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Narrow band imaging and serology in the assessment of premalignant gastric pathology.

White JR, Sami SS, Reddiar D, Mannath J, Ortiz-Fernández-Sordo J, Beg S, Scott R, Thiagarajan P, Ahmad S, Parra-Blanco A, Kasi M, Telakis E, Sultan AA, Davis J, Figgins A, Kaye P, Robinson K, Atherton JC, Ragunath K.

Scand J Gastroenterol. 2018 Dec;53(12):1611-1618. doi: 10.1080/00365521.2018.1542455. Epub 2019 Jan 2.


A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk.

Berthenet E, Yahara K, Thorell K, Pascoe B, Meric G, Mikhail JM, Engstrand L, Enroth H, Burette A, Megraud F, Varon C, Atherton JC, Smith S, Wilkinson TS, Hitchings MD, Falush D, Sheppard SK.

BMC Biol. 2018 Aug 2;16(1):84. doi: 10.1186/s12915-018-0550-3.


Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy.

Sinnett CG, Letley DP, Narayanan GL, Patel SR, Hussein NR, Zaitoun AM, Robinson K, Atherton JC.

J Clin Pathol. 2016 Nov;69(11):968-973. doi: 10.1136/jclinpath-2016-203641. Epub 2016 May 17.


Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells.

Hussain K, Letley DP, Greenaway AB, Kenefeck R, Winter JA, Tomlinson W, Rhead J, Staples E, Kaneko K, Atherton JC, Robinson K.

Front Immunol. 2016 Mar 7;7:71. doi: 10.3389/fimmu.2016.00071. eCollection 2016.


3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors.

Onion D, Argent RH, Reece-Smith AM, Craze ML, Pineda RG, Clarke PA, Ratan HL, Parsons SL, Lobo DN, Duffy JP, Atherton JC, McKenzie AJ, Kumari R, King P, Hall BM, Grabowska AM.

Mol Cancer Ther. 2016 Apr;15(4):753-63. doi: 10.1158/1535-7163.MCT-15-0598. Epub 2016 Feb 12.


Correction for Ferreira et al., A Novel Method for Genotyping the Helicobacter pylori vacA Intermediate Region Directly in Gastric Biopsy Specimens.

Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, Carneiro F, Figueiredo C.

J Clin Microbiol. 2016 Feb;54(2):507. doi: 10.1128/JCM.03173-15. No abstract available.


Expression of the Helicobacter pylori virulence factor vacuolating cytotoxin A (vacA) is influenced by a potential stem-loop structure in the 5' untranslated region of the transcript.

Amilon KR, Letley DP, Winter JA, Robinson K, Atherton JC.

Mol Microbiol. 2015 Dec;98(5):831-46. doi: 10.1111/mmi.13160. Epub 2015 Sep 10.


Reply to "Helicobacter pylori vacA as marker for gastric cancer and gastroduodenal diseases: one but not the only factor".

Memon AA, Atherton JC.

J Clin Microbiol. 2014 Dec;52(12):4452. doi: 10.1128/JCM.02667-14. No abstract available.


Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study.

Memon AA, Hussein NR, Miendje Deyi VY, Burette A, Atherton JC.

J Clin Microbiol. 2014 Aug;52(8):2984-9. doi: 10.1128/JCM.00551-14. Epub 2014 Jun 11.


A role for the vacuolating cytotoxin, VacA, in colonization and Helicobacter pylori-induced metaplasia in the stomach.

Winter JA, Letley DP, Cook KW, Rhead JL, Zaitoun AA, Ingram RJ, Amilon KR, Croxall NJ, Kaye PV, Robinson K, Atherton JC.

J Infect Dis. 2014 Sep 15;210(6):954-63. doi: 10.1093/infdis/jiu154. Epub 2014 Mar 12.


CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori-infected human gastric mucosa.

Cook KW, Letley DP, Ingram RJ, Staples E, Skjoldmose H, Atherton JC, Robinson K.

Gut. 2014 Oct;63(10):1550-9. doi: 10.1136/gutjnl-2013-306253. Epub 2014 Jan 16.


Helicobacter pylori downregulates expression of human β-defensin 1 in the gastric mucosa in a type IV secretion-dependent fashion.

Patel SR, Smith K, Letley DP, Cook KW, Memon AA, Ingram RJ, Staples E, Backert S, Zaitoun AM, Atherton JC, Robinson K.

Cell Microbiol. 2013 Dec;15(12):2080-92. doi: 10.1111/cmi.12174. Epub 2013 Aug 7.


Optimising the quantification of cytokines present at low concentrations in small human mucosal tissue samples using Luminex assays.

Staples E, Ingram RJ, Atherton JC, Robinson K.

J Immunol Methods. 2013 Aug 30;394(1-2):1-9. doi: 10.1016/j.jim.2013.04.009. Epub 2013 May 1.


A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens.

Ferreira RM, Machado JC, Letley D, Atherton JC, Pardo ML, Gonzalez CA, Carneiro F, Figueiredo C.

J Clin Microbiol. 2012 Dec;50(12):3983-9. doi: 10.1128/JCM.02087-12. Epub 2012 Oct 3. Erratum in: J Clin Microbiol. 2016 Feb;54(2):507.


Vacuolating Cytotoxin.

Atherton JC, Cover TL, Papini E, Telford JL.

In: Mobley HLT, Mendz GL, Hazell SL, editors. Helicobacter pylori: Physiology and Genetics. Washington (DC): ASM Press; 2001. Chapter 9.


In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription.

Shen F, Hobley L, Doherty N, Loh JT, Cover TL, Sockett RE, Hardie KR, Atherton JC.

BMC Microbiol. 2010 Aug 6;10:210. doi: 10.1186/1471-2180-10-210.


Helicobacter pylori potentiates epithelial:mesenchymal transition in gastric cancer: links to soluble HB-EGF, gastrin and matrix metalloproteinase-7.

Yin Y, Grabowska AM, Clarke PA, Whelband E, Robinson K, Argent RH, Tobias A, Kumari R, Atherton JC, Watson SA.

Gut. 2010 Aug;59(8):1037-45. doi: 10.1136/gut.2009.199794. Epub 2010 Jun 28.


Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells.

Hussein NR, Argent RH, Marx CK, Patel SR, Robinson K, Atherton JC.

J Infect Dis. 2010 Jul 15;202(2):261-9. doi: 10.1086/653587.


In Helicobacter pylori, LuxS is a key enzyme in cysteine provision through a reverse transsulfuration pathway.

Doherty NC, Shen F, Halliday NM, Barrett DA, Hardie KR, Winzer K, Atherton JC.

J Bacteriol. 2010 Mar;192(5):1184-92. doi: 10.1128/JB.01372-09. Epub 2010 Jan 8.


Helicobacter pylori stimulates dendritic cells to induce interleukin-17 expression from CD4+ T lymphocytes.

Khamri W, Walker MM, Clark P, Atherton JC, Thursz MR, Bamford KB, Lechler RI, Lombardi G.

Infect Immun. 2010 Feb;78(2):845-53. doi: 10.1128/IAI.00524-09. Epub 2009 Nov 16.


Coadaptation of Helicobacter pylori and humans: ancient history, modern implications.

Atherton JC, Blaser MJ.

J Clin Invest. 2009 Sep;119(9):2475-87. doi: 10.1172/JCI38605. Review.


The effect of the human gut-signalling hormone, norepinephrine, on the growth of the gastric pathogen Helicobacter pylori.

Doherty NC, Tobias A, Watson S, Atherton JC.

Helicobacter. 2009 Jun;14(3):223-30. doi: 10.1111/j.1523-5378.2009.00682.x.


Human gastrin: a true growth factor for Helicobacter pylori?

Doherty N, Atherton JC.

Helicobacter. 2009 Aug;14(4):303. doi: 10.1111/j.1523-5378.2009.00688.x. No abstract available.


A study of Helicobacter pylori-associated gastritis patterns in Iraq and their association with strain virulence.

Hussein NR, Napaki SM, Atherton JC.

Saudi J Gastroenterol. 2009 Apr;15(2):125-7. doi: 10.4103/1319-3767.48971.


The clinical utility and diagnostic yield of routine gastric biopsies in the investigation of iron deficiency anemia: a case-control study.

Kaye PV, Garsed K, Ragunath K, Jawhari A, Pick B, Atherton JC.

Am J Gastroenterol. 2008 Nov;103(11):2883-9. doi: 10.1111/j.1572-0241.2008.02121.x. Epub 2008 Sep 4.


Differences in Helicobacter pylori CagA tyrosine phosphorylation motif patterns between western and East Asian strains, and influences on interleukin-8 secretion.

Argent RH, Hale JL, El-Omar EM, Atherton JC.

J Med Microbiol. 2008 Sep;57(Pt 9):1062-7. doi: 10.1099/jmm.0.2008/001818-0.


A study of age-specific Helicobacter pylori seropositivity rates in Iraq.

Hussein NR, Robinson K, Atherton JC.

Helicobacter. 2008 Aug;13(4):306-7. doi: 10.1111/j.1523-5378.2008.00618.x. No abstract available.


Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction.

Tobin NP, Henehan GT, Murphy RP, Atherton JC, Guinan AF, Kerrigan SW, Cox D, Cahill PA, Cummins PM.

Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1403-13. doi: 10.1152/ajpheart.00240.2008. Epub 2008 Jul 25.


Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells.

Kenny S, Duval C, Sammut SJ, Steele I, Pritchard DM, Atherton JC, Argent RH, Dimaline R, Dockray GJ, Varro A.

Am J Physiol Gastrointest Liver Physiol. 2008 Sep;295(3):G431-41. doi: 10.1152/ajpgi.90283.2008. Epub 2008 Jul 3.


Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms.

Basso D, Zambon CF, Letley DP, Stranges A, Marchet A, Rhead JL, Schiavon S, Guariso G, Ceroti M, Nitti D, Rugge M, Plebani M, Atherton JC.

Gastroenterology. 2008 Jul;135(1):91-9. doi: 10.1053/j.gastro.2008.03.041. Epub 2008 Mar 25.


Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses.

Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, Zaitoun AM, Atherton JC.

Gut. 2008 Oct;57(10):1375-85. doi: 10.1136/gut.2007.137539. Epub 2008 May 8.


A case of dysphagia with clinically isolated syndrome.

Edwards LJ, Atherton JC, Zaitoun AM, Constantinescu CS.

Mult Scler. 2008 Jun;14(5):716-7. doi: 10.1177/1352458507087325. Epub 2008 Apr 18. No abstract available.


Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families.

Argent RH, Thomas RJ, Aviles-Jimenez F, Letley DP, Limb MC, El-Omar EM, Atherton JC.

Clin Cancer Res. 2008 Apr 1;14(7):2227-35. doi: 10.1158/1078-0432.CCR-07-2022.


Differences in virulence markers between Helicobacter pylori strains from Iraq and those from Iran: potential importance of regional differences in H. pylori-associated disease.

Hussein NR, Mohammadi M, Talebkhan Y, Doraghi M, Letley DP, Muhammad MK, Argent RH, Atherton JC.

J Clin Microbiol. 2008 May;46(5):1774-9. doi: 10.1128/JCM.01737-07. Epub 2008 Mar 19.


The highly repetitive region of the Helicobacter pylori CagY protein comprises tandem arrays of an alpha-helical repeat module.

Delahay RM, Balkwill GD, Bunting KA, Edwards W, Atherton JC, Searle MS.

J Mol Biol. 2008 Mar 28;377(3):956-71. doi: 10.1016/j.jmb.2008.01.053. Epub 2008 Jan 31.


Functional association between the Helicobacter pylori virulence factors VacA and CagA.

Argent RH, Thomas RJ, Letley DP, Rittig MG, Hardie KR, Atherton JC.

J Med Microbiol. 2008 Feb;57(Pt 2):145-50. doi: 10.1099/jmm.0.47465-0.


The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases.

Atherton JC.

Annu Rev Pathol. 2006;1:63-96. Review.


The presence of dupA in Helicobacter pylori is not significantly associated with duodenal ulceration in Belgium, South Africa, China, or North America.

Argent RH, Burette A, Miendje Deyi VY, Atherton JC.

Clin Infect Dis. 2007 Nov 1;45(9):1204-6. Epub 2007 Sep 21.


A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer.

Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, Eshagh Hosseini M, Atherton JC.

Gastroenterology. 2007 Sep;133(3):926-36. Epub 2007 Jul 3.


The effect of different strains of Helicobacter pylori on platelet aggregation.

Corcoran PA, Atherton JC, Kerrigan SW, Wadstrom T, Murray FE, Peek RM, Fitzgerald DJ, Cox DM, Byrne MF.

Can J Gastroenterol. 2007 Jun;21(6):367-70.


Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.

Reyes-Leon A, Atherton JC, Argent RH, Puente JL, Torres J.

Infect Immun. 2007 Jul;75(7):3445-54. Epub 2007 Apr 16.


The inflammatory and immune response to Helicobacter pylori infection.

Robinson K, Argent RH, Atherton JC.

Best Pract Res Clin Gastroenterol. 2007;21(2):237-59. Review.


Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.

Salama NR, Gonzalez-Valencia G, Deatherage B, Aviles-Jimenez F, Atherton JC, Graham DY, Torres J.

J Bacteriol. 2007 May;189(10):3834-45. Epub 2007 Mar 2.


Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.

Oliveira MJ, Costa AC, Costa AM, Henriques L, Suriano G, Atherton JC, Machado JC, Carneiro F, Seruca R, Mareel M, Leroy A, Figueiredo C.

J Biol Chem. 2006 Nov 17;281(46):34888-96. Epub 2006 Sep 21.


Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management.

Du MQ, Atherton JC.

Gut. 2006 Jun;55(6):886-93. Review. No abstract available.


Effects of Helicobacter pylori on the cadherin-catenin complex.

Bebb JR, Leach L, Zaitoun A, Hand N, Letley DP, Thomas R, Atherton JC.

J Clin Pathol. 2006 Dec;59(12):1261-6. Epub 2006 May 5.


Paired cysteine residues are required for high levels of the Helicobacter pylori autotransporter VacA.

Letley DP, Rhead JL, Bishop K, Atherton JC.

Microbiology. 2006 May;152(Pt 5):1319-25.


Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.

Boughan PK, Argent RH, Body-Malapel M, Park JH, Ewings KE, Bowie AG, Ong SJ, Cook SJ, Sorensen OE, Manzo BA, Inohara N, Klein NJ, Nuñez G, Atherton JC, Bajaj-Elliott M.

J Biol Chem. 2006 Apr 28;281(17):11637-48. Epub 2006 Mar 2.


Can peptic ulcers be healed with 7 days of proton-pump-inhibitor-based triple therapy?

Atherton JC.

Nat Clin Pract Gastroenterol Hepatol. 2005 Aug;2(8):346-7. No abstract available.


All subtypes of the cytotoxin VacA adsorb to the surface of Helicobacter pylori post-secretion.

Fitchen N, Letley DP, O'Shea P, Atherton JC, Williams P, Hardie KR.

J Med Microbiol. 2005 Jul;54(Pt 7):621-630. doi: 10.1099/jmm.0.45946-0.


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