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Items: 1 to 50 of 222

1.

Meta-omics Provides Insights into the Impact of Hydrocarbon Contamination on Microbial Mat Functioning.

Aubé J, Senin P, Bonin P, Pringault O, Jeziorski C, Bouchez O, Klopp C, Guyoneaud R, Goñi-Urriza M.

Microb Ecol. 2020 Feb 19. doi: 10.1007/s00248-020-01493-x. [Epub ahead of print]

PMID:
32076743
2.

Autonomic Arousals as Surrogates for Cortical Arousals Caused by Respiratory Events: A Methodological Optimization Study in the Diagnosis of Sleep Breathing Disorders.

Mayer P, Herrero Babiloni A, Aubé JL, Kaddaha Z, Marshansky S, Rompré PH, Jobin V, Lavigne GJ.

Nat Sci Sleep. 2019 Dec 19;11:423-431. doi: 10.2147/NSS.S234703. eCollection 2019.

3.

HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A.

Andrade D, Mehta M, Griffith J, Oh S, Corbin J, Babu A, De S, Chen A, Zhao YD, Husain S, Roy S, Xu L, Aube J, Janknecht R, Gorospe M, Herman T, Ramesh R, Munshi A.

Cancers (Basel). 2019 Dec 13;11(12). pii: E2014. doi: 10.3390/cancers11122014.

4.

Correction to "Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis".

Quezada LL, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K, Karakaya SS, Javidnia PE, Porras de Francisco E, Amieva MM, Palomo S, Losana AM, Zimmerman M, Ho Liang HP, Zhang J, Dartois V, Sans S, Lagrange S, Goullieux L, Roubert C, Nathan C, Aubé J.

ACS Infect Dis. 2019 Dec 13;5(12):2175. doi: 10.1021/acsinfecdis.9b00395. Epub 2019 Oct 31. No abstract available.

PMID:
31670500
5.

MAIT cells are imprinted by the microbiota in early life and promote tissue repair.

Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y.

Science. 2019 Oct 25;366(6464). pii: eaax6624. doi: 10.1126/science.aax6624.

PMID:
31649166
6.

Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates.

McLaughlin JE, Minshew LM, Gonzalez D, Lamb K, Klus NJ, Aubé J, Cox W, Brouwer KLR.

PLoS One. 2019 Sep 9;14(9):e0222422. doi: 10.1371/journal.pone.0222422. eCollection 2019.

7.

Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.

Kaski SW, White AN, Gross JD, Trexler KR, Wix K, Harland AA, Prisinzano TE, Aubé J, Kinsey SG, Kenakin T, Siderovski DP, Setola V.

J Pharmacol Exp Ther. 2019 Nov;371(2):487-499. doi: 10.1124/jpet.118.255661. Epub 2019 Sep 6.

PMID:
31492823
8.

Revisiting the β-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.

Xiao S, Guo H, Weiner WS, Maddox C, Mao C, Gunosewoyo H, Pelly S, White EL, Rasmussen L, Schoenen FJ, Aubé J, Bishai WR, Lun S.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e01319-19. doi: 10.1128/AAC.01319-19. Print 2019 Nov.

PMID:
31427291
9.

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.

Bian Y, Teper Y, Mathews Griner LA, Aiken TJ, Shukla V, Guha R, Shinn P, Xin HW, Pflicke H, Powers AS, Li D, Jiang JK, Patel P, Rogers SA, Aubé J, Ferrer M, Thomas CJ, Rudloff U.

Mol Cancer Ther. 2019 Nov;18(11):2097-2110. doi: 10.1158/1535-7163.MCT-18-1011. Epub 2019 Aug 8.

PMID:
31395684
10.

Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy.

Xu YP, Lv L, Liu Y, Smith MD, Li WC, Tan XM, Cheng M, Li Z, Bovino M, Aubé J, Xiong Y.

J Clin Invest. 2019 Jul 16;130:4316-4331. doi: 10.1172/JCI129317.

11.

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.

Lopez Quezada L, Silve S, Kelinske M, Liba A, Diaz Gonzalez C, Kotev M, Goullieux L, Sans S, Roubert C, Lagrange S, Bacqué E, Couturier C, Pellet A, Blanc I, Ferron M, Debu F, Li K, Aubé J, Roberts J, Little D, Ling Y, Zhang J, Gold B, Nathan C.

mBio. 2019 Jul 9;10(4). pii: e01405-19. doi: 10.1128/mBio.01405-19.

12.

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.

Lopez Quezada L, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K, Somersan Karakaya S, Javidnia PE, Porras de Francisco E, Amieva MM, Dı Az SP, Mendoza Losana A, Zimmerman M, Liang HH, Zhang J, Dartois V, Sans S, Lagrange S, Goullieux L, Roubert C, Nathan C, Aubé J.

ACS Infect Dis. 2019 Aug 9;5(8):1433-1445. doi: 10.1021/acsinfecdis.9b00112. Epub 2019 Jun 11. Erratum in: ACS Infect Dis. 2019 Dec 13;5(12):2175.

PMID:
31184461
13.

The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells.

Allegri L, Baldan F, Roy S, Aubé J, Russo D, Filetti S, Damante G.

Sci Rep. 2019 May 14;9(1):7374. doi: 10.1038/s41598-019-43894-0.

14.

Is It First the Egg or the Shrimp? - Diversity and Variation in Microbial Communities Colonizing Broods of the Vent Shrimp Rimicaris exoculata During Embryonic Development.

Methou P, Hernández-Ávila I, Aube J, Cueff-Gauchard V, Gayet N, Amand L, Shillito B, Pradillon F, Cambon-Bonavita MA.

Front Microbiol. 2019 Apr 17;10:808. doi: 10.3389/fmicb.2019.00808. eCollection 2019.

15.

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Zimmerman M, McDonald SL, Ho-Liang HP, Porubsky P, Nguyen Q, Pharr CW, Perkowski AJ, Smith R, Schoenen FJ, Gold BS, Zhang D, Nathan CF, Dartois V, Aubé J.

J Antibiot (Tokyo). 2019 Jun;72(6):469-475. doi: 10.1038/s41429-019-0167-y. Epub 2019 Mar 22.

PMID:
30903100
16.

Synthesis of the Nonribosomal Peptide Phevalin and Analogs.

Ramesh R, Bovino MT, Zeng Y, Aubé J.

J Org Chem. 2019 Mar 15;84(6):3647-3651. doi: 10.1021/acs.joc.8b03206. Epub 2019 Mar 1.

PMID:
30821453
17.

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.

Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, Scarry SM, Aubé J, Yang G, Ouerfelli O, Schnappinger D, Ioerger TR, Engelhart CA, McConnell JA, McAulay K, Fay A, Roubert C, Sacchettini J, Nathan C.

Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959. Erratum in: Science. 2019 Jun 21;364(6446):.

18.

The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models.

Fowler KA, Li K, Whitehurst CB, Bruce DW, Moorman NJ, Aubé J, Coghill JM.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. doi: 10.1016/j.bbmt.2019.01.022. Epub 2019 Jan 19.

PMID:
30668984
19.

Human antigen R as a therapeutic target in pathological cardiac hypertrophy.

Green LC, Anthony SR, Slone S, Lanzillotta L, Nieman ML, Wu X, Robbins N, Jones SM, Roy S, Owens AP 3rd, Aube J, Xu L, Lorenz JN, Blaxall BC, Rubinstein J, Benoit JB, Tranter M.

JCI Insight. 2019 Feb 21;4(4). pii: 121541. doi: 10.1172/jci.insight.121541. eCollection 2019 Feb 21.

20.

Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection.

Vorkas CK, Wipperman MF, Li K, Bean J, Bhattarai SK, Adamow M, Wong P, Aubé J, Juste MAJ, Bucci V, Fitzgerald DW, Glickman MS.

JCI Insight. 2018 Oct 4;3(19). pii: 121899. doi: 10.1172/jci.insight.121899.

21.

An Interrupted Schmidt Reaction: C-C Bond Formation Arising from Nitrilium Ion Capture.

Charaschanya M, Li K, Motiwala HF, Aubé J.

Org Lett. 2018 Oct 19;20(20):6354-6358. doi: 10.1021/acs.orglett.8b02531. Epub 2018 Oct 2.

PMID:
30277406
22.

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.

Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Neufeld KL, Xu L.

BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z.

23.

G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons.

Ho JH, Stahl EL, Schmid CL, Scarry SM, Aubé J, Bohn LM.

Sci Signal. 2018 Aug 7;11(542). pii: eaar4309. doi: 10.1126/scisignal.aar4309.

24.

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites.

Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aubé J, Lane JR, Frankowski KJ, Sibley DR.

Mol Pharmacol. 2018 Oct;94(4):1197-1209. doi: 10.1124/mol.118.113175. Epub 2018 Aug 1.

25.

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A.

Cooper JK, Li K, Aubé J, Coppage DA, Konopelski JP.

Org Lett. 2018 Jul 20;20(14):4314-4317. doi: 10.1021/acs.orglett.8b01756. Epub 2018 Jul 9.

26.

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

Fehl C, Vogt CD, Yadav R, Li K, Scott EE, Aubé J.

J Med Chem. 2018 Jun 14;61(11):4946-4960. doi: 10.1021/acs.jmedchem.8b00419. Epub 2018 May 24.

27.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.

28.

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.

Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR.

Front Synaptic Neurosci. 2018 Feb 21;10:2. doi: 10.3389/fnsyn.2018.00002. eCollection 2018.

29.

Reagent-controlled regiodivergent ring expansions of steroids.

Charaschanya M, Aubé J.

Nat Commun. 2018 Mar 5;9(1):934. doi: 10.1038/s41467-018-03248-2.

30.

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

Li K, Vorkas CK, Chaudhry A, Bell DL, Willis RA, Rudensky A, Altman JD, Glickman MS, Aubé J.

PLoS One. 2018 Feb 5;13(2):e0191837. doi: 10.1371/journal.pone.0191837. eCollection 2018.

31.

Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.

Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney EW, Hackler AL, Patrick SL, Weiner WS, Aubé J, Sharlow ER, Morris JC, Golden JE.

ChemMedChem. 2017 Dec 7;12(23):1994-2005. doi: 10.1002/cmdc.201700592. Epub 2017 Nov 16.

32.

Desulfonatronum parangueonense sp. nov., a sulfate-reducing bacterium isolated from sediment of an alkaline crater lake.

Pérez Bernal MF, Souza Brito EM, Bartoli M, Aubé J, Fardeau ML, Cuevas Rodriguez G, Ollivier B, Guyoneaud R, Hirschler-Réa A.

Int J Syst Evol Microbiol. 2017 Dec;67(12):4999-5005. doi: 10.1099/ijsem.0.002399. Epub 2017 Oct 17.

PMID:
29039304
33.

Identification of novel small molecule Beclin 1 mimetics activating autophagy.

Yu J, Lan L, Lewin SJ, Rogers SA, Roy A, Wu X, Gao P, Karanicolas J, Aubé J, Sun B, Xu L.

Oncotarget. 2017 May 18;8(31):51355-51369. doi: 10.18632/oncotarget.17977. eCollection 2017 Aug 1.

34.

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.

Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD, Herman T, Ramesh R, Munshi A.

Sci Rep. 2017 Aug 30;7(1):9694. doi: 10.1038/s41598-017-07787-4.

35.

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.

Bohn LM, Aubé J.

ACS Med Chem Lett. 2017 Jul 5;8(7):694-700. doi: 10.1021/acsmedchemlett.7b00224. eCollection 2017 Jul 13.

36.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

J Med Chem. 2017 Jul 27;60(14):6364-6383. doi: 10.1021/acs.jmedchem.7b00561. Epub 2017 Jul 13.

37.

Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias".

Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1628. doi: 10.1021/acschemneuro.7b00157. Epub 2017 May 25. No abstract available.

PMID:
28541028
38.

Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1.

Petrunak EM, Rogers SA, Aubé J, Scott EE.

Drug Metab Dispos. 2017 Jun;45(6):635-645. doi: 10.1124/dmd.117.075317. Epub 2017 Apr 3.

39.

Report of the 2014-2016 AACP Research and Graduate Affairs Committee.

Eddington Chair ND, Aubé J, Das SK, Ellingrod VL, Hansen R, Madhavan SS, Monks TJ, Morris ME, Lakoski Staff Liaison JM.

Am J Pharm Educ. 2016 Nov 25;80(9):S21. doi: 10.5688/ajpe809S21. No abstract available.

40.

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria.

Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM.

Sci Signal. 2016 Nov 29;9(456):ra117.

41.

Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.

McLeod MC, Aubé J, Frankowski KJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5689-5694. doi: 10.1016/j.bmcl.2016.10.065. Epub 2016 Oct 22.

PMID:
27839919
42.

Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

Scarry SM, Lovell KM, Frankowski KJ, Bohn LM, Aubé J.

J Org Chem. 2016 Nov 4;81(21):10538-10550. Epub 2016 Aug 2.

43.

Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy.

Slone S, Anthony SR, Wu X, Benoit JB, Aube J, Xu L, Tranter M.

Cell Signal. 2016 Nov;28(11):1735-41. doi: 10.1016/j.cellsig.2016.08.005. Epub 2016 Aug 10.

44.

Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction.

Vekariya RH, Aubé J.

Org Lett. 2016 Aug 5;18(15):3534-7. doi: 10.1021/acs.orglett.6b01460. Epub 2016 Jul 26.

PMID:
27458880
46.

The impact of long-term hydrocarbon exposure on the structure, activity, and biogeochemical functioning of microbial mats.

Aubé J, Senin P, Pringault O, Bonin P, Deflandre B, Bouchez O, Bru N, Biritxinaga-Etchart E, Klopp C, Guyoneaud R, Goñi-Urriza M.

Mar Pollut Bull. 2016 Oct 15;111(1-2):115-125. doi: 10.1016/j.marpolbul.2016.07.023. Epub 2016 Jul 20.

PMID:
27449831
47.

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.

Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezada L, Somersan S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson P, Mitscher LA, Porubsky P, Rogers S, Schoenen FJ, Nathan C, Aubé J.

J Med Chem. 2016 Jul 14;59(13):6027-44. doi: 10.1021/acs.jmedchem.5b01833. Epub 2016 Jun 17.

48.

Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.

Singh G, Aubé J.

Org Biomol Chem. 2016 May 14;14(18):4299-303. doi: 10.1039/c6ob00598e.

49.

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.

Schroeder CE, Neuenswander SA, Yao T, Aubé J, Golden JE.

Org Biomol Chem. 2016 Apr 28;14(16):3950-5. doi: 10.1039/c5ob02378e. Epub 2016 Apr 6.

50.

Remodeling and Enhancing Schmidt Reaction Pathways in Hexafluoroisopropanol.

Motiwala HF, Charaschanya M, Day VW, Aubé J.

J Org Chem. 2016 Feb 19;81(4):1593-609. doi: 10.1021/acs.joc.5b02764. Epub 2016 Feb 9.

PMID:
26800244

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