rautio J, Huttunen KM.

Int J Pharm. 2018 Jun 10;544(1):91-99. doi: 10.1016/j.ijpharm.2018.04.025. Epub 2018 Apr 15.

PMID:
29669256
19.

Alcohol and substance use are associated with altered metabolome in the first trimester serum samples of pregnant mothers.

Lehikoinen AI, Kärkkäinen OK, Lehtonen MAS, Auriola SOK, Hanhineva KJ, Heinonen ST.

Eur J Obstet Gynecol Reprod Biol. 2018 Apr;223:79-84. doi: 10.1016/j.ejogrb.2018.02.004. Epub 2018 Feb 17.

PMID:
29500949
20.

Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue.

Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S.

J Pharm Biomed Anal. 2018 Apr 15;152:165-172. doi: 10.1016/j.jpba.2018.01.034. Epub 2018 Jan 31.

PMID:
29414008
21.

Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort.

Shi L, Brunius C, Lehtonen M, Auriola S, Bergdahl IA, Rolandsson O, Hanhineva K, Landberg R.

Diabetologia. 2018 Apr;61(4):849-861. doi: 10.1007/s00125-017-4521-y. Epub 2018 Jan 18.

22.

Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist.

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L.

J Med Chem. 2017 Dec 14;60(23):9885-9904. doi: 10.1021/acs.jmedchem.7b01624. Epub 2017 Dec 5.

23.

Antiandrogens Reduce Intratumoral Androgen Concentrations and Induce Androgen Receptor Expression in Castration-Resistant Prostate Cancer Xenografts.

Knuuttila M, Mehmood A, Huhtaniemi R, Yatkin E, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M.

Am J Pathol. 2018 Jan;188(1):216-228. doi: 10.1016/j.ajpath.2017.08.036. Epub 2017 Nov 7.

PMID:
29126837
24.

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma SI, Hosoya KI, Urtti A, Terasaki T, Tachikawa M.

Mol Pharm. 2017 Nov 6;14(11):3729-3738. doi: 10.1021/acs.molpharmaceut.7b00493. Epub 2017 Oct 12.

PMID:
28954515
25.

Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals.

Fayyaz A, Makwinja S, Auriola S, Raunio H, Juvonen RO.

Planta Med. 2018 Mar;84(5):320-328. doi: 10.1055/s-0043-119886. Epub 2017 Sep 26.

PMID:
28950382
26.

Impact of Chemical Structure on Conjunctival Drug Permeability: Adopting Porcine Conjunctiva and Cassette Dosing for Construction of In Silico Model.

Ramsay E, Ruponen M, Picardat T, Tengvall U, Tuomainen M, Auriola S, Toropainen E, Urtti A, Del Amo EM.

J Pharm Sci. 2017 Sep;106(9):2463-2471. doi: 10.1016/j.xphs.2017.04.061. Epub 2017 May 4.

PMID:
28479360
27.

Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study.

de Mello VD, Paananen J, Lindström J, Lankinen MA, Shi L, Kuusisto J, Pihlajamäki J, Auriola S, Lehtonen M, Rolandsson O, Bergdahl IA, Nordin E, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Landberg R, Eriksson JG, Tuomilehto J, Hanhineva K, Uusitupa M.

Sci Rep. 2017 Apr 11;7:46337. doi: 10.1038/srep46337.

28.

Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells.

Bhattacharya M, Sarkhel S, Peltoniemi J, Broadbridge R, Tuomainen M, Auriola S, Urtti A.

J Control Release. 2017 Apr 10;251:37-48. doi: 10.1016/j.jconrel.2017.02.013. Epub 2017 Feb 16.

PMID:
28213274
29.

Butyrophilin 3A/CD277-Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations.

Nerdal PT, Peters C, Oberg HH, Zlatev H, Lettau M, Quabius ES, Sousa S, Gonnermann D, Auriola S, Olive D, Määttä J, Janssen O, Kabelitz D.

J Immunol. 2016 Oct 15;197(8):3059-3068. Epub 2016 Sep 12.

30.

Increased steroid hormone dehydroepiandrosterone and pregnenolone levels in post-mortem brain samples of alcoholics.

Kärkkäinen O, Häkkinen MR, Auriola S, Kautiainen H, Tiihonen J, Storvik M.

Alcohol. 2016 May;52:63-70. doi: 10.1016/j.alcohol.2016.03.002. Epub 2016 Mar 24.

PMID:
27139239
31.

Uptake of free, calcium-bound and liposomal encapsulated nitrogen containing bisphosphonates by breast cancer cells.

Zlatev HP, Auriola S, Mönkkönen J, Määttä JA.

Eur J Pharm Sci. 2016 Apr 30;86:58-66. doi: 10.1016/j.ejps.2016.02.016. Epub 2016 Mar 5.

PMID:
26957415
32.

Intracellular PK/PD Relationships of Free and Liposomal Doxorubicin: Quantitative Analyses and PK/PD Modeling.

Soininen SK, Vellonen KS, Heikkinen AT, Auriola S, Ranta VP, Urtti A, Ruponen M.

Mol Pharm. 2016 Apr 4;13(4):1358-65. doi: 10.1021/acs.molpharmaceut.6b00008. Epub 2016 Mar 16.

PMID:
26950248
33.

Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.

Soininen SK, Repo JK, Karttunen V, Auriola S, Vähäkangas KH, Ruponen M.

Toxicol Lett. 2015 Dec 3;239(2):108-14. doi: 10.1016/j.toxlet.2015.09.011. Epub 2015 Sep 14.

PMID:
26383631
34.

Discovery of urinary biomarkers of whole grain rye intake in free-living subjects using nontargeted LC-MS metabolite profiling.

Hanhineva K, Brunius C, Andersson A, Marklund M, Juvonen R, Keski-Rahkonen P, Auriola S, Landberg R.

Mol Nutr Food Res. 2015 Nov;59(11):2315-25. doi: 10.1002/mnfr.201500423. Epub 2015 Sep 10.

PMID:
26264776
35.

Zearalenone metabolism in human placental subcellular organelles, JEG-3 cells, and recombinant CYP19A1.

Huuskonen P, Auriola S, Pasanen M.

Placenta. 2015 Sep;36(9):1052-5. doi: 10.1016/j.placenta.2015.06.014. Epub 2015 Jul 7.

PMID:
26188906
36.

Comparison of trapping profiles between d-peptides and glutathione in the identification of reactive metabolites.

Laine JE, Häkkinen MR, Auriola S, Juvonen RO, Pasanen M.

Toxicol Rep. 2015 Jul 9;2:1024-1032. doi: 10.1016/j.toxrep.2015.07.002. eCollection 2015.

37.

Inhibitory effects and oxidation of 6-methylcoumarin, 7-methylcoumarin and 7-formylcoumarin via human CYP2A6 and its mouse and pig orthologous enzymes.

Juvonen RO, Kuusisto M, Fohrgrup C, Pitkänen MH, Nevalainen TJ, Auriola S, Raunio H, Pasanen M, Pentikäinen OT.

Xenobiotica. 2016;46(1):14-24. doi: 10.3109/00498254.2015.1048327. Epub 2015 Jun 11.

PMID:
26068522
38.

CMPF does not associate with impaired glucose metabolism in individuals with features of metabolic syndrome.

Lankinen MA, Hanhineva K, Kolehmainen M, Lehtonen M, Auriola S, Mykkänen H, Poutanen K, Schwab U, Uusitupa M.

PLoS One. 2015 Apr 15;10(4):e0124379. doi: 10.1371/journal.pone.0124379. eCollection 2015.

39.

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells.

Sousa S, Auriola S, Mönkkönen J, Määttä J.

BMC Cancer. 2015 Jan 15;15:4. doi: 10.1186/s12885-015-1005-7.

40.

Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.

Ebert R, Meissner-Weigl J, Zeck S, Määttä J, Auriola S, Coimbra de Sousa S, Mentrup B, Graser S, Rachner TD, Hofbauer LC, Jakob F.

Mol Cancer. 2014 Dec 11;13:265. doi: 10.1186/1476-4598-13-265.

41.

Reactive metabolites in early drug development: predictive in vitro tools.

Pelkonen O, Pasanen M, Tolonen A, Koskinen M, Hakkola J, Abass K, Laine J, Hakkinen M, Juvonen R, Auriola S, Storvik M, Huuskonen P, Rousu T, Rahikkala M.

Curr Med Chem. 2015;22(4):538-50. Review.

PMID:
25312212
42.

Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.

Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M.

Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21.

PMID:
25295702
43.

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.

Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen MR, Awosanya M, Suvitie P, Kujari H, Aittokallio T, Handelsman DJ, Auriola S, Perheentupa A, Poutanen M.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2188-97. doi: 10.1210/jc.2014-1913. Epub 2014 Aug 19.

PMID:
25137424
44.

Quantitative metabolite profiling of edible onion species by NMR and HPLC-MS.

Soininen TH, Jukarainen N, Auriola SO, Julkunen-Tiitto R, Karjalainen R, Vepsäläinen JJ.

Food Chem. 2014 Dec 15;165:499-505. doi: 10.1016/j.foodchem.2014.05.132. Epub 2014 Jun 6.

PMID:
25038704
45.

Castration induces up-regulation of intratumoral androgen biosynthesis and androgen receptor expression in an orthotopic VCaP human prostate cancer xenograft model.

Knuuttila M, Yatkin E, Kallio J, Savolainen S, Laajala TD, Aittokallio T, Oksala R, Häkkinen M, Keski-Rahkonen P, Auriola S, Poutanen M, Mäkelä S.

Am J Pathol. 2014 Aug;184(8):2163-73. doi: 10.1016/j.ajpath.2014.04.010. Epub 2014 Jun 17.

PMID:
24949550
46.

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.

Landreh L, Spinnler K, Schubert K, Häkkinen MR, Auriola S, Poutanen M, Söder O, Svechnikov K, Mayerhofer A.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1227-35. doi: 10.1210/jc.2013-4199. Epub 2014 Mar 31.

PMID:
24684461
47.

Metabolite profiling of leek (Allium porrum L) cultivars by (1) H NMR and HPLC-MS.

Soininen TH, Jukarainen N, Soininen P, Auriola SO, Julkunen-Tiitto R, Oleszek W, Stochmal A, Karjalainen RO, Vepsäläinen JJ.

Phytochem Anal. 2014 May-Jun;25(3):220-8. doi: 10.1002/pca.2495. Epub 2014 Jan 10.

PMID:
24408868
48.

Conjugation of peptides to antisense interleukin-6 via click chemistry.

Wang CF, Auriola S, Hirvonen J, Santos HA.

Curr Med Chem. 2014 Apr;21(10):1247-54.

PMID:
24251570
49.

Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.

Häkkinen MR, Roine A, Auriola S, Tuokko A, Veskimäe E, Keinänen TA, Lehtimäki T, Oksala N, Vepsäläinen J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Dec 15;941:81-9. doi: 10.1016/j.jchromb.2013.10.009. Epub 2013 Oct 15.

PMID:
24185098
50.

LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization.

Keski-Rahkonen P, Huhtinen K, Desai R, Harwood DT, Handelsman DJ, Poutanen M, Auriola S.

J Mass Spectrom. 2013 Sep;48(9):1050-8. doi: 10.1002/jms.3252.

PMID:
24078246

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