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Combined Pulmonary Fibrosis and Emphysema: Pulmonary Function Testing and a Pathophysiology Perspective.

Amariei DE, Dodia N, Deepak J, Hines SE, Galvin JR, Atamas SP, Todd NW.

Medicina (Kaunas). 2019 Sep 10;55(9). pii: E580. doi: 10.3390/medicina55090580. Review.


An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13.

Al-Mutairy EA, Imtiaz FA, Khalid M, Al Qattan S, Saleh S, Mahmoud LM, Al-Saif MM, Al-Haj L, Al-Enazi A, AlJebreen AM, Mohammed SF, Mobeireek AF, Alkattan K, Chisti MA, Luzina IG, Al-Owain M, Weheba I, Abdelsayed AM, Ramzan K, Janssen LJ, Conca W, Alaiya A, Collison KS, Meyer BF, Atamas SP, Khabar KS, Hasday JD, Al-Mohanna F.

Eur Respir J. 2019 Jul 18;54(1). pii: 1802041. doi: 10.1183/13993003.02041-2018. Print 2019 Jul.


Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation.

Luzina IG, Clerman A, Fishelevich R, Todd NW, Lockatell V, Atamas SP.

Cytokine. 2019 Jul;119:1-6. doi: 10.1016/j.cyto.2019.02.015. Epub 2019 Mar 8.


Interstitial Lung Disease and Pulmonary Fibrosis: A Practical Approach for General Medicine Physicians with Focus on the Medical History.

Kalchiem-Dekel O, Galvin JR, Burke AP, Atamas SP, Todd NW.

J Clin Med. 2018 Nov 24;7(12). pii: E476. doi: 10.3390/jcm7120476. Review.


Neuraminidase 1-mediated desialylation of the mucin 1 ectodomain releases a decoy receptor that protects against Pseudomonas aeruginosa lung infection.

Lillehoj EP, Guang W, Hyun SW, Liu A, Hegerle N, Simon R, Cross AS, Ishida H, Luzina IG, Atamas SP, Goldblum SE.

J Biol Chem. 2019 Jan 11;294(2):662-678. doi: 10.1074/jbc.RA118.006022. Epub 2018 Nov 14.


MMP28 in Idiopathic Pulmonary Fibrosis: Beyond the Extracellular Matrix.

Atamas SP.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):5-6. doi: 10.1165/rcmb.2018-0038ED. No abstract available.


Sirtuins and Accelerated Aging in Scleroderma.

Wyman AE, Atamas SP.

Curr Rheumatol Rep. 2018 Mar 17;20(4):16. doi: 10.1007/s11926-018-0724-6. Review.


Transcriptomic evidence of immune activation in macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis.

Luzina IG, Salcedo MV, Rojas-Peña ML, Wyman AE, Galvin JR, Sachdeva A, Clerman A, Kim J, Franks TJ, Britt EJ, Hasday JD, Pham SM, Burke AP, Todd NW, Atamas SP.

Cell Immunol. 2018 Mar;325:1-13. doi: 10.1016/j.cellimm.2018.01.002. Epub 2018 Jan 3.


The full-length interleukin-33 (FLIL33)-importin-5 interaction does not regulate nuclear localization of FLIL33 but controls its intracellular degradation.

Clerman A, Noor Z, Fishelevich R, Lockatell V, Hampton BS, Shah NG, Salcedo MV, Todd NW, Atamas SP, Luzina IG.

J Biol Chem. 2017 Dec 29;292(52):21653-21661. doi: 10.1074/jbc.M117.807636. Epub 2017 Nov 10.


Vascular Endothelial Growth Factor in Idiopathic Pulmonary Fibrosis. An Imbalancing Act.

Atamas SP.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):409-411. doi: 10.1164/rccm.201703-0605ED. No abstract available.


Exposure to febrile-range hyperthermia potentiates Wnt signalling and epithelial-mesenchymal transition gene expression in lung epithelium.

Potla R, Tulapurkar ME, Luzina IG, Atamas SP, Singh IS, Hasday JD.

Int J Hyperthermia. 2018 Feb;34(1):1-10. doi: 10.1080/02656736.2017.1316875. Epub 2017 Apr 26.


Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.

Wyman AE, Noor Z, Fishelevich R, Lockatell V, Shah NG, Todd NW, Atamas SP.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L945-L958. doi: 10.1152/ajplung.00473.2016. Epub 2017 Apr 6.


Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.

Scheraga RG, Thompson C, Tulapurkar ME, Nagarsekar AC, Cowan M, Potla R, Sun J, Cai R, Logun C, Shelhamer J, Todd NW, Singh IS, Luzina IG, Atamas SP, Hasday JD.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L941-L955. doi: 10.1152/ajplung.00262.2016. Epub 2016 Sep 16.


Microscopic organizing pneumonia and cellular non-specific interstitial pneumonia are widespread in macroscopically normal-appearing lung tissue in idiopathic pulmonary fibrosis.

Todd NW, Galvin JR, Sachdeva A, Luzina IG, Atamas SP, Burke AP.

J Heart Lung Transplant. 2016 Nov;35(11):1367-1370. doi: 10.1016/j.healun.2016.07.014. Epub 2016 Jul 27. No abstract available.


The NEU1-selective sialidase inhibitor, C9-butyl-amide-DANA, blocks sialidase activity and NEU1-mediated bioactivities in human lung in vitro and murine lung in vivo.

Hyun SW, Liu A, Liu Z, Cross AS, Verceles AC, Magesh S, Kommagalla Y, Kona C, Ando H, Luzina IG, Atamas SP, Piepenbrink KH, Sundberg EJ, Guang W, Ishida H, Lillehoj EP, Goldblum SE.

Glycobiology. 2016 Aug;26(8):834-49. doi: 10.1093/glycob/cww060. Epub 2016 May 25.


Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis.

Luzina IG, Lockatell V, Hyun SW, Kopach P, Kang PH, Noor Z, Liu A, Lillehoj EP, Lee C, Miranda-Ribera A, Todd NW, Goldblum SE, Atamas SP.

Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L940-54. doi: 10.1152/ajplung.00346.2015. Epub 2016 Mar 18.


Organizing pneumonia/non-specific interstitial pneumonia overlap is associated with unfavorable lung disease progression.

Todd NW, Marciniak ET, Sachdeva A, Kligerman SJ, Galvin JR, Luzina IG, Atamas SP, Burke AP.

Respir Med. 2015 Nov;109(11):1460-8. doi: 10.1016/j.rmed.2015.09.015. Epub 2015 Oct 9.


Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis.

Luzina IG, Lockatell V, Todd NW, Kopach P, Pentikis HS, Atamas SP.

J Pharmacol Exp Ther. 2015 Oct;355(1):13-22. doi: 10.1124/jpet.115.224675. Epub 2015 Jul 24.


Permanent alveolar collapse is the predominant mechanism in idiopathic pulmonary fibrosis.

Todd NW, Atamas SP, Luzina IG, Galvin JR.

Expert Rev Respir Med. 2015 Aug;9(4):411-8. doi: 10.1586/17476348.2015.1067609. Epub 2015 Jul 11.


Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.

Potla R, Singh IS, Atamas SP, Hasday JD.

RNA. 2015 Jul;21(7):1261-73. doi: 10.1261/rna.049122.114. Epub 2015 May 27.


NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release.

Lillehoj EP, Hyun SW, Liu A, Guang W, Verceles AC, Luzina IG, Atamas SP, Kim KC, Goldblum SE.

J Biol Chem. 2015 Jul 24;290(30):18316-31. doi: 10.1074/jbc.M115.657114. Epub 2015 May 11.


The cytokines of pulmonary fibrosis: Much learned, much more to learn.

Luzina IG, Todd NW, Sundararajan S, Atamas SP.

Cytokine. 2015 Jul;74(1):88-100. doi: 10.1016/j.cyto.2014.11.008. Epub 2014 Dec 24. Review.


Human airway epithelia express catalytically active NEU3 sialidase.

Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Sun W, Luzina IG, Webb TJ, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE.

Am J Physiol Lung Cell Mol Physiol. 2014 May 1;306(9):L876-86. doi: 10.1152/ajplung.00322.2013. Epub 2014 Mar 21.


IFN-γ directly controls IL-33 protein level through a STAT1- and LMP2-dependent mechanism.

Kopach P, Lockatell V, Pickering EM, Haskell RE, Anderson RD, Hasday JD, Todd NW, Luzina IG, Atamas SP.

J Biol Chem. 2014 Apr 25;289(17):11829-43. doi: 10.1074/jbc.M113.534396. Epub 2014 Mar 11.


MyD88 mediates the decision to die by apoptosis or necroptosis after UV irradiation.

Harberts E, Fishelevich R, Liu J, Atamas SP, Gaspari AA.

Innate Immun. 2014 Jul;20(5):529-39. doi: 10.1177/1753425913501706. Epub 2013 Sep 18.


Interleukin-33 potentiates bleomycin-induced lung injury.

Luzina IG, Kopach P, Lockatell V, Kang PH, Nagarsekar A, Burke AP, Hasday JD, Todd NW, Atamas SP.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):999-1008. doi: 10.1165/rcmb.2013-0093OC.


Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis.

Todd NW, Scheraga RG, Galvin JR, Iacono AT, Britt EJ, Luzina IG, Burke AP, Atamas SP.

J Inflamm Res. 2013;6:63-70. doi: 10.2147/JIR.S40673. Epub 2013 Mar 27.


Cytokines in chronic respiratory diseases.

Atamas SP, Chapoval SP, Keegan AD.

F1000 Biol Rep. 2013;5:3. doi: 10.3410/B5-3. Epub 2013 Feb 1.


Non-local competition drives both rapid divergence and prolonged stasis in a model of speciation in populations with degenerate resource consumption.

Atamas N, Atamas MS, Atamas F, Atamas SP.

Theor Biol Med Model. 2012 Dec 27;9:56. doi: 10.1186/1742-4682-9-56.


Hyperthermia promotes and prevents respiratory epithelial apoptosis through distinct mechanisms.

Nagarsekar A, Tulapurkar ME, Singh IS, Atamas SP, Shah NG, Hasday JD.

Am J Respir Cell Mol Biol. 2012 Dec;47(6):824-33. doi: 10.1165/rcmb.2012-0105OC. Epub 2012 Sep 6.


Degeneracy allows for both apparent homogeneity and diversification in populations.

Whitacre JM, Atamas SP.

Biosystems. 2012 Oct;110(1):34-42. doi: 10.1016/j.biosystems.2012.08.003. Epub 2012 Aug 10.


Molecular and cellular mechanisms of pulmonary fibrosis.

Todd NW, Luzina IG, Atamas SP.

Fibrogenesis Tissue Repair. 2012 Jul 23;5(1):11. doi: 10.1186/1755-1536-5-11.


Regulation of inflammation by interleukin-4: a review of "alternatives".

Luzina IG, Keegan AD, Heller NM, Rook GA, Shea-Donohue T, Atamas SP.

J Leukoc Biol. 2012 Oct;92(4):753-64. doi: 10.1189/jlb.0412214. Epub 2012 Jul 10. Review.


Relief from within: a peptide therapy for fibrosis.

Atamas SP.

Sci Transl Med. 2012 May 30;4(136):136fs16. doi: 10.1126/scitranslmed.3004138.


Full-length IL-33 promotes inflammation but not Th2 response in vivo in an ST2-independent fashion.

Luzina IG, Pickering EM, Kopach P, Kang PH, Lockatell V, Todd NW, Papadimitriou JC, McKenzie AN, Atamas SP.

J Immunol. 2012 Jul 1;189(1):403-10. doi: 10.4049/jimmunol.1200259. Epub 2012 May 25.


NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not.

Cross AS, Hyun SW, Miranda-Ribera A, Feng C, Liu A, Nguyen C, Zhang L, Luzina IG, Atamas SP, Twaddell WS, Guang W, Lillehoj EP, Puché AC, Huang W, Wang LX, Passaniti A, Goldblum SE.

J Biol Chem. 2012 May 4;287(19):15966-80. doi: 10.1074/jbc.M112.346817. Epub 2012 Mar 8.


Targeted deletion of Jun/AP-1 in alveolar epithelial cells causes progressive emphysema and worsens cigarette smoke-induced lung inflammation.

Reddy NM, Vegiraju S, Irving A, Paun BC, Luzina IG, Atamas SP, Biswal S, Ana NA, Mitzner W, Reddy SP.

Am J Pathol. 2012 Feb;180(2):562-74. doi: 10.1016/j.ajpath.2011.10.029. Erratum in: Am J Pathol. 2017 Apr;187(4):936.


CCR6 is not necessary for functional effects of human CCL18 in a mouse model.

Luzina IG, Atamas SP.

Fibrogenesis Tissue Repair. 2012 Jan 18;5(1):2. doi: 10.1186/1755-1536-5-2.


Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma.

Luzina IG, Lockatell V, Lavania S, Pickering EM, Kang PH, Bashkatova YN, Andreev SM, Atamas SP.

Cytokine. 2012 Apr;58(1):20-6. doi: 10.1016/j.cyto.2011.12.017. Epub 2012 Jan 15.


NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.

Lillehoj EP, Hyun SW, Feng C, Zhang L, Liu A, Guang W, Nguyen C, Luzina IG, Atamas SP, Passaniti A, Twaddell WS, Puché AC, Wang LX, Cross AS, Goldblum SE.

J Biol Chem. 2012 Mar 9;287(11):8214-31. doi: 10.1074/jbc.M111.292888. Epub 2012 Jan 13.


Regulatory T cells and lung fibrosis: a good cell gone bad.

Atamas SP, Fontenot AP.

Am J Respir Crit Care Med. 2011 Dec 1;184(11):1224-6. doi: 10.1164/rccm.201108-1572ED. No abstract available.


Human foetal intestinal fibroblasts are hyper-responsive to lipopolysaccharide stimulation.

Okogbule-Wonodi AC, Li G, Anand B, Luzina IG, Atamas SP, Blanchard T.

Dig Liver Dis. 2012 Jan;44(1):18-23. doi: 10.1016/j.dld.2011.08.017. Epub 2011 Sep 28.


Survival in pulmonary fibrosis combined with emphysema: likely defined by characteristics of specific patient subpopulations.

Todd NW, Atamas SP.

Fibrogenesis Tissue Repair. 2011 Jul 25;4:17. doi: 10.1186/1755-1536-4-17.


Centrilobular emphysema combined with pulmonary fibrosis results in improved survival.

Todd NW, Jeudy J, Lavania S, Franks TJ, Galvin JR, Deepak J, Britt EJ, Atamas SP.

Fibrogenesis Tissue Repair. 2011 Feb 15;4(1):6. doi: 10.1186/1755-1536-4-6.


Alternatively spliced variants of interleukin-4 promote inflammation differentially.

Luzina IG, Lockatell V, Todd NW, Highsmith K, Keegan AD, Hasday JD, Atamas SP.

J Leukoc Biol. 2011 May;89(5):763-70. doi: 10.1189/jlb.0510271. Epub 2011 Feb 1.


Splice isoforms of human interleukin-4 are functionally active in mice in vivo.

Luzina IG, Lockatell V, Todd NW, Keegan AD, Hasday JD, Atamas SP.

Immunology. 2011 Mar;132(3):385-93. doi: 10.1111/j.1365-2567.2010.03393.x. Epub 2011 Jan 10.


Interleukins 4 and 13 modulate gene expression and promote proliferation of primary human tenocytes.

Courneya JP, Luzina IG, Zeller CB, Rasmussen JF, Bocharov A, Schon LC, Atamas SP.

Fibrogenesis Tissue Repair. 2010 Jun 10;3:9. doi: 10.1186/1755-1536-3-9.


Stimulation with type I collagen induces changes in gene expression in peripheral blood mononuclear cells from patients with diffuse cutaneous systemic sclerosis (scleroderma).

Atamas SP, Luzina IG, Ingels J, Choi J, Wong WK, Furst DE, Clements PJ; Investigators of the Oral Collagen Trial in Scleroderma, Postlethwaite AE.

Clin Exp Immunol. 2010 Sep;161(3):426-35. doi: 10.1111/j.1365-2249.2010.04189.x.


Variable prevalence of pulmonary hypertension in patients with advanced interstitial pneumonia.

Todd NW, Lavania S, Park MH, Iacono AT, Franks TJ, Galvin JR, Jeudy J, Britt EJ, Luzina IG, Hasday JD, Atamas SP.

J Heart Lung Transplant. 2010 Feb;29(2):188-94. doi: 10.1016/j.healun.2009.07.025.


Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes.

Luzina IG, Todd NW, Nacu N, Lockatell V, Choi J, Hummers LK, Atamas SP.

Arthritis Rheum. 2009 May;60(5):1530-9. doi: 10.1002/art.24435.

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