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Items: 36

1.

Phase-variable bacterial loci: how bacteria gamble to maximise fitness in changing environments.

Phillips ZN, Tram G, Seib KL, Atack JM.

Biochem Soc Trans. 2019 Aug 30;47(4):1131-1141. doi: 10.1042/BST20180633. Epub 2019 Jul 24. Review.

PMID:
31341035
2.
3.

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation.

Ng PSK, Day CJ, Atack JM, Hartley-Tassell LE, Winter LE, Marshanski T, Padler-Karavani V, Varki A, Barenkamp SJ, Apicella MA, Jennings MP.

MBio. 2019 May 7;10(3). pii: e00422-19. doi: 10.1128/mBio.00422-19.

4.

Phasevarions of bacterial pathogens - phase-variable epigenetic regulators evolving from restriction-modification systems.

Phillips ZN, Husna AU, Jennings MP, Seib KL, Atack JM.

Microbiology. 2019 Sep;165(9):917-928. doi: 10.1099/mic.0.000805. Epub 2019 Apr 17.

PMID:
30994440
5.

Analysis of Invasive Nontypeable Haemophilus influenzae Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes.

Phillips ZN, Brizuela C, Jennison AV, Staples M, Grimwood K, Seib KL, Jennings MP, Atack JM.

Infect Immun. 2019 Apr 23;87(5). pii: e00093-19. doi: 10.1128/IAI.00093-19. Print 2019 Mar.

6.

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Atack JM, Bakaletz LO, Jennings MP.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01500-18. doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.

7.

Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study.

Palmu AA, Ware RS, Lambert SB, Sarna M, Bialasiewicz S, Seib KL, Atack JM, Nissen MD, Grimwood K.

Pediatr Pulmonol. 2019 Mar;54(3):289-296. doi: 10.1002/ppul.24231. Epub 2019 Jan 4.

PMID:
30609299
8.

Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP.

Microbiol Resour Announc. 2018 Jul 19;7(2). pii: e00821-18. doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.

9.

Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.

10.

Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.

Atack JM, Weinert LA, Tucker AW, Husna AU, Wileman TM, F Hadjirin N, Hoa NT, Parkhill J, Maskell DJ, Blackall PJ, Jennings MP.

Nucleic Acids Res. 2018 Nov 30;46(21):11466-11476. doi: 10.1093/nar/gky913.

11.

Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO.

MBio. 2018 Sep 18;9(5). pii: e01682-18. doi: 10.1128/mBio.01682-18.

12.

The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):1103-1107. doi: 10.1016/j.bbrc.2018.06.126. Epub 2018 Jun 27.

13.

A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions.

Atack JM, Yang Y, Seib KL, Zhou Y, Jennings MP.

Nucleic Acids Res. 2018 Apr 20;46(7):3532-3542. doi: 10.1093/nar/gky192.

14.

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Atack JM, Tan A, Bakaletz LO, Jennings MP, Seib KL.

Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13. Review.

15.

The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO.

Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.

16.

The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.

Tan A, Atack JM, Jennings MP, Seib KL.

Front Immunol. 2016 Dec 12;7:586. doi: 10.3389/fimmu.2016.00586. eCollection 2016. Review.

17.

ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO.

J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.

18.

The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits.

VanWagoner TM, Atack JM, Nelson KL, Smith HK, Fox KL, Jennings MP, Stull TL, Smith AL.

Microb Pathog. 2016 Mar;92:60-67. doi: 10.1016/j.micpath.2015.12.006. Epub 2015 Dec 21.

19.

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.

20.

Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.

Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP.

J Infect Dis. 2015 Aug 15;212(4):645-53. doi: 10.1093/infdis/jiv103. Epub 2015 Feb 23.

21.

A random six-phase switch regulates pneumococcal virulence via global epigenetic changes.

Manso AS, Chai MH, Atack JM, Furi L, De Ste Croix M, Haigh R, Trappetti C, Ogunniyi AD, Shewell LK, Boitano M, Clark TA, Korlach J, Blades M, Mirkes E, Gorban AN, Paton JC, Jennings MP, Oggioni MR.

Nat Commun. 2014 Sep 30;5:5055. doi: 10.1038/ncomms6055.

22.

A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells.

Atack JM, Ibranovic I, Ong CL, Djoko KY, Chen NH, Vanden Hoven R, Jennings MP, Edwards JL, McEwan AG.

J Infect Dis. 2014 Oct 15;210(8):1311-8. doi: 10.1093/infdis/jiu230. Epub 2014 Apr 15.

23.

Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.

Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP.

PLoS One. 2014 Feb 28;9(2):e90505. doi: 10.1371/journal.pone.0090505. eCollection 2014.

24.

Distinct physiological roles for the two L-asparaginase isozymes of Escherichia coli.

Srikhanta YN, Atack JM, Beacham IR, Jennings MP.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):362-5. doi: 10.1016/j.bbrc.2013.05.066. Epub 2013 May 31.

PMID:
23726917
25.

Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria.

Atack JM, Srikhanta YN, Djoko KY, Welch JP, Hasri NH, Steichen CT, Vanden Hoven RN, Grimmond SM, Othman DS, Kappler U, Apicella MA, Jennings MP, Edwards JL, McEwan AG.

J Bacteriol. 2013 Jun;195(11):2632-41. doi: 10.1128/JB.02062-12. Epub 2013 Apr 5.

26.

The wonders of flap endonucleases: structure, function, mechanism and regulation.

Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B.

Subcell Biochem. 2012;62:301-26. doi: 10.1007/978-94-007-4572-8_16. Review.

27.

Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases.

Beddows A, Patel N, Finger LD, Atack JM, Williams DM, Grasby JA.

Chem Commun (Camb). 2012 Sep 14;48(71):8895-7. doi: 10.1039/c2cc33400c. Epub 2012 Jul 31.

PMID:
22850542
28.

Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA.

Nucleic Acids Res. 2012 May;40(10):4507-19. doi: 10.1093/nar/gks051. Epub 2012 Feb 8.

29.

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases.

Grasby JA, Finger LD, Tsutakawa SE, Atack JM, Tainer JA.

Trends Biochem Sci. 2012 Feb;37(2):74-84. doi: 10.1016/j.tibs.2011.10.003. Epub 2011 Nov 24. Review.

30.

Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions.

Tomlinson CG, Syson K, Sengerová B, Atack JM, Sayers JR, Swanson L, Tainer JA, Williams NH, Grasby JA.

J Biol Chem. 2011 Sep 2;286(35):30878-87. doi: 10.1074/jbc.M111.230391. Epub 2011 Jul 6.

31.

Brønsted analysis and rate-limiting steps for the T5 flap endonuclease catalyzed hydrolysis of exonucleolytic substrates.

Sengerová B, Tomlinson C, Atack JM, Williams R, Sayers JR, Williams NH, Grasby JA.

Biochemistry. 2010 Sep 21;49(37):8085-93. doi: 10.1021/bi100895j.

PMID:
20698567
32.

Substrate recognition and catalysis by flap endonucleases and related enzymes.

Tomlinson CG, Atack JM, Chapados B, Tainer JA, Grasby JA.

Biochem Soc Trans. 2010 Apr;38(2):433-7. doi: 10.1042/BST0380433. Review.

PMID:
20298197
33.

Oxidative stress in Campylobacter jejuni: responses, resistance and regulation.

Atack JM, Kelly DJ.

Future Microbiol. 2009 Aug;4(6):677-90. doi: 10.2217/fmb.09.44. Review.

PMID:
19659424
34.
35.

The Campylobacter jejuni thiol peroxidases Tpx and Bcp both contribute to aerotolerance and peroxide-mediated stress resistance but have distinct substrate specificities.

Atack JM, Harvey P, Jones MA, Kelly DJ.

J Bacteriol. 2008 Aug;190(15):5279-90. doi: 10.1128/JB.00100-08. Epub 2008 May 30.

36.

Structure, mechanism and physiological roles of bacterial cytochrome c peroxidases.

Atack JM, Kelly DJ.

Adv Microb Physiol. 2007;52:73-106. Review.

PMID:
17027371

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