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Items: 1 to 50 of 87

1.

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors.

Sors A, Panayi F, Bert L, Favale D, Nosjean O, Audinot V, Arrang JM, Buisson B, Steidl E, Delbos JM, Huhtala T, Kontkanen O, Chollet AM, Casara P, Lestage P.

Eur J Pharmacol. 2017 May 15;803:11-23. doi: 10.1016/j.ejphar.2017.03.013. Epub 2017 Mar 21.

PMID:
28336400
2.

Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models.

Della-Zuana O, Audinot V, Levenez V, Ktorza A, Presse F, Nahon JL, Boutin JA.

Front Endocrinol (Lausanne). 2012 Dec 21;3:160. doi: 10.3389/fendo.2012.00160. eCollection 2012.

3.

[G-protein-coupled receptors, the beginning of a new era for therapeutic innovation].

Bril A, Combettes M, Audinot V.

Med Sci (Paris). 2012 Oct;28(10):799-800. doi: 10.1051/medsci/20122810001. Epub 2012 Oct 12. Review. French. No abstract available.

4.

S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.

Millan MJ, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D, Newman-Tancredi A, Kamal M, Boutin JA, Jockers R, Marin P, Bockaert J, Muller O, Dekeyne A, Lavielle G.

J Pharmacol Exp Ther. 2012 Mar;340(3):750-64. doi: 10.1124/jpet.111.187468. Epub 2011 Dec 16.

PMID:
22178752
5.

Synthesis of new 8(S)-HETE analogs and their biological evaluation as activators of the PPAR nuclear receptors.

Liutkus M, Caijo F, Girard AL, Ayral E, Audinot V, Boutin JA, Renard P, Caignard DH, Dacquet C, Ktorza A, Mosset P, Grée R.

J Enzyme Inhib Med Chem. 2010 Oct;25(5):653-72. doi: 10.3109/14756360903468171.

PMID:
20518620
6.

Design, synthesis and pharmacological evaluation of novel naphthalenic derivatives as selective MT(1) melatoninergic ligands.

Mésangeau C, Pérès B, Descamps-François C, Chavatte P, Audinot V, Coumailleau S, Boutin JA, Delagrange P, Bennejean C, Renard P, Caignard DH, Berthelot P, Yous S.

Bioorg Med Chem. 2010 May 15;18(10):3426-36. doi: 10.1016/j.bmc.2010.04.008. Epub 2010 Apr 7.

PMID:
20444610
7.

S38151 [p-guanidinobenzoyl-[Des-Gly(10)]-MCH(7-17)] is a potent and selective antagonist at the MCH(1) receptor and has anti-feeding properties in vivo.

Audinot V, Zuana OD, Fabry N, Ouvry C, Nosjean O, Henlin JM, Fauchère JL, Boutin JA.

Peptides. 2009 Nov;30(11):1997-2007. doi: 10.1016/j.peptides.2009.07.007. Epub 2009 Jul 18.

PMID:
19619599
8.

Design and synthesis of 3-phenyltetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands. Part II.

Durieux S, Chanu A, Bochu C, Audinot V, Coumailleau S, Boutin JA, Delagrange P, Caignard DH, Bennejean C, Renard P, Lesieur D, Berthelot P, Yous S.

Bioorg Med Chem. 2009 Apr 15;17(8):2963-74. doi: 10.1016/j.bmc.2009.03.023. Epub 2009 Mar 18.

PMID:
19329323
9.

Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands.

Poissonnier-Durieux S, Ettaoussi M, Pérès B, Boutin JA, Audinot V, Bennejean C, Delagrange P, Caignard DH, Renard P, Berthelot P, Lesieur D, Yous S.

Bioorg Med Chem. 2008 Sep 15;16(18):8339-48. doi: 10.1016/j.bmc.2008.08.052. Epub 2008 Aug 27.

PMID:
18778943
10.

Molecular cloning and pharmacological characterization of rat melatonin MT1 and MT2 receptors.

Audinot V, Bonnaud A, Grandcolas L, Rodriguez M, Nagel N, Galizzi JP, Balik A, Messager S, Hazlerigg DG, Barrett P, Delagrange P, Boutin JA.

Biochem Pharmacol. 2008 May 15;75(10):2007-19. doi: 10.1016/j.bcp.2008.02.022. Epub 2008 Mar 4.

PMID:
18384758
11.

S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors.

Millan MJ, Mannoury la Cour C, Novi F, Maggio R, Audinot V, Newman-Tancredi A, Cussac D, Pasteau V, Boutin JA, Dubuffet T, Lavielle G.

J Pharmacol Exp Ther. 2008 Feb;324(2):587-99. Epub 2007 Nov 16.

PMID:
18024789
12.

Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake".

Chartrel N, Alvear-Perez R, Leprince J, Iturrioz X, Reaux-Le Goazigo A, Audinot V, Chomarat P, Coge F, Nosjean O, Rodriguez M, Galizzi JP, Boutin JA, Vaudry H, Llorens-Cortes C.

Science. 2007 Feb 9;315(5813):766; author reply 766.

13.

The use of IRES-based bicistronic vectors allows the stable expression of recombinant G-protein coupled receptors such as NPY5 and histamine 4.

Allera-Moreau C, Chomarat P, Audinot V, Cogé F, Gillard M, Martineau Y, Boutin JA, Prats AC.

Biochimie. 2006 Jun;88(6):737-46. Epub 2006 Jun 21.

14.

New ligands at the melatonin binding site MT(3).

Boussard MF, Truche S, Rousseau-Rojas A, Briss S, Descamps S, Droual M, Wierzbicki M, Ferry G, Audinot V, Delagrange P, Boutin JA.

Eur J Med Chem. 2006 Mar;41(3):306-20. Epub 2006 Jan 18.

PMID:
16414149
15.

Molecular tools to study melatonin pathways and actions.

Boutin JA, Audinot V, Ferry G, Delagrange P.

Trends Pharmacol Sci. 2005 Aug;26(8):412-9. Review.

PMID:
15992934
16.

Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay.

Beauverger P, Rodriguez M, Nicolas JP, Audinot V, Lamamy V, Dromaint S, Nagel N, Macia C, Léopold O, Galizzi JP, Caignard DH, Aldana I, Monge A, Chomarat P, Boutin JA.

Cell Signal. 2005 Apr;17(4):489-96.

PMID:
15601626
17.

Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors.

Larraya C, Guillard J, Renard P, Audinot V, Boutin JA, Delagrange P, Bennejean C, Viaud-Massuard MC.

Eur J Med Chem. 2004 Jun;39(6):515-26.

PMID:
15183910
18.

A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor.

Della-Zuana O, Revereault L, Beck-Sickinger A, Monge A, Caignard DH, Fauchère JL, Henlin JM, Audinot V, Boutin JA, Chamorro S, Félétou M, Levens N.

Int J Obes Relat Metab Disord. 2004 Apr;28(4):628-39.

PMID:
14758341
19.

Molecular pharmacology of the ovine melatonin receptor: comparison with recombinant human MT1 and MT2 receptors.

Mailliet F, Audinot V, Malpaux B, Bonnaud A, Delagrange P, Migaud M, Barrett P, Viaud-Massuard MC, Lesieur D, Lefoulon F, Renard P, Boutin JA.

Biochem Pharmacol. 2004 Feb 15;67(4):667-77.

PMID:
14757166
20.

Synthesis of 5-substituted-2,3-dihydro-1,4-benzoxathiins: biological evaluation as melatonin receptors ligands.

Charton I, Suzenet F, Boutin JA, Audinot V, Delagrange P, Bennejean C, Renard P, Guillaumet G.

J Enzyme Inhib Med Chem. 2003 Apr;18(2):187-93.

PMID:
12943203
21.

Design, synthesis and in vitro evaluation of novel benzo[b]thiophene derivatives as serotonin N-acetyltransferase (AANAT) inhibitors.

Mesangeau C, Yous S, Chavatte P, Ferry G, Audinot V, Boutin JA, Delagrange P, Bennejean C, Renard P, Lesieur D.

J Enzyme Inhib Med Chem. 2003 Apr;18(2):119-25.

PMID:
12943195
22.

New selective ligands of human cloned melatonin MT1 and MT2 receptors.

Audinot V, Mailliet F, Lahaye-Brasseur C, Bonnaud A, Le Gall A, Amossé C, Dromaint S, Rodriguez M, Nagel N, Galizzi JP, Malpaux B, Guillaumet G, Lesieur D, Lefoulon F, Renard P, Delagrange P, Boutin JA.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Jun;367(6):553-61. Epub 2003 May 23.

PMID:
12764576
23.

Design, synthesis and in vitro evaluation of novel derivatives as serotonin N-acetyltransferase inhibitors.

Beaurain N, Mésangeau C, Chavatte P, Ferry G, Audinot V, Boutin JA, Delagrange P, Bennejean C, Yous S.

J Enzyme Inhib Med Chem. 2002 Dec;17(6):409-14.

PMID:
12683677
24.

Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.

Descamps-François C, Yous S, Chavatte P, Audinot V, Bonnaud A, Boutin JA, Delagrange P, Bennejean C, Renard P, Lesieur D.

J Med Chem. 2003 Mar 27;46(7):1127-9.

PMID:
12646022
25.

Design and synthesis of 3-phenyl tetrahydronaphthalenic derivatives as new selective MT2 melatoninergic ligands.

Yous S, Durieux-Poissonnier S, Lipka-Belloli E, Guelzim H, Bochu C, Audinot V, Boutin JA, Delagrange P, Bennejean C, Renard P, Lesieur D.

Bioorg Med Chem. 2003 Mar 6;11(5):753-9.

PMID:
12538005
26.

Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.

Dang ZC, Audinot V, Papapoulos SE, Boutin JA, Löwik CW.

J Biol Chem. 2003 Jan 10;278(2):962-7. Epub 2002 Nov 5.

27.

Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform.

Rodriguez M, Audinot V, Dromaint S, Macia C, Lamamy V, Beauverger P, Rique H, Imbert J, Nicolas JP, Boutin JA, Galizzi JP.

Biochem J. 2003 Feb 1;369(Pt 3):667-73.

28.
29.
30.

Ligand modulation of [35S]GTPgammaS binding at human alpha(2A), alpha(2B) and alpha(2C) adrenoceptors.

Audinot V, Fabry N, Nicolas JP, Beauverger P, Newman-Tancredi A, Millan MJ, Try A, Bornancin F, Canet E, Boutin JA.

Cell Signal. 2002 Oct;14(10):829-37.

PMID:
12135704
31.

Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance.

Maulon-Feraille L, Della Zuana O, Suply T, Rovere-Jovene C, Audinot V, Levens N, Boutin JA, Duhault J, Nahon JL.

J Pharmacol Exp Ther. 2002 Aug;302(2):766-73.

PMID:
12130742
32.

SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.

Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA.

Biochem Biophys Res Commun. 2002 Jul 26;295(4):841-8.

PMID:
12127971
33.

Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.

Wallez V, Durieux-Poissonnier S, Chavatte P, Boutin JA, Audinot V, Nicolas JP, Bennejean C, Delagrange P, Renard P, Lesieur D.

J Med Chem. 2002 Jun 20;45(13):2788-800.

PMID:
12061881
34.

Melanin-concentrating hormone and its receptors: state of the art.

Boutin JA, Suply T, Audinot V, Rodriguez M, Beauverger P, Nicolas JP, Galizzi JP, Fauchère JL.

Can J Physiol Pharmacol. 2002 May;80(5):388-95. Review.

PMID:
12056544
35.

Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Millan MJ, Newman-Tancredi A, Lochon S, Touzard M, Aubry S, Audinot V.

Pharmacol Biochem Behav. 2002 Apr;71(4):589-98.

PMID:
11888550
36.

Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2.

Rodriguez M, Beauverger P, Naime I, Rique H, Ouvry C, Souchaud S, Dromaint S, Nagel N, Suply T, Audinot V, Boutin JA, Galizzi JP.

Mol Pharmacol. 2001 Oct;60(4):632-9.

PMID:
11562423
37.

SLC-1 receptor mediates effect of melanin-concentrating hormone on feeding behavior in rat: a structure-activity study.

Suply T, Della Zuana O, Audinot V, Rodriguez M, Beauverger P, Duhault J, Canet E, Galizzi JP, Nahon JL, Levens N, Boutin JA.

J Pharmacol Exp Ther. 2001 Oct;299(1):137-46.

PMID:
11561073
38.

Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)(1B) and h5-HT(1D) receptors.

Audinot V, Newman-Tancredi A, Cussac D, Millan MJ.

Neuropsychopharmacology. 2001 Sep;25(3):410-22.

39.

[125I]-S36057: a new and highly potent radioligand for the melanin-concentrating hormone receptor.

Audinot V, Lahaye C, Suply T, Beauverger P, Rodriguez M, Galizzi JP, Fauchère JL, Boutin JA.

Br J Pharmacol. 2001 Jun;133(3):371-8.

40.

Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization.

Millan MJ, Cussac D, Milligan G, Carr C, Audinot V, Gobert A, Lejeune F, Rivet JM, Brocco M, Duqueyroix D, Nicolas JP, Boutin JA, Newman-Tancredi A.

J Pharmacol Exp Ther. 2001 Jun;297(3):876-87.

PMID:
11356907
41.

Genomic organization and characterization of splice variants of the human histamine H3 receptor.

Cogé F, Guénin SP, Audinot V, Renouard-Try A, Beauverger P, Macia C, Ouvry C, Nagel N, Rique H, Boutin JA, Galizzi JP.

Biochem J. 2001 Apr 15;355(Pt 2):279-88.

42.

Structure-activity relationship studies of melanin-concentrating hormone (MCH)-related peptide ligands at SLC-1, the human MCH receptor.

Audinot V, Beauverger P, Lahaye C, Suply T, Rodriguez M, Ouvry C, Lamamy V, Imbert J, Rique H, Nahon JL, Galizzi JP, Canet E, Levens N, Fauchere JL, Boutin JA.

J Biol Chem. 2001 Apr 27;276(17):13554-62. Epub 2001 Jan 18.

43.

Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties.

Cordi AA, Berque-Bestel I, Persigand T, Lacoste JM, Newman-Tancredi A, Audinot V, Millan MJ.

J Med Chem. 2001 Mar 1;44(5):787-805.

PMID:
11262089
44.

S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.

Millan MJ, Dekeyne A, Newman-Tancredi A, Cussac D, Audinot V, Milligan G, Duqueyroix D, Girardon S, Mullot J, Boutin JA, Nicolas JP, Renouard-Try A, Lacoste JM, Cordi A.

J Pharmacol Exp Ther. 2000 Dec;295(3):1192-205.

PMID:
11082457
45.
46.

Inverse agonism and constitutive activity as functional correlates of serotonin h5-HT(1B) receptor/G-protein stoichiometry.

Newman-Tancredi A, Audinot V, Moreira C, Verrièle L, Millan MJ.

Mol Pharmacol. 2000 Nov;58(5):1042-9.

PMID:
11040052
47.

S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626.

Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, Lavielle G.

J Pharmacol Exp Ther. 2000 Jun;293(3):1048-62.

PMID:
10869410
48.

Benzamides derived from 1,2-diaminocyclopropane as novel ligands for human D2 and D3 dopamine receptors.

Yang D, Kefi S, Audinot V, Millan MJ, Langlois M.

Bioorg Med Chem. 2000 Feb;8(2):321-7.

PMID:
10722154
49.

Activation of dopamine D(3) receptors induces c-fos expression in primary cultures of rat striatal neurons.

Morris BJ, Newman-Tancredi A, Audinot V, Simpson CS, Millan MJ.

J Neurosci Res. 2000 Mar 15;59(6):740-9.

PMID:
10700011
50.

Blockade of NMDA receptors in the nucleus accumbens elicits spontaneous tail-flicks in rats.

Millan MJ, Audinot V, Honoré P, Bervoets K, Veiga S, Brocco M.

Eur J Pharmacol. 2000 Jan 24;388(1):37-47.

PMID:
10657545

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