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Items: 41

1.

Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.

Shi Y, O'Connor SP, Sitkoff D, Zhang J, Shi M, Bisaha SN, Wang Y, Li C, Ruan Z, Lawrence RM, Klei HE, Kish K, Liu EC, Seiler SM, Schweizer L, Steinbacher TE, Schumacher WA, Robl JA, Macor JE, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7516-21. doi: 10.1016/j.bmcl.2011.06.098. Epub 2011 Jun 28.

PMID:
22041058
2.

Aroylguanidine-based factor Xa inhibitors: the discovery of BMS-344577.

Shi Y, Li C, O'Connor SP, Zhang J, Shi M, Bisaha SN, Wang Y, Sitkoff D, Pudzianowski AT, Huang C, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6882-9. doi: 10.1016/j.bmcl.2009.10.084. Epub 2009 Oct 23.

PMID:
19896847
3.

Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors.

Shi Y, Zhang J, Shi M, O'Connor SP, Bisaha SN, Li C, Sitkoff D, Pudzianowski AT, Chong S, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. doi: 10.1016/j.bmcl.2009.06.014. Epub 2009 Jun 13.

PMID:
19541481
4.

Design, structure-activity relationships, X-ray crystal structure, and energetic contributions of a critical P1 pharmacophore: 3-chloroindole-7-yl-based factor Xa inhibitors.

Shi Y, Sitkoff D, Zhang J, Klei HE, Kish K, Liu EC, Hartl KS, Seiler SM, Chang M, Huang C, Youssef S, Steinbacher TE, Schumacher WA, Grazier N, Pudzianowski A, Apedo A, Discenza L, Yanchunas J, Stein PD, Atwal KS.

J Med Chem. 2008 Dec 11;51(23):7541-51. doi: 10.1021/jm800855x.

PMID:
18998662
5.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

Simpkins LM, Bolton S, Pi Z, Sutton JC, Kwon C, Zhao G, Magnin DR, Augeri DJ, Gungor T, Rotella DP, Sun Z, Liu Y, Slusarchyk WS, Marcinkeviciene J, Robertson JG, Wang A, Robl JA, Atwal KS, Zahler RL, Parker RA, Kirby MS, Hamann LG.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6476-80. Epub 2007 Oct 1.

PMID:
17937986
6.

Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors.

Shi Y, Sitkoff D, Zhang J, Han W, Hu Z, Stein PD, Wang Y, Kennedy LJ, O'Connor SP, Ahmad S, Liu EC, Seiler SM, Lam PY, Robl JA, Macor JE, Atwal KS, Zahler R.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5952-8. Epub 2007 Aug 21.

PMID:
17855089
7.

Benzopyran sulfonamides as KV1.5 potassium channel blockers.

Lloyd J, Atwal KS, Finlay HJ, Nyman M, Huynh T, Bhandaru R, Kover A, Schmidt J, Vaccaro W, Conder ML, Jenkins-West T, Levesque P.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3271-5. Epub 2007 Apr 10.

PMID:
17462888
8.

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.

Atwal KS, O'Neil SV, Ahmad S, Doweyko L, Kirby M, Dorso CR, Chandrasena G, Chen BC, Zhao R, Zahler R.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4796-9. Epub 2006 Jul 25.

PMID:
16870436
9.

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.

Shi Y, Zhang J, Stein PD, Shi M, O'Connor SP, Bisaha SN, Li C, Atwal KS, Bisacchi GS, Sitkoff D, Pudzianowski AT, Liu EC, Hartl KS, Seiler SM, Youssef S, Steinbacher TE, Schumacher WA, Rendina AR, Bozarth JM, Peterson TL, Zhang G, Zahler R.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5453-8. Epub 2005 Oct 5. Erratum in: Bioorg Med Chem Lett. 2006 Mar 1;16(5):1449.

PMID:
16213711
10.

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.

Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1435-40.

PMID:
15713402
11.

Excessive ATP hydrolysis in ischemic myocardium by mitochondrial F1F0-ATPase: effect of selective pharmacological inhibition of mitochondrial ATPase hydrolase activity.

Grover GJ, Atwal KS, Sleph PG, Wang FL, Monshizadegan H, Monticello T, Green DW.

Am J Physiol Heart Circ Physiol. 2004 Oct;287(4):H1747-55. Erratum in: Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H484.

12.

Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase.

Hamann LG, Ding CZ, Miller AV, Madsen CS, Wang P, Stein PD, Pudzianowski AT, Green DW, Monshizadegan H, Atwal KS.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):1031-4.

PMID:
15013017
13.

N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase.

Atwal KS, Ahmad S, Ding CZ, Stein PD, Lloyd J, Hamann LG, Green DW, Ferrara FN, Wang P, Rogers WL, Doweyko LM, Miller AV, Bisaha SN, Schmidt JB, Li L, Yost KJ, Lan HJ, Madsen CS.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):1027-30.

PMID:
15013016
14.

Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.

Atwal KS, Wang P, Rogers WL, Sleph P, Monshizadegan H, Ferrara FN, Traeger S, Green DW, Grover GJ.

J Med Chem. 2004 Feb 26;47(5):1081-4.

PMID:
14971888
15.

One-pot synthesis and conformational features of n,n'-disubstituted ketene aminals.

Shi Y, Zhang J, Grazier N, Stein PD, Atwal KS, Traeger SC, Callahan SP, Malley MF, Galella MA, Gougoutas JZ.

J Org Chem. 2004 Jan 9;69(1):188-91.

PMID:
14703396
16.

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Ngu K, Combs DW, Wu SC, Weinstein DS, Liu W, Chen BC, Chandrasena G, Dorso CR, Kirby M, Atwal KS.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):177-80.

PMID:
14684323
17.

Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.

Ahmad S, Doweyko L, Ashfaq A, Ferrara FN, Bisaha SN, Schmidt JB, DiMarco J, Conder ML, Jenkins-West T, Normandin DE, Russell AD, Smith MA, Levesque PC, Lodge NJ, Lloyd J, Stein PD, Atwal KS.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):99-102.

PMID:
14684307
18.
19.

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.

Lloyd J, Schmidt JB, Rovnyak G, Ahmad S, Atwal KS, Bisaha SN, Doweyko LM, Stein PD, Traeger SC, Mathur A, Conder ML, DiMarco J, Harper TW, Jenkins-West T, Levesque PC, Normandin DE, Russell AD, Serafino RP, Smith MA, Lodge NJ.

J Med Chem. 2001 Nov 8;44(23):3764-7.

PMID:
11689063
20.

Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.

Ahmad S, Doweyko LM, Dugar S, Grazier N, Ngu K, Wu SC, Yost KJ, Chen BC, Gougoutas JZ, DiMarco JD, Lan SJ, Gavin BJ, Chen AY, Dorso CR, Serafino R, Kirby M, Atwal KS.

J Med Chem. 2001 Sep 27;44(20):3302-10.

PMID:
11563929
21.

Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity.

Grover GJ, D'Alonzo AJ, Garlid KD, Bajgar R, Lodge NJ, Sleph PG, Darbenzio RB, Hess TA, Smith MA, Paucek P, Atwal KS.

J Pharmacol Exp Ther. 2001 Jun;297(3):1184-92.

PMID:
11356945
22.

Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines.

Ding CZ, Rovnyak GC, Misra RN, Grover GJ, Miller AV, Ahmed SZ, Kelly Y, Normandin DE, Sleph PG, Atwal KS.

J Med Chem. 1999 Sep 9;42(18):3711-7.

PMID:
10479302
23.

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

Atwal KS, Grover GJ, Lodge NJ, Normandin DE, Traeger SC, Sleph PG, Cohen RB, Bryson CC, Dickinson KE.

J Med Chem. 1998 Jan 29;41(3):271-5. No abstract available.

PMID:
9464357
24.

Nucleotide regulation and characteristics of potassium channel opener binding to skeletal muscle membranes.

Dickinson KE, Bryson CC, Cohen RB, Rogers L, Green DW, Atwal KS.

Mol Pharmacol. 1997 Sep;52(3):473-81.

PMID:
9281610
25.

Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity.

Rovnyak GC, Ahmed SZ, Ding CZ, Dzwonczyk S, Ferrara FN, Humphreys WG, Grover GJ, Santafianos D, Atwal KS, Baird AJ, McLaughlin LG, Normandin DE, Sleph PG, Traeger SC.

J Med Chem. 1997 Jan 3;40(1):24-34.

PMID:
9016325
26.

Cardioselective antiischemic ATP-sensitive potassium channel openers. 4. Structure-activity studies on benzopyranylcyanoguanidines: replacement of the benzopyran portion.

Atwal KS, Ferrara FN, Ding CZ, Grover GJ, Sleph PG, Dzwonczyk S, Baird AJ, Normandin DE.

J Med Chem. 1996 Jan 5;39(1):304-13.

PMID:
8568821
27.

Cardioselective anti-ischemic ATP-sensitive potassium channel openers. 3. Structure-activity studies on benzopyranyl cyanoguanidines: modification of the cyanoguanidine portion.

Atwal KS, Grover GJ, Ahmed SZ, Sleph PG, Dzwonczyk S, Baird AJ, Normandin DE.

J Med Chem. 1995 Aug 18;38(17):3236-45.

PMID:
7650676
28.

Cardioselective antiischemic ATP-sensitive potassium channel openers. 2. Structure-activity studies on benzopyranylcyanoguanidines: modification of the benzopyran ring.

Atwal KS, Grover GJ, Ferrara FN, Ahmed SZ, Sleph PG, Dzwonczyk S, Normandin DE.

J Med Chem. 1995 May 26;38(11):1966-73.

PMID:
7783128
29.

Cardioprotective profile of the cardiac-selective ATP-sensitive potassium channel opener BMS-180448.

Grover GJ, McCullough JR, D'Alonzo AJ, Sargent CA, Atwal KS.

J Cardiovasc Pharmacol. 1995 Jan;25(1):40-50.

PMID:
7723352
30.

Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.

Atwal KS.

J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-7. Review.

PMID:
7898103
31.

Cardioselective anti-ischemic ATP-sensitive potassium channel openers.

Atwal KS, Grover GJ, Ahmed SZ, Ferrara FN, Harper TW, Kim KS, Sleph PG, Dzwonczyk S, Russell AD, Moreland S, et al.

J Med Chem. 1993 Nov 26;36(24):3971-4. No abstract available.

PMID:
8254626
32.

Dihydropyrimidine angiotensin II receptor antagonists.

Atwal KS, Ahmed SZ, Bird JE, Delaney CL, Dickinson KE, Ferrara FN, Hedberg A, Miller AV, Moreland S, O'Reilly BC, et al.

J Med Chem. 1992 Dec 11;35(25):4751-63.

PMID:
1469703
33.

Modulation of potassium channels by organic molecules.

Atwal KS.

Med Res Rev. 1992 Nov;12(6):569-91. Review. No abstract available.

PMID:
1435016
34.

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents.

Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O'Reilly BC, Schwartz J, Malley MF.

J Med Chem. 1992 Aug 21;35(17):3254-63.

PMID:
1387168
35.

Cardioprotective effects of the potassium channel opener cromakalim: stereoselectivity and effects on myocardial adenine nucleotides.

Grover GJ, Newburger J, Sleph PG, Dzwonczyk S, Taylor SC, Ahmed SZ, Atwal KS.

J Pharmacol Exp Ther. 1991 Apr;257(1):156-62.

PMID:
2019983
36.

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.

Atwal KS, Swanson BN, Unger SE, Floyd DM, Moreland S, Hedberg A, O'Reilly BC.

J Med Chem. 1991 Feb;34(2):806-11.

PMID:
1995904
37.

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Kimball SD, Floyd DM, Moreland S, Swanson BN, Gougoutas JZ, Schwartz J, Smillie KM, Malley MF.

J Med Chem. 1990 Sep;33(9):2629-35.

PMID:
2391701
38.

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines.

Atwal KS, Rovnyak GC, Schwartz J, Moreland S, Hedberg A, Gougoutas JZ, Malley MF, Floyd DM.

J Med Chem. 1990 May;33(5):1510-5.

PMID:
2329573
40.

Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects.

Atwal KS, O'Reilly BC, Ruby EP, Turk CF, Aberg G, Asaad MM, Bergey JL, Moreland S, Powell JR.

J Med Chem. 1987 Apr;30(4):627-35.

PMID:
2435902
41.

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