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Items: 15

1.

ZAP-70 in Signaling, Biology, and Disease.

Au-Yeung BB, Shah NH, Shen L, Weiss A.

Annu Rev Immunol. 2018 Apr 26;36:127-156. doi: 10.1146/annurev-immunol-042617-053335. Epub 2017 Dec 13.

PMID:
29237129
2.

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A.

Mol Cell. 2017 Aug 3;67(3):498-511.e6. doi: 10.1016/j.molcel.2017.06.024. Epub 2017 Jul 20.

3.

IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.

Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J.

J Immunol. 2017 Mar 15;198(6):2445-2456. doi: 10.4049/jimmunol.1601453. Epub 2017 Feb 3.

4.

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.

Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3679-88. doi: 10.1073/pnas.1413726111. Epub 2014 Aug 18.

5.

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.

Ross JO, Melichar HJ, Au-Yeung BB, Herzmark P, Weiss A, Robey EA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2550-8. doi: 10.1073/pnas.1408482111. Epub 2014 Jun 9.

6.

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.

Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A.

Nat Immunol. 2014 Jul;15(7):687-94. doi: 10.1038/ni.2918. Epub 2014 Jun 8. Erratum in: Nat Immunol. 2015 Feb;16(2):214.

7.

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A.

Elife. 2014 May 13;3:e02270. doi: 10.7554/eLife.02270.

8.

Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM.

Elife. 2014 Mar 4;3:e01310. doi: 10.7554/eLife.01310.

9.

Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.

Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS.

Immunity. 2013 Sep 19;39(3):560-72. doi: 10.1016/j.immuni.2013.08.005. Epub 2013 Aug 29.

10.

Itk controls the spatiotemporal organization of T cell activation.

Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C.

Sci Signal. 2011 Oct 4;4(193):ra66. doi: 10.1126/scisignal.2001821.

11.

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.

Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A.

Nat Immunol. 2010 Dec;11(12):1085-92. doi: 10.1038/ni.1955. Epub 2010 Oct 31.

12.

ZAP-70: an essential kinase in T-cell signaling.

Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A.

Cold Spring Harb Perspect Biol. 2010 May;2(5):a002279. doi: 10.1101/cshperspect.a002279. Review.

13.

The structure, regulation, and function of ZAP-70.

Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A.

Immunol Rev. 2009 Mar;228(1):41-57. doi: 10.1111/j.1600-065X.2008.00753.x. Review.

PMID:
19290920
14.

A key role for Itk in both IFN gamma and IL-4 production by NKT cells.

Au-Yeung BB, Fowell DJ.

J Immunol. 2007 Jul 1;179(1):111-9.

15.

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