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Items: 1 to 50 of 166

1.

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.

Brain. 2019 Jun 1;142(6):1503-1527. doi: 10.1093/brain/awz099.

2.

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.

Walker L, Stefanis L, Attems J.

J Neurochem. 2019 Mar 20. doi: 10.1111/jnc.14698. [Epub ahead of print] Review.

PMID:
30892688
3.

Neurodegenerative Diseases and Ageing.

Walker L, McAleese KE, Erskine D, Attems J.

Subcell Biochem. 2019;91:75-106. doi: 10.1007/978-981-13-3681-2_4. Review.

PMID:
30888650
4.

Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration.

Tilley BS, Smith C, Pavese N, Attems J.

BMJ Case Rep. 2019 Mar 7;12(3). pii: e228305. doi: 10.1136/bcr-2018-228305.

5.

Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.

Erskine D, Taylor JP, Thomas A, Collerton D, McKeith I, Khundakar A, Attems J, Morris C.

Neurosci Bull. 2019 Apr;35(2):295-300. doi: 10.1007/s12264-019-00341-4. Epub 2019 Feb 6. No abstract available.

PMID:
30729454
6.

Dementia with Lewy bodies: an update and outlook.

Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I.

Mol Neurodegener. 2019 Jan 21;14(1):5. doi: 10.1186/s13024-019-0306-8. Review.

7.

Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.

Patterson L, Rushton SP, Attems J, Thomas AJ, Morris CM.

Brain Pathol. 2018 Dec 24. doi: 10.1111/bpa.12697. [Epub ahead of print]

PMID:
30582885
8.

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease.

McAleese KE, Graham S, Dey M, Walker L, Erskine D, Johnson M, Johnston E, Thomas AJ, McKeith IG, DeCarli C, Attems J.

Brain Pathol. 2019 May;29(3):414-424. doi: 10.1111/bpa.12685. Epub 2019 Jan 29.

PMID:
30485582
9.

High prevalence of focal and multi-focal somatic genetic variants in the human brain.

Keogh MJ, Wei W, Aryaman J, Walker L, van den Ameele J, Coxhead J, Wilson I, Bashton M, Beck J, West J, Chen R, Haudenschild C, Bartha G, Luo S, Morris CM, Jones NS, Attems J, Chinnery PF.

Nat Commun. 2018 Oct 15;9(1):4257. doi: 10.1038/s41467-018-06331-w.

10.

A new visual rating scale for Ioflupane imaging in Lewy body disease.

Lloyd JJ, Petrides G, Donaghy PC, Colloby SJ, Attems J, O'Brien JT, Roberts G, Thomas AJ.

Neuroimage Clin. 2018;20:823-829. doi: 10.1016/j.nicl.2018.09.012. Epub 2018 Sep 20.

11.

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326.

PMID:
30219847
12.

Frequency and signature of somatic variants in 1461 human brain exomes.

Wei W, Keogh MJ, Aryaman J, Golder Z, Kullar PJ, Wilson I, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Sarraj SA, Morris CM, Ansorge O, Jones NS, Ironside JW, Chinnery PF.

Genet Med. 2019 Apr;21(4):904-912. doi: 10.1038/s41436-018-0274-3. Epub 2018 Sep 14.

13.

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease.

Nicolas G, Acuña-Hidalgo R, Keogh MJ, Quenez O, Steehouwer M, Lelieveld S, Rousseau S, Richard AC, Oud MS, Marguet F, Laquerrière A, Morris CM, Attems J, Smith C, Ansorge O, Al Sarraj S, Frebourg T, Campion D, Hannequin D, Wallon D, Gilissen C, Chinnery PF, Veltman JA, Hoischen A.

Alzheimers Dement. 2018 Dec;14(12):1632-1639. doi: 10.1016/j.jalz.2018.06.3056. Epub 2018 Aug 13.

14.

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.

Chai YL, Chong JR, Weng J, Howlett D, Halsey A, Lee JH, Attems J, Aarsland D, Francis PT, Chen CP, Lai MKP.

Brain Pathol. 2019 Jan;29(1):63-74. doi: 10.1111/bpa.12631. Epub 2018 Oct 17.

PMID:
30051532
15.

Phosphorylation of different tau sites during progression of Alzheimer's disease.

Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B.

Acta Neuropathol Commun. 2018 Jun 29;6(1):52. doi: 10.1186/s40478-018-0557-6.

16.

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.

Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I, Gurwitz D.

Sci Rep. 2018 May 31;8(1):8465. doi: 10.1038/s41598-018-26547-6.

17.

Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease?

McAleese KE, Walker L, Colloby SJ, Taylor JP, Thomas AJ, DeCarli C, Attems J.

Brain. 2018 Jun 1;141(6):e44. doi: 10.1093/brain/awy084. No abstract available.

PMID:
29668888
18.

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L.

Alzheimers Dement. 2018 Aug;14(8):1022-1037. doi: 10.1016/j.jalz.2018.02.017. Epub 2018 Apr 7.

19.

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies.

Erskine D, Ding J, Thomas AJ, Kaganovich A, Khundakar AA, Hanson PS, Taylor JP, McKeith IG, Attems J, Cookson MR, Morris CM.

Mov Disord. 2018 Jul;33(6):982-991. doi: 10.1002/mds.27333. Epub 2018 Mar 23.

PMID:
29570843
20.

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.

Thomas AJ, Mahin-Babaei F, Saidi M, Lett D, Taylor JP, Walker L, Attems J.

Alzheimers Res Ther. 2018 Mar 1;10(1):27. doi: 10.1186/s13195-018-0356-0.

21.

Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn.

Sutovsky S, Smolek T, Turcani P, Petrovic R, Brandoburova P, Jadhav S, Novak P, Attems J, Zilka N.

J Neural Transm (Vienna). 2018 Jun;125(6):965-976. doi: 10.1007/s00702-018-1850-z. Epub 2018 Feb 5.

PMID:
29404783
22.

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study.

Gatt A, Ekonomou A, Somani A, Thuret S, Howlett D, Corbett A, Johnson M, Perry E, Attems J, Francis P, Aarsland D, Ballard C.

Dement Geriatr Cogn Disord. 2017;44(5-6):283-293. doi: 10.1159/000484437. Epub 2018 Jan 27.

PMID:
29393203
23.

Proteomics for synaptic markers of cognitive decline in neurodegenerative diseases.

Attems J, Jellinger K.

Brain. 2018 Feb 1;141(2):329-331. doi: 10.1093/brain/awx360. No abstract available.

PMID:
29390123
24.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI.

Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

25.

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains.

Keogh MJ, Wei W, Aryaman J, Wilson I, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Jones N, Ironside JW, Chinnery PF.

J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):813-816. doi: 10.1136/jnnp-2017-317234. Epub 2018 Jan 13.

26.

Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.

Erskine D, Patterson L, Alexandris A, Hanson PS, McKeith IG, Attems J, Morris CM.

Acta Neuropathol. 2018 Jan;135(1):153-154. doi: 10.1007/s00401-017-1787-6. Epub 2017 Nov 13. No abstract available.

PMID:
29134319
27.

Author response: Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z.

Neurology. 2017 Aug 15;89(7):751. doi: 10.1212/WNL.0000000000004254. No abstract available.

PMID:
28808169
28.

Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease.

McAleese KE, Walker L, Graham S, Moya ELJ, Johnson M, Erskine D, Colloby SJ, Dey M, Martin-Ruiz C, Taylor JP, Thomas AJ, McKeith IG, De Carli C, Attems J.

Acta Neuropathol. 2017 Sep;134(3):459-473. doi: 10.1007/s00401-017-1738-2. Epub 2017 Jun 21.

29.

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review.

30.

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.

31.

The multi-morbid old brain.

Attems J.

Acta Neuropathol. 2017 Aug;134(2):169-170. doi: 10.1007/s00401-017-1723-9. No abstract available.

PMID:
28509946
32.

Interactions of pathological proteins in neurodegenerative diseases.

Spires-Jones TL, Attems J, Thal DR.

Acta Neuropathol. 2017 Aug;134(2):187-205. doi: 10.1007/s00401-017-1709-7. Epub 2017 Apr 11. Review.

33.

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

Alghamdi A, Vallortigara J, Howlett DR, Broadstock M, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Attems J, Francis PT, Whitfield DR.

J Alzheimers Dis. 2017;57(2):373-386. doi: 10.3233/JAD-160946.

34.

Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.

Walker L, McAleese KE, Johnson M, Khundakar AA, Erskine D, Thomas AJ, McKeith IG, Attems J.

J Neural Transm (Vienna). 2017 Jun;124(6):671-683. doi: 10.1007/s00702-017-1702-2. Epub 2017 Mar 6.

35.

PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer.

Gschwantler-Kaulich D, Tan YY, Fuchs EM, Hudelist G, Köstler WJ, Reiner A, Leser C, Salama M, Attems J, Deutschmann C, Zielinski CC, Singer CF.

PLoS One. 2017 Mar 2;12(3):e0172911. doi: 10.1371/journal.pone.0172911. eCollection 2017.

36.

Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF.

Acta Neuropathol Commun. 2017 Feb 22;5(1):17. doi: 10.1186/s40478-017-0419-7. No abstract available.

37.

Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.

Erskine D, Thomas AJ, Taylor JP, Savage MA, Attems J, McKeith IG, Morris CM, Khundakar AA.

Am J Geriatr Psychiatry. 2017 Jun;25(6):595-604. doi: 10.1016/j.jagp.2017.01.005. Epub 2017 Jan 10.

PMID:
28190674
38.

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF.

Acta Neuropathol Commun. 2017 Feb 2;5(1):13. doi: 10.1186/s40478-016-0404-6. Erratum in: Acta Neuropathol Commun. 2017 Feb 22;5(1):17.

39.

Specific patterns of neuronal loss in the pulvinar nucleus in dementia with lewy bodies.

Erskine D, Thomas AJ, Attems J, Taylor JP, McKeith IG, Morris CM, Khundakar AA.

Mov Disord. 2017 Mar;32(3):414-422. doi: 10.1002/mds.26887. Epub 2017 Jan 6.

PMID:
28059471
40.

Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline.

Skrobot OA, Attems J, Esiri M, Hortobágyi T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S.

Brain. 2017 Feb;140(2):e13. doi: 10.1093/brain/aww305. Epub 2016 Dec 21. No abstract available.

41.

Genetic compendium of 1511 human brains available through the UK Medical Research Council Brain Banks Network Resource.

Keogh MJ, Wei W, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF.

Genome Res. 2017 Jan;27(1):165-173. doi: 10.1101/gr.210609.116. Epub 2016 Dec 21.

42.

Alzheimer's disease pathology in synucleinopathies.

Attems J.

Lancet Neurol. 2017 Jan;16(1):22-23. doi: 10.1016/S1474-4422(16)30282-4. No abstract available.

PMID:
27979344
43.

Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z.

Neurology. 2017 Jan 17;88(3):276-283. doi: 10.1212/WNL.0000000000003512. Epub 2016 Dec 9.

44.

Increased Transforming Growth Factor β2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies is Correlated with Disease Severity and Soluble Aβ42 Load.

Chong JR, Chai YL, Lee JH, Howlett D, Attems J, Ballard CG, Aarsland D, Francis PT, Chen CP, Lai MK.

J Alzheimers Dis. 2017;56(1):157-166. doi: 10.3233/JAD-160781.

PMID:
27911312
45.

Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection.

Plum S, Steinbach S, Attems J, Keers S, Riederer P, Gerlach M, May C, Marcus K.

Sci Rep. 2016 Nov 14;6:37139. doi: 10.1038/srep37139.

46.
47.

Extended post-mortem delay times should not be viewed as a deterrent to the scientific investigation of human brain tissue: a study from the Brains for Dementia Research Network Neuropathology Study Group, UK.

Robinson AC, Palmer L, Love S, Hamard M, Esiri M, Ansorge O, Lett D, Attems J, Morris C, Troakes C, Selvackadunco S, King A, Al-Sarraj S, Mann DM.

Acta Neuropathol. 2016 Nov;132(5):753-755. Epub 2016 Sep 15. No abstract available.

PMID:
27638700
48.

Post-mortem assessment in vascular dementia: advances and aspirations.

McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kövari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J.

BMC Med. 2016 Aug 26;14(1):129. doi: 10.1186/s12916-016-0676-5. Review.

49.

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment.

Skrobot OA, Attems J, Esiri M, Hortobágyi T, Ironside JW, Kalaria RN, King A, Lammie GA, Mann D, Neal J, Ben-Shlomo Y, Kehoe PG, Love S.

Brain. 2016 Nov 1;139(11):2957-2969. doi: 10.1093/brain/aww214.

PMID:
27591113
50.

Systems proteomic analysis reveals that clusterin and tissue inhibitor of metalloproteinases 3 increase in leptomeningeal arteries affected by cerebral amyloid angiopathy.

Manousopoulou A, Gatherer M, Smith C, Nicoll JAR, Woelk CH, Johnson M, Kalaria R, Attems J, Garbis SD, Carare RO.

Neuropathol Appl Neurobiol. 2017 Oct;43(6):492-504. doi: 10.1111/nan.12342. Epub 2016 Oct 5.

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