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Items: 1 to 50 of 178

1.

Relationship Between Tau, β Amyloid and α-Synuclein Pathologies.

Walker L, Attems J.

Adv Exp Med Biol. 2019;1184:169-176. doi: 10.1007/978-981-32-9358-8_14.

PMID:
32096037
2.

The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies.

Marschallinger J, Altendorfer B, Rockenstein E, Holztrattner M, Garnweidner-Raith J, Pillichshammer N, Leister I, Hutter-Paier B, Strempfl K, Unger MS, Chishty M, Felder T, Johnson M, Attems J, Masliah E, Aigner L.

Neurotherapeutics. 2020 Feb 18. doi: 10.1007/s13311-020-00836-3. [Epub ahead of print]

PMID:
32072462
3.

The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy.

Owasil R, O'Neill R, Keable A, Nimmo J, MacGregor Sharp M, Kelly L, Saito S, Simpson JE, Weller RO, Smith C, Attems J, Wharton SB, Yuen HM, Carare RO.

Int J Mol Sci. 2020 Feb 12;21(4). pii: E1225. doi: 10.3390/ijms21041225.

4.

Fulminant corticobasal degeneration: a distinct variant with predominant neuronal tau aggregates.

Ling H, Gelpi E, Davey K, Jaunmuktane Z, Mok KY, Jabbari E, Simone R, R'Bibo L, Brandner S, Ellis MJ, Attems J, Mann D, Halliday GM, Al-Sarraj S, Hedreen J, Ironside JW, Kovacs GG, Kovari E, Love S, Vonsattel JPG, Allinson KSJ, Hansen D, Bradshaw T, Setó-Salvia N, Wray S, de Silva R, Morris HR, Warner TT, Hardy J, Holton JL, Revesz T.

Acta Neuropathol. 2020 Apr;139(4):717-734. doi: 10.1007/s00401-019-02119-4. Epub 2020 Jan 16.

5.

The first year.

Attems J.

Acta Neuropathol. 2020 Jan;139(1):1-2. doi: 10.1007/s00401-019-02113-w. Epub 2019 Dec 12. No abstract available.

PMID:
31832772
6.

Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants.

Prokopenko I, Miyakawa G, Zheng B, Heikkinen J, Petrova Quayle D, Udeh-Momoh C, Claringbould A, Neumann J, Haytural H, Kaakinen MA, Loizidou E, Meissner E, Bertram L; BIOS consortium, Gveric DO, Gentleman SM, Attems J, Perneczky R, Arzberger T, Muglia P, Lill CM, Parkkinen L, Middleton LT.

Alzheimers Dement (N Y). 2019 Nov 20;5:814-824. doi: 10.1016/j.trci.2019.08.005. eCollection 2019.

7.

Lewy body pathology is more prevalent in older individuals with mitochondrial disease than controls.

Erskine D, Reeve AK, Polvikoski T, Schaefer AM, Taylor RW, Lax NZ, El-Agnaf O, Attems J, Gorman GS, Turnbull DM, Ng YS.

Acta Neuropathol. 2020 Jan;139(1):219-221. doi: 10.1007/s00401-019-02105-w. Epub 2019 Nov 28. No abstract available.

8.

Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study.

Ivashko-Pachima Y, Hadar A, Grigg I, Korenková V, Kapitansky O, Karmon G, Gershovits M, Sayas CL, Kooy RF, Attems J, Gurwitz D, Gozes I.

Mol Psychiatry. 2019 Oct 30. doi: 10.1038/s41380-019-0563-5. [Epub ahead of print]

PMID:
31664177
9.

Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders.

Alexandris AS, Walker L, Liu AKL, McAleese KE, Johnson M, Pearce RKB, Gentleman SM, Attems J.

Neuropathol Appl Neurobiol. 2019 Aug 27. doi: 10.1111/nan.12577. [Epub ahead of print]

PMID:
31454423
10.

Reply: LATE to the PART-y.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murray ME, Nag S, Seeley WW, Sperling RA, White CL, Schneider JA.

Brain. 2019 Sep 1;142(9):e48. doi: 10.1093/brain/awz226. No abstract available.

PMID:
31359039
11.

Neuropathological Changes in Dementia With Lewy Bodies and the Cingulate Island Sign.

Patterson L, Firbank MJ, Colloby SJ, Attems J, Thomas AJ, Morris CM.

J Neuropathol Exp Neurol. 2019 May 24. pii: nlz047. doi: 10.1093/jnen/nlz047. [Epub ahead of print]

12.

Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies.

Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Piqué A, Thom T, Rizzoli S, Schmitz M, Li J, Zerr I, Attems J, Jahn O, Outeiro TF.

Cell Rep. 2019 Jul 2;28(1):65-77.e6. doi: 10.1016/j.celrep.2019.06.009.

13.

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White Iii CL, Yu L, Schneider JA.

Brain. 2019 Jun 1;142(6):1503-1527. doi: 10.1093/brain/awz099. Erratum in: Brain. 2019 Jul 1;142(7):e37.

14.

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies - current issues and future directions.

Walker L, Stefanis L, Attems J.

J Neurochem. 2019 Sep;150(5):467-474. doi: 10.1111/jnc.14698. Epub 2019 Apr 23. Review.

PMID:
30892688
15.

Neurodegenerative Diseases and Ageing.

Walker L, McAleese KE, Erskine D, Attems J.

Subcell Biochem. 2019;91:75-106. doi: 10.1007/978-981-13-3681-2_4. Review.

PMID:
30888650
16.

Rare histotype of sporadic Creutzfeldt-Jakob disease, clinically suspected as corticobasal degeneration.

Tilley BS, Smith C, Pavese N, Attems J.

BMJ Case Rep. 2019 Mar 7;12(3). pii: e228305. doi: 10.1136/bcr-2018-228305.

17.

Pathological Changes to the Subcortical Visual System and its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.

Erskine D, Taylor JP, Thomas A, Collerton D, McKeith I, Khundakar A, Attems J, Morris C.

Neurosci Bull. 2019 Apr;35(2):295-300. doi: 10.1007/s12264-019-00341-4. Epub 2019 Feb 6. No abstract available.

18.

Dementia with Lewy bodies: an update and outlook.

Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn D, Donaghy P, Morris C, Taylor JP, Thomas A, Attems J, McKeith I.

Mol Neurodegener. 2019 Jan 21;14(1):5. doi: 10.1186/s13024-019-0306-8. Review.

19.

Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.

Patterson L, Rushton SP, Attems J, Thomas AJ, Morris CM.

Brain Pathol. 2019 Jul;29(4):544-557. doi: 10.1111/bpa.12697. Epub 2019 Jan 29.

20.

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease.

McAleese KE, Graham S, Dey M, Walker L, Erskine D, Johnson M, Johnston E, Thomas AJ, McKeith IG, DeCarli C, Attems J.

Brain Pathol. 2019 May;29(3):414-424. doi: 10.1111/bpa.12685. Epub 2019 Jan 29.

PMID:
30485582
21.

High prevalence of focal and multi-focal somatic genetic variants in the human brain.

Keogh MJ, Wei W, Aryaman J, Walker L, van den Ameele J, Coxhead J, Wilson I, Bashton M, Beck J, West J, Chen R, Haudenschild C, Bartha G, Luo S, Morris CM, Jones NS, Attems J, Chinnery PF.

Nat Commun. 2018 Oct 15;9(1):4257. doi: 10.1038/s41467-018-06331-w.

22.

A new visual rating scale for Ioflupane imaging in Lewy body disease.

Lloyd JJ, Petrides G, Donaghy PC, Colloby SJ, Attems J, O'Brien JT, Roberts G, Thomas AJ.

Neuroimage Clin. 2018;20:823-829. doi: 10.1016/j.nicl.2018.09.012. Epub 2018 Sep 20.

23.

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326.

24.

Frequency and signature of somatic variants in 1461 human brain exomes.

Wei W, Keogh MJ, Aryaman J, Golder Z, Kullar PJ, Wilson I, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Sarraj SA, Morris CM, Ansorge O, Jones NS, Ironside JW, Chinnery PF.

Genet Med. 2019 Apr;21(4):904-912. doi: 10.1038/s41436-018-0274-3. Epub 2018 Sep 14.

25.

Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer's disease.

Nicolas G, Acuña-Hidalgo R, Keogh MJ, Quenez O, Steehouwer M, Lelieveld S, Rousseau S, Richard AC, Oud MS, Marguet F, Laquerrière A, Morris CM, Attems J, Smith C, Ansorge O, Al Sarraj S, Frebourg T, Campion D, Hannequin D, Wallon D, Gilissen C, Chinnery PF, Veltman JA, Hoischen A.

Alzheimers Dement. 2018 Dec;14(12):1632-1639. doi: 10.1016/j.jalz.2018.06.3056. Epub 2018 Aug 13.

26.

Lysosomal cathepsin D is upregulated in Alzheimer's disease neocortex and may be a marker for neurofibrillary degeneration.

Chai YL, Chong JR, Weng J, Howlett D, Halsey A, Lee JH, Attems J, Aarsland D, Francis PT, Chen CP, Lai MKP.

Brain Pathol. 2019 Jan;29(1):63-74. doi: 10.1111/bpa.12631. Epub 2018 Oct 17.

PMID:
30051532
27.

Phosphorylation of different tau sites during progression of Alzheimer's disease.

Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B.

Acta Neuropathol Commun. 2018 Jun 29;6(1):52. doi: 10.1186/s40478-018-0557-6.

28.

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease.

Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I, Gurwitz D.

Sci Rep. 2018 May 31;8(1):8465. doi: 10.1038/s41598-018-26547-6.

29.

Cortical tau pathology: a major player in fibre-specific white matter reductions in Alzheimer's disease?

McAleese KE, Walker L, Colloby SJ, Taylor JP, Thomas AJ, DeCarli C, Attems J.

Brain. 2018 Jun 1;141(6):e44. doi: 10.1093/brain/awy084. No abstract available.

PMID:
29668888
30.

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?

Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L.

Alzheimers Dement. 2018 Aug;14(8):1022-1037. doi: 10.1016/j.jalz.2018.02.017. Epub 2018 Apr 7.

31.

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies.

Erskine D, Ding J, Thomas AJ, Kaganovich A, Khundakar AA, Hanson PS, Taylor JP, McKeith IG, Attems J, Cookson MR, Morris CM.

Mov Disord. 2018 Jul;33(6):982-991. doi: 10.1002/mds.27333. Epub 2018 Mar 23.

32.

Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia.

Thomas AJ, Mahin-Babaei F, Saidi M, Lett D, Taylor JP, Walker L, Attems J.

Alzheimers Res Ther. 2018 Mar 1;10(1):27. doi: 10.1186/s13195-018-0356-0.

33.

Neuropathology and biochemistry of early onset familial Alzheimer's disease caused by presenilin-1 missense mutation Thr116Asn.

Sutovsky S, Smolek T, Turcani P, Petrovic R, Brandoburova P, Jadhav S, Novak P, Attems J, Zilka N.

J Neural Transm (Vienna). 2018 Jun;125(6):965-976. doi: 10.1007/s00702-018-1850-z. Epub 2018 Feb 5.

PMID:
29404783
34.

Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study.

Gatt A, Ekonomou A, Somani A, Thuret S, Howlett D, Corbett A, Johnson M, Perry E, Attems J, Francis P, Aarsland D, Ballard C.

Dement Geriatr Cogn Disord. 2017;44(5-6):283-293. doi: 10.1159/000484437. Epub 2018 Jan 27.

PMID:
29393203
35.

Proteomics for synaptic markers of cognitive decline in neurodegenerative diseases.

Attems J, Jellinger K.

Brain. 2018 Feb 1;141(2):329-331. doi: 10.1093/brain/awx360. No abstract available.

PMID:
29390123
36.

Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.

Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI.

Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z.

37.

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains.

Keogh MJ, Wei W, Aryaman J, Wilson I, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Jones N, Ironside JW, Chinnery PF.

J Neurol Neurosurg Psychiatry. 2018 Aug;89(8):813-816. doi: 10.1136/jnnp-2017-317234. Epub 2018 Jan 13.

38.

Regional levels of physiological α-synuclein are directly associated with Lewy body pathology.

Erskine D, Patterson L, Alexandris A, Hanson PS, McKeith IG, Attems J, Morris CM.

Acta Neuropathol. 2018 Jan;135(1):153-154. doi: 10.1007/s00401-017-1787-6. Epub 2017 Nov 13. No abstract available.

PMID:
29134319
39.

Author response: Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z.

Neurology. 2017 Aug 15;89(7):751. doi: 10.1212/WNL.0000000000004254. No abstract available.

PMID:
28808169
40.

Parietal white matter lesions in Alzheimer's disease are associated with cortical neurodegenerative pathology, but not with small vessel disease.

McAleese KE, Walker L, Graham S, Moya ELJ, Johnson M, Erskine D, Colloby SJ, Dey M, Martin-Ruiz C, Taylor JP, Thomas AJ, McKeith IG, De Carli C, Attems J.

Acta Neuropathol. 2017 Sep;134(3):459-473. doi: 10.1007/s00401-017-1738-2. Epub 2017 Jun 21.

41.

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K.

Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review.

42.

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.

43.

The multi-morbid old brain.

Attems J.

Acta Neuropathol. 2017 Aug;134(2):169-170. doi: 10.1007/s00401-017-1723-9. No abstract available.

PMID:
28509946
44.

Interactions of pathological proteins in neurodegenerative diseases.

Spires-Jones TL, Attems J, Thal DR.

Acta Neuropathol. 2017 Aug;134(2):187-205. doi: 10.1007/s00401-017-1709-7. Epub 2017 Apr 11. Review.

45.

Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

Alghamdi A, Vallortigara J, Howlett DR, Broadstock M, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Attems J, Francis PT, Whitfield DR.

J Alzheimers Dis. 2017;57(2):373-386. doi: 10.3233/JAD-160946.

46.

Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts.

Walker L, McAleese KE, Johnson M, Khundakar AA, Erskine D, Thomas AJ, McKeith IG, Attems J.

J Neural Transm (Vienna). 2017 Jun;124(6):671-683. doi: 10.1007/s00702-017-1702-2. Epub 2017 Mar 6.

47.

PTEN expression as a predictor for the response to trastuzumab-based therapy in Her-2 overexpressing metastatic breast cancer.

Gschwantler-Kaulich D, Tan YY, Fuchs EM, Hudelist G, Köstler WJ, Reiner A, Leser C, Salama M, Attems J, Deutschmann C, Zielinski CC, Singer CF.

PLoS One. 2017 Mar 2;12(3):e0172911. doi: 10.1371/journal.pone.0172911. eCollection 2017.

48.

Erratum to: Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF.

Acta Neuropathol Commun. 2017 Feb 22;5(1):17. doi: 10.1186/s40478-017-0419-7. No abstract available.

49.

Neuronal Loss and Α-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.

Erskine D, Thomas AJ, Taylor JP, Savage MA, Attems J, McKeith IG, Morris CM, Khundakar AA.

Am J Geriatr Psychiatry. 2017 Jun;25(6):595-604. doi: 10.1016/j.jagp.2017.01.005. Epub 2017 Jan 10.

PMID:
28190674
50.

Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.

Wei W, Keogh MJ, Wilson I, Coxhead J, Ryan S, Rollinson S, Griffin H, Kurzawa-Akanbi M, Santibanez-Koref M, Talbot K, Turner MR, McKenzie CA, Troakes C, Attems J, Smith C, Al Sarraj S, Morris CM, Ansorge O, Pickering-Brown S, Ironside JW, Chinnery PF.

Acta Neuropathol Commun. 2017 Feb 2;5(1):13. doi: 10.1186/s40478-016-0404-6. Erratum in: Acta Neuropathol Commun. 2017 Feb 22;5(1):17.

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