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Items: 1 to 50 of 179

1.

Vitamin D and the nutritional environment in functions of intestinal stem cells: Implications for tumorigenesis and prevention.

Li W, Peregrina K, Houston M, Augenlicht LH.

J Steroid Biochem Mol Biol. 2019 Nov 26;198:105556. doi: 10.1016/j.jsbmb.2019.105556. [Epub ahead of print] Review.

PMID:
31783155
2.

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaaw3521. doi: 10.1126/scitranslmed.aaw3521.

PMID:
31776290
3.

The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesis.

Li W, Zimmerman SE, Peregrina K, Houston M, Mayoral J, Zhang J, Maqbool S, Zhang Z, Cai Y, Ye K, Augenlicht LH.

Carcinogenesis. 2019 Aug 22;40(8):937-946. doi: 10.1093/carcin/bgz106.

PMID:
31169292
4.

MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa.

Tadesse S, Corner G, Dhima E, Houston M, Guha C, Augenlicht L, Velcich A.

Oncotarget. 2017 Apr 6;8(42):71456-71470. doi: 10.18632/oncotarget.16886. eCollection 2017 Sep 22.

5.

Modelling western dietary habits in the mouse: easier said than done.

Fodde R, Schmitt M, Schewe M, Augenlicht LH.

Hepatobiliary Surg Nutr. 2017 Apr;6(2):138-140. doi: 10.21037/hbsn.2017.01.20. No abstract available.

6.

Environmental Impact on Intestinal Stem Cell Functions in Mucosal Homeostasis and Tumorigenesis.

Augenlicht LH.

J Cell Biochem. 2017 May;118(5):943-952. doi: 10.1002/jcb.25719. Epub 2017 Jan 11. Review.

7.

NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.

Srinivasan T, Walters J, Bu P, Than EB, Tung KL, Chen KY, Panarelli N, Milsom J, Augenlicht L, Lipkin SM, Shen X.

Cancer Res. 2016 Jun 1;76(11):3411-21. doi: 10.1158/0008-5472.CAN-15-3198. Epub 2016 Apr 11.

8.

Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells.

Srinivasan T, Than EB, Bu P, Tung KL, Chen KY, Augenlicht L, Lipkin SM, Shen X.

Sci Rep. 2016 May 16;6:26069. doi: 10.1038/srep26069.

9.

Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial.

Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR.

Am J Clin Nutr. 2016 May;103(5):1224-31. doi: 10.3945/ajcn.114.105304. Epub 2016 Mar 23.

10.

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM.

J Biol Chem. 2015 Jun 19;290(25):15392. doi: 10.1074/jbc.A114.557546. No abstract available.

11.

Real time analysis of metabolic profile in ex vivo mouse intestinal crypt organoid cultures.

Bas T, Augenlicht LH.

J Vis Exp. 2014 Nov 3;(93):e52026. doi: 10.3791/52026.

12.

Hidden effects of mouse chow.

Augenlicht L.

Science. 2014 Nov 7;346(6210):710. doi: 10.1126/science.346.6210.710-a. No abstract available.

PMID:
25378612
13.

Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions.

Peregrina K, Houston M, Daroqui C, Dhima E, Sellers RS, Augenlicht LH.

Carcinogenesis. 2015 Jan;36(1):25-31. doi: 10.1093/carcin/bgu221. Epub 2014 Oct 24.

14.

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, Sieber OM, Augenlicht LH, Dhillon AS, Weber TK, Mariadason JM.

J Biol Chem. 2014 Sep 5;289(36):25306-16. doi: 10.1074/jbc.M114.557546. Epub 2014 Jul 18. Erratum in: J Biol Chem. 2015 Jun 19;290(25):15392. Dávaos-Salas, Mercedes [Corrected to Dávalos-Salas, Mercedes].

15.

The Role of STAT1 for Crosstalk between Fibroblasts and Colon Cancer Cells.

Kaler P, Owusu BY, Augenlicht L, Klampfer L.

Front Oncol. 2014 Apr 30;4:88. doi: 10.3389/fonc.2014.00088. eCollection 2014.

16.

Circulating soluble cytokine receptors and colorectal cancer risk.

Ho GY, Wang T, Zheng SL, Tinker L, Xu J, Rohan TE, Wassertheil-Smoller S, Xue X, Augenlicht LH, Peters U, Phipps AI, Strickler HD, Gunter MJ, Cushman M.

Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):179-88. doi: 10.1158/1055-9965.EPI-13-0545. Epub 2013 Nov 5.

17.

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.

Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A.

Science. 2013 Oct 25;342(6157):447-53. doi: 10.1126/science.1237910. Epub 2013 Sep 26.

18.

STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.

Nguyen AV, Wu YY, Liu Q, Wang D, Nguyen S, Loh R, Pang J, Friedman K, Orlofsky A, Augenlicht L, Pollard JW, Lin EY.

Neoplasia. 2013 Sep;15(9):998-1008.

19.

The effect of lung cancer on cytokine expression in peripheral blood mononuclear cells.

Chang DH, Rutledge JR, Patel AA, Heerdt BG, Augenlicht LH, Korst RJ.

PLoS One. 2013 Jun 6;8(6):e64456. doi: 10.1371/journal.pone.0064456. Print 2013.

20.

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.

Huffman DM, Augenlicht LH, Zhang X, Lofrese JJ, Atzmon G, Chamberland JP, Mantzoros CS.

Cancer Prev Res (Phila). 2013 Mar;6(3):177-87. doi: 10.1158/1940-6207.CAPR-12-0414.

21.

Activating mutations in β-catenin in colon cancer cells alter their interaction with macrophages; the role of snail.

Kaler P, Augenlicht L, Klampfer L.

PLoS One. 2012;7(9):e45462. doi: 10.1371/journal.pone.0045462. Epub 2012 Sep 21.

22.

Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice.

Bastie CC, Gaffney-Stomberg E, Lee TW, Dhima E, Pessin JE, Augenlicht LH.

J Nutr. 2012 May;142(5):859-65. doi: 10.3945/jn.111.149914. Epub 2012 Mar 21.

23.

Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.

Houston MA, Augenlicht LH, Heerdt BG.

PLoS One. 2011;6(9):e25207. doi: 10.1371/journal.pone.0025207. Epub 2011 Sep 23.

24.

Intestinal epithelial-specific PTEN inactivation results in tumor formation.

Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11.

25.

Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity.

Houston MA, Augenlicht LH, Heerdt BG.

Int J Cell Biol. 2011;2011:978583. doi: 10.1155/2011/978583. Epub 2011 Jul 2.

26.

Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365.

Papetti M, Augenlicht LH.

Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G508-18. doi: 10.1152/ajpgi.00066.2011. Epub 2011 Jul 7.

27.

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer.

Wang D, Peregrina K, Dhima E, Lin EY, Mariadason JM, Augenlicht LH.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10272-7. doi: 10.1073/pnas.1017668108. Epub 2011 Jun 7.

28.

MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.

Papetti M, Augenlicht LH.

J Cell Physiol. 2011 Mar;226(3):785-91. doi: 10.1002/jcp.22399.

29.

Transcriptional attenuation in colon carcinoma cells in response to butyrate.

Daroqui MC, Augenlicht LH.

Cancer Prev Res (Phila). 2010 Oct;3(10):1292-302. doi: 10.1158/1940-6207.CAPR-10-0083. Epub 2010 Sep 14.

30.

Prediction and testing of biological networks underlying intestinal cancer.

Patel VN, Bebek G, Mariadason JM, Wang D, Augenlicht LH, Chance MR.

PLoS One. 2010 Sep 1;5(9). pii: e12497. doi: 10.1371/journal.pone.0012497.

31.

Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells.

Seetharam RN, Sood A, Basu-Mallick A, Augenlicht LH, Mariadason JM, Goel S.

Anticancer Res. 2010 Jul;30(7):2531-8.

PMID:
20682979
32.

Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells.

Kaler P, Galea V, Augenlicht L, Klampfer L.

PLoS One. 2010 Jul 22;5(7):e11700. doi: 10.1371/journal.pone.0011700.

33.

Altered dynamics of intestinal cell maturation in Apc1638N/+ mice.

Wang D, Pezo RC, Corner G, Sison C, Lesser ML, Shenoy SM, Mariadason JM, Singer RH, Augenlicht LH.

Cancer Res. 2010 Jul 1;70(13):5348-57. doi: 10.1158/0008-5472.CAN-09-4593. Epub 2010 Jun 22.

34.

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.

Wilson AJ, Chueh AC, Tögel L, Corner GA, Ahmed N, Goel S, Byun DS, Nasser S, Houston MA, Jhawer M, Smartt HJ, Murray LB, Nicholas C, Heerdt BG, Arango D, Augenlicht LH, Mariadason JM.

Cancer Res. 2010 Jan 15;70(2):609-20. doi: 10.1158/0008-5472.CAN-09-2327. Epub 2010 Jan 12.

35.

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis.

Deng L, Zhou JF, Sellers RS, Li JF, Nguyen AV, Wang Y, Orlofsky A, Liu Q, Hume DA, Pollard JW, Augenlicht L, Lin EY.

Am J Pathol. 2010 Feb;176(2):952-67. doi: 10.2353/ajpath.2010.090622. Epub 2009 Dec 30.

36.

Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling.

Guilmeau S, Flandez M, Mariadason JM, Augenlicht LH.

Oncogene. 2010 Feb 18;29(7):992-1002. doi: 10.1038/onc.2009.393. Epub 2009 Nov 23.

PMID:
19935714
37.

Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors.

Ganepola GA, Mazziotta RM, Weeresinghe D, Corner GA, Parish CJ, Chang DH, Tebbutt NC, Murone C, Ahmed N, Augenlicht LH, Mariadason JM.

Clin Exp Metastasis. 2010;27(1):1-9. doi: 10.1007/s10585-009-9295-2. Epub 2009 Nov 1.

PMID:
19882219
38.

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.

Yuan Z, Shin J, Wilson A, Goel S, Ling YH, Ahmed N, Dopeso H, Jhawer M, Nasser S, Montagna C, Fordyce K, Augenlicht LH, Aaltonen LA, Arango D, Weber TK, Mariadason JM.

Cancer Res. 2009 Oct 1;69(19):7811-8. doi: 10.1158/0008-5472.CAN-09-0986. Epub 2009 Sep 29. Erratum in: Cancer Res. 2010 Feb 1;70(3):1275.

39.

The NF-κB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1β.

Kaler P, Godasi BN, Augenlicht L, Klampfer L.

Cancer Microenviron. 2009 Sep 25;2(1):69-80. doi: 10.1007/s12307-009-0030-y. eCollection 2009 Dec.

40.

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.

Itano O, Yang K, Fan K, Kurihara N, Shinozaki H, Abe S, Jin B, Gravaghi C, Edelmann W, Augenlicht L, Kopelovich L, Kucherlapati R, Lamprecht S, Lipkin M.

Carcinogenesis. 2009 Nov;30(11):1923-6. doi: 10.1093/carcin/bgp200. Epub 2009 Sep 15.

41.

Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3.

Kaler P, Augenlicht L, Klampfer L.

Oncogene. 2009 Nov 5;28(44):3892-902. doi: 10.1038/onc.2009.247. Epub 2009 Aug 24.

42.

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.

Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD.

Exp Cell Res. 2009 May 1;315(8):1415-28. doi: 10.1016/j.yexcr.2009.02.002. Epub 2009 Feb 14.

43.

Chemoprevention of colorectal neoplasia by estrogen: potential role of vitamin D activity.

Protiva P, Cross HS, Hopkins ME, Kállay E, Bises G, Dreyhaupt E, Augenlicht L, Lipkin M, Lesser M, Livote E, Holt PR.

Cancer Prev Res (Phila). 2009 Jan;2(1):43-51. doi: 10.1158/1940-6207.CAPR-08-0103.

44.

Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.

Maier S, Daroqui MC, Scherer S, Roepcke S, Velcich A, Shenoy SM, Singer RH, Augenlicht LH.

J Cell Physiol. 2009 Mar;218(3):638-42. doi: 10.1002/jcp.21642.

45.

Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer.

Newmark HL, Yang K, Kurihara N, Fan K, Augenlicht LH, Lipkin M.

Carcinogenesis. 2009 Jan;30(1):88-92. doi: 10.1093/carcin/bgn229. Epub 2008 Nov 18.

46.

KLF4 regulation in intestinal epithelial cell maturation.

Flandez M, Guilmeau S, Blache P, Augenlicht LH.

Exp Cell Res. 2008 Dec 10;314(20):3712-23. doi: 10.1016/j.yexcr.2008.10.004. Epub 2008 Oct 21.

47.

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

Yang K, Kurihara N, Fan K, Newmark H, Rigas B, Bancroft L, Corner G, Livote E, Lesser M, Edelmann W, Velcich A, Lipkin M, Augenlicht L.

Cancer Res. 2008 Oct 1;68(19):7803-10. doi: 10.1158/0008-5472.CAN-08-1209.

48.

Proteomic changes during intestinal cell maturation in vivo.

Chang J, Chance MR, Nicholas C, Ahmed N, Guilmeau S, Flandez M, Wang D, Byun DS, Nasser S, Albanese JM, Corner GA, Heerdt BG, Wilson AJ, Augenlicht LH, Mariadason JM.

J Proteomics. 2008 Dec 2;71(5):530-46. doi: 10.1016/j.jprot.2008.08.003. Epub 2008 Sep 12.

49.

Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.

Yang K, Popova NV, Yang WC, Lozonschi I, Tadesse S, Kent S, Bancroft L, Matise I, Cormier RT, Scherer SJ, Edelmann W, Lipkin M, Augenlicht L, Velcich A.

Cancer Res. 2008 Sep 15;68(18):7313-22. doi: 10.1158/0008-5472.CAN-08-0598.

50.

Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice.

Yang K, Lamprecht SA, Shinozaki H, Fan K, Yang W, Newmark HL, Kopelovich L, Edelmann W, Jin B, Gravaghi C, Augenlicht L, Kucherlapati R, Lipkin M.

J Nutr. 2008 Sep;138(9):1658-63.

PMID:
18716166

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