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Items: 1 to 50 of 201

1.

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.

Lan L, Liu H, Smith AR, Appelman C, Yu J, Larsen S, Marquez RT, Wu X, Liu FY, Gao P, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Neufeld KL, Xu L.

BMC Cancer. 2018 Aug 10;18(1):809. doi: 10.1186/s12885-018-4704-z.

2.

G protein signaling-biased agonism at the κ-opioid receptor is maintained in striatal neurons.

Ho JH, Stahl EL, Schmid CL, Scarry SM, Aubé J, Bohn LM.

Sci Signal. 2018 Aug 7;11(542). pii: eaar4309. doi: 10.1126/scisignal.aar4309.

PMID:
30087177
3.

Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites.

Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aube J, Lane JR, Frankowski KJ, Sibley DR.

Mol Pharmacol. 2018 Aug 1. pii: mol.118.113175. doi: 10.1124/mol.118.113175. [Epub ahead of print]

4.

Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A.

Cooper JK, Li K, Aubé J, Coppage DA, Konopelski JP.

Org Lett. 2018 Jul 20;20(14):4314-4317. doi: 10.1021/acs.orglett.8b01756. Epub 2018 Jul 9.

PMID:
29984999
5.

Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.

Fehl C, Vogt CD, Yadav R, Li K, Scott EE, Aubé J.

J Med Chem. 2018 Jun 14;61(11):4946-4960. doi: 10.1021/acs.jmedchem.8b00419. Epub 2018 May 24.

PMID:
29792703
6.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.

PMID:
29769289
7.

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor.

Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR.

Front Synaptic Neurosci. 2018 Feb 21;10:2. doi: 10.3389/fnsyn.2018.00002. eCollection 2018.

8.

Reagent-controlled regiodivergent ring expansions of steroids.

Charaschanya M, Aubé J.

Nat Commun. 2018 Mar 5;9(1):934. doi: 10.1038/s41467-018-03248-2.

9.

Synthesis, stabilization, and characterization of the MR1 ligand precursor 5-amino-6-D-ribitylaminouracil (5-A-RU).

Li K, Vorkas CK, Chaudhry A, Bell DL, Willis RA, Rudensky A, Altman JD, Glickman MS, Aubé J.

PLoS One. 2018 Feb 5;13(2):e0191837. doi: 10.1371/journal.pone.0191837. eCollection 2018.

10.

Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase 1.

Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney EW, Hackler AL, Patrick SL, Weiner WS, Aubé J, Sharlow ER, Morris JC, Golden JE.

ChemMedChem. 2017 Dec 7;12(23):1994-2005. doi: 10.1002/cmdc.201700592. Epub 2017 Nov 16.

PMID:
29105342
11.

Desulfonatronum parangueonense sp. nov., a sulfate-reducing bacterium isolated from sediment of an alkaline crater lake.

Pérez Bernal MF, Souza Brito EM, Bartoli M, Aubé J, Fardeau ML, Cuevas Rodriguez G, Ollivier B, Guyoneaud R, Hirschler-Réa A.

Int J Syst Evol Microbiol. 2017 Dec;67(12):4999-5005. doi: 10.1099/ijsem.0.002399. Epub 2017 Oct 17.

PMID:
29039304
12.

Identification of novel small molecule Beclin 1 mimetics activating autophagy.

Yu J, Lan L, Lewin SJ, Rogers SA, Roy A, Wu X, Gao P, Karanicolas J, Aubé J, Sun B, Xu L.

Oncotarget. 2017 May 18;8(31):51355-51369. doi: 10.18632/oncotarget.17977. eCollection 2017 Aug 1.

13.

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells.

Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD, Herman T, Ramesh R, Munshi A.

Sci Rep. 2017 Aug 30;7(1):9694. doi: 10.1038/s41598-017-07787-4.

14.

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor.

Bohn LM, Aubé J.

ACS Med Chem Lett. 2017 Jul 5;8(7):694-700. doi: 10.1021/acsmedchemlett.7b00224. eCollection 2017 Jul 13.

15.

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

J Med Chem. 2017 Jul 27;60(14):6364-6383. doi: 10.1021/acs.jmedchem.7b00561. Epub 2017 Jul 13.

16.

Correction to "Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias".

Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1628. doi: 10.1021/acschemneuro.7b00157. Epub 2017 May 25. No abstract available.

PMID:
28541028
17.

Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1.

Petrunak EM, Rogers SA, Aubé J, Scott EE.

Drug Metab Dispos. 2017 Jun;45(6):635-645. doi: 10.1124/dmd.117.075317. Epub 2017 Apr 3.

18.

Report of the 2014-2016 AACP Research and Graduate Affairs Committee.

Eddington Chair ND, Aubé J, Das SK, Ellingrod VL, Hansen R, Madhavan SS, Monks TJ, Morris ME, Lakoski Staff Liaison JM.

Am J Pharm Educ. 2016 Nov 25;80(9):S21. doi: 10.5688/ajpe809S21. No abstract available.

19.

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria.

Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, Aubé J, Jones SR, Martin TJ, Bohn LM.

Sci Signal. 2016 Nov 29;9(456):ra117.

20.

Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.

McLeod MC, Aubé J, Frankowski KJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5689-5694. doi: 10.1016/j.bmcl.2016.10.065. Epub 2016 Oct 22.

PMID:
27839919
21.

Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

Scarry SM, Lovell KM, Frankowski KJ, Bohn LM, Aubé J.

J Org Chem. 2016 Nov 4;81(21):10538-10550. Epub 2016 Aug 2.

22.

Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy.

Slone S, Anthony SR, Wu X, Benoit JB, Aube J, Xu L, Tranter M.

Cell Signal. 2016 Nov;28(11):1735-41. doi: 10.1016/j.cellsig.2016.08.005. Epub 2016 Aug 10.

23.

Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction.

Vekariya RH, Aubé J.

Org Lett. 2016 Aug 5;18(15):3534-7. doi: 10.1021/acs.orglett.6b01460. Epub 2016 Jul 26.

PMID:
27458880
25.

The impact of long-term hydrocarbon exposure on the structure, activity, and biogeochemical functioning of microbial mats.

Aubé J, Senin P, Pringault O, Bonin P, Deflandre B, Bouchez O, Bru N, Biritxinaga-Etchart E, Klopp C, Guyoneaud R, Goñi-Urriza M.

Mar Pollut Bull. 2016 Oct 15;111(1-2):115-125. doi: 10.1016/j.marpolbul.2016.07.023. Epub 2016 Jul 20.

PMID:
27449831
26.

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.

Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezada L, Somersan S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson P, Mitscher LA, Porubsky P, Rogers S, Schoenen FJ, Nathan C, Aubé J.

J Med Chem. 2016 Jul 14;59(13):6027-44. doi: 10.1021/acs.jmedchem.5b01833. Epub 2016 Jun 17.

27.

Synthesis of cyclic 1,3-diols as scaffolds for spatially directed libraries.

Singh G, Aubé J.

Org Biomol Chem. 2016 May 14;14(18):4299-303. doi: 10.1039/c6ob00598e.

28.

One-pot, regiospecific assembly of (E)-benzamidines from δ- and γ-amino acids via an intramolecular aminoquinazolinone rearrangement.

Schroeder CE, Neuenswander SA, Yao T, Aubé J, Golden JE.

Org Biomol Chem. 2016 Apr 28;14(16):3950-5. doi: 10.1039/c5ob02378e. Epub 2016 Apr 6.

29.

Remodeling and Enhancing Schmidt Reaction Pathways in Hexafluoroisopropanol.

Motiwala HF, Charaschanya M, Day VW, Aubé J.

J Org Chem. 2016 Feb 19;81(4):1593-609. doi: 10.1021/acs.joc.5b02764. Epub 2016 Feb 9.

PMID:
26800244
30.

Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol.

Motiwala HF, Yin Q, Aubé J.

Molecules. 2015 Dec 29;21(1):E45. doi: 10.3390/molecules21010045.

31.

N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.

Roy S, Šileikytė J, Neuenswander B, Hedrick MP, Chung TD, Aubé J, Schoenen FJ, Forte MA, Bernardi P.

ChemMedChem. 2016 Feb 4;11(3):283-8. doi: 10.1002/cmdc.201500545. Epub 2015 Dec 23.

32.

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol.

Motiwala HF, Vekariya RH, Aubé J.

Org Lett. 2015 Nov 6;17(21):5484-7. doi: 10.1021/acs.orglett.5b02851. Epub 2015 Oct 23.

PMID:
26496158
33.

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization.

Frankowski KJ, Liu R, Milligan GL, Moeller KD, Aubé J.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10555-8. doi: 10.1002/anie.201504775.

34.

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

ACS Comb Sci. 2015 Oct 12;17(10):641-52. doi: 10.1021/acscombsci.5b00101. Epub 2015 Sep 17.

35.

Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus.

Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:600-9. doi: 10.1016/j.neuropharm.2015.08.027. Epub 2015 Aug 25.

36.

Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.

Roy S, Šileikytė J, Schiavone M, Neuenswander B, Argenton F, Aubé J, Hedrick MP, Chung TD, Forte MA, Bernardi P, Schoenen FJ.

ChemMedChem. 2015 Oct;10(10):1655-71. doi: 10.1002/cmdc.201500284. Epub 2015 Aug 18.

37.

A Pan-GTPase Inhibitor as a Molecular Probe.

Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, Wandinger-Ness A, Sklar LA.

PLoS One. 2015 Aug 6;10(8):e0134317. doi: 10.1371/journal.pone.0134317. eCollection 2015.

38.

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting.

Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM.

Neuropharmacology. 2015 Dec;99:131-41. doi: 10.1016/j.neuropharm.2015.07.001. Epub 2015 Jul 6.

39.
40.

DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.

Gowthaman R, Miller SA, Rogers S, Khowsathit J, Lan L, Bai N, Johnson DK, Liu C, Xu L, Anbanandam A, Aubé J, Roy A, Karanicolas J.

J Med Chem. 2016 May 12;59(9):4152-70. doi: 10.1021/acs.jmedchem.5b00150. Epub 2015 Jul 10.

41.

Temperature dependence of turnover in a Sc(OTf)3-catalyzed intramolecular Schmidt reaction.

Fehl C, Hirt EE, Li SW, Aubé J.

Tetrahedron Lett. 2015 Jun 3;56(23):3137-3140.

42.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team.

Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Review.

43.

Contrasted effects of natural complex mixtures of PAHs and metals on oxygen cycle in a microbial mat.

Pringault O, Aube J, Bouchez O, Klopp C, Mariette J, Escudie F, Senin P, Goni-Urriza M.

Chemosphere. 2015 Sep;135:189-201. doi: 10.1016/j.chemosphere.2015.04.037. Epub 2015 May 15.

PMID:
25957138
44.

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

Lan L, Appelman C, Smith AR, Yu J, Larsen S, Marquez RT, Liu H, Wu X, Gao P, Roy A, Anbanandam A, Gowthaman R, Karanicolas J, De Guzman RN, Rogers S, Aubé J, Ji M, Cohen RS, Neufeld KL, Xu L.

Mol Oncol. 2015 Aug;9(7):1406-20. doi: 10.1016/j.molonc.2015.03.014. Epub 2015 Apr 10.

45.

Domino Acylation/Diels-Alder Synthesis of N-Alkyl-octahydroisoquinolin-1-one-8-carboxylic Acids under Low-Solvent Conditions.

Slauson SR, Pemberton R, Ghosh P, Tantillo DJ, Aubé J.

J Org Chem. 2015 May 15;80(10):5260-71. doi: 10.1021/acs.joc.5b00804. Epub 2015 May 1.

PMID:
25901898
46.

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM.

ACS Chem Neurosci. 2015 Aug 19;6(8):1411-9. doi: 10.1021/acschemneuro.5b00092. Epub 2015 May 1. Erratum in: ACS Chem Neurosci. 2017 Jul 19;8(7):1628.

47.

Small Molecules Targeting the Mitochondrial Permeability Transition.

Sileikyte J, Roy S, Porubsky P, Neuenswander B, Wang J, Hedrick M, Pinkerton AB, Salaniwal S, Kung P, Mangravita-Novo A, Smith LH, Bourdette DN, Jackson MR, Aubé J, Chung TDY, Schoenen FJ, Forte MA, Bernardi P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

48.

An efficient computational model to predict protonation at the amide nitrogen and reactivity along the C-N rotational pathway.

Szostak R, Aubé J, Szostak M.

Chem Commun (Camb). 2015 Apr 14;51(29):6395-8. doi: 10.1039/c5cc01034a.

49.

Identification and validation of novel small molecule disruptors of HuR-mRNA interaction.

Wu X, Lan L, Wilson DM, Marquez RT, Tsao WC, Gao P, Roy A, Turner BA, McDonald P, Tunge JA, Rogers SA, Dixon DA, Aubé J, Xu L.

ACS Chem Biol. 2015 Jun 19;10(6):1476-84. doi: 10.1021/cb500851u. Epub 2015 Mar 17.

50.

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.

Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J.

Bioorg Med Chem. 2015 Jul 15;23(14):3948-56. doi: 10.1016/j.bmc.2014.12.033. Epub 2014 Dec 23.

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