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Items: 1 to 50 of 296

1.

Codeine delays gastric emptying through inhibition of gastric motility as assessed with a novel diagnostic intragastric balloon catheter.

Goelen N, de Hoon J, Morales JF, Varon C, Van Huffel S, Augustijns P, Mols R, Herbots M, Verbeke K, Vanuytsel T, Tack J, Janssen P.

Neurogastroenterol Motil. 2019 Oct 9:e13733. doi: 10.1111/nmo.13733. [Epub ahead of print]

PMID:
31595608
2.

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems.

Boyd BJ, Bergström CAS, Vinarov Z, Kuentz M, Brouwers J, Augustijns P, Brandl M, Bernkop-Schnürch A, Shrestha N, Préat V, Müllertz A, Bauer-Brandl A, Jannin V.

Eur J Pharm Sci. 2019 Sep 1;137:104967. doi: 10.1016/j.ejps.2019.104967. Epub 2019 Jun 25.

3.

Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation.

Berben P, Ashworth L, Beato S, Bevernage J, Bruel JL, Butler J, Dressman J, Schäfer K, Hutchins P, Klumpp L, Mann J, Nicolai J, Ojala K, Patel S, Powell S, Rosenblatt K, Tomaszewska I, Williams J, Augustijns P.

Eur J Pharm Biopharm. 2019 Jul;140:141-148. doi: 10.1016/j.ejpb.2019.04.017. Epub 2019 Apr 30.

PMID:
31051249
4.

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Vertzoni M, Augustijns P, Grimm M, Koziolek M, Lemmens G, Parrott N, Pentafragka C, Reppas C, Rubbens J, Van Den Αbeele J, Vanuytsel T, Weitschies W, Wilson CG.

Eur J Pharm Sci. 2019 Jun 15;134:153-175. doi: 10.1016/j.ejps.2019.04.013. Epub 2019 Apr 13.

5.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Koziolek M, Alcaro S, Augustijns P, Basit AW, Grimm M, Hens B, Hoad CL, Jedamzik P, Madla CM, Maliepaard M, Marciani L, Maruca A, Parrott N, Pávek P, Porter CJH, Reppas C, van Riet-Nales D, Rubbens J, Statelova M, Trevaskis NL, Valentová K, Vertzoni M, Čepo DV, Corsetti M.

Eur J Pharm Sci. 2019 Jun 15;134:31-59. doi: 10.1016/j.ejps.2019.04.003. Epub 2019 Apr 8.

6.

Co-existing colloidal phases of human duodenal aspirates: Intraindividual fluctuations and interindividual variability in relation to molecular composition.

Elvang PA, Bohsen MS, Stein PC, Bauer-Brandl A, Riethorst D, Brouwers J, Augustijns P, Brandl M.

J Pharm Biomed Anal. 2019 Jun 5;170:22-29. doi: 10.1016/j.jpba.2019.03.026. Epub 2019 Mar 15.

PMID:
30903926
7.

Immobilizing sulfotransferase 1A1 on magnetic microparticles and their evaluation using capillary electrophoresis.

Ramana P, Adams E, Augustijns P, Van Schepdael A.

Electrophoresis. 2019 Sep;40(18-19):2271-2276. doi: 10.1002/elps.201900016. Epub 2019 Mar 25.

PMID:
30882918
8.

Predicting iron absorption from an effervescent iron supplement in obese patients before and after Roux-en-Y gastric bypass: a preliminary study.

Gesquiere I, Steenackers N, Lannoo M, Foulon V, Mertens A, Gils A, de Hoon J, Augustijns P, Matthys C, Van der Schueren B.

J Trace Elem Med Biol. 2019 Mar;52:68-73. doi: 10.1016/j.jtemb.2018.12.002. Epub 2018 Dec 7.

PMID:
30732902
9.

The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir.

Kubbinga M, Augustijns P, García MA, Heinen C, Wortelboer HM, Verwei M, Langguth P.

Eur J Pharm Biopharm. 2019 Mar;136:147-155. doi: 10.1016/j.ejpb.2019.01.021. Epub 2019 Jan 22.

PMID:
30682491
10.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration.

Butler J, Hens B, Vertzoni M, Brouwers J, Berben P, Dressman J, Andreas CJ, Schaefer KJ, Mann J, McAllister M, Jamei M, Kostewicz E, Kesisoglou F, Langguth P, Minekus M, Müllertz A, Schilderink R, Koziolek M, Jedamzik P, Weitschies W, Reppas C, Augustijns P.

Eur J Pharm Biopharm. 2019 Mar;136:70-83. doi: 10.1016/j.ejpb.2018.12.010. Epub 2018 Dec 20.

11.

Gastric and Duodenal Diclofenac Concentrations in Healthy Volunteers after Intake of the FDA Standard Meal: In Vivo Observations and in Vitro Explorations.

Rubbens J, Brouwers J, Tack J, Augustijns P.

Mol Pharm. 2019 Feb 4;16(2):573-582. doi: 10.1021/acs.molpharmaceut.8b00865. Epub 2019 Jan 9.

PMID:
30571131
12.

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.

Stakenborg N, Labeeuw E, Gomez-Pinilla PJ, De Schepper S, Aerts R, Goverse G, Farro G, Appeltans I, Meroni E, Stakenborg M, Viola MF, Gonzalez-Dominguez E, Bosmans G, Alpizar YA, Wolthuis A, D'Hoore A, Van Beek K, Verheijden S, Verhaegen M, Derua R, Waelkens E, Moretti M, Gotti C, Augustijns P, Talavera K, Vanden Berghe P, Matteoli G, Boeckxstaens GE.

Gut. 2019 Aug;68(8):1406-1416. doi: 10.1136/gutjnl-2018-317263. Epub 2018 Nov 24.

13.

Altered duodenal bile salt concentration and receptor expression in functional dyspepsia.

Beeckmans D, Riethorst D, Augustijns P, Vanuytsel T, Farré R, Tack J, Vanheel H.

United European Gastroenterol J. 2018 Nov;6(9):1347-1355. doi: 10.1177/2050640618799120. Epub 2018 Sep 4.

14.

Intestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS.

Chalet C, Hollebrands B, Duchateau GS, Augustijns P.

Xenobiotica. 2019 Aug;49(8):945-952. doi: 10.1080/00498254.2018.1509246. Epub 2018 Sep 28.

PMID:
30085847
15.

Introduction to the OrBiTo decision tree to select the most appropriate in vitro methodology for release testing of solid oral dosage forms during development.

Andreas CJ, Rosenberger J, Butler J, Augustijns P, McAllister M, Abrahamsson B, Dressman J.

Eur J Pharm Biopharm. 2018 Sep;130:207-213. doi: 10.1016/j.ejpb.2018.07.003. Epub 2018 Jul 3. Review.

PMID:
30064698
16.

Gastric fluid composition in a paediatric population: Age-dependent changes relevant for gastrointestinal drug disposition.

Van Den Abeele J, Rayyan M, Hoffman I, Van de Vijver E, Zhu W, Augustijns P.

Eur J Pharm Sci. 2018 Oct 15;123:301-311. doi: 10.1016/j.ejps.2018.07.022. Epub 2018 Jul 10.

PMID:
30006179
17.

Exploring gastric drug absorption in fasted and fed state rats.

Rubbens J, Mols R, Brouwers J, Augustijns P.

Int J Pharm. 2018 Sep 5;548(1):636-641. doi: 10.1016/j.ijpharm.2018.07.017. Epub 2018 Jul 4.

PMID:
29981414
18.

Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®.

Berben P, Stappaerts J, Vink MJA, Domínguez-Vega E, Somsen GW, Brouwers J, Augustijns P.

Eur J Pharm Biopharm. 2018 Nov;132:231-236. doi: 10.1016/j.ejpb.2018.06.025. Epub 2018 Jun 27.

PMID:
29959034
19.

Human intestinal fluid factors affecting intestinal drug permeation in vitro.

Riethorst D, Brouwers J, Motmans J, Augustijns P.

Eur J Pharm Sci. 2018 Aug 30;121:338-346. doi: 10.1016/j.ejps.2018.06.007. Epub 2018 Jun 15.

PMID:
29902511
20.

Human intestinal fluid layer separation: The effect on colloidal structures & solubility of lipophilic compounds.

Riethorst D, Mitra A, Kesisoglou F, Xu W, Tack J, Brouwers J, Augustijns P.

Eur J Pharm Biopharm. 2018 Aug;129:104-110. doi: 10.1016/j.ejpb.2018.05.026. Epub 2018 May 24.

PMID:
29802985
21.

The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration.

Kourentas A, Vertzoni M, Barmpatsalou V, Augustijns P, Beato S, Butler J, Holm R, Ouwerkerk N, Rosenberg J, Tajiri T, Tannergren C, Symillides M, Reppas C.

AAPS J. 2018 May 24;20(4):71. doi: 10.1208/s12248-018-0231-8.

PMID:
29797293
22.

Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers.

Chalet C, Rubbens J, Tack J, Duchateau GS, Augustijns P.

J Pharm Pharmacol. 2018 Aug;70(8):1002-1008. doi: 10.1111/jphp.12929. Epub 2018 May 15.

PMID:
29761870
23.

Drug permeability profiling using cell-free permeation tools: Overview and applications.

Berben P, Bauer-Brandl A, Brandl M, Faller B, Flaten GE, Jacobsen AC, Brouwers J, Augustijns P.

Eur J Pharm Sci. 2018 Jul 1;119:219-233. doi: 10.1016/j.ejps.2018.04.016. Epub 2018 Apr 13. Review.

24.

Iron deficiency after bariatric surgery: what is the real problem?

Steenackers N, Van der Schueren B, Mertens A, Lannoo M, Grauwet T, Augustijns P, Matthys C.

Proc Nutr Soc. 2018 Nov;77(4):445-455. doi: 10.1017/S0029665118000149. Epub 2018 Apr 5. Review.

PMID:
29619914
25.

Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes.

Keemink J, Deferm N, De Bruyn T, Augustijns P, Bouillon T, Annaert P.

AAPS J. 2018 Feb 21;20(2):33. doi: 10.1208/s12248-018-0188-7.

PMID:
29468289
26.

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors.

Ramana P, Schejbal J, Houthoofd K, Martens J, Adams E, Augustijns P, Glatz Z, Van Schepdael A.

Electrophoresis. 2018 Apr;39(7):981-988. doi: 10.1002/elps.201700434. Epub 2018 Jan 19.

PMID:
29315710
27.

The effect of 2-hydroxypropyl-β-cyclodextrin on the intestinal permeation through mucus.

Stappaerts J, Berben P, Cevik I, Augustijns P.

Eur J Pharm Sci. 2018 Mar 1;114:238-244. doi: 10.1016/j.ejps.2017.12.014. Epub 2017 Dec 20.

PMID:
29274442
28.

The artificial membrane insert system as predictive tool for formulation performance evaluation.

Berben P, Brouwers J, Augustijns P.

Int J Pharm. 2018 Feb 15;537(1-2):22-29. doi: 10.1016/j.ijpharm.2017.12.025. Epub 2017 Dec 12.

PMID:
29241703
29.

Identification of phase-II metabolites of flavonoids by liquid chromatography-ion-mobility spectrometry-mass spectrometry.

Chalet C, Hollebrands B, Janssen HG, Augustijns P, Duchateau G.

Anal Bioanal Chem. 2018 Jan;410(2):471-482. doi: 10.1007/s00216-017-0737-4. Epub 2017 Nov 22.

PMID:
29167932
30.

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

Oorts M, Keemink J, Deferm N, Adriaensen R, Richert L, Augustijns P, Annaert P.

J Pharmacol Toxicol Methods. 2018 Mar - Apr;90:31-38. doi: 10.1016/j.vascn.2017.10.007. Epub 2017 Oct 25.

PMID:
29079456
31.

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range.

Lubin A, Sheng S, Cabooter D, Augustijns P, Cuyckens F.

J Chromatogr A. 2017 Nov 17;1524:101-107. doi: 10.1016/j.chroma.2017.09.053. Epub 2017 Sep 27.

PMID:
28989028
32.

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

Nicolaï J, Thevelin L, Bing Q, Stieger B, Chanteux H, Augustijns P, Annaert P.

Pharm Res. 2017 Nov;34(11):2336-2348. doi: 10.1007/s11095-017-2241-0. Epub 2017 Aug 21.

33.

Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System.

Berben P, Brouwers J, Augustijns P.

J Pharm Sci. 2018 Jan;107(1):250-256. doi: 10.1016/j.xphs.2017.08.002. Epub 2017 Aug 19.

PMID:
28826878
34.

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation, and Precipitation of Posaconazole.

Hens B, Pathak SM, Mitra A, Patel N, Liu B, Patel S, Jamei M, Brouwers J, Augustijns P, Turner DB.

Mol Pharm. 2017 Dec 4;14(12):4321-4333. doi: 10.1021/acs.molpharmaceut.7b00396. Epub 2017 Sep 5.

PMID:
28817288
35.

Advances in Capillary Electrophoretically Mediated Microanalysis for On-line Enzymatic and Derivatization Reactions.

Huang S, Paul P, Ramana P, Adams E, Augustijns P, Van Schepdael A.

Electrophoresis. 2018 Jan;39(1):97-110. doi: 10.1002/elps.201700262. Epub 2017 Sep 13. Review.

PMID:
28815641
36.

Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish.

Kislyuk S, Kroonen J, Adams E, Augustijns P, de Witte P, Cabooter D.

Talanta. 2017 Nov 1;174:780-788. doi: 10.1016/j.talanta.2017.06.075. Epub 2017 Jun 28.

PMID:
28738654
37.

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study.

Mann J, Dressman J, Rosenblatt K, Ashworth L, Muenster U, Frank K, Hutchins P, Williams J, Klumpp L, Wielockx K, Berben P, Augustijns P, Holm R, Hofmann M, Patel S, Beato S, Ojala K, Tomaszewska I, Bruel JL, Butler J.

Mol Pharm. 2017 Dec 4;14(12):4192-4201. doi: 10.1021/acs.molpharmaceut.7b00198. Epub 2017 Aug 23.

PMID:
28737403
38.

Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

Rubbens J, Riethorst D, Brouwers J, Wolfs K, Adams E, Tack J, Augustijns P.

Mol Pharm. 2017 Dec 4;14(12):4202-4208. doi: 10.1021/acs.molpharmaceut.7b00252. Epub 2017 Aug 11.

PMID:
28731350
39.

The impact of guest compounds on cyclodextrin aggregation behavior: A series of structurally related parabens.

Stappaerts J, Do Thi T, Dominguez-Vega E, Somsen GW, Van den Mooter G, Augustijns P.

Int J Pharm. 2017 Aug 30;529(1-2):442-450. doi: 10.1016/j.ijpharm.2017.07.026. Epub 2017 Jul 10.

PMID:
28705618
40.

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools.

Van Den Abeele J, Schilderink R, Schneider F, Mols R, Minekus M, Weitschies W, Brouwers J, Tack J, Augustijns P.

Mol Pharm. 2017 Dec 4;14(12):4220-4232. doi: 10.1021/acs.molpharmaceut.7b00253. Epub 2017 Jul 7.

PMID:
28621952
41.

Exploring drug solubility in fasted human intestinal fluid aspirates: Impact of inter-individual variability, sampling site and dilution.

de la Cruz-Moreno MP, Montejo C, Aguilar-Ros A, Dewe W, Beck B, Stappaerts J, Tack J, Augustijns P.

Int J Pharm. 2017 Aug 7;528(1-2):471-484. doi: 10.1016/j.ijpharm.2017.05.072. Epub 2017 Jun 4.

PMID:
28591618
42.

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

Lubin A, De Vries R, Cabooter D, Augustijns P, Cuyckens F.

J Pharm Biomed Anal. 2017 Aug 5;142:225-231. doi: 10.1016/j.jpba.2017.05.003. Epub 2017 May 4.

PMID:
28521276
43.

Evaluation of real-life dosing of oral medicines with respect to fluid and food intake in a Dutch-speaking population.

Hens B, Van Den Abeele J, Rubbens J, Keirsebilck M, Roelens J, Schreurs C, Verheyen K, Casteels M, Laekeman G, Augustijns P.

J Clin Pharm Ther. 2017 Aug;42(4):467-474. doi: 10.1111/jcpt.12535. Epub 2017 Apr 27.

PMID:
28452061
44.

Gastrointestinal behavior of itraconazole in humans - Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution.

Berben P, Mols R, Brouwers J, Tack J, Augustijns P.

Int J Pharm. 2017 Jun 30;526(1-2):235-243. doi: 10.1016/j.ijpharm.2017.04.057. Epub 2017 Apr 24.

PMID:
28450167
45.

Gastrointestinal behavior of itraconazole in humans - Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution.

Brouwers J, Geboers S, Mols R, Tack J, Augustijns P.

Int J Pharm. 2017 Jun 15;525(1):211-217. doi: 10.1016/j.ijpharm.2017.04.029. Epub 2017 Apr 13.

PMID:
28414135
46.

The Effect of Sparkling Water on Intraluminal Formulation Behavior and Systemic Drug Performance.

Van Den Abeele J, Brouwers J, Deloose E, Tack J, Augustijns P.

J Pharm Sci. 2017 Sep;106(9):2472-2482. doi: 10.1016/j.xphs.2017.03.039. Epub 2017 Apr 7.

PMID:
28392455
47.

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

Fattah S, Shinde AB, Matic M, Baes M, van Schaik RHN, Allegaert K, Parmentier C, Richert L, Augustijns P, Annaert P.

Pharm Res. 2017 Jun;34(6):1309-1319. doi: 10.1007/s11095-017-2148-9. Epub 2017 Mar 31.

PMID:
28364304
48.

Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.

Riekes MK, Dereymaker A, Berben P, Augustijns P, Stulzer HK, Van den Mooter G.

Int J Pharm. 2017 Mar 30;520(1-2):49-58. doi: 10.1016/j.ijpharm.2017.01.053. Epub 2017 Jan 30.

PMID:
28153650
49.

Trapping magnetic nanoparticles for in-line capillary electrophoresis in a liquid based capillary coolant system.

Ramana P, Adams E, Augustijns P, Van Schepdael A.

Talanta. 2017 Mar 1;164:148-153. doi: 10.1016/j.talanta.2016.11.028. Epub 2016 Nov 17.

PMID:
28107909
50.

Evaluation of immobilized hFMO3 on magnetic nanoparticles by capillary zone electrophoresis.

Ramana P, Herman W, Hiroux C, Adams E, Augustijns P, Van Schepdael A.

Bioanalysis. 2017 Feb;9(3):289-296. doi: 10.4155/bio-2016-0151. Epub 2017 Jan 13.

PMID:
28084789

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