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Effect of intermittent or continuous feed on muscle wasting in critical illness: A phase II clinical trial.

McNelly AS, Bear DE, Connolly BA, Arbane G, Allum L, Tarbhai A, Cooper JA, Hopkins PA, Wise MP, Brealey D, Rooney K, Cupitt J, Carr B, Koelfat K, Damink SO, Atherton PJ, Hart N, Montgomery HE, Puthucheary ZA.

Chest. 2020 Apr 2. pii: S0012-3692(20)30584-5. doi: 10.1016/j.chest.2020.03.045. [Epub ahead of print]


The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men.

Davies RW, Bass JJ, Carson BP, Norton C, Kozior M, Wilkinson DJ, Brook MS, Atherton PJ, Smith K, Jakeman PM.

Nutrients. 2020 Mar 21;12(3). pii: E845. doi: 10.3390/nu12030845.



Miller BF, Reid JJ, Price JC, Lin HL, Atherton PJ, Smith K.

J Appl Physiol (1985). 2020 Mar 26. doi: 10.1152/japplphysiol.00855.2019. [Epub ahead of print]


Challenges and practical recommendations for successfully recruiting inactive, statin-free older adults to clinical trials.

Deane CS, Phillips BE, Smith K, Steele AM, Libretto T, Statton SA, Atherton PJ, Etheridge T.

BMC Res Notes. 2020 Mar 24;13(1):174. doi: 10.1186/s13104-020-05017-1.


An update on nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies.

Brook MS, Wilkinson DJ, Atherton PJ.

Curr Opin Clin Nutr Metab Care. 2020 May;23(3):174-180. doi: 10.1097/MCO.0000000000000652.


Exploring the Association between Vascular Dysfunction and Skeletal Muscle Mass, Strength and Function in Healthy Adults: A Systematic Review.

Dvoretskiy S, Lieblein-Boff JC, Jonnalagadda S, Atherton PJ, Phillips BE, Pereira SL.

Nutrients. 2020 Mar 7;12(3). pii: E715. doi: 10.3390/nu12030715. Review.


High levels of physical activity in later life are associated with enhanced markers of mitochondrial metabolism.

Joanisse S, Ashcroft S, Wilkinson DJ, Pollock RD, O'Brien KA, Phillips BE, Smith K, Lazarus NR, Harridge S, Atherton PJ, Philp A.

J Gerontol A Biol Sci Med Sci. 2020 Jan 14. pii: glaa005. doi: 10.1093/gerona/glaa005. [Epub ahead of print]


The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts.

Ashcroft SP, Bass JJ, Kazi AA, Atherton PJ, Philp A.

Am J Physiol Cell Physiol. 2020 Mar 1;318(3):C536-C541. doi: 10.1152/ajpcell.00568.2019. Epub 2020 Jan 15.


Network analysis of human muscle adaptation to aging and contraction.

Willis CRG, Ames RM, Deane CS, Phillips BE, Boereboom CL, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Kadi F, Szewczyk NJ, Atherton PJ, Etheridge T.

Aging (Albany NY). 2020 Jan 7;12(1):740-755. doi: 10.18632/aging.102653. Epub 2020 Jan 7.


Effects of a multidisciplinary quality of life intervention on sleep quality in patients with advanced cancer receiving radiation therapy - CORRIGENDUM.

Gentry MT, Atherton PJ, Lapid M, Rosen PS, Kung S, Richardson J, Niazi SK, Bobo WV, Clark MM, Rummans TA.

Palliat Support Care. 2019 Oct 23:1. doi: 10.1017/S147895151900083X. [Epub ahead of print] No abstract available.


The effect of oral essential amino acids on incretin hormone production in youth and ageing.

Abdulla H, Bass JJ, Stokes T, Gorissen SHM, McGlory C, Phillips BE, Phillips SM, Smith K, Idris I, Atherton PJ.

Endocrinol Diabetes Metab. 2019 Jul 26;2(4):e00085. doi: 10.1002/edm2.85. eCollection 2019 Oct.


Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men.

Gharahdaghi N, Rudrappa S, Brook MS, Idris I, Crossland H, Hamrock C, Abdul Aziz MH, Kadi F, Tarum J, Greenhaff PL, Constantin-Teodosiu D, Cegielski J, Phillips BE, Wilkinson DJ, Szewczyk NJ, Smith K, Atherton PJ.

J Cachexia Sarcopenia Muscle. 2019 Dec;10(6):1276-1294. doi: 10.1002/jcsm.12472. Epub 2019 Sep 30.


Effects of a multidisciplinary quality of life intervention on sleep quality in patients with advanced cancer receiving radiation therapy.

Gentry MT, Atherton PJ, Lapid M, Rosen PS, Kung S, Richardson J, Niazi SK, Bobo WV, Clark MM, Rummans TA.

Palliat Support Care. 2019 Sep 26:1-7. doi: 10.1017/S1478951519000750. [Epub ahead of print]


A statistical and biological response to an informatics appraisal of healthy aging gene signatures.

Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE, Atherton PJ.

Genome Biol. 2019 Aug 2;20(1):152. doi: 10.1186/s13059-019-1734-z.


Differential Stimulation of Post-Exercise Myofibrillar Protein Synthesis in Humans Following Isonitrogenous, Isocaloric Pre-Exercise Feeding.

Davies RW, Bass JJ, Carson BP, Norton C, Kozior M, Amigo-Benavent M, Wilkinson DJ, Brook MS, Atherton PJ, Smith K, Jakeman PM.

Nutrients. 2019 Jul 19;11(7). pii: E1657. doi: 10.3390/nu11071657.


Gene-based analysis of angiogenesis, mitochondrial and insulin-related pathways in skeletal muscle of older individuals following nutraceutical supplementation.

Crossland H, Pereira SL, Smith K, Phillips BE, Atherton PJ.

J Funct Foods. 2019 May;56:216-223. doi: 10.1016/j.jff.2019.03.022.


Longevity-related molecular pathways are subject to midlife "switch" in humans.

Timmons JA, Volmar CH, Crossland H, Phillips BE, Sood S, Janczura KJ, Törmäkangas T, Kujala UM, Kraus WE, Atherton PJ, Wahlestedt C.

Aging Cell. 2019 Aug;18(4):e12970. doi: 10.1111/acel.12970. Epub 2019 Jun 6.


Integrated Myofibrillar Protein Synthesis in Recovery From Unaccustomed and Accustomed Resistance Exercise With and Without Multi-ingredient Supplementation in Overweight Older Men.

Bell KE, Brook MS, Snijders T, Kumbhare D, Parise G, Smith K, Atherton PJ, Phillips SM.

Front Nutr. 2019 Apr 11;6:40. doi: 10.3389/fnut.2019.00040. eCollection 2019.


The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Gallagher IJ, Kadi F, Szewczyk NJ, Atherton PJ, Etheridge T.

Aging (Albany NY). 2019 Apr 15;11(7):2111-2126. doi: 10.18632/aging.101904.


It's not just about protein turnover: the role of ribosomal biogenesis and satellite cells in the regulation of skeletal muscle hypertrophy.

Brook MS, Wilkinson DJ, Smith K, Atherton PJ.

Eur J Sport Sci. 2019 Aug;19(7):952-963. doi: 10.1080/17461391.2019.1569726. Epub 2019 Feb 9. Review.


Androgen Mediation-and Antiandrogens Mitigation-of the Epidermal Growth Factor Receptor (EGFR) Inhibitor-Induced Rash: Results From a Pilot Randomized Trial and Small Translational Case Series.

Le-Rademacher JG, Rowland K, Atherton PJ, Dakhil C, Sun Z, Tan A, Schmidt L, Nguyen PL, Radecki Breitkopf C, Pittelkow M, Tindall D, Menon S, Jatoi A.

Am J Hosp Palliat Care. 2019 Jun;36(6):519-525. doi: 10.1177/1049909118819820. Epub 2019 Jan 2.


The efficacy of 'static' training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Herrod PJJ, Blackwell JEM, Moss BF, Gates A, Atherton PJ, Lund JN, Williams JP, Phillips BE.

Eur J Appl Physiol. 2019 Mar;119(3):645-652. doi: 10.1007/s00421-018-4054-1. Epub 2018 Dec 27.


Daily Lisinopril vs Placebo for Prevention of Chemoradiation-Induced Pulmonary Distress in Patients With Lung Cancer (Alliance MC1221): A Pilot Double-Blind Randomized Trial.

Sio TT, Atherton PJ, Pederson LD, Zhen WK, Mutter RW, Garces YI, Ma DJ, Leenstra JL, Rwigema JM, Dakhil S, Bearden JD, van der Veen SJ, Ganti AK, Schild SE, Miller RC.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):686-696. doi: 10.1016/j.ijrobp.2018.10.035. Epub 2018 Nov 2.


A double-blind placebo controlled trial into the impacts of HMB supplementation and exercise on free-living muscle protein synthesis, muscle mass and function, in older adults.

Din USU, Brook MS, Selby A, Quinlan J, Boereboom C, Abdullah H, Franchi M, Narici MV, Phillips BE, Williams JW, Rathmacher JA, Wilkinson DJ, Atherton PJ, Smith K.

Clin Nutr. 2019 Oct;38(5):2071-2078. doi: 10.1016/j.clnu.2018.09.025. Epub 2018 Sep 27.


Phase 1 study of pomalidomide and dexamethasone for relapsed/refractory primary CNS or vitreoretinal lymphoma.

Tun HW, Johnston PB, DeAngelis LM, Atherton PJ, Pederson LD, Koenig PA, Reeder CB, Omuro AMP, Schiff D, O'Neill B, Pulido J, Jaeckle KA, Grommes C, Witzig TE.

Blood. 2018 Nov 22;132(21):2240-2248. doi: 10.1182/blood-2018-02-835496. Epub 2018 Sep 27.


Physiological adaptations to resistance training in rats selectively bred for low and high response to aerobic exercise training.

Ahtiainen JP, Lensu S, Ruotsalainen I, Schumann M, Ihalainen JK, Fachada V, Mendias CL, Brook MS, Smith K, Atherton PJ, Koch LG, Britton SL, Kainulainen H.

Exp Physiol. 2018 Nov;103(11):1513-1523. doi: 10.1113/EP087144. Epub 2018 Oct 9.


Food texture: A potential dietary consideration for obesity prevention?

Etheridge T, Atherton PJ.

Exp Physiol. 2018 Oct;103(10):1298-1299. doi: 10.1113/EP087241. Epub 2018 Aug 26. No abstract available.


The metabolic and molecular mechanisms of hyperammonaemia- and hyperethanolaemia-induced protein catabolism in skeletal muscle cells.

Crossland H, Smith K, Atherton PJ, Wilkinson DJ.

J Cell Physiol. 2018 Dec;233(12):9663-9673. doi: 10.1002/jcp.26881. Epub 2018 Aug 24.


The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans.

Wilkinson DJ, Piasecki M, Atherton PJ.

Ageing Res Rev. 2018 Nov;47:123-132. doi: 10.1016/j.arr.2018.07.005. Epub 2018 Jul 23. Review.


A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease.

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar CH, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE.

Nucleic Acids Res. 2018 Sep 6;46(15):7772-7792. doi: 10.1093/nar/gky570.


Metabolic phenotype of skeletal muscle in early critical illness.

Puthucheary ZA, Astin R, Mcphail MJW, Saeed S, Pasha Y, Bear DE, Constantin D, Velloso C, Manning S, Calvert L, Singer M, Batterham RL, Gomez-Romero M, Holmes E, Steiner MC, Atherton PJ, Greenhaff P, Edwards LM, Smith K, Harridge SD, Hart N, Montgomery HE.

Thorax. 2018 Oct;73(10):926-935. doi: 10.1136/thoraxjnl-2017-211073. Epub 2018 Jul 6.


The effect of acute oral phosphatidic acid ingestion on myofibrillar protein synthesis and intracellular signaling in older males.

Smeuninx B, Nishimura Y, McKendry J, Limb M, Smith K, Atherton PJ, Breen L.

Clin Nutr. 2019 Jun;38(3):1423-1432. doi: 10.1016/j.clnu.2018.06.963. Epub 2018 Jun 21.


Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle.

Gnimassou O, Fernández-Verdejo R, Brook M, Naslain D, Balan E, Sayda M, Cegielski J, Nielens H, Decottignies A, Demoulin JB, Smith K, Atherton PJ, Francaux M, Deldicque L.

FASEB J. 2018 Oct;32(10):5272-5284. doi: 10.1096/fj.201800049RR. Epub 2018 Apr 19.


Regional regulation of focal adhesion kinase after concentric and eccentric loading is related to remodelling of human skeletal muscle.

Franchi MV, Ruoss S, Valdivieso P, Mitchell KW, Smith K, Atherton PJ, Narici MV, Flück M.

Acta Physiol (Oxf). 2018 Jul;223(3):e13056. doi: 10.1111/apha.13056. Epub 2018 Mar 3.


A 4-week, lifestyle-integrated, home-based exercise training programme elicits improvements in physical function and lean mass in older men and women: a pilot study.

Cegielski J, Brook MS, Quinlan JI, Wilkinson DJ, Smith K, Atherton PJ, Phillips BE.

Version 2. F1000Res. 2017 Jul 26 [revised 2017 Jan 1];6:1235. doi: 10.12688/f1000research.11894.2. eCollection 2017.


Systemic and local effects of vaginal dehydroepiandrosterone (DHEA): NCCTG N10C1 (Alliance).

Barton DL, Shuster LT, Dockter T, Atherton PJ, Thielen J, Birrell SN, Sood R, Griffin P, Terstriep SA, Mattar B, Lafky JM, Loprinzi CL.

Support Care Cancer. 2018 Apr;26(4):1335-1343. doi: 10.1007/s00520-017-3960-9. Epub 2017 Nov 21.


Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly.

Wåhlin-Larsson B, Wilkinson DJ, Strandberg E, Hosford-Donovan A, Atherton PJ, Kadi F.

Cell Physiol Biochem. 2017;44(1):267-278. doi: 10.1159/000484679. Epub 2017 Nov 9.


Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism.

Wilkinson DJ, Hossain T, Limb MC, Phillips BE, Lund J, Williams JP, Brook MS, Cegielski J, Philp A, Ashcroft S, Rathmacher JA, Szewczyk NJ, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2068-2075. doi: 10.1016/j.clnu.2017.09.024. Epub 2017 Oct 6.


A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: A proof-of-concept study.

Crossland H, Smith K, Atherton PJ, Wilkinson DJ.

Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):608-614. doi: 10.1016/j.bbrc.2017.10.085. Epub 2017 Oct 17.


Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Wilkinson DJ, Bukhari SSI, Phillips BE, Limb MC, Cegielski J, Brook MS, Rankin D, Mitchell WK, Kobayashi H, Williams JP, Lund J, Greenhaff PL, Smith K, Atherton PJ.

Clin Nutr. 2018 Dec;37(6 Pt A):2011-2021. doi: 10.1016/j.clnu.2017.09.008. Epub 2017 Sep 23.


Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Mitchell WK, Phillips BE, Hill I, Greenhaff P, Lund JN, Williams JP, Rankin D, Wilkinson DJ, Smith K, Atherton PJ.

Clin Sci (Lond). 2017 Oct 27;131(21):2643-2653. doi: 10.1042/CS20171230. Print 2017 Nov 1.


Muscle and Tendon Contributions to Reduced Rate of Torque Development in Healthy Older Males.

Quinlan JI, Maganaris CN, Franchi MV, Smith K, Atherton PJ, Szewczyk NJ, Greenhaff PL, Phillips BE, Blackwell JI, Boereboom C, Williams JP, Lund J, Narici MV.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):539-545. doi: 10.1093/gerona/glx149.


A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.

Phillips BE, Kelly BM, Lilja M, Ponce-González JG, Brogan RJ, Morris DL, Gustafsson T, Kraus WE, Atherton PJ, Vollaard NBJ, Rooyackers O, Timmons JA.

Front Endocrinol (Lausanne). 2017 Sep 8;8:229. doi: 10.3389/fendo.2017.00229. eCollection 2017.


Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance).

Barton DL, Sloan JA, Shuster LT, Gill P, Griffin P, Flynn K, Terstriep SA, Rana FN, Dockter T, Atherton PJ, Tsai M, Sturtz K, Lafky JM, Riepl M, Thielen J, Loprinzi CL.

Support Care Cancer. 2018 Feb;26(2):643-650. doi: 10.1007/s00520-017-3878-2. Epub 2017 Sep 18.


The efficacy of unsupervised home-based exercise regimens in comparison to supervised laboratory-based exercise training upon cardio-respiratory health facets.

Blackwell J, Atherton PJ, Smith K, Doleman B, Williams JP, Lund JN, Phillips BE.

Physiol Rep. 2017 Sep;5(17). pii: e13390. doi: 10.14814/phy2.13390.


Physiological adaptations to resistance exercise as a function of age.

Phillips BE, Williams JP, Greenhaff PL, Smith K, Atherton PJ.

JCI Insight. 2017 Sep 7;2(17). pii: 95581. doi: 10.1172/jci.insight.95581. eCollection 2017 Sep 7.


Electrical pulse stimulation: an in vitro exercise model for the induction of human skeletal muscle cell hypertrophy. A proof-of-concept study.

Tarum J, Folkesson M, Atherton PJ, Kadi F.

Exp Physiol. 2017 Nov 1;102(11):1405-1413. doi: 10.1113/EP086581. Epub 2017 Oct 4.


Nutrient modulation in the management of disease-induced muscle wasting: evidence from human studies.

Brook MS, Wilkinson DJ, Atherton PJ.

Curr Opin Clin Nutr Metab Care. 2017 Nov;20(6):433-439. doi: 10.1097/MCO.0000000000000413. Review.


A novel D2O tracer method to quantify RNA turnover as a biomarker of de novo ribosomal biogenesis, in vitro, in animal models, and in human skeletal muscle.

Brook MS, Wilkinson DJ, Mitchell WK, Lund JL, Phillips BE, Szewczyk NJ, Kainulainen H, Lensu S, Koch LG, Britton SL, Greenhaff PL, Smith K, Atherton PJ.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E681-E689. doi: 10.1152/ajpendo.00157.2017. Epub 2017 Aug 15.


A dynamic ribosomal biogenesis response is not required for IGF-1-mediated hypertrophy of human primary myotubes.

Crossland H, Timmons JA, Atherton PJ.

FASEB J. 2017 Dec;31(12):5196-5207. doi: 10.1096/fj.201700329R. Epub 2017 Aug 3.

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