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Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol O-Methyltransferase.

Ernst G, Akuma D, Au V, Buchler IP, Byers S, Carr GV, Defays S, de León P, Demaude T, DePasquale M, Durieu V, Huang Y, Jigorel E, Kimos M, Kolobova A, Montel F, Moureau F, Poslusney M, Swinnen D, Vandergeten MC, Van Houtvin N, Wei H, White N, Wood M, Barrow JC.

ACS Med Chem Lett. 2019 Oct 22;10(11):1573-1578. doi: 10.1021/acsmedchemlett.9b00345. eCollection 2019 Nov 14.


Predictors of non-cystic fibrosis bronchiectasis in Indigenous adult residents of central Australia: results of a case-control study.

Einsiedel L, Pham H, Au V, Hatami S, Wilson K, Spelman T, Jersmann H.

ERJ Open Res. 2019 Dec 2;5(4). pii: 00001-2019. doi: 10.1183/23120541.00001-2019. eCollection 2019 Oct.


Intraoperative surfactant administration during neonatal sacrococcygeal teratoma resection.

Au V, Gregory G, Sinskey J.

Paediatr Anaesth. 2019 Nov;29(11):1148-1150. doi: 10.1111/pan.13724. Epub 2019 Aug 30.


The Important Role of Coordination Geometry on Photophysical Properties of Blue-Green Emitting Ruthenium(II) Diisocyano Complexes Bearing 2-Benzoxazol-2-ylphenolate.

Ho PY, Cheng SC, Yiu SM, Au VK, Xiang J, Leung CF, Ko CC.

Inorg Chem. 2019 Sep 3;58(17):11372-11381. doi: 10.1021/acs.inorgchem.9b00560. Epub 2019 Aug 14.


Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity.

Calizo RC, Bhattacharya S, van Hasselt JGC, Wei C, Wong JS, Wiener RJ, Ge X, Wong NJ, Lee JJ, Cuttitta CM, Jayaraman G, Au VH, Janssen W, Liu T, Li H, Salem F, Jaimes EA, Murphy B, Campbell KN, Azeloglu EU.

Nat Commun. 2019 May 3;10(1):2061. doi: 10.1038/s41467-019-09936-x.


Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21.

Ng PML, Kaliaperumal N, Lee CY, Chin WJ, Tan HC, Au VB, Goh AX, Tan QW, Yeo DSG, Connolly JE, Wang CI.

J Immunol. 2019 Apr 15;202(8):2307-2319. doi: 10.4049/jimmunol.1800462. Epub 2019 Feb 22.


Stepwise Expansion of Layered Metal-Organic Frameworks for Nonstochastic Exfoliation into Porous Nanosheets.

Au VK, Nakayashiki K, Huang H, Suginome S, Sato H, Aida T.

J Am Chem Soc. 2019 Jan 9;141(1):53-57. doi: 10.1021/jacs.8b09987. Epub 2018 Dec 27.


CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans.

Au V, Li-Leger E, Raymant G, Flibotte S, Chen G, Martin K, Fernando L, Doell C, Rosell FI, Wang S, Edgley ML, Rougvie AE, Hutter H, Moerman DG.

G3 (Bethesda). 2019 Jan 9;9(1):135-144. doi: 10.1534/g3.118.200778.


CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance.

McDiarmid TA, Au V, Loewen AD, Liang J, Mizumoto K, Moerman DG, Rankin CH.

Dis Model Mech. 2018 Nov 26;11(12). pii: dmm036517. doi: 10.1242/dmm.036517.


Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B.

J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350. Epub 2018 Oct 5.


Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.

Buchler I, Akuma D, Au V, Carr G, de León P, DePasquale M, Ernst G, Huang Y, Kimos M, Kolobova A, Poslusney M, Wei H, Swinnen D, Montel F, Moureau F, Jigorel E, Schulze MED, Wood M, Barrow JC.

J Med Chem. 2018 Nov 8;61(21):9647-9665. doi: 10.1021/acs.jmedchem.8b01126. Epub 2018 Oct 19.


Distinct "Immunoallertypes" of Disease and High Frequencies of Sensitization in Non-Cystic Fibrosis Bronchiectasis.

Mac Aogáin M, Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Ong TC, Tiong YS, Wong KN, Narayanan S, Au VB, Marlier D, Keir HR, Tee A, Abisheganaden JA, Koh MS, Wang Y, Connolly JE, Chew FT, Chalmers JD, Chotirmall SH.

Am J Respir Crit Care Med. 2019 Apr 1;199(7):842-853. doi: 10.1164/rccm.201807-1355OC.


Dataset of plasma and aqueous humor cytokine profiles in patients with exudative age related macular degeneration and polypoidal choroidal vasculopathy.

Balne PK, Agrawal R, Au VB, Lee B, Ghosh A, Sethu S, Agrawal M, Narayanan R, Connolly J.

Data Brief. 2018 May 24;19:1570-1573. doi: 10.1016/j.dib.2018.05.085. eCollection 2018 Aug.


Failing to thrive, abdominal pain and vomiting: A hairy situation.

Au VA, Wong JP, Venu I, Moodie RG, Etoom Y, Kieswetter L, Gerstle JT, Wong PD.

Paediatr Child Health. 2018 May;23(3):173-175. doi: 10.1093/pch/pxx210. Epub 2018 Feb 3. No abstract available.


Ameliorating the biological impacts of childhood adversity: A review of intervention programs.

Purewal Boparai SK, Au V, Koita K, Oh DL, Briner S, Burke Harris N, Bucci M.

Child Abuse Negl. 2018 Jul;81:82-105. doi: 10.1016/j.chiabu.2018.04.014. Epub 2018 May 1.


A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.

Wiesenfahrt T, Duanmu J, Snider F, Moerman D, Au V, Li-Leger E, Flibotte S, Parker DM, Marshall CJ, Nishimura EO, Mains PE, McGhee JD.

G3 (Bethesda). 2018 May 4;8(5):1425-1437. doi: 10.1534/g3.118.200079.


The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans.

Lissemore JL, Connors E, Liu Y, Qiao L, Yang B, Edgley ML, Flibotte S, Taylor J, Au V, Moerman DG, Maine EM.

G3 (Bethesda). 2018 May 4;8(5):1535-1544. doi: 10.1534/g3.118.300551.


Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties.

Wong BY, Wong HL, Wong YC, Au VK, Chan MY, Yam VW.

Chem Sci. 2017 Oct 1;8(10):6936-6946. doi: 10.1039/c7sc02410j. Epub 2017 Aug 23.


Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles.

Balne PK, Au VB, Tong L, Ghosh A, Agrawal M, Connolly J, Agrawal R.

J Vis Exp. 2017 Oct 13;(128). doi: 10.3791/55993.


Offsetting the Effects of Neighborhood Disadvantage on Problem Drinking.

Karriker-Jaffe KJ, Au V, Frendo M, Mericle AA.

J Community Psychol. 2017 Jul;45(5):678-684. doi: 10.1002/jcop.21881. Epub 2017 Feb 21.


MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes.

Mok CA, Au V, Thompson OA, Edgley ML, Gevirtzman L, Yochem J, Lowry J, Memar N, Wallenfang MR, Rasoloson D, Bowerman B, Schnabel R, Seydoux G, Moerman DG, Waterston RH.

Genetics. 2017 Oct;207(2):447-463. doi: 10.1534/genetics.117.300179. Epub 2017 Aug 21.


Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cells.

Leong C, Bigliardi PL, Sriram G, Au VB, Connolly J, Bigliardi-Qi M.

Photochem Photobiol. 2018 Jan;94(1):150-157. doi: 10.1111/php.12817. Epub 2017 Sep 25.


Dataset of longitudinal analysis of tear cytokine levels, CD4, CD8 counts and HIV viral load in dry eye patients with HIV infection.

Balne PK, Agrawal R, Au VB, Lee B, Loo E, Tong L, Ghosh A, Teoh SC, Connolly J, Tan P.

Data Brief. 2017 Feb 3;11:152-154. doi: 10.1016/j.dib.2017.01.014. eCollection 2017 Apr.


Luminescent Bis-Cyclometalated Gold(III) Complexes with Alkynyl Ligands of Hexaphenylbenzene and Hexabenzocoronene Derivatives and Their Supramolecular Assembly.

Yim KC, Au VK, Wong KM, Yam VW.

Chemistry. 2017 Apr 27;23(24):5772-5786. doi: 10.1002/chem.201606052. Epub 2017 Apr 10.


Dataset of tear film cytokine levels in dry eye disease (DED) patients with and without HIV infection.

Balne PK, Agrawal R, Au VB, Lee B, Loo E, Tong L, Ghosh A, Teoh SC, Connolly J, Tan P.

Data Brief. 2016 Nov 26;10:14-16. eCollection 2017 Feb.


Luminescent Dinuclear Bis-Cyclometalated Gold(III) Alkynyls and Their Solvent-Dependent Morphologies through Supramolecular Self-Assembly.

Yim KC, Au VK, Hung LL, Wong KM, Yam VW.

Chemistry. 2016 Nov 2;22(45):16258-16270. doi: 10.1002/chem.201603186. Epub 2016 Sep 28.


Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005058. doi: 10.1371/journal.pntd.0005058. eCollection 2016 Oct.


Urinary neutrophil gelatinase-associated lipocalin (NGAL) distinguishes sustained from transient acute kidney injury after general surgery.

Au V, Feit J, Barasch J, Sladen RN, Wagener G.

Kidney Int Rep. 2016 May;1(1):3-9. Epub 2016 Apr 30.


A distinct cytokines profile in tear film of dry eye disease (DED) patients with HIV infection.

Agrawal R, Balne PK, Veerappan A, Au VB, Lee B, Loo E, Ghosh A, Tong L, Teoh SC, Connolly J, Tan P.

Cytokine. 2016 Dec;88:77-84. doi: 10.1016/j.cyto.2016.08.026. Epub 2016 Aug 29.


Dataset of aqueous humor cytokine profile in HIV patients with Cytomegalovirus (CMV) retinitis.

Iyer JV, Agrawal R, Yeo TK, Gunasekeran DV, Balne PK, Lee B, Au VB, Connolly J, Teoh SC.

Data Brief. 2016 Jul 9;8:1232-42. doi: 10.1016/j.dib.2016.06.050. eCollection 2016 Sep.


Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG, Leroux MR.

PLoS Genet. 2016 Aug 10;12(8):e1006235. doi: 10.1371/journal.pgen.1006235. eCollection 2016 Aug.


Aqueous humor immune factors and cytomegalovirus (CMV) levels in CMV retinitis through treatment - The CRIGSS study.

Iyer JV, Agrawal R, Yeo TK, Gunasekeran DV, Balne PK, Lee B, Au VB, Connolly J, Teoh SC.

Cytokine. 2016 Aug;84:56-62. doi: 10.1016/j.cyto.2016.05.009. Epub 2016 May 27.


UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.

Safdar K, Gu A, Xu X, Au V, Taylor J, Flibotte S, Moerman DG, Maine EM.

G3 (Bethesda). 2016 Jul 7;6(7):2125-34. doi: 10.1534/g3.116.027805.


Synthesis, characterization, electrochemistry, and photophysical studies of triarylamine-containing zinc(II) diimine bis-thiolate complexes.

Yu T, Au VK, Tsang DP, Chan MY, Yam VW.

Dalton Trans. 2015 Nov 21;44(43):18983-92. doi: 10.1039/c5dt02920a.


Dual Esterase- and Steroid-Responsive Energy Transfer Modulation of Ruthenium(II) and Rhenium(I) Complex Functionalized Gold Nanoparticles.

Leung FC, Au VK, Song HO, Yam VW.

Chemistry. 2015 Nov 9;21(46):16448-54. doi: 10.1002/chem.201501808. Epub 2015 Sep 23.


Light-Emitting Self-Assembled Materials Based on d(8) and d(10) Transition Metal Complexes.

Yam VW, Au VK, Leung SY.

Chem Rev. 2015 Aug 12;115(15):7589-728. doi: 10.1021/acs.chemrev.5b00074. Epub 2015 Jul 9. No abstract available.


Organic memory devices based on a bis-cyclometalated alkynylgold(III) complex.

Au VK, Wu D, Yam VW.

J Am Chem Soc. 2015 Apr 15;137(14):4654-7. doi: 10.1021/jacs.5b02113. Epub 2015 Apr 1.


Higher human T-lymphotropic virus type 1 subtype C proviral loads are associated with bronchiectasis in indigenous australians: results of a case-control study.

Einsiedel L, Cassar O, Goeman E, Spelman T, Au V, Hatami S, Joseph S, Gessain A.

Open Forum Infect Dis. 2014 May 28;1(1):ofu023. doi: 10.1093/ofid/ofu023. eCollection 2014 Mar.


Luminescence color switching of supramolecular assemblies of discrete molecular decanuclear gold(I) sulfido complexes.

Hau FK, Lee TK, Cheng EC, Au VK, Yam VW.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15900-5. doi: 10.1073/pnas.1418824111. Epub 2014 Oct 31.


Synthesis, characterization, self-assembly, gelation, morphology and computational studies of alkynylgold(III) complexes of 2,6-bis(benzimidazol-2'-yl)pyridine derivatives.

Yim KC, Lam ES, Wong KM, Au VK, Ko CC, Lam WH, Yam VW.

Chemistry. 2014 Aug 4;20(32):9930-9. doi: 10.1002/chem.201402876. Epub 2014 Jul 15.


Prognostic marker microRNA-125b inhibits tumorigenic properties of hepatocellular carcinoma cells via suppressing tumorigenic molecule eIF5A2.

Tsang FH, Au V, Lu WJ, Shek FH, Liu AM, Luk JM, Fan ST, Poon RT, Lee NP.

Dig Dis Sci. 2014 Oct;59(10):2477-87. doi: 10.1007/s10620-014-3184-5. Epub 2014 May 9.


Förster resonance energy transfer studies of luminescent gold nanoparticles functionalized with ruthenium(II) and rhenium(I) complexes: modulation via esterase hydrolysis.

Leung FC, Tam AY, Au VK, Li MJ, Yam VW.

ACS Appl Mater Interfaces. 2014 May 14;6(9):6644-53. doi: 10.1021/am500350c. Epub 2014 Apr 22.


Functionalized bis-cyclometalated alkynylgold(III) complexes: synthesis, characterization, electrochemistry, photophysics, photochemistry, and electroluminescence studies.

Au VK, Tsang DP, Wong KM, Chan MY, Zhu N, Yam VW.

Inorg Chem. 2013 Nov 4;52(21):12713-25. doi: 10.1021/ic4019212. Epub 2013 Oct 21.


Symptomatic metastatic pulmonary calcification in a renal transplant recipient.

Sachdev A, Barbara JA, Au V, Henderson DW, Bowden JJ.

Intern Med J. 2013 Sep;43(9):1046-7. doi: 10.1111/imj.12243. No abstract available.


Deep red to near-infrared emitting rhenium(I) complexes: synthesis, characterization, electrochemistry, photophysics, and electroluminescence studies.

Yu T, Tsang DP, Au VK, Lam WH, Chan MY, Yam VW.

Chemistry. 2013 Sep 27;19(40):13418-27. doi: 10.1002/chem.201301841. Epub 2013 Aug 19.


The million mutation project: a new approach to genetics in Caenorhabditis elegans.

Thompson O, Edgley M, Strasbourger P, Flibotte S, Ewing B, Adair R, Au V, Chaudhry I, Fernando L, Hutter H, Kieffer A, Lau J, Lee N, Miller A, Raymant G, Shen B, Shendure J, Taylor J, Turner EH, Hillier LW, Moerman DG, Waterston RH.

Genome Res. 2013 Oct;23(10):1749-62. doi: 10.1101/gr.157651.113. Epub 2013 Jun 25.


Luminescent metallogels of bis-cyclometalated alkynylgold(III) complexes.

Au VK, Zhu N, Yam VW.

Inorg Chem. 2013 Jan 18;52(2):558-67. doi: 10.1021/ic3007519. Epub 2012 Jul 19.


Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.

Zhang Z, Lee JC, Lin L, Olivas V, Au V, LaFramboise T, Abdel-Rahman M, Wang X, Levine AD, Rho JK, Choi YJ, Choi CM, Kim SW, Jang SJ, Park YS, Kim WS, Lee DH, Lee JS, Miller VA, Arcila M, Ladanyi M, Moonsamy P, Sawyers C, Boggon TJ, Ma PC, Costa C, Taron M, Rosell R, Halmos B, Bivona TG.

Nat Genet. 2012 Jul 1;44(8):852-60. doi: 10.1038/ng.2330.


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