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Items: 1 to 50 of 70

1.

Ultra-soft X-ray system for imaging the early cellular responses to X-ray induced DNA damage.

Kochan JA, van den Belt M, von der Lippe J, Desclos ECB, Steurer B, Hoebe RA, Scutigliani EM, Verhoeven J, Stap J, Bosch R, Rijpkema M, van Oven C, van Veen HA, Stellingwerf I, Vriend LEM, Marteijn JA, Aten JA, Krawczyk PM.

Nucleic Acids Res. 2019 Sep 26;47(17):e100. doi: 10.1093/nar/gkz609.

2.

Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining.

Bergs JW, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJ, Kanaar R, Aten JA, Franken NA.

DNA Repair (Amst). 2013 Jan 1;12(1):38-45. doi: 10.1016/j.dnarep.2012.10.008. Epub 2012 Dec 11.

PMID:
23237939
3.

Chromatin mobility is increased at sites of DNA double-strand breaks.

Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NA, Aten JA.

J Cell Sci. 2012 May 1;125(Pt 9):2127-33. doi: 10.1242/jcs.089847. Epub 2012 Feb 10.

4.

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9851-6. doi: 10.1073/pnas.1101053108. Epub 2011 May 9.

5.

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma.

Mir SE, De Witt Hamer PC, Krawczyk PM, Balaj L, Claes A, Niers JM, Van Tilborg AA, Zwinderman AH, Geerts D, Kaspers GJ, Peter Vandertop W, Cloos J, Tannous BA, Wesseling P, Aten JA, Noske DP, Van Noorden CJ, Würdinger T.

Cancer Cell. 2010 Sep 14;18(3):244-57. doi: 10.1016/j.ccr.2010.08.011.

6.

Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines.

Cate RT, Krawczyk P, Stap J, Aten JA, Franken NA.

Oncol Lett. 2010 Jul;1(4):765-769. Epub 2010 Jul 1.

7.

An ultrasoft X-ray multi-microbeam irradiation system for studies of DNA damage responses by fixed- and live-cell fluorescence microscopy.

van Oven C, Krawczyk PM, Stap J, Melo AM, Piazzetta MH, Gobbi AL, van Veen HA, Verhoeven J, Aten JA.

Eur Biophys J. 2009 Jul;38(6):721-8. doi: 10.1007/s00249-009-0472-7. Epub 2009 Jun 3.

8.

Heterochromatin protein 1 is recruited to various types of DNA damage.

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.

J Cell Biol. 2009 May 18;185(4):577-86. doi: 10.1083/jcb.200810035.

9.

Analysis of the mobility of DNA double-strand break-containing chromosome domains in living mammalian cells.

Krawczyk PM, Stap J, Hoebe RA, van Oven CH, Kanaar R, Aten JA.

Methods Mol Biol. 2008;463:309-20. doi: 10.1007/978-1-59745-406-3_19.

PMID:
18951175
10.

Advanced preparative techniques to establish probes for molecular cytogenetics.

Stap J, Aten JA, Lillington D, Shelling A, Young BD.

Curr Protoc Cytom. 2001 May;Chapter 8:Unit 8.6. doi: 10.1002/0471142956.cy0806s05.

PMID:
18770744
11.

Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cells.

Stap J, Krawczyk PM, Van Oven CH, Barendsen GW, Essers J, Kanaar R, Aten JA.

Nat Methods. 2008 Mar;5(3):261-6. doi: 10.1038/nmeth.f.206.

PMID:
18309310
12.

Polyglutamine expansion accelerates the dynamics of ataxin-1 and does not result in aggregate formation.

Krol HA, Krawczyk PM, Bosch KS, Aten JA, Hol EM, Reits EA.

PLoS One. 2008 Jan 30;3(1):e1503. doi: 10.1371/journal.pone.0001503.

13.

DNA double-strand breaks are not sufficient to initiate recruitment of TRF2.

Williams ES, Stap J, Essers J, Ponnaiya B, Luijsterburg MS, Krawczyk PM, Ullrich RL, Aten JA, Bailey SM.

Nat Genet. 2007 Jun;39(6):696-8; author reply 698-9. No abstract available.

PMID:
17534357
14.

Clustering of double strand break-containing chromosome domains is not inhibited by inactivation of major repair proteins.

Krawczyk PM, Stap J, van Oven C, Hoebe R, Aten JA.

Radiat Prot Dosimetry. 2006;122(1-4):150-3. Epub 2007 Jan 17.

PMID:
17229782
15.

Mitochondrial PO2 measured by delayed fluorescence of endogenous protoporphyrin IX.

Mik EG, Stap J, Sinaasappel M, Beek JF, Aten JA, van Leeuwen TG, Ince C.

Nat Methods. 2006 Nov;3(11):939-45.

PMID:
17060918
16.

Chromosomal organization: mingling with the neighbors.

Aten JA, Kanaar R.

PLoS Biol. 2006 May;4(5):e155. Epub 2006 May 16. No abstract available.

17.

Induction and detection of bystander effects after combined treatment of cells with 5-bromo-2'-deoxyurine, Hoechst 33 258 and ultraviolet A light.

Xiao Y, de Feyter E, Van Oven CH, Stap J, Hoebe R, Havenith S, Van Noorden CJ, Aten JA.

Int J Radiat Biol. 2004 Feb;80(2):105-14.

PMID:
15164792
18.

Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.

Aten JA, Stap J, Krawczyk PM, van Oven CH, Hoebe RA, Essers J, Kanaar R.

Science. 2004 Jan 2;303(5654):92-5.

19.

Induction of chromosome aberrations in unirradiated chromatin after partial irradiation of a cell nucleus.

Ludwików G, Xiao Y, Hoebe RA, Franken NA, Darroudi F, Stap J, Van Oven CH, Van Noorden CJ, Aten JA.

Int J Radiat Biol. 2002 Apr;78(4):239-47.

PMID:
12020435
20.

A method for the selective irradiation of part of a genome.

Ludwików G, Hoebe RA, Franken NA, van Oven CH, Stap J, Aten JA.

Acta Oncol. 2000;39(6):693-8.

PMID:
11130006
21.

Fine structural in situ analysis of nascent DNA movement following DNA replication.

Jaunin F, Visser AE, Cmarko D, Aten JA, Fakan S.

Exp Cell Res. 2000 Nov 1;260(2):313-23.

PMID:
11035926
22.

High resolution analysis of interphase chromosome domains.

Visser AE, Jaunin F, Fakan S, Aten JA.

J Cell Sci. 2000 Jul;113 ( Pt 14):2585-93.

23.
24.

Difference in sperm head volume as a theoretical basis for sorting X- and Y-bearing spermatozoa: potentials and limitations.

van Munster EB, Stap J, Hoebe RA, te Meerman GJ, Aten JA.

Theriogenology. 1999 Dec;52(8):1281-93.

PMID:
10735076
25.

Difference in volume of X- and Y-chromosome-bearing bovine sperm heads matches difference in DNA content.

van Munster EB, Stap J, Hoebe RA, te Meerman GJ, Aten JA.

Cytometry. 1999 Feb 1;35(2):125-8.

26.
28.

Spatial distributions of early and late replicating chromatin in interphase chromosome territories.

Visser AE, Eils R, Jauch A, Little G, Bakker PJ, Cremer T, Aten JA.

Exp Cell Res. 1998 Sep 15;243(2):398-407.

PMID:
9743599
29.
30.
31.
32.

Mapping of DNA replication sites in situ by fluorescence microscopy.

van Driel R, Manders EM, de Jong L, Stap J, Aten JA.

Methods Cell Biol. 1998;53:455-69. Review. No abstract available.

PMID:
9348520
33.

Dynamic behavior of DNA replication domains.

Manders EM, Stap J, Strackee J, van Driel R, Aten JA.

Exp Cell Res. 1996 Aug 1;226(2):328-35.

PMID:
8806436
34.

Largest contour segmentation: a tool for the localization of spots in confocal images.

Manders EM, Hoebe R, Strackee J, Vossepoel AM, Aten JA.

Cytometry. 1996 Jan 1;23(1):15-21.

35.

RNA polymerase II transcription is concentrated outside replication domains throughout S-phase.

Wansink DG, Manders EE, van der Kraan I, Aten JA, van Driel R, de Jong L.

J Cell Sci. 1994 Jun;107 ( Pt 6):1449-56.

36.

Flow cytometric detection of chromosome abnormalities by measuring centromeric index, DNA content, and DNA base composition.

Rens W, Boschman GA, Hoovers JM, Manders EM, Slater RM, Stap J, Aten JA.

Anal Cell Pathol. 1994 May;6(4):359-75.

PMID:
8060891
37.
38.

Construction of mouse chromosome-specific DNA libraries and their use for the detection of X-ray-induced aberrations.

Boei JJ, Balajee AS, de Boer P, Rens W, Aten JA, Mullenders LH, Natarajan AT.

Int J Radiat Biol. 1994 May;65(5):583-90.

PMID:
7910197
39.

Application and detection of IdUrd and CldUrd as two independent cell-cycle markers.

Aten JA, Stap J, Hoebe R, Bakker PJ.

Methods Cell Biol. 1994;41:317-26. Review. No abstract available.

PMID:
7861969
40.

Time-optimized analysis of slit-scan chromosome profiles on a general-purpose personal computer.

Heilig R, Hausmann M, Rens W, Aten JA, Cremer C.

Comput Appl Biosci. 1993 Aug;9(4):381-5.

PMID:
8402203
41.
42.

Micronuclei expression in tumors as a test for radiation sensitivity.

Bakker PJ, Tukker LJ, Stap J, Veenhof CH, Aten JA.

Radiother Oncol. 1993 Jan;26(1):69-72.

PMID:
8438089
43.

Identification of a tumor marker chromosome by flow sorting, DNA amplification in vitro, and in situ hybridization of the amplified product.

Boschman GA, Buys CH, van der Veen AY, Rens W, Osinga J, Slater RM, Aten JA.

Genes Chromosomes Cancer. 1993 Jan;6(1):10-6.

PMID:
7680216
44.

Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopy.

Manders EM, Stap J, Brakenhoff GJ, van Driel R, Aten JA.

J Cell Sci. 1992 Nov;103 ( Pt 3):857-62.

45.

Detection of recurrent chromosome abnormalities in Ewing's sarcoma and peripheral neuroectodermal tumor cells using bivariate flow karyotyping.

Boschman GA, Rens W, Manders EM, Slater RM, Versteeg R, Aten JA.

Genes Chromosomes Cancer. 1992 Nov;5(4):375-84.

PMID:
1283326
46.

DNA double labelling with IdUrd and CldUrd for spatial and temporal analysis of cell proliferation and DNA replication.

Aten JA, Bakker PJ, Stap J, Boschman GA, Veenhof CH.

Histochem J. 1992 May;24(5):251-9.

PMID:
1376726
47.

Semi-automated detection of aberrant chromosomes in bivariate flow karyotypes.

Boschman GA, Manders EM, Rens W, Slater R, Aten JA.

Cytometry. 1992;13(5):469-77.

48.

Trichobilharzia ocellata in Lymnaea stagnalis: a flow cytometric approach to study its effects on hemocytes.

Amen RI, Aten JA, Baggen JM, Meuleman EA, de Lange-de Klerk ES, Sminia T.

J Invertebr Pathol. 1992 Jan;59(1):95-8.

PMID:
1541851
49.
50.

Effect of aniosmotic media on the volume of the T-lymphocyte nucleus.

Hoekstra AG, Aten JA, Sloot PM.

Biophys J. 1991 Apr;59(4):765-74.

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