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Items: 1 to 50 of 179

1.

8-Modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription.

Vivet-Boudou V, Isel C, Sleiman M, Smyth R, Ben Gaied N, Barhoum P, Laumond G, Bec G, Götte M, Mak J, Aubertin AM, Burger A, Marquet R.

PLoS One. 2011;6(11):e27456. doi: 10.1371/journal.pone.0027456. Epub 2011 Nov 7.

2.

HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.

Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C.

J Virol. 2011 Jan;85(2):1077-85. doi: 10.1128/JVI.01619-10. Epub 2010 Nov 17.

3.

Stimulation of HIV-1 replication in immature dendritic cells in contact with primary CD4 T or B lymphocytes.

Holl V, Xu K, Peressin M, Lederle A, Biedma ME, Delaporte M, Decoville T, Schmidt S, Laumond G, Aubertin AM, Moog C.

J Virol. 2010 May;84(9):4172-82. doi: 10.1128/JVI.01567-09. Epub 2010 Feb 10.

4.

5-Modified-2'-dU and 2'-dC as mutagenic anti HIV-1 proliferation agents: synthesis and activity.

El Safadi Y, Paillart JC, Laumond G, Aubertin AM, Burger A, Marquet R, Vivet-Boudou V.

J Med Chem. 2010 Feb 25;53(4):1534-45. doi: 10.1021/jm901758f.

PMID:
20112915
5.

Synthesis and anti-HIV evaluation of water-soluble calixarene-based bithiazolyl podands.

Mourer M, Psychogios N, Laumond G, Aubertin AM, Regnouf-de-Vains JB.

Bioorg Med Chem. 2010 Jan 1;18(1):36-45. doi: 10.1016/j.bmc.2009.11.016. Epub 2009 Nov 12.

PMID:
19944610
6.

Bis-14-membered ring diketal diamines: synthesis and evaluation of their anti-HIV and anti-tumoral activities.

Affani R, Pélissier F, Aubertin AM, Dugat D.

Eur J Med Chem. 2009 Aug;44(8):3138-46. doi: 10.1016/j.ejmech.2009.03.008. Epub 2009 Mar 24.

7.

Peptide-poly(L-lysine citramide) conjugates and their in vitro anti-HIV behavior.

Couffin-Hoarau AC, Aubertin AM, Boustta M, Schmidt S, Fehrentz JA, Martinez J, Vert M.

Biomacromolecules. 2009 Apr 13;10(4):865-76. doi: 10.1021/bm801376v.

PMID:
19296658
8.

A step further in the SATE mononucleotide prodrug approach.

Peyrottes S, Villard AL, Coussot G, Augustijns P, Lefebvre I, Aubertin AM, Gosselin G, Périgaud C.

Nucleic Acids Symp Ser (Oxf). 2008;(52):539-40. doi: 10.1093/nass/nrn273.

PMID:
18776492
9.

Phenyl phosphotriester derivatives of AZT: variations upon the SATE moiety.

Villard AL, Coussot G, Lefebvre I, Augustijns P, Aubertin AM, Gosselin G, Peyrottes S, Périgaud C.

Bioorg Med Chem. 2008 Aug 1;16(15):7321-9. doi: 10.1016/j.bmc.2008.06.024. Epub 2008 Jun 18.

PMID:
18585917
10.

Inhibitors interacting with the magnesium binding site of reverse transcriptase: synthesis and biological activity studies of 3'-(omega-amino-acyl) amino-3'-deoxy-thymidine.

Goud TV, Aubertin AM, Biellmann JF.

Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):495-505. doi: 10.1080/15257770802088902.

PMID:
18569788
11.

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

Zampella A, Sepe V, Luciano P, Bellotta F, Monti MC, D'Auria MV, Jepsen T, Petek S, Adeline MT, Laprévôte O, Aubertin AM, Debitus C, Poupat C, Ahond A.

J Org Chem. 2008 Jul 18;73(14):5319-27. doi: 10.1021/jo800583b. Epub 2008 Jun 19.

PMID:
18563935
12.

[Nef and PPAR-gamma interact to suppress Stat5 expression in CD34+ progenitors from infected macaques].

Prost S, Le Dantec M, Augé S, Le Grand R, Derdouch S, Auregan G, Déglon N, Relouzat F, Aubertin AM, Maillere B, Dusanter-Fourt I, Kirszenbaum M.

Med Sci (Paris). 2008 May;24(5):551-3. doi: 10.1051/medsci/2008245551. French. No abstract available.

13.

Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARgamma/STAT5 signaling pathway in macaques.

Prost S, Le Dantec M, Augé S, Le Grand R, Derdouch S, Auregan G, Déglon N, Relouzat F, Aubertin AM, Maillere B, Dusanter-Fourt I, Kirszenbaum M.

J Clin Invest. 2008 May;118(5):1765-75. doi: 10.1172/JCI33037.

14.

Hepatitis C virus structural proteins do not prevent human dendritic cell maturation.

Thumann C, Schvoerer E, Abraham JD, Bohbot A, Stoll-Keller F, Aubertin AM, Kieny MP.

Gastroenterol Clin Biol. 2008 Jan;32(1 Pt. 1):59-68. doi: 10.1016/j.gcb.2007.12.006. Epub 2008 Mar 4.

15.

Synthesis and primary evaluation of novel HIV-1 inhibitors.

El Safadi Y, Marquet R, Aubertin AM, Vivet-Boudou V.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1161-5.

PMID:
18058557
16.

Synthesis and anti-HIV evaluation of hybrid-type prodrugs conjugating HIV integrase inhibitors with d4t by self-cleavable spacers containing an amino acid residue.

Fossey C, Huynh NT, Vu AH, Vidu A, Zarafu I, Laduree D, Schmidt S, Laumond G, Aubertin AM.

J Enzyme Inhib Med Chem. 2007 Oct;22(5):608-19.

PMID:
18035829
17.

Synthesis of prodrug-type anti-HIV agents conjugating a REVERSE transcriptase inhibitor to a HIV-1 integrase inhibitor by a spontaneously cleavable linker.

Fossey C, Vu AH, Vidu A, Zarafu I, Laduree D, Schmidt S, Laumond G, Aubertin AM.

J Enzyme Inhib Med Chem. 2007 Oct;22(5):591-607.

PMID:
18035828
18.

Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors.

Roche D, Greiner J, Aubertin AM, Vierling P.

Eur J Med Chem. 2008 Jul;43(7):1506-18. Epub 2007 Sep 14.

PMID:
17950955
19.

CD4+ CCR5+ T-cell dynamics during simian immunodeficiency virus infection of Chinese rhesus macaques.

Monceaux V, Viollet L, Petit F, Cumont MC, Kaufmann GR, Aubertin AM, Hurtrel B, Silvestri G, Estaquier J.

J Virol. 2007 Dec;81(24):13865-75. Epub 2007 Sep 26.

20.

Synthesis and antiviral evaluation of AZT analogues with A spacer arm between glucidic and base moieties. Part II.

Roy V, Zerrouki R, Krausz P, Laumond G, Aubertin AM.

Nucleosides Nucleotides Nucleic Acids. 2007;26(5):413-21.

PMID:
17578740
21.
22.
23.

AZT and AZT-monophosphate prodrugs incorporating HIV-protease substrate fragment: synthesis and evaluation as specific drug delivery systems.

Liotard JF, Mehiri M, Di Giorgio A, Boggetto N, Reboud-Ravaux M, Aubertin AM, Condom R, Patino N.

Antivir Chem Chemother. 2006;17(4):193-213.

PMID:
17066898
24.

Efavirenz in plasma from HIV-infected patients does not directly block reverse transcriptase activity in cell-free assays but inhibits HIV replication in cellular assays.

Burrer R, Spiridon G, Einius-Haessig S, Richert S, Salmon-Ceron D, Pancino G, Aubertin AM, Moog C.

AIDS Res Hum Retroviruses. 2006 Sep;22(9):865-9.

PMID:
16989611
25.

Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cells.

Holl V, Peressin M, Decoville T, Schmidt S, Zolla-Pazner S, Aubertin AM, Moog C.

J Virol. 2006 Jun;80(12):6177-81.

26.

Targeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell.

Ennifar E, Paillart JC, Bodlenner A, Walter P, Weibel JM, Aubertin AM, Pale P, Dumas P, Marquet R.

Nucleic Acids Res. 2006 May 5;34(8):2328-39. Print 2006.

27.

Efficient inhibition of HIV-1 replication in human immature monocyte-derived dendritic cells by purified anti-HIV-1 IgG without induction of maturation.

Holl V, Peressin M, Schmidt S, Decoville T, Zolla-Pazner S, Aubertin AM, Moog C.

Blood. 2006 Jun 1;107(11):4466-74. Epub 2006 Feb 9.

28.

Synthesis and antiviral activity of aryl phosphoramidate derivatives of beta-D- and beta-L-C-5-substituted 2',3'-didehydro-2',3'-dideoxy-uridine bearing linker arms.

Ladurée D, Fossey C, Delbederi Z, Sugeac E, Schmidt S, Laumond G, Aubertin AM.

J Enzyme Inhib Med Chem. 2005 Dec;20(6):533-49.

PMID:
16408789
29.

Dendritic catanionic assemblies: in vitro anti-HIV activity of phosphorus-containing dendrimers bearing galbeta1cer analogues.

Blanzat M, Turrin CO, Aubertin AM, Couturier-Vidal C, Caminade AM, Majoral JP, Rico-Lattes I, Lattes A.

Chembiochem. 2005 Dec;6(12):2207-13.

PMID:
16317767
30.

Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

Didierjean J, Isel C, Querré F, Mouscadet JF, Aubertin AM, Valnot JY, Piettre SR, Marquet R.

Antimicrob Agents Chemother. 2005 Dec;49(12):4884-94.

31.

New acyclonucleosides: synthesis and anti-HIV activity.

Hadj-Bouazza A, Zerrouki R, Krausz P, Laumond G, Aubertin AM, Champavier Y.

Nucleosides Nucleotides Nucleic Acids. 2005;24(8):1249-63.

PMID:
16270666
32.

Detection of human immunodeficiency virus type 1 Nef and CD4 physical interaction in living human cells by using bioluminescence resonance energy transfer.

Cluet D, Bertsch C, Beyer C, Gloeckler L, Erhardt M, Gut JP, Galzi JL, Aubertin AM.

J Virol. 2005 Jul;79(13):8629-36.

33.

Disease progression in macaques with low SIV replication levels: on the relevance of TREC counts.

Ho Tsong Fang R, Khatissian E, Monceaux V, Cumont MC, Beq S, Ameisen JC, Aubertin AM, Israël N, Estaquier J, Hurtrel B.

AIDS. 2005 Apr 29;19(7):663-73.

PMID:
15821392
35.

Synthesis of 5-alkynylated d4T analogues as potential HIV-1 reverse transcriptase inhibitors.

Ciurea A, Fossey C, Gavriliu D, Delbederi Z, Sugeac E, Laduree D, Schmidt S, Laumond G, Aubertin AM.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):511-9.

PMID:
15662955
36.

Synthesis and anti-HIV activity of some [Nucleoside Reverse Transcriptase Inhibitor]-C5'-linker-[Integrase Inhibitor] heterodimers as inhibitors of HIV replication.

Sugeac E, Fossey C, Ladurée D, Schmidt S, Laumond G, Aubertin AM.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):497-509.

PMID:
15662954
37.

Tat-neutralizing versus Tat-protecting antibodies in rhesus macaques vaccinated with Tat peptides.

Belliard G, Hurtrel B, Moreau E, Lafont BA, Monceaux V, Roques B, Desgranges C, Aubertin AM, Le Grand R, Muller S.

Vaccine. 2005 Feb 3;23(11):1399-407.

PMID:
15661389
38.

Synthesis and antiviral evaluation of D4T analogues with a spacer arm between glucidic and base moieties.

Roy V, Zerrouki R, Krausz P, Schmidt S, Aubertin AM.

Nucleosides Nucleotides Nucleic Acids. 2004;23(10):1625-37.

PMID:
15620100
39.

Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages.

Holl V, Hemmerter S, Burrer R, Schmidt S, Bohbot A, Aubertin AM, Moog C.

J Immunol. 2004 Nov 15;173(10):6274-83.

40.

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

Roy B, Verri A, Lossani A, Spadari S, Focher F, Aubertin AM, Gosselin G, Mathé C, Périgaud C.

Biochem Pharmacol. 2004 Aug 15;68(4):711-8.

PMID:
15276078
41.

Structural variability of the initiation complex of HIV-1 reverse transcription.

Goldschmidt V, Paillart JC, Rigourd M, Ehresmann B, Aubertin AM, Ehresmann C, Marquet R.

J Biol Chem. 2004 Aug 20;279(34):35923-31. Epub 2004 Jun 11.

42.

A possible improvement for structure-based drug design illustrated by the discovery of a Tat HIV-1 inhibitor.

Montembault M, Vo-Thanh G, Deyine A, Fargeas V, Villiéras M, Adjou A, Dubreuil D, Esquieu D, Grégoire C, Opi S, Péloponèse JM, Campbell G, Watkins J, de Mareuil J, Aubertin AM, Bailly C, Loret E, Lebreton J.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1543-6.

PMID:
15006399
43.

[Immunomodulating effect of HCV during the development of chronic hepatitis C: toward new therapeutic approaches].

Stoll-Keller F, Schvoerer E, Thumann C, Navas MC, Aubertin AM.

Bull Acad Natl Med. 2003;187(6):1147-60; discussion 1160-1. French.

PMID:
14978874
44.

Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity.

Gaucher B, Rouquayrol M, Roche D, Greiner J, Aubertin AM, Vierling P.

Org Biomol Chem. 2004 Feb 7;2(3):345-57. Epub 2004 Jan 5.

PMID:
14747863
45.

Cyclic PNA-based compound directed against HIV-1 TAR RNA: modelling, liquid-phase synthesis and TAR binding.

Depecker G, Patino N, Di Giorgio C, Terreux R, Cabrol-Bass D, Bailly C, Aubertin AM, Condom R.

Org Biomol Chem. 2004 Jan 7;2(1):74-9. Epub 2003 Nov 27.

PMID:
14737662
46.

New bicyclam-GalCer analogue conjugates: synthesis and in vitro anti-HIV activity.

Daoudi JM, Greiner J, Aubertin AM, Vierling P.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):495-8.

PMID:
14698189
47.

1,3-dihydrobenzo[c]furan nucleoside analogues: additional studies of the thymine derivative.

Egron D, Périgaud C, Gosselin G, Aubertin AM, Faraj A, Sélouane M, Postel D, Len C.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4473-5.

PMID:
14643349
48.

Synthesis, stability, and biological evaluation of 1,3-dihydrobenzo[c]furan analogue of d4T and its SATE pronucleotide.

Len C, Selouane A, Postel D, Villa P, Aubertin AM, Egron D, Gosselin G, Périgaud C.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):943-5.

PMID:
14565317
49.

SATE (aryl) phosphotriester series. I. Synthesis and biological evaluation.

Peyrottes S, Gosselin G, Aubertin AM, Périgaud C.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):903-5.

PMID:
14565307
50.

Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.

Jochum A, Schlienger N, Gosselin G, Imbach JL, Aubertin AM, Périgaud C.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):899-901.

PMID:
14565306

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