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Items: 1 to 50 of 166

1.

Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.

Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleeman JP.

PLoS Genet. 2019 Jun 27;15(6):e1008216. doi: 10.1371/journal.pgen.1008216. eCollection 2019 Jun.

2.

VEGFR1+ metastasis-associated macrophages contribute to metastatic angiogenesis and influence colorectal cancer patient outcome.

Freire Valls A, Knipper K, Giannakouri E, Sarachaga V, Hinterkopf S, Wuehrl M, Shen Y, Radhakrishnan P, Klose J, Ulrich A, Schneider M, Augustin HG, Ruiz de Almodovar C, Schmidt T.

Clin Cancer Res. 2019 Jun 25. pii: clincanres.2123.2018. doi: 10.1158/1078-0432.CCR-18-2123. [Epub ahead of print]

PMID:
31239322
3.

Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Meln I, Wolff G, Gajek T, Koddebusch J, Lerch S, Harbrecht L, Hong W, Bayindir-Buchhalter I, Krunic D, Augustin HG, Vegiopoulos A.

Mol Metab. 2019 Jun;24:139-148. doi: 10.1016/j.molmet.2019.03.012. Epub 2019 Apr 5.

4.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

PMID:
30936549
5.

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration.

Kim J, Park JR, Choi J, Park I, Hwang Y, Bae H, Kim Y, Choi W, Yang JM, Han S, Chung TY, Kim P, Kubota Y, Augustin HG, Oh WY, Koh GY.

Sci Adv. 2019 Feb 13;5(2):eaau6732. doi: 10.1126/sciadv.aau6732. eCollection 2019 Feb.

6.

Cytokine-Like 1 Is a Novel Proangiogenic Factor Secreted by and Mediating Functions of Endothelial Progenitor Cells.

Schneller D, Hofer-Warbinek R, Sturtzel C, Lipnik K, Gencelli B, Seltenhammer M, Wen M, Testori J, Bilban M, Borowski A, Windwarder M, Kapel SS, Besemfelder E, Cejka P, Habertheuer A, Schlechta B, Majdic O, Altmann F, Kocher A, Augustin HG, Luttmann W, Hofer E.

Circ Res. 2019 Jan 18;124(2):243-255. doi: 10.1161/CIRCRESAHA.118.313645.

PMID:
30582450
7.

Endothelial cell fitness dictates the source of regenerating liver vasculature.

Singhal M, Liu X, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG, Hu J.

J Exp Med. 2018 Oct 1;215(10):2497-2508. doi: 10.1084/jem.20180008. Epub 2018 Sep 7.

8.

T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin.

Bauer C, Abdul Pari AA, Umansky V, Utikal J, Boukamp P, Augustin HG, Goerdt S, Géraud C, Felcht M.

Cancer Immunol Immunother. 2018 Jul;67(7):1147-1157. doi: 10.1007/s00262-018-2171-7. Epub 2018 May 24.

PMID:
29799076
9.

Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly.

Kim KH, Nakaoka Y, Augustin HG, Koh GY.

Cell Rep. 2018 May 22;23(8):2455-2466. doi: 10.1016/j.celrep.2018.04.080.

10.

Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. Review.

11.

Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance.

Maida A, Zota A, Vegiopoulos A, Appak-Baskoy S, Augustin HG, Heikenwalder M, Herzig S, Rose AJ.

J Nutr Biochem. 2018 Jul;57:189-196. doi: 10.1016/j.jnutbio.2018.03.027. Epub 2018 Apr 7.

PMID:
29751292
12.

The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium.

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG.

Elife. 2018 May 11;7. pii: e34423. doi: 10.7554/eLife.34423.

13.

Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis.

La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG.

J Clin Invest. 2018 Feb 1;128(2):834-845. doi: 10.1172/JCI94674. Epub 2018 Jan 22.

14.

Inhibition of Endothelial Notch Signaling Impairs Fatty Acid Transport and Leads to Metabolic and Vascular Remodeling of the Adult Heart.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A.

Circulation. 2018 Jun 12;137(24):2592-2608. doi: 10.1161/CIRCULATIONAHA.117.029733. Epub 2018 Jan 20.

PMID:
29353241
15.

Microvascular Mural Cell Organotypic Heterogeneity and Functional Plasticity.

Holm A, Heumann T, Augustin HG.

Trends Cell Biol. 2018 Apr;28(4):302-316. doi: 10.1016/j.tcb.2017.12.002. Epub 2018 Jan 5. Review.

PMID:
29307447
16.

Preclinical mouse solid tumour models: status quo, challenges and perspectives.

Gengenbacher N, Singhal M, Augustin HG.

Nat Rev Cancer. 2017 Dec;17(12):751-765. doi: 10.1038/nrc.2017.92. Epub 2017 Oct 27. Review.

PMID:
29077691
17.

Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice.

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavszky V, Schledzewski K, Goerdt S, Koch PS.

Hepatology. 2018 Aug;68(2):707-722. doi: 10.1002/hep.29613. Epub 2018 Feb 1.

18.

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M.

Cell Metab. 2017 Dec 5;26(6):842-855.e5. doi: 10.1016/j.cmet.2017.09.018. Epub 2017 Oct 19.

19.

Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma.

Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY.

J Clin Invest. 2017 Oct 2;127(10):3877-3896. doi: 10.1172/JCI94668. Epub 2017 Sep 18.

20.

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology.

Augustin HG, Koh GY.

Science. 2017 Aug 25;357(6353). pii: eaal2379. doi: 10.1126/science.aal2379. Epub 2017 Aug 3. Review.

PMID:
28775214
21.

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation.

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG.

Nat Commun. 2017 Jul 18;8:16106. doi: 10.1038/ncomms16106.

22.

Plastic roles of pericytes in the blood-retinal barrier.

Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, Koh GY.

Nat Commun. 2017 May 16;8:15296. doi: 10.1038/ncomms15296.

23.

Models in Translational Oncology: A Public Resource Database for Preclinical Cancer Research.

Galuschka C, Proynova R, Roth B, Augustin HG, Müller-Decker K.

Cancer Res. 2017 May 15;77(10):2557-2563. doi: 10.1158/0008-5472.CAN-16-3099. Review.

24.

Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin.

Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG.

EMBO Mol Med. 2017 Jun;9(6):741-749. doi: 10.15252/emmm.201607222.

25.

Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A.

Manavski Y, Abel T, Hu J, Kleinlützum D, Buchholz CJ, Belz C, Augustin HG, Boon RA, Dimmeler S.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3993-3998. doi: 10.1073/pnas.1613392114. Epub 2017 Mar 27.

26.

VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation.

Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG, Ruhrberg C.

J Exp Med. 2017 Apr 3;214(4):1049-1064. doi: 10.1084/jem.20160311. Epub 2017 Mar 13.

27.

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

Géraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S.

J Clin Invest. 2017 Mar 1;127(3):1099-1114. doi: 10.1172/JCI90086. Epub 2017 Feb 20.

28.

Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells.

Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):495-505. doi: 10.1161/ATVBAHA.116.308455. Epub 2017 Jan 26.

PMID:
28126825
29.

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

Park JS, Kim IK, Han S, Park I, Kim C, Bae J, Oh SJ, Lee S, Kim JH, Woo DC, He Y, Augustin HG, Kim I, Lee D, Koh GY.

Cancer Cell. 2017 Jan 9;31(1):157-158. doi: 10.1016/j.ccell.2016.12.009. No abstract available.

30.

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

Park JS, Kim IK, Han S, Park I, Kim C, Bae J, Oh SJ, Lee S, Kim JH, Woo DC, He Y, Augustin HG, Kim I, Lee D, Koh GY.

Cancer Cell. 2016 Dec 12;30(6):953-967. doi: 10.1016/j.ccell.2016.10.018. Erratum in: Cancer Cell. 2017 Jan 9;31(1):157-158.

31.

A Synopsis of the "Influence of Epigenetics, Genetics, and Immunology" Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium.

Harrill AH, Moggs JG, Adkins KK, Augustin HG, Johnson RC, Leach MW.

Toxicol Pathol. 2017 Jan;45(1):114-118. doi: 10.1177/0192623316670781. Epub 2016 Oct 5. Review.

PMID:
27708198
32.

Endosialin-Expressing Pericytes Promote Metastatic Dissemination.

Viski C, König C, Kijewska M, Mogler C, Isacke CM, Augustin HG.

Cancer Res. 2016 Sep 15;76(18):5313-25. doi: 10.1158/0008-5472.CAN-16-0932.

33.

Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability.

Rathnakumar K, Savant S, Giri H, Ghosh A, Fisslthaler B, Fleming I, Ram U, Bera AK, Augustin HG, Dixit M.

J Thromb Haemost. 2016 Aug;14(8):1655-67. doi: 10.1111/jth.13376. Epub 2016 Jul 27.

34.

Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression.

Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Gaida MM, Büchler MW, Strobel O, Hackert T, Giese NA, Augustin HG, Hoheisel JD.

Cancer Res. 2016 Jul 15;76(14):4149-59. doi: 10.1158/0008-5472.CAN-15-0390. Epub 2016 May 23.

35.

Commentary on Folkman: "How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?".

Augustin HG.

Cancer Res. 2016 May 15;76(10):2854-6. doi: 10.1158/0008-5472.CAN-16-1123.

36.

Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL.

Am J Pathol. 2016 Jul;186(7):1874-1889. doi: 10.1016/j.ajpath.2016.03.010. Epub 2016 May 10.

37.

Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation.

Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG.

Sci Signal. 2016 Apr 26;9(425):ra42. doi: 10.1126/scisignal.aad3812.

PMID:
27117252
38.

Amelioration of sepsis by TIE2 activation-induced vascular protection.

Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim YI, Kim P, Kim I, Koh GY.

Sci Transl Med. 2016 Apr 20;8(335):335ra55. doi: 10.1126/scitranslmed.aad9260.

PMID:
27099174
39.

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG.

Dev Cell. 2016 Jan 11;36(1):79-93. doi: 10.1016/j.devcel.2015.12.015.

40.

MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA.

J Mol Cell Cardiol. 2015 Nov;88:111-9. doi: 10.1016/j.yjmcc.2015.10.009. Epub 2015 Oct 9.

PMID:
26456066
41.

The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells.

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG.

Cell Rep. 2015 Sep 22;12(11):1761-73. doi: 10.1016/j.celrep.2015.08.024. Epub 2015 Sep 3.

42.

Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis.

Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A.

EMBO Mol Med. 2015 Oct;7(10):1267-84. doi: 10.15252/emmm.201404922.

43.

Mechanisms of Vessel Pruning and Regression.

Korn C, Augustin HG.

Dev Cell. 2015 Jul 6;34(1):5-17. doi: 10.1016/j.devcel.2015.06.004. Review.

44.

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain.

Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R.

Cancer Cell. 2015 Jun 8;27(6):780-96. doi: 10.1016/j.ccell.2015.04.017. Erratum in: Cancer Cell. 2015 Aug 10;28(2):270.

45.

Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis.

Klose R, Berger C, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A.

Cardiovasc Res. 2015 Jul 1;107(1):153-63. doi: 10.1093/cvr/cvv151. Epub 2015 May 14.

PMID:
25975260
46.

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association.

Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S; American Heart Association Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia.

Circ Res. 2015 May 22;116(11):e99-132. doi: 10.1161/RES.0000000000000054. Epub 2015 Apr 30. No abstract available.

47.

Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T.

FASEB J. 2015 Jul;29(7):3076-84. doi: 10.1096/fj.14-267633. Epub 2015 Apr 9.

PMID:
25857554
48.

Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis.

Teichert M, Stumpf C, Booken N, Wobser M, Nashan D, Hallermann C, Mogler C, Müller CS, Becker JC, Moritz RK, Andrulis M, Nicolay JP, Goerdt S, Thomas M, Klemke CD, Augustin HG, Felcht M.

Exp Dermatol. 2015 Jun;24(6):424-9. doi: 10.1111/exd.12688. Epub 2015 Apr 16.

PMID:
25776770
49.

Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage.

Mogler C, Wieland M, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG.

EMBO Mol Med. 2015 Mar;7(3):332-8. doi: 10.15252/emmm.201404246.

50.

Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth.

Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG.

Cancer Cell. 2014 Dec 8;26(6):880-895. doi: 10.1016/j.ccell.2014.11.005.

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