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Items: 1 to 50 of 161

1.

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype.

Peng Y, Shapiro SL, Banduseela VC, Dieterich IA, Hewitt KJ, Bresnick EH, Kong G, Zhang J, Schueler KL, Keller MP, Attie AD, Hacker TA, Sullivan R, Kielar-Grevstad E, Arriola Apelo SI, Lamming DW, Anderson RM, Puglielli L.

Aging Cell. 2018 Jul 27:e12820. doi: 10.1111/acel.12820. [Epub ahead of print]

2.

Genetic Drivers of Pancreatic Islet Function.

Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD.

Genetics. 2018 May;209(1):335-356. doi: 10.1534/genetics.118.300864. Epub 2018 Mar 22.

PMID:
29567659
3.

Islet proteomics reveals genetic variation in dopamine production resulting in altered insulin secretion.

Mitok KA, Freiberger EC, Schueler KL, Rabaglia ME, Stapleton DS, Kwiecien NW, Malec PA, Hebert AS, Broman AT, Kennedy RT, Keller MP, Coon JJ, Attie AD.

J Biol Chem. 2018 Apr 20;293(16):5860-5877. doi: 10.1074/jbc.RA117.001102. Epub 2018 Mar 1.

PMID:
29496998
4.

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

Ye R, Gordillo R, Shao M, Onodera T, Chen Z, Chen S, Lin X, SoRelle JA, Li X, Tang M, Keller MP, Kuliawat R, Attie AD, Gupta RK, Holland WL, Beutler B, Herz J, Scherer PE.

J Clin Invest. 2018 Mar 1;128(3):1178-1189. doi: 10.1172/JCI97702. Epub 2018 Feb 19.

5.

Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells.

Lin J, Zheng S, Attie AD, Keller MP, Bernlohr DA, Blaner WS, Newberry EP, Davidson NO, Chen A.

J Lipid Res. 2018 Mar;59(3):416-428. doi: 10.1194/jlr.M077487. Epub 2018 Jan 9.

PMID:
29317465
6.

Targeted Mass Spectrometry Approach Enabled Discovery of O-Glycosylated Insulin and Related Signaling Peptides in Mouse and Human Pancreatic Islets.

Yu Q, Canales A, Glover MS, Das R, Shi X, Liu Y, Keller MP, Attie AD, Li L.

Anal Chem. 2017 Sep 5;89(17):9184-9191. doi: 10.1021/acs.analchem.7b01926. Epub 2017 Aug 7.

PMID:
28726377
7.

BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.

Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ.

J Cell Biol. 2017 Jul 3;216(7):2151-2166. doi: 10.1083/jcb.201702099. Epub 2017 Jun 16.

8.

Statistical Methods for Latent Class Quantitative Trait Loci Mapping.

Ye S, Bacher R, Keller MP, Attie AD, Kendziorski C.

Genetics. 2017 Jul;206(3):1309-1317. doi: 10.1534/genetics.117.203885. Epub 2017 May 26.

9.

Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes.

Kreznar JH, Keller MP, Traeger LL, Rabaglia ME, Schueler KL, Stapleton DS, Zhao W, Vivas EI, Yandell BS, Broman AT, Hagenbuch B, Attie AD, Rey FE.

Cell Rep. 2017 Feb 14;18(7):1739-1750. doi: 10.1016/j.celrep.2017.01.062.

10.

How mice are indispensable for understanding obesity and diabetes genetics.

Attie AD, Churchill GA, Nadeau JH.

Curr Opin Endocrinol Diabetes Obes. 2017 Apr;24(2):83-91. doi: 10.1097/MED.0000000000000321. Review.

11.

The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.

Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD.

PLoS Genet. 2016 Dec 9;12(12):e1006466. doi: 10.1371/journal.pgen.1006466. eCollection 2016 Dec.

12.

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues.

Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, Keller MP, Attie AD, Rey FE, Denu JM.

Mol Cell. 2016 Dec 1;64(5):982-992. doi: 10.1016/j.molcel.2016.10.025. Epub 2016 Nov 23.

13.

Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3.

Paul PK, Rabaglia ME, Wang CY, Stapleton DS, Leng N, Kendziorski C, Lewis PW, Keller MP, Attie AD.

Cell Cycle. 2016 Dec;15(23):3191-3202. Epub 2016 Oct 18.

14.

Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.

Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW.

Cell Rep. 2016 Oct 4;17(2):527-540. doi: 10.1016/j.celrep.2016.09.005.

15.

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism.

Baughman JM, Rose CM, Kolumam G, Webster JD, Wilkerson EM, Merrill AE, Rhoads TW, Noubade R, Katavolos P, Lesch J, Stapleton DS, Rabaglia ME, Schueler KL, Asuncion R, Domeyer M, Zavala-Solorio J, Reich M, DeVoss J, Keller MP, Attie AD, Hebert AS, Westphall MS, Coon JJ, Kirkpatrick DS, Dey A.

Cell Rep. 2016 Jul 12;16(2):583-595. doi: 10.1016/j.celrep.2016.05.096. Epub 2016 Jun 30.

16.

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S.

Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.

17.

The Dissection of Expression Quantitative Trait Locus Hotspots.

Tian J, Keller MP, Broman AT, Kendziorski C, Yandell BS, Attie AD, Broman KW.

Genetics. 2016 Apr;202(4):1563-74. doi: 10.1534/genetics.115.183624. Epub 2016 Feb 2.

18.

The Mouse Universal Genotyping Array: From Substrains to Subspecies.

Morgan AP, Fu CP, Kao CY, Welsh CE, Didion JP, Yadgary L, Hyacinth L, Ferris MT, Bell TA, Miller DR, Giusti-Rodriguez P, Nonneman RJ, Cook KD, Whitmire JK, Gralinski LE, Keller M, Attie AD, Churchill GA, Petkov P, Sullivan PF, Brennan JR, McMillan L, Pardo-Manuel de Villena F.

G3 (Bethesda). 2015 Dec 18;6(2):263-79. doi: 10.1534/g3.115.022087.

19.

Genetic Architectures of Quantitative Variation in RNA Editing Pathways.

Gu T, Gatti DM, Srivastava A, Snyder EM, Raghupathy N, Simecek P, Svenson KL, Dotu I, Chuang JH, Keller MP, Attie AD, Braun RE, Churchill GA.

Genetics. 2016 Feb;202(2):787-98. doi: 10.1534/genetics.115.179481. Epub 2015 Nov 27.

20.

Global Identification of Protein Post-translational Modifications in a Single-Pass Database Search.

Shortreed MR, Wenger CD, Frey BL, Sheynkman GM, Scalf M, Keller MP, Attie AD, Smith LM.

J Proteome Res. 2015 Nov 6;14(11):4714-20. doi: 10.1021/acs.jproteome.5b00599. Epub 2015 Sep 29.

21.

How do reducing equivalents increase insulin secretion?

Attie AD.

J Clin Invest. 2015 Oct 1;125(10):3754-6. doi: 10.1172/JCI84011. Epub 2015 Sep 21.

22.

Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.

Tian J, Keller MP, Oler AT, Rabaglia ME, Schueler KL, Stapleton DS, Broman AT, Zhao W, Kendziorski C, Yandell BS, Hagenbuch B, Broman KW, Attie AD.

Genetics. 2015 Nov;201(3):1253-62. doi: 10.1534/genetics.115.179432. Epub 2015 Sep 18.

23.

The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors.

Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, Attie AD, Yates JR 3rd, Ghosh A, de Wit J.

Neuron. 2015 Aug 19;87(4):764-80. doi: 10.1016/j.neuron.2015.08.007.

24.

Identification and Correction of Sample Mix-Ups in Expression Genetic Data: A Case Study.

Broman KW, Keller MP, Broman AT, Kendziorski C, Yandell BS, Sen Ś, Attie AD.

G3 (Bethesda). 2015 Aug 19;5(10):2177-86. doi: 10.1534/g3.115.019778.

25.

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.

Mol Endocrinol. 2015 Sep;29(9):1243-53. doi: 10.1210/me.2014-1335. Epub 2015 Jul 28.

26.

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP.

Circ Heart Fail. 2014 Nov;7(6):1022-31. doi: 10.1161/CIRCHEARTFAILURE.114.001469. Epub 2014 Sep 18.

27.

RNA-Seq alignment to individualized genomes improves transcript abundance estimates in multiparent populations.

Munger SC, Raghupathy N, Choi K, Simons AK, Gatti DM, Hinerfeld DA, Svenson KL, Keller MP, Attie AD, Hibbs MA, Graber JH, Chesler EJ, Churchill GA.

Genetics. 2014 Sep;198(1):59-73. doi: 10.1534/genetics.114.165886.

28.

A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo.

Johnson LM, Barrick S, Hager MV, McFedries A, Homan EA, Rabaglia ME, Keller MP, Attie AD, Saghatelian A, Bisello A, Gellman SH.

J Am Chem Soc. 2014 Sep 17;136(37):12848-51. doi: 10.1021/ja507168t. Epub 2014 Sep 5.

29.

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells.

Kebede MA, Oler AT, Gregg T, Balloon AJ, Johnson A, Mitok K, Rabaglia M, Schueler K, Stapleton D, Thorstenson C, Wrighton L, Floyd BJ, Richards O, Raines S, Eliceiri K, Seidah NG, Rhodes C, Keller MP, Coon JL, Audhya A, Attie AD.

J Clin Invest. 2014 Oct;124(10):4240-56. doi: 10.1172/JCI74072. Epub 2014 Aug 26.

30.

Insights into obesity and diabetes at the intersection of mouse and human genetics.

Kebede MA, Attie AD.

Trends Endocrinol Metab. 2014 Oct;25(10):493-501. doi: 10.1016/j.tem.2014.06.006. Epub 2014 Jul 15. Review.

31.

Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.

Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD.

J Biol Chem. 2014 Sep 5;289(36):25276-86. doi: 10.1074/jbc.M114.575985. Epub 2014 Jul 7.

32.

Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion.

Soni MS, Rabaglia ME, Bhatnagar S, Shang J, Ilkayeva O, Mynatt R, Zhou YP, Schadt EE, Thornberry NA, Muoio DM, Keller MP, Attie AD.

Diabetes. 2014 Nov;63(11):3805-14. doi: 10.2337/db13-1677. Epub 2014 Jun 26.

33.

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Martin OJ, Lai L, Soundarapandian MM, Leone TC, Zorzano A, Keller MP, Attie AD, Muoio DM, Kelly DP.

Circ Res. 2014 Feb 14;114(4):626-36. doi: 10.1161/CIRCRESAHA.114.302562. Epub 2013 Dec 23.

34.

Neutron-encoded protein quantification by peptide carbamylation.

Ulbrich A, Merrill AE, Hebert AS, Westphall MS, Keller MP, Attie AD, Coon JJ.

J Am Soc Mass Spectrom. 2014 Jan;25(1):6-9. doi: 10.1007/s13361-013-0765-z. Epub 2013 Oct 29.

35.

Zinc, insulin, and the liver: a ménage à trois.

O'Halloran TV, Kebede M, Philips SJ, Attie AD.

J Clin Invest. 2013 Oct;123(10):4136-9. doi: 10.1172/JCI72325. Epub 2013 Sep 24.

36.

Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.

Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.

J Biol Chem. 2013 Sep 6;288(36):26209-19. doi: 10.1074/jbc.M113.483396. Epub 2013 Jul 17.

37.

The regulation of ApoB metabolism by insulin.

Haas ME, Attie AD, Biddinger SB.

Trends Endocrinol Metab. 2013 Aug;24(8):391-7. doi: 10.1016/j.tem.2013.04.001. Epub 2013 May 27. Review.

38.

Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide.

Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S.

J Neurosci. 2013 Apr 17;33(16):7099-107. doi: 10.1523/JNEUROSCI.5270-12.2013.

39.

Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.

Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD.

Diabetes. 2013 Jun;62(6):1904-12. doi: 10.2337/db12-0769. Epub 2013 Jan 24.

40.

Modeling causality for pairs of phenotypes in system genetics.

Neto EC, Broman AT, Keller MP, Attie AD, Zhang B, Zhu J, Yandell BS.

Genetics. 2013 Mar;193(3):1003-13. doi: 10.1534/genetics.112.147124. Epub 2013 Jan 3.

41.

Integrative analysis of a cross-loci regulation network identifies App as a gene regulating insulin secretion from pancreatic islets.

Tu Z, Keller MP, Zhang C, Rabaglia ME, Greenawalt DM, Yang X, Wang IM, Dai H, Bruss MD, Lum PY, Zhou YP, Kemp DM, Kendziorski C, Yandell BS, Attie AD, Schadt EE, Zhu J.

PLoS Genet. 2012;8(12):e1003107. doi: 10.1371/journal.pgen.1003107. Epub 2012 Dec 6.

42.

A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis.

Grimsrud PA, Carson JJ, Hebert AS, Hubler SL, Niemi NM, Bailey DJ, Jochem A, Stapleton DS, Keller MP, Westphall MS, Yandell BS, Attie AD, Coon JJ, Pagliarini DJ.

Cell Metab. 2012 Nov 7;16(5):672-83. doi: 10.1016/j.cmet.2012.10.004.

43.

Quantile-based permutation thresholds for quantitative trait loci hotspots.

Neto EC, Keller MP, Broman AF, Attie AD, Jansen RC, Broman KW, Yandell BS.

Genetics. 2012 Aug;191(4):1355-65. doi: 10.1534/genetics.112.139451. Epub 2012 Jun 1.

44.

Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis.

Wang CY, Stapleton DS, Schueler KL, Rabaglia ME, Oler AT, Keller MP, Kendziorski CM, Broman KW, Yandell BS, Schadt EE, Attie AD.

J Lipid Res. 2012 Aug;53(8):1493-501. doi: 10.1194/jlr.M025239. Epub 2012 May 23.

45.

Genome scans for transmission ratio distortion regions in mice.

Casellas J, Gularte RJ, Farber CR, Varona L, Mehrabian M, Schadt EE, Lusis AJ, Attie AD, Yandell BS, Medrano JF.

Genetics. 2012 May;191(1):247-59. doi: 10.1534/genetics.111.135988. Epub 2012 Feb 23.

46.

Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.

Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, Attie AD.

PLoS Genet. 2011 Oct;7(10):e1002323. doi: 10.1371/journal.pgen.1002323. Epub 2011 Oct 6.

47.

Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity.

Raines SM, Richards OC, Schneider LR, Schueler KL, Rabaglia ME, Oler AT, Stapleton DS, Genové G, Dawson JA, Betsholtz C, Attie AD.

Am J Physiol Endocrinol Metab. 2011 Sep;301(3):E517-26. doi: 10.1152/ajpendo.00241.2011. Epub 2011 Jun 14.

49.

A model selection approach for expression quantitative trait loci (eQTL) mapping.

Wang P, Dawson JA, Keller MP, Yandell BS, Thornberry NA, Zhang BB, Wang IM, Schadt EE, Attie AD, Kendziorski C.

Genetics. 2011 Feb;187(2):611-21. doi: 10.1534/genetics.110.122796. Epub 2010 Nov 29.

50.

Gastrointestinal hormones and the regulation of β-cell mass.

Lavine JA, Attie AD.

Ann N Y Acad Sci. 2010 Nov;1212:41-58. doi: 10.1111/j.1749-6632.2010.05802.x. Epub 2010 Oct 29. Review.

PMID:
21039588

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