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Items: 1 to 50 of 79

1.

Acetaminophen Overdose as a Potential Risk Factor for Parkinson's Disease.

Bohler S, Liu X, Krauskopf J, Caiment F, Aubrecht J, Nicolaes GAF, Kleinjans JCS, Briedé JJ.

Clin Transl Sci. 2019 Jul 15. doi: 10.1111/cts.12663. [Epub ahead of print]

PMID:
31305025
2.

Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.

Aleo MD, Aubrecht J, D Bonin P, Burt DA, Colangelo J, Luo L, Schomaker S, Swiss R, Kirby S, C Rigdon G, Dua P.

Pharmacol Res Perspect. 2019 Feb;7(1):e00467. doi: 10.1002/prp2.467.

3.

Assessment of the performance of the TGx-DDI biomarker to detect DNA damage-inducing agents using quantitative RT-PCR in TK6 cells.

Cho E, Buick JK, Williams A, Chen R, Li HH, Corton JC, Fornace AJ Jr, Aubrecht J, Yauk CL.

Environ Mol Mutagen. 2019 Mar;60(2):122-133. doi: 10.1002/em.22257. Epub 2018 Nov 29.

4.

Assessment of serum bile acid profiles as biomarkers of liver injury and liver disease in humans.

Luo L, Aubrecht J, Li D, Warner RL, Johnson KJ, Kenny J, Colangelo JL.

PLoS One. 2018 Mar 7;13(3):e0193824. doi: 10.1371/journal.pone.0193824. eCollection 2018.

5.

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.

Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, Watkins PB.

Hepatology. 2019 Feb;69(2):760-773. doi: 10.1002/hep.29802. Epub 2018 Jun 27.

PMID:
29357190
6.

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs.

Li HH, Chen R, Hyduke DR, Williams A, Frötschl R, Ellinger-Ziegelbauer H, O'Lone R, Yauk CL, Aubrecht J, Fornace AJ Jr.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10881-E10889. doi: 10.1073/pnas.1714109114. Epub 2017 Dec 4.

7.

What evidence do we need for biomarker qualification?

Leptak C, Menetski JP, Wagner JA, Aubrecht J, Brady L, Brumfield M, Chin WW, Hoffmann S, Kelloff G, Lavezzari G, Ranganathan R, Sauer JM, Sistare FD, Zabka T, Wholley D.

Sci Transl Med. 2017 Nov 22;9(417). pii: eaal4599. doi: 10.1126/scitranslmed.aal4599. Review.

PMID:
29167393
8.

Integration of the TGx-28.65 genomic biomarker with the flow cytometry micronucleus test to assess the genotoxicity of disperse orange and 1,2,4-benzenetriol in human TK6 cells.

Buick JK, Williams A, Kuo B, Wills JW, Swartz CD, Recio L, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Mutat Res. 2017 Dec;806:51-62. doi: 10.1016/j.mrfmmm.2017.09.002. Epub 2017 Sep 13.

PMID:
29017062
9.

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.

Krauskopf J, de Kok TM, Schomaker SJ, Gosink M, Burt DA, Chandler P, Warner RL, Johnson KJ, Caiment F, Kleinjans JC, Aubrecht J.

PLoS One. 2017 May 17;12(5):e0177928. doi: 10.1371/journal.pone.0177928. eCollection 2017.

10.

Self-swept holmium fiber laser near 2100 nm.

Aubrecht J, Peterka P, Koška P, Podrazký O, Todorov F, Honzátko P, Kašík I.

Opt Express. 2017 Feb 20;25(4):4120-4125. doi: 10.1364/OE.25.004120.

PMID:
28241618
11.

Validation of Transcriptomics-Based In Vitro Methods.

Corvi R, Vilardell M, Aubrecht J, Piersma A.

Adv Exp Med Biol. 2016;856:243-257.

PMID:
27671726
12.

Reflectivity of transient Bragg reflection gratings in fiber laser with laser-wavelength self-sweeping: erratum.

Peterka P, Honzátko P, Koška P, Todorov F, Aubrecht J, Podrazký O, Kašík I.

Opt Express. 2016 Jul 11;24(14):16222-3. doi: 10.1364/OE.24.016222.

PMID:
27410889
13.

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9.

Yauk CL, Buick JK, Williams A, Swartz CD, Recio L, Li HH, Fornace AJ Jr, Thomson EM, Aubrecht J.

Environ Mol Mutagen. 2016 May;57(4):243-60. doi: 10.1002/em.22004. Epub 2016 Mar 4.

14.

Enhanced pump absorption efficiency in coiled and twisted double-clad thulium-doped fibers.

Koška P, Peterka P, Aubrecht J, Podrazký O, Todorov F, Becker M, Baravets Y, Honzátko P, Kašík I.

Opt Express. 2016 Jan 11;24(1):102-7. doi: 10.1364/OE.24.000102.

PMID:
26832241
15.

A Randomized Controlled Trial of a Mobile Health Intervention to Promote Self-Management After Lung Transplantation.

DeVito Dabbs A, Song MK, Myers BA, Li R, Hawkins RP, Pilewski JM, Bermudez CA, Aubrecht J, Begey A, Connolly M, Alrawashdeh M, Dew MA.

Am J Transplant. 2016 Jul;16(7):2172-80. doi: 10.1111/ajt.13701. Epub 2016 Mar 14.

16.

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells.

Williams A, Buick JK, Moffat I, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Data Brief. 2015 Aug 24;5:77-83. doi: 10.1016/j.dib.2015.08.013. eCollection 2015 Dec.

17.

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.

Li HH, Hyduke DR, Chen R, Heard P, Yauk CL, Aubrecht J, Fornace AJ Jr.

Environ Mol Mutagen. 2015 Jul;56(6):505-19. doi: 10.1002/em.21941. Epub 2015 Mar 2.

18.

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.

Buick JK, Moffat I, Williams A, Swartz CD, Recio L, Hyduke DR, Li HH, Fornace AJ Jr, Aubrecht J, Yauk CL.

Environ Mol Mutagen. 2015 Jul;56(6):520-34. doi: 10.1002/em.21940. Epub 2015 Mar 2.

19.

Reflectivity of transient Bragg reflection gratings in fiber laser with laser-wavelength self-sweeping.

Peterka P, Honzátko P, Koška P, Todorov F, Aubrecht J, Podrazký O, Kašík I.

Opt Express. 2014 Dec 1;22(24):30024-31. doi: 10.1364/OE.22.030024. Erratum in: Opt Express. 2016 Jul 11;24(14):16222-3.

PMID:
25606932
20.

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water.

Moffat I, Chepelev N, Labib S, Bourdon-Lacombe J, Kuo B, Buick JK, Lemieux F, Williams A, Halappanavar S, Malik A, Luijten M, Aubrecht J, Hyduke DR, Fornace AJ Jr, Swartz CD, Recio L, Yauk CL.

Crit Rev Toxicol. 2015 Jan;45(1):1-43. doi: 10.3109/10408444.2014.973934. Review.

21.

Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.

Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC.

Toxicol Sci. 2015 Feb;143(2):268-76. doi: 10.1093/toxsci/kfu232. Epub 2014 Oct 29.

PMID:
25359176
22.

Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics.

Burt D, Crowell SJ, Ackley DC, Magee TV, Aubrecht J.

Drug Chem Toxicol. 2014 Apr;37(2):204-12. doi: 10.3109/01480545.2013.834360. Epub 2013 Oct 16.

PMID:
24128070
23.

Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

Luo L, Schomaker S, Houle C, Aubrecht J, Colangelo JL.

Toxicol Sci. 2014 Jan;137(1):12-25. doi: 10.1093/toxsci/kft221. Epub 2013 Oct 1.

PMID:
24085190
24.

Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury.

Aubrecht J, Schomaker SJ, Amacher DE.

Genome Med. 2013 Sep 27;5(9):85. doi: 10.1186/gm489. eCollection 2013.

25.

The current status of biomarkers for predicting toxicity.

Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F.

Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1391-408. doi: 10.1517/17425255.2013.827170. Epub 2013 Aug 21. Review.

26.

Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics.

Amacher DE, Schomaker SJ, Aubrecht J.

Mol Diagn Ther. 2013 Dec;17(6):343-54. doi: 10.1007/s40291-013-0049-0. Review.

PMID:
23868512
27.

Clinical trials of health information technology interventions intended for patient use: unique issues and considerations.

DeVito Dabbs A, Song MK, Myers B, Hawkins RP, Aubrecht J, Begey A, Connolly M, Li R, Pilewski JM, Bermudez CA, Dew MA.

Clin Trials. 2013;10(6):896-906. doi: 10.1177/1740774513493149. Epub 2013 Jul 18.

28.

Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.

Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM.

J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18.

PMID:
23735048
29.

Serum glutamate dehydrogenase as a potential biomarker of mitochondrial dysfunction.

Aubrecht J, Schomaker S.

Toxicol Sci. 2013 Jul;134(1):223. doi: 10.1093/toxsci/kft088. Epub 2013 Apr 5. No abstract available.

PMID:
23564644
30.

Assessment of emerging biomarkers of liver injury in human subjects.

Schomaker S, Warner R, Bock J, Johnson K, Potter D, Van Winkle J, Aubrecht J.

Toxicol Sci. 2013 Apr;132(2):276-83. doi: 10.1093/toxsci/kft009. Epub 2013 Jan 20.

PMID:
23339181
31.

Quality of recipient-caregiver relationship and psychological distress are correlates of self-care agency after lung transplantation.

DeVito Dabbs A, Terhorst L, Song MK, Shellmer DA, Aubrecht J, Connolly M, Dew MA.

Clin Transplant. 2013 Jan-Feb;27(1):113-20. doi: 10.1111/ctr.12017. Epub 2012 Sep 24.

32.

Daily burdens of recipients and family caregivers after lung transplant.

Xu J, Adeboyejo O, Wagley E, Aubrecht J, Song MK, Thiry L, Dabbs AD.

Prog Transplant. 2012 Mar;22(1):41-7; quiz 48.

33.

Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow.

Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N.

Exp Hematol. 2012 Jan;40(1):3-13.e3. doi: 10.1016/j.exphem.2011.09.009. Epub 2011 Oct 12.

34.

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).

Wager TT, Pettersen BA, Schmidt AW, Spracklin DK, Mente S, Butler TW, Howard H, Lettiere DJ, Rubitski DM, Wong DF, Nedza FM, Nelson FR, Rollema H, Raggon JW, Aubrecht J, Freeman JK, Marcek JM, Cianfrogna J, Cook KW, James LC, Chatman LA, Iredale PA, Banker MJ, Homiski ML, Munzner JB, Chandrasekaran RY.

J Med Chem. 2011 Nov 10;54(21):7602-20. doi: 10.1021/jm200939b. Epub 2011 Oct 7.

PMID:
21928839
35.

An intervention fidelity framework for technology-based behavioral interventions.

Devito Dabbs A, Song MK, Hawkins R, Aubrecht J, Kovach K, Terhorst L, Connolly M, McNulty M, Callan J.

Nurs Res. 2011 Sep-Oct;60(5):340-7. doi: 10.1097/NNR.0b013e31822cc87d.

36.

Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat.

Fielden MR, Adai A, Dunn RT 2nd, Olaharski A, Searfoss G, Sina J, Aubrecht J, Boitier E, Nioi P, Auerbach S, Jacobson-Kram D, Raghavan N, Yang Y, Kincaid A, Sherlock J, Chen SJ, Car B; Predictive Safety Testing Consortium, Carcinogenicity Working Group.

Toxicol Sci. 2011 Nov;124(1):54-74. doi: 10.1093/toxsci/kfr202. Epub 2011 Aug 2.

PMID:
21813463
37.

Data safety and monitoring for research involving remote health monitoring.

Kovach KA, Aubrecht JA, Dew MA, Myers B, Dabbs AD.

Telemed J E Health. 2011 Sep;17(7):574-9. doi: 10.1089/tmj.2010.0219. Epub 2011 Jul 12.

38.

A high G418-resistant neo(R) transgenic mouse and mouse embryonic fibroblast (MEF) feeder layers for cytotoxicity and gene targeting in vivo and in vitro.

Aubrecht J, Goad ME, Czopik AK, Lerner CP, Johnson KA, Simpson EM, Schiestl RH.

Drug Chem Toxicol. 2011 Oct;34(4):433-9. doi: 10.3109/01480545.2010.544316. Epub 2011 Jul 11.

PMID:
21740348
39.

Moving forward in human cancer risk assessment.

Paules RS, Aubrecht J, Corvi R, Garthoff B, Kleinjans JC.

Environ Health Perspect. 2011 Jun;119(6):739-43. doi: 10.1289/ehp.1002735. Epub 2010 Dec 13.

40.

Database management systems--their place in nursing informatics education.

Courtney KL, Goodwin LK, Aubrecht J.

Comput Inform Nurs. 2011 Jan-Feb;29(1):7-12. doi: 10.1097/NCN.0b013e3181fb5be0. No abstract available.

PMID:
21099538
41.

New and emerging technologies for genetic toxicity testing.

Lynch AM, Sasaki JC, Elespuru R, Jacobson-Kram D, Thybaud V, De Boeck M, Aardema MJ, Aubrecht J, Benz RD, Dertinger SD, Douglas GR, White PA, Escobar PA, Fornace A Jr, Honma M, Naven RT, Rusling JF, Schiestl RH, Walmsley RM, Yamamura E, van Benthem J, Kim JH.

Environ Mol Mutagen. 2011 Apr;52(3):205-23. doi: 10.1002/em.20614. Epub 2010 Aug 25. Review.

PMID:
20740635
42.

Predicting safety toleration of pharmaceutical chemical leads: cytotoxicity correlations to exploratory toxicity studies.

Benbow JW, Aubrecht J, Banker MJ, Nettleton D, Aleo MD.

Toxicol Lett. 2010 Sep 1;197(3):175-82. doi: 10.1016/j.toxlet.2010.05.016. Epub 2010 May 31.

PMID:
20576494
43.

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact.

Goodsaid FM, Amur S, Aubrecht J, Burczynski ME, Carl K, Catalano J, Charlab R, Close S, Cornu-Artis C, Essioux L, Fornace AJ Jr, Hinman L, Hong H, Hunt I, Jacobson-Kram D, Jawaid A, Laurie D, Lesko L, Li HH, Lindpaintner K, Mayne J, Morrow P, Papaluca-Amati M, Robison TW, Roth J, Schuppe-Koistinen I, Shi L, Spleiss O, Tong W, Truter SL, Vonderscher J, Westelinck A, Zhang L, Zineh I.

Nat Rev Drug Discov. 2010 Jun;9(6):435-45. doi: 10.1038/nrd3116. Review.

PMID:
20514070
44.

Inter-laboratory evaluation of the bioluminescent Salmonella reverse mutation assay using 10 model chemicals.

Ackerman J, Sharma R, Hitchcock J, Hayashi T, Nagai Y, Li S, Lu S, Miret J, Tang K, Spence F, Aubrecht J.

Mutagenesis. 2009 Sep;24(5):433-8. doi: 10.1093/mutage/gep026. Epub 2009 Jul 6.

PMID:
19581339
45.

Concordance analysis of an in vitro micronucleus screening assay and the regulatory chromosome aberration assay using pharmaceutical drug candidates.

Homiski ML, Muehlbauer PA, Dobo KL, Schuler MJ, Aubrecht J.

Environ Mol Mutagen. 2010 Jan;51(1):39-47. doi: 10.1002/em.20507.

PMID:
19551811
46.

Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms.

Ellinger-Ziegelbauer H, Fostel JM, Aruga C, Bauer D, Boitier E, Deng S, Dickinson D, Le Fevre AC, Fornace AJ Jr, Grenet O, Gu Y, Hoflack JC, Shiiyama M, Smith R, Snyder RD, Spire C, Tanaka G, Aubrecht J.

Toxicol Sci. 2009 Aug;110(2):341-52. doi: 10.1093/toxsci/kfp103. Epub 2009 May 22.

47.

Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes.

Benbow JW, Andrews KA, Aubrecht J, Beebe D, Boyer D, Doran S, Homiski M, Hui Y, McPherson K, Parker JC, Treadway J, Vanvolkenberg M, Zembrowski WJ.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2220-3. doi: 10.1016/j.bmcl.2009.02.099. Epub 2009 Feb 28.

PMID:
19285862
48.

Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists.

Kalgutkar AS, Bauman JN, McClure KF, Aubrecht J, Cortina SR, Paralkar J.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1559-63. doi: 10.1016/j.bmcl.2009.02.032. Epub 2009 Feb 12.

PMID:
19246199
49.

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches.

Guyton KZ, Kyle AD, Aubrecht J, Cogliano VJ, Eastmond DA, Jackson M, Keshava N, Sandy MS, Sonawane B, Zhang L, Waters MD, Smith MT.

Mutat Res. 2009 Mar-Jun;681(2-3):230-40. doi: 10.1016/j.mrrev.2008.10.001. Epub 2008 Nov 1. Review.

PMID:
19010444
50.

Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity.

Ellinger-Ziegelbauer H, Aubrecht J, Kleinjans JC, Ahr HJ.

Toxicol Lett. 2009 Apr 10;186(1):36-44. doi: 10.1016/j.toxlet.2008.08.017. Epub 2008 Sep 4. Review.

PMID:
18822359

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