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Items: 48


Evaluating Sufficient Similarity of Botanical Dietary Supplements: Combining Chemical and In Vitro Biological Data.

Ryan KR, Huang MC, Ferguson SS, Waidyanatha S, Ramaiahgari S, Rice JR, Dunlap PE, Auerbach SS, Mutlu E, Cristy T, Peirfelice J, DeVito MJ, Smith-Roe SL, Rider CV.

Toxicol Sci. 2019 Dec 1;172(2):316-329. doi: 10.1093/toxsci/kfz189.


Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Hsieh JH, Smith-Roe SL, Huang R, Sedykh A, Shockley KR, Auerbach SS, Merrick BA, Xia M, Tice RR, Witt KL.

Chem Res Toxicol. 2019 Jul 15;32(7):1384-1401. doi: 10.1021/acs.chemrestox.9b00053. Epub 2019 Jun 18.


A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.

Pelch K, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh JH, Svoboda D, Auerbach SS, Parham FM, Masten SA, Walker V, Rooney A, Thayer KA.

Toxicology. 2019 Aug 1;424:152235. doi: 10.1016/j.tox.2019.06.006. Epub 2019 Jun 12. Review.


Arsenite malignantly transforms human prostate epithelial cells in vitro by gene amplification of mutated KRAS.

Merrick BA, Phadke DP, Bostrom MA, Shah RR, Wright GM, Wang X, Gordon O, Pelch KE, Auerbach SS, Paules RS, DeVito MJ, Waalkes MP, Tokar EJ.

PLoS One. 2019 Apr 22;14(4):e0215504. doi: 10.1371/journal.pone.0215504. eCollection 2019.


Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements.

Hubbard TD, Hsieh JH, Rider CV, Sipes NS, Sedykh A, Collins BJ, Auerbach SS, Xia M, Huang R, Walker NJ, DeVito MJ.

Appl In Vitro Toxicol. 2019 Mar 1;5(1):10-25. doi: 10.1089/aivt.2018.0020. Epub 2019 Mar 9.


The Power of Resolution: Contextualized Understanding of Biological Responses to Liver Injury Chemicals Using High-throughput Transcriptomics and Benchmark Concentration Modeling.

Ramaiahgari SC, Auerbach SS, Saddler TO, Rice JR, Dunlap PE, Sipes NS, DeVito MJ, Shah RR, Bushel PR, Merrick BA, Paules RS, Ferguson SS.

Toxicol Sci. 2019 Jun 1;169(2):553-566. doi: 10.1093/toxsci/kfz065.


NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7 [Internet].

Gwinn WM, Bousquet RW, Perry CE, Urbano NC, Auerbach SS.

Durham (NC): National Toxicology Program; 2018 Dec.


Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements.

Roberts GK, Gardner D, Foster PM, Howard PC, Lui E, Walker L, van Breemen RB, Auerbach SS, Rider C.

Food Chem Toxicol. 2019 Feb;124:431-438. doi: 10.1016/j.fct.2018.12.026. Epub 2018 Dec 21. Review.


A Comparison of the TempO-Seq S1500+ Platform to RNA-Seq and Microarray Using Rat Liver Mode of Action Samples.

Bushel PR, Paules RS, Auerbach SS.

Front Genet. 2018 Oct 30;9:485. doi: 10.3389/fgene.2018.00485. eCollection 2018.


BMDExpress 2: enhanced transcriptomic dose-response analysis workflow.

Phillips JR, Svoboda DL, Tandon A, Patel S, Sedykh A, Mav D, Kuo B, Yauk CL, Yang L, Thomas RS, Gift JS, Davis JA, Olszyk L, Merrick BA, Paules RS, Parham F, Saddler T, Shah RR, Auerbach SS.

Bioinformatics. 2019 May 15;35(10):1780-1782. doi: 10.1093/bioinformatics/bty878.


Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals.

Klaren WD, Ring C, Harris MA, Thompson CM, Borghoff S, Sipes NS, Hsieh JH, Auerbach SS, Rager JE.

Toxicol Sci. 2019 Jan 1;167(1):157-171. doi: 10.1093/toxsci/kfy220.


Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure.

Auerbach SS, Xu M, Merrick BA, Hoenerhoff MJ, Phadke D, Taxman DJ, Shah R, Hong HL, Ton TV, Kovi RC, Sills RC, Pandiri AR.

Toxicol Pathol. 2018 Aug;46(6):706-718. doi: 10.1177/0192623318789398. Epub 2018 Jul 25.


How similar is similar enough? A sufficient similarity case study with Ginkgo biloba extract.

Catlin NR, Collins BJ, Auerbach SS, Ferguson SS, Harnly JM, Gennings C, Waidyanatha S, Rice GE, Smith-Roe SL, Witt KL, Rider CV.

Food Chem Toxicol. 2018 Aug;118:328-339. doi: 10.1016/j.fct.2018.05.013. Epub 2018 May 9.


Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells.

Smith-Roe SL, Swartz CD, Shepard KG, Bryce SM, Dertinger SD, Waidyanatha S, Kissling GE, Auerbach SS, Witt KL.

Environ Mol Mutagen. 2018 Jun;59(5):416-426. doi: 10.1002/em.22182. Epub 2018 Apr 18.


A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics.

Mav D, Shah RR, Howard BE, Auerbach SS, Bushel PR, Collins JB, Gerhold DL, Judson RS, Karmaus AL, Maull EA, Mendrick DL, Merrick BA, Sipes NS, Svoboda D, Paules RS.

PLoS One. 2018 Feb 20;13(2):e0191105. doi: 10.1371/journal.pone.0191105. eCollection 2018.


Identification of Estrogen-Related Receptor α Agonists in the Tox21 Compound Library.

Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M.

Endocrinology. 2018 Feb 1;159(2):744-753. doi: 10.1210/en.2017-00658.


Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort.

Rager JE, Auerbach SS, Chappell GA, Martin E, Thompson CM, Fry RC.

Chem Res Toxicol. 2017 Oct 16;30(10):1911-1920. doi: 10.1021/acs.chemrestox.7b00221. Epub 2017 Sep 27.


An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.

Environ Sci Technol. 2017 Sep 19;51(18):10786-10796. doi: 10.1021/acs.est.7b00650. Epub 2017 Sep 6.


Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites.

Perera L, Li Y, Coons LA, Houtman R, van Beuningen R, Goodwin B, Auerbach SS, Teng CT.

Toxicol In Vitro. 2017 Oct;44:287-302. doi: 10.1016/j.tiv.2017.07.020. Epub 2017 Jul 24.


Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.

Witt KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR.

Environ Mol Mutagen. 2017 Aug;58(7):494-507. doi: 10.1002/em.22112. Epub 2017 Jul 17.


Correction: Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.

PLoS One. 2017 Jul 7;12(7):e0181291. doi: 10.1371/journal.pone.0181291. eCollection 2017.


Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.

PLoS One. 2017 May 22;12(5):e0177902. doi: 10.1371/journal.pone.0177902. eCollection 2017. Erratum in: PLoS One. 2017 Jul 7;12 (7):e0181291.


Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators.

Teng CT, Hsieh JH, Zhao J, Huang R, Xia M, Martin N, Gao X, Dixon D, Auerbach SS, Witt KL, Merrick BA.

SLAS Discov. 2017 Jul;22(6):720-731. doi: 10.1177/2472555216689772. Epub 2017 Jan 31.


Evaluation of 4-methylcyclohexanemethanol (MCHM) in a combined irritancy and Local Lymph Node Assay (LLNA) in mice.

Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.

Food Chem Toxicol. 2017 Jul;105:99-105. doi: 10.1016/j.fct.2017.03.034. Epub 2017 Mar 22.


Systems biology for organotypic cell cultures.

Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.

ALTEX. 2017;34(2):301-310. doi: 10.14573/altex.1608221. Epub 2016 Nov 14.


The Importance of the Biological Impact of Exposure to the Concept of the Exposome.

Dennis KK, Auerbach SS, Balshaw DM, Cui Y, Fallin MD, Smith MT, Spira A, Sumner S, Miller GW.

Environ Health Perspect. 2016 Oct;124(10):1504-1510. Epub 2016 Jun 3. Review.


RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights.

Auerbach SS, Phadke DP, Mav D, Holmgren S, Gao Y, Xie B, Shin JH, Shah RR, Merrick BA, Tice RR.

J Appl Toxicol. 2015 Jul;35(7):766-80. doi: 10.1002/jat.3068. Epub 2014 Nov 6.


The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance.

Wang C, Gong B, Bushel PR, Thierry-Mieg J, Thierry-Mieg D, Xu J, Fang H, Hong H, Shen J, Su Z, Meehan J, Li X, Yang L, Li H, Łabaj PP, Kreil DP, Megherbi D, Gaj S, Caiment F, van Delft J, Kleinjans J, Scherer A, Devanarayan V, Wang J, Yang Y, Qian HR, Lancashire LJ, Bessarabova M, Nikolsky Y, Furlanello C, Chierici M, Albanese D, Jurman G, Riccadonna S, Filosi M, Visintainer R, Zhang KK, Li J, Hsieh JH, Svoboda DL, Fuscoe JC, Deng Y, Shi L, Paules RS, Auerbach SS, Tong W.

Nat Biotechnol. 2014 Sep;32(9):926-32. doi: 10.1038/nbt.3001. Epub 2014 Aug 24.


Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action.

Gusenleitner D, Auerbach SS, Melia T, Gómez HF, Sherr DH, Monti S.

PLoS One. 2014 Jul 24;9(7):e102579. doi: 10.1371/journal.pone.0102579. eCollection 2014.


Transcriptomic profiling of rat liver samples in a comprehensive study design by RNA-Seq.

Gong B, Wang C, Su Z, Hong H, Thierry-Mieg J, Thierry-Mieg D, Shi L, Auerbach SS, Tong W, Xu J.

Sci Data. 2014 Aug 26;1:140021. doi: 10.1038/sdata.2014.21. eCollection 2014.


Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework.

Thomas RS, Philbert MA, Auerbach SS, Wetmore BA, Devito MJ, Cote I, Rowlands JC, Whelan MP, Hays SM, Andersen ME, Meek ME, Reiter LW, Lambert JC, Clewell HJ 3rd, Stephens ML, Zhao QJ, Wesselkamper SC, Flowers L, Carney EW, Pastoor TP, Petersen DD, Yauk CL, Nong A.

Toxicol Sci. 2013 Nov;136(1):4-18. doi: 10.1093/toxsci/kft178. Epub 2013 Aug 19.


Biological networks for predicting chemical hepatocarcinogenicity using gene expression data from treated mice and relevance across human and rat species.

Thomas R, Thomas RS, Auerbach SS, Portier CJ.

PLoS One. 2013 May 30;8(5):e63308. doi: 10.1371/journal.pone.0063308. Print 2013.


RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.

Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.

PLoS One. 2013 Apr 22;8(4):e61768. doi: 10.1371/journal.pone.0061768. Print 2013.


Harnessing genomics to identify environmental determinants of heritable disease.

Yauk CL, Lucas Argueso J, Auerbach SS, Awadalla P, Davis SR, Demarini DM, Douglas GR, Dubrova YE, Elespuru RK, Glover TW, Hales BF, Hurles ME, Klein CB, Lupski JR, Manchester DK, Marchetti F, Montpetit A, Mulvihill JJ, Robaire B, Robbins WA, Rouleau GA, Shaughnessy DT, Somers CM, Taylor JG 6th, Trasler J, Waters MD, Wilson TE, Witt KL, Bishop JB.

Mutat Res. 2013 Jan-Mar;752(1):6-9. doi: 10.1016/j.mrrev.2012.08.002. Epub 2012 Aug 28.


Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.

Pandiri AR, Sills RC, Ziglioli V, Ton TV, Hong HH, Lahousse SA, Gerrish KE, Auerbach SS, Shockley KR, Bushel PR, Peddada SD, Hoenerhoff MJ.

Toxicol Pathol. 2012 Dec;40(8):1141-59. doi: 10.1177/0192623312447543. Epub 2012 Jun 11.


Testing an aflatoxin B1 gene signature in rat archival tissues.

Merrick BA, Auerbach SS, Stockton PS, Foley JF, Malarkey DE, Sills RC, Irwin RD, Tice RR.

Chem Res Toxicol. 2012 May 21;25(5):1132-44. doi: 10.1021/tx3000945. Epub 2012 May 4.


Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.

Hoenerhoff MJ, Pandiri AR, Lahousse SA, Hong HH, Ton TV, Masinde T, Auerbach SS, Gerrish K, Bushel PR, Shockley KR, Peddada SD, Sills RC.

Toxicol Pathol. 2011 Jun;39(4):678-99. doi: 10.1177/0192623311407213. Epub 2011 May 13.


Comparative phenotypic assessment of cardiac pathology, physiology, and gene expression in C3H/HeJ, C57BL/6J, and B6C3F1/J mice.

Auerbach SS, Thomas R, Shah R, Xu H, Vallant MK, Nyska A, Dunnick JK.

Toxicol Pathol. 2010 Oct;38(6):923-42. doi: 10.1177/0192623310382864.


Predicting the hepatocarcinogenic potential of alkenylbenzene flavoring agents using toxicogenomics and machine learning.

Auerbach SS, Shah RR, Mav D, Smith CS, Walker NJ, Vallant MK, Boorman GA, Irwin RD.

Toxicol Appl Pharmacol. 2010 Mar 15;243(3):300-14. doi: 10.1016/j.taap.2009.11.021. Epub 2009 Dec 11.


Toxicity and carcinogenicity studies of methylene blue trihydrate in F344N rats and B6C3F1 mice.

Auerbach SS, Bristol DW, Peckham JC, Travlos GS, Hébert CD, Chhabra RS.

Food Chem Toxicol. 2010 Jan;48(1):169-77. doi: 10.1016/j.fct.2009.09.034. Epub 2009 Oct 3.


Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ.

Mol Pharmacol. 2009 May;75(5):1005-13. doi: 10.1124/mol.108.053702. Epub 2009 Feb 11.


A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein.

Auerbach SS, Mahler J, Travlos GS, Irwin RD.

Toxicology. 2008 Nov 20;253(1-3):79-88. doi: 10.1016/j.tox.2008.08.014. Epub 2008 Sep 4.


Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites.

Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ.

Nucleic Acids Res. 2007;35(7):2177-90. Epub 2007 Mar 13.


CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics.

Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ.

Drug Metab Dispos. 2007 Mar;35(3):428-39. Epub 2006 Dec 28.


Alternatively spliced isoforms of the human constitutive androstane receptor.

Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ.

Nucleic Acids Res. 2003 Jun 15;31(12):3194-207.


Requirement for TAF(II)250 acetyltransferase activity in cell cycle progression.

Dunphy EL, Johnson T, Auerbach SS, Wang EH.

Mol Cell Biol. 2000 Feb;20(4):1134-9.

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