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Items: 1 to 50 of 127

1.

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.

Joshi AA, Vaidya SS, St-Pierre MV, Mikheev AM, Desino KE, Nyandege AN, Audus KL, Unadkat JD, Gerk PM.

Pharm Res. 2016 Dec;33(12):2847-2878. Epub 2016 Sep 19. Review.

2.

Editorial.

Audus KL.

J Pharm Sci. 2016 Feb;105(2):369. doi: 10.1016/S0022-3549(15)00179-3. No abstract available.

PMID:
26869405
3.

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

J Pharm Sci. 2016 Feb;105(2):370-385. doi: 10.1002/jps.24687. Epub 2016 Jan 29. No abstract available.

PMID:
26453244
4.

Editorial.

Audus KL.

J Pharm Sci. 2015 Feb;104(2):288-9. doi: 10.1002/jps.24349. Epub 2015 Jan 15. No abstract available.

PMID:
25594867
5.

The permeation of dynorphin A 1-6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability.

Sloan CD, Audus KL, Aldrich JV, Lunte SM.

Peptides. 2012 Dec;38(2):414-7. doi: 10.1016/j.peptides.2012.09.031. Epub 2012 Oct 6.

6.

Analytical and biological methods for probing the blood-brain barrier.

Kuhnline Sloan CD, Nandi P, Linz TH, Aldrich JV, Audus KL, Lunte SM.

Annu Rev Anal Chem (Palo Alto Calif). 2012;5:505-31. doi: 10.1146/annurev-anchem-062011-143002. Review.

7.

Going global: the report of the 2009-2010 Research and Graduate Affairs Committee.

Audus KL, Moreton JE, Normann SA, Sands CD 3rd, Seaba HH, Wincor MZ, Sagraves R, Miller KW; Research and Graduate Affairs Committee.

Am J Pharm Educ. 2010 Dec 15;74(10):S8. No abstract available.

8.

Lipopolysaccharide increases the expression of multidrug resistance-associated protein 1 (MRP1) in RAW 264.7 macrophages.

Silverstein PS, Audus KL, Qureshi N, Kumar A.

J Neuroimmune Pharmacol. 2010 Dec;5(4):516-20. doi: 10.1007/s11481-009-9180-4. Epub 2009 Nov 6.

9.

MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells.

Mitra P, Audus KL.

Int J Pharm. 2010 Jan 15;384(1-2):15-23. doi: 10.1016/j.ijpharm.2009.09.033. Epub 2009 Sep 25.

10.

(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a novel neuroprotective agent.

Desino KE, Ansar S, Georg GI, Himes RH, Michaelis ML, Powell DR, Reiff EA, Telikepalli H, Audus KL.

J Med Chem. 2009 Dec 10;52(23):7537-43. doi: 10.1021/jm900254k.

11.

TCP-FA4: a derivative of tranylcypromine showing improved blood-brain permeability.

Desino KE, Pignatello R, Guccione S, Basile L, Ansar S, Michaelis ML, Ramsay RR, Audus KL.

Biochem Pharmacol. 2009 Dec 1;78(11):1412-7. doi: 10.1016/j.bcp.2009.07.027. Epub 2009 Aug 11.

PMID:
19679106
12.

Expression and functional activities of selected sulfotransferase isoforms in BeWo cells and primary cytotrophoblast cells.

Mitra P, Audus KL.

Biochem Pharmacol. 2009 Dec 15;78(12):1475-82. doi: 10.1016/j.bcp.2009.07.013. Epub 2009 Jul 30.

13.

Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability.

Turunen BJ, Ge H, Oyetunji J, Desino KE, Vasandani V, Güthe S, Himes RH, Audus KL, Seelig A, Georg GI.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5971-4. doi: 10.1016/j.bmcl.2008.09.103. Epub 2008 Oct 2.

14.

Contributions of phosphorylation to regulation of OCTN2 uptake of carnitine are minimal in BeWo cells.

Rytting E, Audus KL.

Biochem Pharmacol. 2008 Feb 1;75(3):745-51. Epub 2007 Sep 19.

15.

Effects of low oxygen levels on the expression and function of transporter OCTN2 in BeWo cells.

Rytting E, Audus KL.

J Pharm Pharmacol. 2007 Aug;59(8):1095-102.

PMID:
17725851
16.

Sequence recognition of alpha-LFA-1-derived peptides by ICAM-1 cell receptors: inhibitors of T-cell adhesion.

Yusuf-Makagiansar H, Yakovleva TV, Tejo BA, Jones K, Hu Y, Verkhivker GM, Audus KL, Siahaan TJ.

Chem Biol Drug Des. 2007 Sep;70(3):237-46.

PMID:
17718718
17.

A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.

Ansar S, Burlison JA, Hadden MK, Yu XM, Desino KE, Bean J, Neckers L, Audus KL, Michaelis ML, Blagg BS.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1984-90. Epub 2007 Jan 17.

PMID:
17276679
18.

Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells.

Rytting E, Bryan J, Southard M, Audus KL.

Biochem Pharmacol. 2007 Mar 15;73(6):891-900. Epub 2006 Dec 1.

19.

Investigation of the metabolism of substance P at the blood-brain barrier using LC-MS/MS.

Chappa AK, Cooper JD, Audus KL, Lunte SM.

J Pharm Biomed Anal. 2007 Mar 12;43(4):1409-15. Epub 2006 Nov 21.

20.

Characteristics of substance P transport across the blood-brain barrier.

Chappa AK, Audus KL, Lunte SM.

Pharm Res. 2006 Jun;23(6):1201-8. Epub 2006 Jun 1.

PMID:
16729222
21.

In vitro models for studying trophoblast transcellular transport.

Bode CJ, Jin H, Rytting E, Silverstein PS, Young AM, Audus KL.

Methods Mol Med. 2006;122:225-39.

22.

Tetrazole compounds: the effect of structure and pH on Caco-2 cell permeability.

Young AM, Audus KL, Proudfoot J, Yazdanian M.

J Pharm Sci. 2006 Apr;95(4):717-25.

PMID:
16498570
23.

Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells.

Spletstoser JT, Turunen BJ, Desino K, Rice A, Datta A, Dutta D, Huff JK, Himes RH, Audus KL, Seelig A, Georg GI.

Bioorg Med Chem Lett. 2006 Feb;16(3):495-8. Epub 2005 Nov 10.

PMID:
16289636
24.

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells.

Ge H, Vasandani V, Huff JK, Audus KL, Himes RH, Seelig A, Georg GI.

Bioorg Med Chem Lett. 2006 Jan 15;16(2):433-6. Epub 2005 Nov 3.

PMID:
16271474
26.

Effect of bisphenol A on drug efflux in BeWo, a human trophoblast-like cell line.

Jin H, Audus KL.

Placenta. 2005 Apr;26 Suppl A:S96-S103.

PMID:
15837075
27.
28.

National Institute on Drug Abuse Conference report on placental proteins, drug transport, and fetal development.

Thadani PV, Strauss JF 3rd, Dey SK, Anderson VM, Audus KL, Coats KS, Cross JC, Erlebacher A, Ganapathy V, Linzer DI, Miller RK, Novak DA, Rapaka RS, Sadovsky Y, Salafia CM, Soares M, Unadkat J.

Am J Obstet Gynecol. 2004 Dec;191(6):1858-62. Review.

PMID:
15592265
29.

{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents.

Michaelis ML, Ansar S, Chen Y, Reiff ER, Seyb KI, Himes RH, Audus KL, Georg GI.

J Pharmacol Exp Ther. 2005 Feb;312(2):659-68. Epub 2004 Sep 16.

PMID:
15375176
30.

Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells.

Rytting E, Audus KL.

J Pharmacol Exp Ther. 2005 Jan;312(1):192-8. Epub 2004 Aug 17.

PMID:
15316089
31.

Uptake studies for evaluating activity of efflux transporters in a cell line representative of the blood-brain barrier.

Silverstein PS, Karunaratne DN, Audus KL.

Curr Protoc Pharmacol. 2004 Feb;Chapter 7:Unit7.7. doi: 10.1002/0471141755.ph0707s23.

PMID:
21956812
32.

Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors.

Rice A, Michaelis ML, Georg G, Liu Y, Turunen B, Audus KL.

J Mol Neurosci. 2003;20(3):339-43.

PMID:
14501017
33.
34.

Efflux transporters of the human placenta.

Young AM, Allen CE, Audus KL.

Adv Drug Deliv Rev. 2003 Jan 21;55(1):125-32. Review.

PMID:
12535577
35.

The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.

Avery ML, Meek CE, Audus KL.

Placenta. 2003 Jan;24(1):45-52.

PMID:
12495659
36.

Increasing paracellular porosity by E-cadherin peptides: discovery of bulge and groove regions in the EC1-domain of E-cadherin.

Sinaga E, Jois SD, Avery M, Makagiansar IT, Tambunan US, Audus KL, Siahaan TJ.

Pharm Res. 2002 Aug;19(8):1170-9.

PMID:
12240943
37.

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro.

Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT.

J Pharm Sci. 2002 Sep;91(9):1991-2002.

PMID:
12210046
38.

Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers.

Hugger ED, Audus KL, Borchardt RT.

J Pharm Sci. 2002 Sep;91(9):1980-90.

PMID:
12210045
39.
40.

Transport and metabolism of opioid peptides across BeWo cells, an in vitro model of the placental barrier.

Ampasavate C, Chandorkar GA, Vande Velde DG, Stobaugh JF, Audus KL.

Int J Pharm. 2002 Feb 21;233(1-2):85-98.

PMID:
11897413
41.

Contribution of efflux pump activity to the delivery of pulmonary therapeutics.

Hamilton KO, Yazdanian MA, Audus KL.

Curr Drug Metab. 2002 Feb;3(1):1-12. Review.

PMID:
11876574
42.

Investigation of substance P transport across the blood-brain barrier.

Freed AL, Audus KL, Lunte SM.

Peptides. 2002 Jan;23(1):157-65.

PMID:
11814631
43.
44.

Carrier-mediated transport of folic acid in BeWo cell monolayers as a model of the human trophoblast.

Takahashi T, Utoguchi N, Takara A, Yamamoto N, Nakanishi T, Tanaka K, Audus KL, Watanabe Y.

Placenta. 2001 Nov;22(10):863-9.

PMID:
11718574
46.

Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands.

Hamilton KO, Yazdanian MA, Audus KL.

Int J Pharm. 2001 Oct 9;228(1-2):171-9.

PMID:
11576779
47.

Multidrug resistance-associated protein-1 functional activity in Calu-3 cells.

Hamilton KO, Topp E, Makagiansar I, Siahaan T, Yazdanian M, Audus KL.

J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.

PMID:
11504821
48.
49.

Nitric oxide and blood-brain barrier integrity.

Thiel VE, Audus KL.

Antioxid Redox Signal. 2001 Apr;3(2):273-8. Review.

PMID:
11396481
50.

Conjugation with L-Glutamate for in vivo brain drug delivery.

Sakaeda T, Tada Y, Sugawara T, Ryu T, Hirose F, Yoshikawa T, Hirano K, Kupczyk-Subotkowska L, Siahaan TJ, Audus KL, Stella VJ.

J Drug Target. 2001;9(1):23-37.

PMID:
11378521

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