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Items: 1 to 50 of 390

1.

Pillars Article: Identification of an Additional Class of C3-Binding Membrane Proteins of Human Peripheral Blood Leukocytes and Cell Lines. Proc. Natl. Acad. Sci. UAS. 1985. 82: 859-863.

Cole JL, Housley GA Jr, Dykman TR, Macdermott RP, Atkinson JP.

J Immunol. 2019 Jul 1;203(1):6-10. No abstract available.

PMID:
31209142
2.

Fat-Produced Adipsin Regulates Inflammatory Arthritis.

Li Y, Zou W, Brestoff JR, Rohatgi N, Wu X, Atkinson JP, Harris CA, Teitelbaum SL.

Cell Rep. 2019 Jun 4;27(10):2809-2816.e3. doi: 10.1016/j.celrep.2019.05.032.

3.

Reply.

Kim AHJ, Strand V, Atkinson JP.

Arthritis Rheumatol. 2019 May 10. doi: 10.1002/art.40923. [Epub ahead of print]

PMID:
31074940
4.

Development and Optimization of an ELISA to Quantitate C3(H 2 O) as a Marker of Human Disease.

Elvington M, Liszewski MK, Liszewski AR, Kulkarni HS, Hachem RR, Mohanakumar T, Kim AHJ, Atkinson JP.

Front Immunol. 2019 Apr 4;10:703. doi: 10.3389/fimmu.2019.00703. eCollection 2019.

5.

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice.

Smith-Jackson K, Yang Y, Denton H, Pappworth IY, Cooke K, Barlow PN, Atkinson JP, Liszewski MK, Pickering MC, Kavanagh D, Cook HT, Marchbank KJ.

J Clin Invest. 2019 Mar 1;129(3):1061-1075. doi: 10.1172/JCI99296. Epub 2019 Feb 4.

6.

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation.

Eriksson O, Chiu J, Hogg PJ, Atkinson JP, Liszewski MK, Flaumenhaft R, Furie B.

J Biol Chem. 2019 Mar 29;294(13):4878-4888. doi: 10.1074/jbc.RA118.006792. Epub 2019 Jan 22.

PMID:
30670593
7.

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials.

Gupta S, Lau K, Harding CO, Shepherd G, Boyer R, Atkinson JP, Knight V, Olbertz J, Larimore K, Gu Z, Li M, Rosen O, Zoog SJ, Weng HH, Schweighardt B.

EBioMedicine. 2018 Nov;37:366-373. doi: 10.1016/j.ebiom.2018.10.038. Epub 2018 Oct 23.

8.

Association of Blood Concentrations of Complement Split Product iC3b and Serum C3 With Systemic Lupus Erythematosus Disease Activity.

Kim AHJ, Strand V, Sen DP, Fu Q, Mathis NL, Schmidt MJ, Bruchas RR, Staten NR, Olson PK, Stiening CM, Atkinson JP.

Arthritis Rheumatol. 2019 Mar;71(3):420-430. doi: 10.1002/art.40747. Epub 2019 Jan 24.

PMID:
30294950
9.

Intracellular C3 Protects Human Airway Epithelial Cells from Stress-associated Cell Death.

Kulkarni HS, Elvington ML, Perng YC, Liszewski MK, Byers DE, Farkouh C, Yusen RD, Lenschow DJ, Brody SL, Atkinson JP.

Am J Respir Cell Mol Biol. 2019 Feb;60(2):144-157. doi: 10.1165/rcmb.2017-0405OC.

PMID:
30156437
10.

TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia.

Kothari PH, Kolar GR, Jen JC, Hajj-Ali R, Bertram P, Schmidt RE, Atkinson JP.

Brain Pathol. 2018 Nov;28(6):806-821. doi: 10.1111/bpa.12626. Epub 2018 Oct 10.

11.

Preface to the Special issue for the 27th International complement workshop.

Tenner AJ, Atkinson JP, Holers VM.

Mol Immunol. 2018 Oct;102:1-2. doi: 10.1016/j.molimm.2018.07.010. Epub 2018 Jul 27. No abstract available.

PMID:
30060927
12.

Timing and mechanism of conceptus demise in a complement regulatory membrane protein deficient mouse.

Triebwasser MP, Wu X, Bertram P, Hourcade DE, Nelson DM, Atkinson JP.

Am J Reprod Immunol. 2018 Oct;80(4):e12997. doi: 10.1111/aji.12997. Epub 2018 Jun 20.

13.

Contribution of Adipose-Derived Factor D/Adipsin to Complement Alternative Pathway Activation: Lessons from Lipodystrophy.

Wu X, Hutson I, Akk AM, Mascharak S, Pham CTN, Hourcade DE, Brown R, Atkinson JP, Harris CA.

J Immunol. 2018 Apr 15;200(8):2786-2797. doi: 10.4049/jimmunol.1701668. Epub 2018 Mar 12.

14.

Transcriptional Profiling of Synovial Macrophages Using Minimally Invasive Ultrasound-Guided Synovial Biopsies in Rheumatoid Arthritis.

Mandelin AM 2nd, Homan PJ, Shaffer AM, Cuda CM, Dominguez ST, Bacalao E, Carns M, Hinchcliff M, Lee J, Aren K, Thakrar A, Montgomery AB, Bridges SL Jr, Bathon JM, Atkinson JP, Fox DA, Matteson EL, Buckley CD, Pitzalis C, Parks D, Hughes LB, Geraldino-Pardilla L, Ike R, Phillips K, Wright K, Filer A, Kelly S, Ruderman EM, Morgan V, Abdala-Valencia H, Misharin AV, Budinger GS, Bartom ET, Pope RM, Perlman H, Winter DR.

Arthritis Rheumatol. 2018 Jun;70(6):841-854. doi: 10.1002/art.40453. Epub 2018 May 3.

15.

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?

Kulkarni HS, Liszewski MK, Brody SL, Atkinson JP.

J Allergy Clin Immunol. 2018 May;141(5):1582-1586.e1. doi: 10.1016/j.jaci.2017.11.046. Epub 2018 Jan 12. No abstract available.

16.

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

Lokki AI, Daly E, Triebwasser M, Kurki MI, Roberson EDO, Häppölä P, Auro K, Perola M, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Salmon JE, Meri S, Daly M, Atkinson JP, Laivuori H.

Hypertension. 2017 Aug;70(2):365-371. doi: 10.1161/HYPERTENSIONAHA.117.09406. Epub 2017 Jun 26.

17.

DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice.

Sakai T, Miyazaki T, Shin DM, Kim YS, Qi CF, Fariss R, Munasinghe J, Wang H, Kovalchuk AL, Kothari PH, Fermaintt CS, Atkinson JP, Perrino FW, Yan N, Morse HC 3rd.

J Autoimmun. 2017 Jul;81:13-23. doi: 10.1016/j.jaut.2017.03.001. Epub 2017 Mar 18.

18.

Complement's hidden arsenal: New insights and novel functions inside the cell.

Liszewski MK, Elvington M, Kulkarni HS, Atkinson JP.

Mol Immunol. 2017 Apr;84:2-9. doi: 10.1016/j.molimm.2017.01.004. Epub 2017 Feb 10. Review.

19.

A C3(H20) recycling pathway is a component of the intracellular complement system.

Elvington M, Liszewski MK, Bertram P, Kulkarni HS, Atkinson JP.

J Clin Invest. 2017 Mar 1;127(3):970-981. doi: 10.1172/JCI89412. Epub 2017 Feb 13.

20.

Complement Dysregulation and Disease: Insights from Contemporary Genetics.

Liszewski MK, Java A, Schramm EC, Atkinson JP.

Annu Rev Pathol. 2017 Jan 24;12:25-52. doi: 10.1146/annurev-pathol-012615-044145. Epub 2016 Dec 5. Review.

21.

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.

Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B.

J Clin Invest. 2016 Dec 1;126(12):4640-4653. doi: 10.1172/JCI85856. Epub 2016 Nov 14.

22.

Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin-Mediated Neutralization.

Thiemmeca S, Tamdet C, Punyadee N, Prommool T, Songjaeng A, Noisakran S, Puttikhunt C, Atkinson JP, Diamond MS, Ponlawat A, Avirutnan P.

J Immunol. 2016 Nov 15;197(10):4053-4065. Epub 2016 Oct 19.

23.

Evolution of the complement system: from defense of the single cell to guardian of the intravascular space.

Elvington M, Liszewski MK, Atkinson JP.

Immunol Rev. 2016 Nov;274(1):9-15. doi: 10.1111/imr.12474. Review.

24.

Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.

Stam AH, Kothari PH, Shaikh A, Gschwendter A, Jen JC, Hodgkinson S, Hardy TA, Hayes M, Kempster PA, Kotschet KE, Bajema IM, van Duinen SG, Maat-Schieman MLC, de Jong PTVM, de Smet MD, de Wolff-Rouendaal D, Dijkman G, Pelzer N, Kolar GR, Schmidt RE, Lacey J, Joseph D, Fintak DR, Grand MG, Brunt EM, Liapis H, Hajj-Ali RA, Kruit MC, van Buchem MA, Dichgans M, Frants RR, van den Maagdenberg AMJM, Haan J, Baloh RW, Atkinson JP, Terwindt GM, Ferrari MD.

Brain. 2016 Nov 1;139(11):2909-2922. doi: 10.1093/brain/aww217. No abstract available.

25.

Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD.

Wagner EK, Raychaudhuri S, Villalonga MB, Java A, Triebwasser MP, Daly MJ, Atkinson JP, Seddon JM.

Sci Rep. 2016 Aug 30;6:31531. doi: 10.1038/srep31531.

26.

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.

Lyzogubov VV, Bora PS, Wu X, Horn LE, de Roque R, Rudolf XV, Atkinson JP, Bora NS.

Am J Pathol. 2016 Aug;186(8):2088-2104. doi: 10.1016/j.ajpath.2016.03.021. Epub 2016 Jun 11.

27.

Von Willebrand factor regulates complement on endothelial cells.

Noone DG, Riedl M, Pluthero FG, Bowman ML, Liszewski MK, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson JP, Palaniyar N, Kahr WH, Licht C.

Kidney Int. 2016 Jul;90(1):123-34. doi: 10.1016/j.kint.2016.03.023. Epub 2016 May 25.

28.

Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.

Forneris F, Wu J, Xue X, Ricklin D, Lin Z, Sfyroera G, Tzekou A, Volokhina E, Granneman JC, Hauhart R, Bertram P, Liszewski MK, Atkinson JP, Lambris JD, Gros P.

EMBO J. 2016 May 17;35(10):1133-49. doi: 10.15252/embj.201593673. Epub 2016 Mar 24.

29.

Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, Mastroeni D, Clarke EV, Rogers J, Atkinson JP, Tenner AJ.

PLoS One. 2016 Feb 25;11(2):e0149792. doi: 10.1371/journal.pone.0149792. eCollection 2016.

30.

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases.

Lintner KE, Wu YL, Yang Y, Spencer CH, Hauptmann G, Hebert LA, Atkinson JP, Yu CY.

Front Immunol. 2016 Feb 15;7:36. doi: 10.3389/fimmu.2016.00036. eCollection 2016. Review.

31.

Rare Variants in the Functional Domains of Complement Factor H Are Associated With Age-Related Macular Degeneration.

Triebwasser MP, Roberson ED, Yu Y, Schramm EC, Wagner EK, Raychaudhuri S, Seddon JM, Atkinson JP.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6873-8. doi: 10.1167/iovs.15-17432.

32.

A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H.

Chauvet S, Roumenina LT, Bruneau S, Marinozzi MC, Rybkine T, Schramm EC, Java A, Atkinson JP, Aldigier JC, Bridoux F, Touchard G, Fremeaux-Bacchi V.

J Am Soc Nephrol. 2016 Jun;27(6):1665-77. doi: 10.1681/ASN.2015040348. Epub 2015 Oct 15.

33.

Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation.

Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ, Atkinson JP, Morse HC 3rd, Lehrman MA, Yan N.

Immunity. 2015 Sep 15;43(3):463-74. doi: 10.1016/j.immuni.2015.07.022. Epub 2015 Aug 25.

34.

Role of complement receptor 1 (CR1; CD35) on epithelial cells: A model for understanding complement-mediated damage in the kidney.

Java A, Liszewski MK, Hourcade DE, Zhang F, Atkinson JP.

Mol Immunol. 2015 Oct;67(2 Pt B):584-95. doi: 10.1016/j.molimm.2015.07.016. Epub 2015 Aug 7.

35.

Complement regulator CD46: genetic variants and disease associations.

Liszewski MK, Atkinson JP.

Hum Genomics. 2015 Jun 10;9:7. doi: 10.1186/s40246-015-0029-z. Review.

36.

Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels.

Kavanagh D, Yu Y, Schramm EC, Triebwasser M, Wagner EK, Raychaudhuri S, Daly MJ, Atkinson JP, Seddon JM.

Hum Mol Genet. 2015 Jul 1;24(13):3861-70. doi: 10.1093/hmg/ddv091. Epub 2015 Mar 18.

37.

A quantitative lateral flow assay to detect complement activation in blood.

Schramm EC, Staten NR, Zhang Z, Bruce SS, Kellner C, Atkinson JP, Kyttaris VC, Tsokos GC, Petri M, Sander Connolly E, Olson PK.

Anal Biochem. 2015 May 15;477:78-85. doi: 10.1016/j.ab.2015.01.024. Epub 2015 Feb 4.

38.

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome.

Schramm EC, Roumenina LT, Rybkine T, Chauvet S, Vieira-Martins P, Hue C, Maga T, Valoti E, Wilson V, Jokiranta S, Smith RJ, Noris M, Goodship T, Atkinson JP, Fremeaux-Bacchi V.

Blood. 2015 Apr 9;125(15):2359-69. doi: 10.1182/blood-2014-10-609073. Epub 2015 Jan 21.

39.

Complement regulators in human disease: lessons from modern genetics.

Liszewski MK, Atkinson JP.

J Intern Med. 2015 Mar;277(3):294-305. doi: 10.1111/joim.12338. Epub 2015 Jan 16. Review.

40.

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

Watson R, Wearmouth E, McLoughlin AC, Jackson A, Ward S, Bertram P, Bennaceur K, Barker CE, Pappworth IY, Kavanagh D, Lea SM, Atkinson JP, Goodship TH, Marchbank KJ.

Mol Immunol. 2015 Feb;63(2):287-96. doi: 10.1016/j.molimm.2014.07.017. Epub 2014 Aug 21.

41.

Genetic variants in the complement system predisposing to age-related macular degeneration: a review.

Schramm EC, Clark SJ, Triebwasser MP, Raychaudhuri S, Seddon J, Atkinson JP.

Mol Immunol. 2014 Oct;61(2):118-125. doi: 10.1016/j.molimm.2014.06.032. Epub 2014 Jul 15. Review.

42.

Complement regulatory protein CD46 protects against choroidal neovascularization in mice.

Lyzogubov V, Wu X, Jha P, Tytarenko R, Triebwasser M, Kolar G, Bertram P, Bora PS, Atkinson JP, Bora NS.

Am J Pathol. 2014 Sep;184(9):2537-48. doi: 10.1016/j.ajpath.2014.06.001. Epub 2014 Jul 11.

43.

Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.

Yu Y, Triebwasser MP, Wong EK, Schramm EC, Thomas B, Reynolds R, Mardis ER, Atkinson JP, Daly M, Raychaudhuri S, Kavanagh D, Seddon JM.

Hum Mol Genet. 2014 Oct 1;23(19):5283-93. doi: 10.1093/hmg/ddu226. Epub 2014 May 20.

44.

Deficient IFN signaling by myeloid cells leads to MAVS-dependent virus-induced sepsis.

Pinto AK, Ramos HJ, Wu X, Aggarwal S, Shrestha B, Gorman M, Kim KY, Suthar MS, Atkinson JP, Gale M Jr, Diamond MS.

PLoS Pathog. 2014 Apr 17;10(4):e1004086. doi: 10.1371/journal.ppat.1004086. eCollection 2014 Apr.

45.

Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation.

Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C.

Immunity. 2013 Dec 12;39(6):1143-57. doi: 10.1016/j.immuni.2013.10.018. Epub 2013 Dec 5.

46.

Using mutagenesis and structural biology to map the binding site for the Plasmodium falciparum merozoite protein PfRh4 on the human immune adherence receptor.

Park HJ, Guariento M, Maciejewski M, Hauhart R, Tham WH, Cowman AF, Schmidt CQ, Mertens HD, Liszewski MK, Hourcade DE, Barlow PN, Atkinson JP.

J Biol Chem. 2014 Jan 3;289(1):450-63. doi: 10.1074/jbc.M113.520346. Epub 2013 Nov 8.

47.

Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.

Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, Gong Y, Wang L, Thurman JM, Wu X, Atkinson JP, Chao W.

J Immunol. 2013 Dec 1;191(11):5625-35. doi: 10.4049/jimmunol.1301903. Epub 2013 Oct 23.

48.

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

Seddon JM, Yu Y, Miller EC, Reynolds R, Tan PL, Gowrisankar S, Goldstein JI, Triebwasser M, Anderson HE, Zerbib J, Kavanagh D, Souied E, Katsanis N, Daly MJ, Atkinson JP, Raychaudhuri S.

Nat Genet. 2013 Nov;45(11):1366-70. doi: 10.1038/ng.2741. Epub 2013 Sep 15.

49.

The role of the immune response in age-related macular degeneration.

Whitcup SM, Sodhi A, Atkinson JP, Holers VM, Sinha D, Rohrer B, Dick AD.

Int J Inflam. 2013;2013:348092. doi: 10.1155/2013/348092. Epub 2013 May 23.

50.

Immunology of age-related macular degeneration.

Ambati J, Atkinson JP, Gelfand BD.

Nat Rev Immunol. 2013 Jun;13(6):438-51. doi: 10.1038/nri3459. Review.

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