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Items: 27


Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma.

Kuonen F, Huskey NE, Shankar G, Jaju P, Whitson RJ, Rieger KE, Atwood SX, Sarin KY, Oro AE.

J Invest Dermatol. 2019 Jan 29. pii: S0022-202X(19)30041-7. doi: 10.1016/j.jid.2018.11.035. [Epub ahead of print]


MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.

Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, Oro AE.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12407-E12416. doi: 10.1073/pnas.1816177115. Epub 2018 Dec 7.


Actin polymerization controls cilia-mediated signaling.

Drummond ML, Li M, Tarapore E, Nguyen TTL, Barouni BJ, Cruz S, Tan KC, Oro AE, Atwood SX.

J Cell Biol. 2018 Sep 3;217(9):3255-3266. doi: 10.1083/jcb.201703196. Epub 2018 Jun 26.


Illuminating Alternative Strategies to Treat Targeted Chemotherapy-Resistant Sporadic Basal Cell Carcinoma.

Nguyen TTL, Atwood SX.

J Invest Dermatol. 2018 May;138(5):1017-1019. doi: 10.1016/j.jid.2017.11.013.


Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas.

Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH Jr, Tang JY, Oro AE.

Nat Med. 2018 Mar;24(3):271-281. doi: 10.1038/nm.4476. Epub 2018 Feb 5.


Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.

Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE.

JCI Insight. 2017 Nov 2;2(21). pii: 97071. doi: 10.1172/jci.insight.97071.


Cell-Selective Bioorthogonal Metabolic Labeling of RNA.

Nguyen K, Fazio M, Kubota M, Nainar S, Feng C, Li X, Atwood SX, Bredy TW, Spitale RC.

J Am Chem Soc. 2017 Feb 15;139(6):2148-2151. doi: 10.1021/jacs.6b11401. Epub 2017 Feb 7.


Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions.

Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE.

PLoS One. 2016 Dec 28;11(12):e0168031. doi: 10.1371/journal.pone.0168031. eCollection 2016.


sm"FISH"ing for Hedgehog.

Drummond ML, Atwood SX.

J Invest Dermatol. 2017 Jan;137(1):13-15. doi: 10.1016/j.jid.2016.07.021. Review.


Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma.

Ally MS, Ransohoff K, Sarin K, Atwood SX, Rezaee M, Bailey-Healy I, Kim J, Beachy PA, Chang AL, Oro A, Tang JY, Colevas AD.

JAMA Dermatol. 2016 Apr;152(4):452-6. doi: 10.1001/jamadermatol.2015.5473.


Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma.

Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY.

J Invest Dermatol. 2015 Dec;135(12):3197-3200. doi: 10.1038/jid.2015.339. Epub 2015 Sep 8. No abstract available. Erratum in: J Invest Dermatol. 2016 Apr;136(4):882. Nguyen, Christine B [corrected to Nguyen, Christie B].


RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.

Cancer Res. 2015 Sep 1;75(17):3623-35. doi: 10.1158/0008-5472.CAN-14-2999-T. Epub 2015 Jun 30.


Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma.

Atwood SX, Sarin KY, Li JR, Yao CY, Urman NM, Chang ALS, Tang JY, Oro AE.

J Invest Dermatol. 2015 Aug;135(8):2138-2141. doi: 10.1038/jid.2015.115. Epub 2015 Mar 24. No abstract available.


Smoothened variants explain the majority of drug resistance in basal cell carcinoma.

Atwood SX, Sarin KY, Whitson RJ, Li JR, Kim G, Rezaee M, Ally MS, Kim J, Yao C, Chang AL, Oro AE, Tang JY.

Cancer Cell. 2015 Mar 9;27(3):342-53. doi: 10.1016/j.ccell.2015.02.002.


Advanced treatment for basal cell carcinomas.

Atwood SX, Whitson RJ, Oro AE.

Cold Spring Harb Perspect Med. 2014 Jul 1;4(7):a013581. doi: 10.1101/cshperspect.a013581. Review.


Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.

Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ.

Nat Med. 2014 Jul;20(7):732-40. doi: 10.1038/nm.3613. Epub 2014 Jun 29.


"Atypical" regulation of Hedgehog-dependent cancers.

Atwood SX, Oro AE.

Cancer Cell. 2014 Feb 10;25(2):133-4. doi: 10.1016/j.ccr.2014.01.027.


Identification of genes promoting skin youthfulness by genome-wide association study.

Chang ALS, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N.

J Invest Dermatol. 2014 Mar;134(3):651-657. doi: 10.1038/jid.2013.381. Epub 2013 Sep 13.


Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal carcinomas in Gorlin syndrome.

Chang AL, Atwood SX, Tartar DM, Oro AE.

JAMA Dermatol. 2013 May;149(5):639-41. doi: 10.1001/jamadermatol.2013.30. No abstract available.


"Patch"ing up our tumor signaling knowledge.

Atwood SX, Whitson RJ, Oro AE.

J Invest Dermatol. 2013 May;133(5):1131-3. doi: 10.1038/jid.2012.506.


Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration.

Woo WM, Atwood SX, Zhen HH, Oro AE.

J Vis Exp. 2013 Feb 28;(72):e4344. doi: 10.3791/4344.


GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

Atwood SX, Li M, Lee A, Tang JY, Oro AE.

Nature. 2013 Feb 28;494(7438):484-8. doi: 10.1038/nature11889.


Hedgehog pathway inhibition and the race against tumor evolution.

Atwood SX, Chang AL, Oro AE.

J Cell Biol. 2012 Oct 15;199(2):193-7. doi: 10.1083/jcb.201207140.


Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement.

Graybill C, Wee B, Atwood SX, Prehoda KE.

J Biol Chem. 2012 Jun 15;287(25):21003-11. doi: 10.1074/jbc.M112.360495. Epub 2012 Apr 27.


MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling.

Bershteyn M, Atwood SX, Woo WM, Li M, Oro AE.

Dev Cell. 2010 Aug 17;19(2):270-83. doi: 10.1016/j.devcel.2010.07.009.


aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.

Atwood SX, Prehoda KE.

Curr Biol. 2009 May 12;19(9):723-9. doi: 10.1016/j.cub.2009.03.056. Epub 2009 Apr 16.


Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.

Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE.

J Cell Sci. 2007 Sep 15;120(Pt 18):3200-6. Epub 2007 Aug 28.

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