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Multi-platform Approach for Microbial Biomarker Identification Using Borrelia burgdorferi as a Model.

Pflughoeft KJ, Mash M, Hasenkampf NR, Jacobs MB, Tardo AC, Magee DM, Song L, LaBaer J, Philipp MT, Embers ME, AuCoin DP.

Front Cell Infect Microbiol. 2019 Jun 11;9:179. doi: 10.3389/fcimb.2019.00179. eCollection 2019.


Evaluation of a Rapid Diagnostic Test for Detection of Burkholderia pseudomallei in the Lao People's Democratic Republic.

Woods KL, Boutthasavong L, NicFhogartaigh C, Lee SJ, Davong V, AuCoin DP, Dance DAB.

J Clin Microbiol. 2018 Jun 25;56(7). pii: e02002-17. doi: 10.1128/JCM.02002-17. Print 2018 Jul.


Immunoglobulin G subclass switching impacts sensitivity of an immunoassay targeting Francisella tularensis lipopolysaccharide.

Nualnoi T, Kirosingh A, Basallo K, Hau D, Gates-Hollingsworth MA, Thorkildson P, Crump RB, Reed DE, Pandit S, AuCoin DP.

PLoS One. 2018 Apr 9;13(4):e0195308. doi: 10.1371/journal.pone.0195308. eCollection 2018.


Performance evaluation of Active Melioidosis Detect-Lateral Flow Assay (AMD-LFA) for diagnosis of melioidosis in endemic settings with limited resources.

Shaw T, Tellapragada C, Ke V, AuCoin DP, Mukhopadhyay C.

PLoS One. 2018 Mar 26;13(3):e0194595. doi: 10.1371/journal.pone.0194595. eCollection 2018.


Deciphering minimal antigenic epitopes associated with Burkholderia pseudomallei and Burkholderia mallei lipopolysaccharide O-antigens.

Tamigney Kenfack M, Mazur M, Nualnoi T, Shaffer TL, Ngassimou A, Blériot Y, Marrot J, Marchetti R, Sintiprungrat K, Chantratita N, Silipo A, Molinaro A, AuCoin DP, Burtnick MN, Brett PJ, Gauthier C.

Nat Commun. 2017 Jul 24;8(1):115. doi: 10.1038/s41467-017-00173-8.


Genome-scale analysis of the genes that contribute to Burkholderia pseudomallei biofilm formation identifies a crucial exopolysaccharide biosynthesis gene cluster.

Borlee GI, Plumley BA, Martin KH, Somprasong N, Mangalea MR, Islam MN, Burtnick MN, Brett PJ, Steinmetz I, AuCoin DP, Belisle JT, Crick DC, Schweizer HP, Borlee BR.

PLoS Negl Trop Dis. 2017 Jun 28;11(6):e0005689. doi: 10.1371/journal.pntd.0005689. eCollection 2017 Jun.


Development of Immunoassays for Burkholderia pseudomallei Typical and Atypical Lipopolysaccharide Strain Typing.

Nualnoi T, Norris MH, Tuanyok A, Brett PJ, Burtnick MN, Keim PS, Settles EW, Allender CJ, AuCoin DP.

Am J Trop Med Hyg. 2017 Feb 8;96(2):358-367. doi: 10.4269/ajtmh.16-0308. Epub 2016 Dec 19.


Thermoregulation of Biofilm Formation in Burkholderia pseudomallei Is Disrupted by Mutation of a Putative Diguanylate Cyclase.

Plumley BA, Martin KH, Borlee GI, Marlenee NL, Burtnick MN, Brett PJ, AuCoin DP, Bowen RA, Schweizer HP, Borlee BR.

J Bacteriol. 2017 Feb 14;199(5). pii: e00780-16. doi: 10.1128/JB.00780-16. Print 2017 Mar 1.


In vivo Distribution and Clearance of Purified Capsular Polysaccharide from Burkholderia pseudomallei in a Murine Model.

Nualnoi T, Kirosingh A, Pandit SG, Thorkildson P, Brett PJ, Burtnick MN, AuCoin DP.

PLoS Negl Trop Dis. 2016 Dec 12;10(12):e0005217. doi: 10.1371/journal.pntd.0005217. eCollection 2016 Dec.


Pasteur revisited: An unexpected finding in Bacillus anthracis vaccine strains.

Thorkildson P, Kinney HL, AuCoin DP.

Virulence. 2016 Jul 3;7(5):506-7. doi: 10.1080/21505594.2016.1186325. Epub 2016 May 10. No abstract available.


Towards Development of Improved Serodiagnostics for Tularemia by Use of Francisella tularensis Proteome Microarrays.

Nakajima R, Escudero R, Molina DM, Rodríguez-Vargas M, Randall A, Jasinskas A, Pablo J, Felgner PL, AuCoin DP, Anda P, Davies DH.

J Clin Microbiol. 2016 Jul;54(7):1755-1765. doi: 10.1128/JCM.02784-15. Epub 2016 Apr 20.


Contribution of murine IgG Fc regions to antibody binding to the capsule of Burkholderia pseudomallei.

Dillon MJ, Loban RA, Reed DE, Thorkildson P, Pflughoeft KJ, Pandit SG, Brett PJ, Burtnick MN, AuCoin DP.

Virulence. 2016 Aug 17;7(6):691-701. doi: 10.1080/21505594.2016.1176655. Epub 2016 Apr 20.


Burkholderia pseudomallei Capsular Polysaccharide Recognition by a Monoclonal Antibody Reveals Key Details toward a Biodefense Vaccine and Diagnostics against Melioidosis.

Marchetti R, Dillon MJ, Burtnick MN, Hubbard MA, Kenfack MT, Blériot Y, Gauthier C, Brett PJ, AuCoin DP, Lanzetta R, Silipo A, Molinaro A.

ACS Chem Biol. 2015 Oct 16;10(10):2295-302. doi: 10.1021/acschembio.5b00502. Epub 2015 Aug 5.


Fibronectin-binding protein of Borrelia hermsii expressed in the blood of mice with relapsing fever.

Lewis ER, Marcsisin RA, Campeau Miller SA, Hue F, Phillips A, Aucoin DP, Barbour AG.

Infect Immun. 2014 Jun;82(6):2520-31. doi: 10.1128/IAI.01582-14. Epub 2014 Mar 31.


Development of a prototype lateral flow immunoassay (LFI) for the rapid diagnosis of melioidosis.

Houghton RL, Reed DE, Hubbard MA, Dillon MJ, Chen H, Currie BJ, Mayo M, Sarovich DS, Theobald V, Limmathurotsakul D, Wongsuvan G, Chantratita N, Peacock SJ, Hoffmaster AR, Duval B, Brett PJ, Burtnick MN, Aucoin DP.

PLoS Negl Trop Dis. 2014 Mar 20;8(3):e2727. doi: 10.1371/journal.pntd.0002727. eCollection 2014 Mar.


In Vivo Microbial Antigen Discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections.

Chaves SJ, Schegg K, Kozel TR, Aucoin DP.

Methods Mol Biol. 2013;1061:155-65. doi: 10.1007/978-1-62703-589-7_9.


Unraveling the interaction between the LPS O-antigen of Burkholderia anthina and the 5D8 monoclonal antibody by using a multidisciplinary chemical approach, with synthesis, NMR, and molecular modeling methods.

Marchetti R, Canales A, Lanzetta R, Nilsson I, Vogel C, Reed DE, Aucoin DP, Jiménez-Barbero J, Molinaro A, Silipo A.

Chembiochem. 2013 Aug 19;14(12):1485-93. doi: 10.1002/cbic.201300225. Epub 2013 Jul 22.


Constant domains influence binding of mouse-human chimeric antibodies to the capsular polypeptide of Bacillus anthracis.

Hubbard MA, Thorkildson P, Kozel TR, AuCoin DP.

Virulence. 2013 Aug 15;4(6):483-8. doi: 10.4161/viru.25711. Epub 2013 Jul 17.


IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis.

Hovenden M, Hubbard MA, Aucoin DP, Thorkildson P, Reed DE, Welch WH, Lyons CR, Lovchik JA, Kozel TR.

PLoS Pathog. 2013;9(4):e1003306. doi: 10.1371/journal.ppat.1003306. Epub 2013 Apr 18.


Polysaccharide specific monoclonal antibodies provide passive protection against intranasal challenge with Burkholderia pseudomallei.

AuCoin DP, Reed DE, Marlenee NL, Bowen RA, Thorkildson P, Judy BM, Torres AG, Kozel TR.

PLoS One. 2012;7(4):e35386. doi: 10.1371/journal.pone.0035386. Epub 2012 Apr 17.


In vivo microbial antigen discovery: finding the 'needle in the haystack'.

AuCoin DP.

Expert Rev Mol Diagn. 2012 Apr;12(3):219-21. doi: 10.1586/erm.12.8. No abstract available.


A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection.

Nieves W, Asakrah S, Qazi O, Brown KA, Kurtz J, Aucoin DP, McLachlan JB, Roy CJ, Morici LA.

Vaccine. 2011 Oct 26;29(46):8381-9. doi: 10.1016/j.vaccine.2011.08.058. Epub 2011 Aug 24.


Identification of circulating bacterial antigens by in vivo microbial antigen discovery.

Nuti DE, Crump RB, Dwi Handayani F, Chantratita N, Peacock SJ, Bowen R, Felgner PL, Davies DH, Wu T, Lyons CR, Brett PJ, Burtnick MN, Kozel TR, AuCoin DP.

MBio. 2011 Aug 16;2(4). pii: e00136-11. doi: 10.1128/mBio.00136-11. Print 2011.


Genotypic characterisation of Giardia from domestic dogs in the USA.

Covacin C, Aucoin DP, Elliot A, Thompson RC.

Vet Parasitol. 2011 Apr 19;177(1-2):28-32. doi: 10.1016/j.vetpar.2010.11.029. Epub 2010 Nov 21.


Identification of Burkholderia cepacia complex bacteria with a lipopolysaccharide-specific monoclonal antibody.

AuCoin DP, Crump RB, Thorkildson P, Nuti DE, LiPuma JJ, Kozel TR.

J Med Microbiol. 2010 Jan;59(Pt 1):41-7. doi: 10.1099/jmm.0.012500-0.


Human cytomegalovirus exploits ESCRT machinery in the process of virion maturation.

Tandon R, AuCoin DP, Mocarski ES.

J Virol. 2009 Oct;83(20):10797-807. doi: 10.1128/JVI.01093-09. Epub 2009 Jul 29.


Rapid detection of the poly-gamma-D-glutamic acid capsular antigen of Bacillus anthracis by latex agglutination.

AuCoin DP, Sutherland MD, Percival AL, Lyons CR, Lovchik JA, Kozel TR.

Diagn Microbiol Infect Dis. 2009 Jun;64(2):229-32. doi: 10.1016/j.diagmicrobio.2009.02.001. Epub 2009 Apr 2.


Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule.

Kozel TR, Thorkildson P, Brandt S, Welch WH, Lovchik JA, AuCoin DP, Vilai J, Lyons CR.

Infect Immun. 2007 Jan;75(1):152-63. Epub 2006 Oct 23.


p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes.

Singer CA, Baker KJ, McCaffrey A, AuCoin DP, Dechert MA, Gerthoffer WT.

Am J Physiol Lung Cell Mol Physiol. 2003 Nov;285(5):L1087-98. Epub 2003 Jul 18.


Concentration of enrofloxacin and its active metabolite in alveolar macrophages and pulmonary epithelial lining fluid of dogs.

Hawkins EC, Boothe DM, Guinn A, Aucoin DP, Ngyuen J.

J Vet Pharmacol Ther. 1998 Feb;21(1):18-23.


Pharmacokinetics of ceftriaxone in mares.

Gardner SY, Aucoin DP.

J Vet Pharmacol Ther. 1994 Apr;17(2):155-6. No abstract available.


Pharmacokinetics of ibuprofen in lactating dairy cows.

DeGraves FJ, Anderson KL, Aucoin DP.

Am J Vet Res. 1993 Jul;54(7):1133-5.


Comparison of the disposition of carbimazole and methimazole in clinically normal cats.

Peterson ME, Aucoin DP.

Res Vet Sci. 1993 May;54(3):351-5.


Pharmacokinetics of ibuprofen in lactating dairy goats.

DeGraves FJ, Anderson KL, Aucoin DP.

Am J Vet Res. 1993 Mar;54(3):434-7.


Enrofloxacin treatment of long-tailed macaques with acute bacillary dysentery due to multiresistant Shigella flexneri IV.

Line AS, Paul-Murphy J, Aucoin DP, Hirsh DC.

Lab Anim Sci. 1992 Jun;42(3):240-4.


Pharmacokinetic disposition of cefazolin in serum and tissue during canine total hip replacement.

Richardson DC, Aucoin DP, DeYoung DJ, Tyczkowska KL, DeYoung BA.

Vet Surg. 1992 Jan-Feb;21(1):1-4.


Rapid high-performance liquid chromatographic method for the determination of propranolol levels in canine and feline plasma.

Hedeen KM, Tyczkowska K, Aucoin DP, Norton RM.

J Chromatogr. 1991 Dec 6;572(1-2):239-45.


Pharmacokinetics of intravenous and oral methimazole following single- and multiple-dose administration in normal cats.

Trepanier LA, Peterson ME, Aucoin DP.

J Vet Pharmacol Ther. 1991 Dec;14(4):367-73.


Intramuscular and oral disposition of enrofloxacin in African grey parrots following single and multiple doses.

Flammer K, Aucoin DP, Whitt DA.

J Vet Pharmacol Ther. 1991 Dec;14(4):359-66.


Efficacy of chloramphenicol, enrofloxacin, and tetracycline for treatment of experimental Rocky Mountain spotted fever in dogs.

Breitschwerdt EB, Davidson MG, Aucoin DP, Levy MG, Szabados NS, Hegarty BC, Kuehne AL, James RL.

Antimicrob Agents Chemother. 1991 Nov;35(11):2375-81.


Effect of hyperthermia on the in vitro hydrolysis of melphalan.

Riviere JE, Page RL, Aucoin DP, Rogers RA, Williams PL.

Int J Hyperthermia. 1991 May-Jun;7(3):527-9.


Pharmacokinetics of methimazole in normal cats and cats with hyperthyroidism.

Trepanier LA, Peterson ME, Aucoin DP.

Res Vet Sci. 1991 Jan;50(1):69-74.


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