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Items: 16


High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting.

Mair B, Aldridge PM, Atwal RS, Philpott D, Zhang M, Masud SN, Labib M, Tong AHY, Sargent EH, Angers S, Moffat J, Kelley SO.

Nat Biomed Eng. 2019 Oct;3(10):796-805. doi: 10.1038/s41551-019-0454-8. Epub 2019 Sep 23.


Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites.

Kedaigle AJ, Fraenkel E, Atwal RS, Wu M, Gusella JF, MacDonald ME, Kaye JA, Finkbeiner S, Mattis VB, Tom CM, Svendsen C, King AR, Chen Y, Stocksdale JT, Lim RG, Casale M, Wang PH, Thompson LM, Akimov SS, Ratovitski T, Arbez N, Ross CA.

Hum Mol Genet. 2019 Feb 15. pii: ddy430. doi: 10.1093/hmg/ddy430. [Epub ahead of print]


Haplotype-based stratification of Huntington's disease.

Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.

Eur J Hum Genet. 2017 Nov;25(11):1202-1209. doi: 10.1038/ejhg.2017.125. Epub 2017 Aug 23.


Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.

Gasset-Rosa F, Chillon-Marinas C, Goginashvili A, Atwal RS, Artates JW, Tabet R, Wheeler VC, Bang AG, Cleveland DW, Lagier-Tourenne C.

Neuron. 2017 Apr 5;94(1):48-57.e4. doi: 10.1016/j.neuron.2017.03.027.


Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.

Shin JW, Kim KH, Chao MJ, Atwal RS, Gillis T, MacDonald ME, Gusella JF, Lee JM.

Hum Mol Genet. 2016 Oct 15;25(20):4566-4576. doi: 10.1093/hmg/ddw286.


Novel allele-specific quantification methods reveal no effects of adult onset CAG repeats on HTT mRNA and protein levels.

Shin A, Shin B, Shin JW, Kim KH, Atwal RS, Hope JM, Gillis T, Leszyk JD, Shaffer SA, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS, Lee JM.

Hum Mol Genet. 2017 Apr 1;26(7):1258-1267. doi: 10.1093/hmg/ddx033.


Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.

Caron NS, Hung CL, Atwal RS, Truant R.

Hum Mol Genet. 2014 May 1;23(9):2324-38. doi: 10.1093/hmg/ddt625. Epub 2013 Dec 11.


Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.

Desmond CR, Atwal RS, Xia J, Truant R.

J Biol Chem. 2012 Nov 16;287(47):39626-33. doi: 10.1074/jbc.M112.412379. Epub 2012 Sep 25.


Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A, Steffan JS, Fouad K, Truant R, Sipione S.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3528-33. doi: 10.1073/pnas.1114502109. Epub 2012 Feb 13.


Kinase inhibitors modulate huntingtin cell localization and toxicity.

Atwal RS, Desmond CR, Caron N, Maiuri T, Xia J, Sipione S, Truant R.

Nat Chem Biol. 2011 May 29;7(7):453-60. doi: 10.1038/nchembio.582.


Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Munsie L, Caron N, Atwal RS, Marsden I, Wild EJ, Bamburg JR, Tabrizi SJ, Truant R.

Hum Mol Genet. 2011 May 15;20(10):1937-51. doi: 10.1093/hmg/ddr075. Epub 2011 Feb 25.


Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.

Truant R, Atwal RS, Desmond C, Munsie L, Tran T.

FEBS J. 2008 Sep;275(17):4252-62. doi: 10.1111/j.1742-4658.2008.06561.x. Epub 2008 Jul 15. Review.


Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Atwal RS, Xia J, Pinchev D, Taylor J, Epand RM, Truant R.

Hum Mol Genet. 2007 Nov 1;16(21):2600-15. Epub 2007 Aug 18.


Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Truant R, Atwal RS, Burtnik A.

Prog Neurobiol. 2007 Nov;83(4):211-27. Epub 2007 Jan 22. Review.


Canadian Association of Neurosciences Review: polyglutamine expansion neurodegenerative diseases.

Truant R, Raymond LA, Xia J, Pinchev D, Burtnik A, Atwal RS.

Can J Neurol Sci. 2006 Aug;33(3):278-91. Review.


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