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Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia.

Touahri Y, Dixit R, Kofoed RH, Miloska K, Park E, Raeisossadati R, Markham-Coultes K, David LA, Rijal H, Zhao J, Lynch M, Hynynen K, Aubert I, Schuurmans C.

Theranostics. 2020 Feb 10;10(7):2982-2999. doi: 10.7150/thno.42611. eCollection 2020.


Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer's disease.

Xhima K, Markham-Coultes K, Nedev H, Heinen S, Saragovi HU, Hynynen K, Aubert I.

Sci Adv. 2020 Jan 22;6(4):eaax6646. doi: 10.1126/sciadv.aax6646. eCollection 2020 Jan.


Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease.

Weber-Adrian D, Kofoed RH, Chan JWY, Silburt J, Noroozian Z, Kügler S, Hynynen K, Aubert I.

Theranostics. 2019 Oct 18;9(26):8127-8137. doi: 10.7150/thno.36718. eCollection 2019.


First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound.

Abrahao A, Meng Y, Llinas M, Huang Y, Hamani C, Mainprize T, Aubert I, Heyn C, Black SE, Hynynen K, Lipsman N, Zinman L.

Nat Commun. 2019 Sep 26;10(1):4373. doi: 10.1038/s41467-019-12426-9.


Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.

Meng Y, Abrahao A, Heyn CC, Bethune AJ, Huang Y, Pople CB, Aubert I, Hamani C, Zinman L, Hynynen K, Black SE, Lipsman N.

Ann Neurol. 2019 Dec;86(6):975-980. doi: 10.1002/ana.25604. Epub 2019 Oct 17.


MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.

Noroozian Z, Xhima K, Huang Y, Kaspar BK, Kügler S, Hynynen K, Aubert I.

Methods Mol Biol. 2019;1950:177-197. doi: 10.1007/978-1-4939-9139-6_10.


The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging.

Vecchio LM, Meng Y, Xhima K, Lipsman N, Hamani C, Aubert I.

Brain Plast. 2018 Dec 12;4(1):17-52. doi: 10.3233/BPL-180069. Review.


Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound.

Xhima K, Nabbouh F, Hynynen K, Aubert I, Tandon A.

Mov Disord. 2018 Oct;33(10):1567-1579. doi: 10.1002/mds.101. Epub 2018 Sep 28.


Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease.

Poon CT, Shah K, Lin C, Tse R, Kim KK, Mooney S, Aubert I, Stefanovic B, Hynynen K.

Sci Rep. 2018 Sep 19;8(1):14061. doi: 10.1038/s41598-018-32250-3.


Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.

Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C, Aubert I, Boutet A, Smith GS, Hynynen K, Black SE.

Nat Commun. 2018 Jul 25;9(1):2336. doi: 10.1038/s41467-018-04529-6.


Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease.

Liu M, Jevtic S, Markham-Coultes K, Ellens NPK, O'Reilly MA, Hynynen K, Aubert I, McLaurin J.

Brain Res. 2018 Jan 1;1678:138-145. doi: 10.1016/j.brainres.2017.10.015. Epub 2017 Oct 21.


Disrupting the blood-brain barrier with focused ultrasound: Perspectives on inflammation and regeneration.

Silburt J, Lipsman N, Aubert I.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6735-E6736. doi: 10.1073/pnas.1710761114. Epub 2017 Aug 10. No abstract available.


Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules.

Savla R, Mrsny RJ, Park K, Aubert I, Stamoran C.

Pharm Res. 2017 Jun;34(6):1149-1151. doi: 10.1007/s11095-017-2156-9. Epub 2017 Apr 6.


Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease.

Morrone CD, Thomason LA, Brown ME, Aubert I, McLaurin J.

PLoS One. 2016 Oct 21;11(10):e0165393. doi: 10.1371/journal.pone.0165393. eCollection 2016.


P53 regulates disruption of neuronal development in the adult hippocampus after irradiation.

Li YQ, Cheng ZC, Liu SW, Aubert I, Wong CS.

Cell Death Discov. 2016 Oct 3;2:16072. eCollection 2016.


The Benefits of Exercise and Metabolic Interventions for the Prevention and Early Treatment of Alzheimer's Disease.

Maliszewska-Cyna E, Lynch M, Oore JJ, Nagy PM, Aubert I.

Curr Alzheimer Res. 2017;14(1):47-60. Review.


Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability.

Mooney SJ, Shah K, Yeung S, Burgess A, Aubert I, Hynynen K.

PLoS One. 2016 Jul 26;11(7):e0159892. doi: 10.1371/journal.pone.0159892. eCollection 2016.


A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease.

Maliszewska-Cyna E, Xhima K, Aubert I.

J Alzheimers Dis. 2016 May 6;53(1):243-57. doi: 10.3233/JAD-150660.


Overexpression of the vesicular acetylcholine transporter enhances dendritic complexity of adult-born hippocampal neurons and improves acquisition of spatial memory during aging.

Nagy PM, Aubert I.

Neurobiol Aging. 2015 May;36(5):1881-9. doi: 10.1016/j.neurobiolaging.2015.02.021. Epub 2015 Feb 27.


Gene delivery to the spinal cord using MRI-guided focused ultrasound.

Weber-Adrian D, Thévenot E, O'Reilly MA, Oakden W, Akens MK, Ellens N, Markham-Coultes K, Burgess A, Finkelstein J, Yee AJ, Whyne CM, Foust KD, Kaspar BK, Stanisz GJ, Chopra R, Hynynen K, Aubert I.

Gene Ther. 2015 Jul;22(7):568-77. doi: 10.1038/gt.2015.25. Epub 2015 Apr 23.


Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior.

Burgess A, Dubey S, Yeung S, Hough O, Eterman N, Aubert I, Hynynen K.

Radiology. 2014 Dec;273(3):736-45. doi: 10.1148/radiol.14140245. Epub 2014 Sep 15.


A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles.

Oakden W, Kwiecien JM, O'Reilly MA, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ.

J Neurosci Methods. 2014 Sep 30;235:92-100. doi: 10.1016/j.jneumeth.2014.06.018. Epub 2014 Jun 23.


Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice.

Scarcelli T, Jordão JF, O'Reilly MA, Ellens N, Hynynen K, Aubert I.

Brain Stimul. 2014 Mar-Apr;7(2):304-7. doi: 10.1016/j.brs.2013.12.012. Epub 2014 Jan 28.


Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice.

Kanemoto S, Griffin J, Markham-Coultes K, Aubert I, Tandon A, George-Hyslop PS, Fraser PE.

Neuroscience. 2014 Mar 7;261:52-9. doi: 10.1016/j.neuroscience.2013.12.021. Epub 2013 Dec 20.


Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.

Jordão JF, Thévenot E, Markham-Coultes K, Scarcelli T, Weng YQ, Xhima K, O'Reilly M, Huang Y, McLaurin J, Hynynen K, Aubert I.

Exp Neurol. 2013 Oct;248:16-29. doi: 10.1016/j.expneurol.2013.05.008. Epub 2013 May 21.


Miniaturized electrochemical system for cholinesterase inhibitor detection.

Veloso AJ, Nagy PM, Zhang B, Dhar D, Liang A, Ibrahim T, Mikhaylichenko S, Aubert I, Kerman K.

Anal Chim Acta. 2013 Apr 24;774:73-8. doi: 10.1016/j.aca.2013.02.033. Epub 2013 Mar 13.


Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.

Thévenot E, Jordão JF, O'Reilly MA, Markham K, Weng YQ, Foust KD, Kaspar BK, Hynynen K, Aubert I.

Hum Gene Ther. 2012 Nov;23(11):1144-55. doi: 10.1089/hum.2012.013. Epub 2012 Oct 15.


Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice.

Girão da Cruz MT, Jordão J, Dasilva KA, Ayala-Grosso CA, Ypsilanti A, Weng YQ, Laferla FM, McLaurin J, Aubert I.

J Alzheimers Dis. 2012;32(2):267-72. doi: 10.3233/JAD-2012-100732.


Endothelial cells regulate p53-dependent apoptosis of neural progenitors after irradiation.

Lu F, Li YQ, Aubert I, Wong CS.

Cell Death Dis. 2012 Jun 21;3:e324. doi: 10.1038/cddis.2012.59.


Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus.

Nagy PM, Aubert I.

Neuroscience. 2012 Aug 30;218:1-11. doi: 10.1016/j.neuroscience.2012.05.047. Epub 2012 May 26.


The cell adhesion molecule L1 regulates the expression of choline acetyltransferase and the development of septal cholinergic neurons.

Cui X, Weng YQ, Frappé I, Burgess A, Girão da Cruz MT, Schachner M, Aubert I.

Brain Behav. 2011 Nov;1(2):73-86. doi: 10.1002/brb3.15.


Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.

Krantic S, Isorce N, Mechawar N, Davoli MA, Vignault E, Albuquerque M, Chabot JG, Moyse E, Chauvin JP, Aubert I, McLaurin J, Quirion R.

J Alzheimers Dis. 2012;29(2):293-308. doi: 10.3233/JAD-2011-110830.


Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.

Burgess A, Ayala-Grosso CA, Ganguly M, Jordão JF, Aubert I, Hynynen K.

PLoS One. 2011;6(11):e27877. doi: 10.1371/journal.pone.0027877. Epub 2011 Nov 16.


Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology.

Fenili D, Weng YQ, Aubert I, Nitz M, McLaurin J.

PLoS One. 2011;6(8):e24032. doi: 10.1371/journal.pone.0024032. Epub 2011 Aug 26.


Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes.

Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A.

J Biol Chem. 2011 Oct 14;286(41):35863-73. doi: 10.1074/jbc.M111.253450. Epub 2011 Aug 17.


The use of vascular access ports for blood collection in feline blood donors.

Aubert I, Abrams-Ogg AC, Sylvestre AM, Dyson DH, Allen DG, Johnstone IB.

Can J Vet Res. 2011 Jan;75(1):25-34.


Focused ultrasound: crossing barriers to treat Alzheimer's disease.

Burgess A, Aubert I, Hynynen K.

Ther Deliv. 2011 Mar;2(3):281-6. No abstract available.


Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate.

Barraud Q, Obeid I, Aubert I, Barrière G, Contamin H, McGuire S, Ravenscroft P, Porras G, Tison F, Bezard E, Ghorayeb I.

PLoS One. 2010 Oct 13;5(10):e13306. doi: 10.1371/journal.pone.0013306.


Abrogation of early apoptosis does not alter late inhibition of hippocampal neurogenesis after irradiation.

Li YQ, Aubert I, Wong CS.

Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1213-22. doi: 10.1016/j.ijrobp.2010.01.015.


Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.

Jordão JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, McLaurin J, Hynynen K, Aubert I.

PLoS One. 2010 May 11;5(5):e10549. doi: 10.1371/journal.pone.0010549.


Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.

Ahmed MR, Berthet A, Bychkov E, Porras G, Li Q, Bioulac BH, Carl YT, Bloch B, Kook S, Aubert I, Dovero S, Doudnikoff E, Gurevich VV, Gurevich EV, Bezard E.

Sci Transl Med. 2010 Apr 21;2(28):28ra28. doi: 10.1126/scitranslmed.3000664.


p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain.

Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD.

Nat Neurosci. 2010 May;13(5):559-66. doi: 10.1038/nn.2513. Epub 2010 Mar 28.


Loss of neuronal protein expression in mouse hippocampus after irradiation.

Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS.

J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi: 10.1097/NEN.0b013e3181d1afe4.


Stem cell transplantation for neurometabolic and neurodegenerative diseases.

Shihabuddin LS, Aubert I.

Neuropharmacology. 2010 May;58(6):845-54. doi: 10.1016/j.neuropharm.2009.12.015. Epub 2009 Dec 28. Review.


Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats.

Nagra G, Koh L, Aubert I, Kim M, Johnston M.

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1312-21. doi: 10.1152/ajpregu.00307.2009. Epub 2009 Sep 2.


High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster.

Reese R, Charron G, Nadjar A, Aubert I, Thiolat ML, Hamann M, Richter A, Bezard E, Meissner WG.

Neurobiol Dis. 2009 Sep;35(3):399-405. doi: 10.1016/j.nbd.2009.05.022. Epub 2009 Jun 6.


Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.

Berton O, Guigoni C, Li Q, Bioulac BH, Aubert I, Gross CE, Dileone RJ, Nestler EJ, Bezard E.

Biol Psychiatry. 2009 Sep 15;66(6):554-61. doi: 10.1016/j.biopsych.2009.04.005. Epub 2009 May 28.


Cytoplasmic expression of human telomerase catalytic protein (hTERT) in neutrophils: an immunoelectron microscopy study.

Lepreux S, Doudnikoff E, Aubert I, Bioulac-Sage P, Bloch B, Martin-Negrier ML.

Ultrastruct Pathol. 2008 Sep-Oct;32(5):178-83. doi: 10.1080/01913120802034504.


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