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Items: 1 to 50 of 216

1.

DNA sequence repeats identify numerous Type I restriction-modification systems that are potential epigenetic regulators controlling phase-variable regulons; phasevarions.

Atack JM, Guo C, Yang L, Zhou Y, Jennings MP.

FASEB J. 2020 Jan;34(1):1038-1051. doi: 10.1096/fj.201901536RR. Epub 2019 Nov 28.

PMID:
31914596
2.

The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.

Blakeway LV, Tan A, Jurcisek JA, Bakaletz LO, Atack JM, Peak IR, Seib KL.

BMC Microbiol. 2019 Dec 9;19(1):276. doi: 10.1186/s12866-019-1660-y.

3.

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile.

Ward SE, Harries MH, Aldegheri L, Bradford AM, Ballini E, Dawson L, Lacroix L, Pardoe J, Starr K, Weil A, Waters K, Atack JR, Woolley M.

J Psychopharmacol. 2020 Jan;34(1):93-102. doi: 10.1177/0269881119872198. Epub 2019 Nov 26.

PMID:
31766938
4.

Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABAAR) Modulators Acting at the Benzodiazepine Binding Site: An Update.

Maramai S, Benchekroun M, Ward SE, Atack JR.

J Med Chem. 2019 Dec 5. doi: 10.1021/acs.jmedchem.9b01312. [Epub ahead of print]

PMID:
31738537
5.

Closed Complete Annotated Genome Sequences of Five Haemophilus influenzae Biogroup aegyptius Strains.

Phillips ZN, Tram G, Jennings MP, Atack JM.

Microbiol Resour Announc. 2019 Nov 7;8(45). pii: e01198-19. doi: 10.1128/MRA.01198-19.

6.
7.

Phase-variable bacterial loci: how bacteria gamble to maximise fitness in changing environments.

Phillips ZN, Tram G, Seib KL, Atack JM.

Biochem Soc Trans. 2019 Aug 30;47(4):1131-1141. doi: 10.1042/BST20180633. Epub 2019 Jul 24. Review.

PMID:
31341035
8.
9.

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation.

Ng PSK, Day CJ, Atack JM, Hartley-Tassell LE, Winter LE, Marshanski T, Padler-Karavani V, Varki A, Barenkamp SJ, Apicella MA, Jennings MP.

mBio. 2019 May 7;10(3). pii: e00422-19. doi: 10.1128/mBio.00422-19.

10.

The Molecular Basis for Apolipoprotein E4 as the Major Risk Factor for Late-Onset Alzheimer's Disease.

Raulin AC, Kraft L, Al-Hilaly YK, Xue WF, McGeehan JE, Atack JR, Serpell L.

J Mol Biol. 2019 May 31;431(12):2248-2265. doi: 10.1016/j.jmb.2019.04.019. Epub 2019 Apr 30.

11.

Phasevarions of bacterial pathogens - phase-variable epigenetic regulators evolving from restriction-modification systems.

Phillips ZN, Husna AU, Jennings MP, Seib KL, Atack JM.

Microbiology. 2019 Sep;165(9):917-928. doi: 10.1099/mic.0.000805. Epub 2019 Apr 17.

PMID:
30994440
12.

Analysis of Invasive Nontypeable Haemophilus influenzae Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes.

Phillips ZN, Brizuela C, Jennison AV, Staples M, Grimwood K, Seib KL, Jennings MP, Atack JM.

Infect Immun. 2019 Apr 23;87(5). pii: e00093-19. doi: 10.1128/IAI.00093-19. Print 2019 Mar.

13.

A Biophysical Approach to the Identification of Novel ApoE Chemical Probes.

Kraft L, Serpell LC, Atack JR.

Biomolecules. 2019 Jan 29;9(2). pii: E48. doi: 10.3390/biom9020048.

14.

High-Depth RNA-Seq Data Sets for Studying Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae.

Atack JM, Bakaletz LO, Jennings MP.

Microbiol Resour Announc. 2019 Jan 10;8(2). pii: e01500-18. doi: 10.1128/MRA.01500-18. eCollection 2019 Jan.

15.

Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study.

Palmu AA, Ware RS, Lambert SB, Sarna M, Bialasiewicz S, Seib KL, Atack JM, Nissen MD, Grimwood K.

Pediatr Pulmonol. 2019 Mar;54(3):289-296. doi: 10.1002/ppul.24231. Epub 2019 Jan 4.

PMID:
30609299
16.

Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP.

Microbiol Resour Announc. 2018 Jul 19;7(2). pii: e00821-18. doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.

17.

Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.

18.

Streptococcus suis contains multiple phase-variable methyltransferases that show a discrete lineage distribution.

Atack JM, Weinert LA, Tucker AW, Husna AU, Wileman TM, F Hadjirin N, Hoa NT, Parkhill J, Maskell DJ, Blackall PJ, Jennings MP.

Nucleic Acids Res. 2018 Nov 30;46(21):11466-11476. doi: 10.1093/nar/gky913.

19.

The X-ray structure of human calbindin-D28K: an improved model.

Noble JW, Almalki R, Roe SM, Wagner A, Duman R, Atack JR.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):1008-1014. doi: 10.1107/S2059798318011610. Epub 2018 Oct 2.

20.

Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.

Kraft L, Roe SM, Gill R, Atack JR.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):973-978. doi: 10.1107/S2059798318010380. Epub 2018 Oct 2.

PMID:
30289407
21.

Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae.

Brockman KL, Azzari PN, Branstool MT, Atack JM, Schulz BL, Jen FE, Jennings MP, Bakaletz LO.

mBio. 2018 Sep 18;9(5). pii: e01682-18. doi: 10.1128/mBio.01682-18.

22.

Combining Sanford Arylations on Benzodiazepines with the Nuisance Effect.

Khan R, Boonseng S, Kemmitt PD, Felix R, Coles SJ, Tizzard GJ, Williams G, Simmonds O, Harvey JL, Atack J, Cox H, Spencer J.

Adv Synth Catal. 2017 Sep 18;359(18):3261-3269. doi: 10.1002/adsc.201700626. Epub 2017 Aug 2.

23.

The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2-6 linked N-acetylneuraminic acid glycans.

Atack JM, Day CJ, Poole J, Brockman KL, Bakaletz LO, Barenkamp SJ, Jennings MP.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):1103-1107. doi: 10.1016/j.bbrc.2018.06.126. Epub 2018 Jun 27.

24.

Evidence That Sedative Effects of Benzodiazepines Involve Unexpected GABAA Receptor Subtypes: Quantitative Observation Studies in Rhesus Monkeys.

Duke AN, Meng Z, Platt DM, Atack JR, Dawson GR, Reynolds DS, Tiruveedhula VVNPB, Li G, Stephen MR, Sieghart W, Cook JM, Rowlett JK.

J Pharmacol Exp Ther. 2018 Jul;366(1):145-157. doi: 10.1124/jpet.118.249250. Epub 2018 May 2.

25.

A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions.

Atack JM, Yang Y, Seib KL, Zhou Y, Jennings MP.

Nucleic Acids Res. 2018 Apr 20;46(7):3532-3542. doi: 10.1093/nar/gky192.

26.

Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Atack JM, Tan A, Bakaletz LO, Jennings MP, Seib KL.

Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13. Review.

27.

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase.

West RA, O'Doherty OG, Askwith T, Atack J, Beswick P, Laverick J, Paradowski M, Pennicott LE, Rao SPS, Williams G, Ward SE.

Eur J Med Chem. 2017 Dec 1;141:676-689. doi: 10.1016/j.ejmech.2017.09.067. Epub 2017 Oct 6.

28.

The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils.

Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO.

Sci Rep. 2017 Jun 9;7(1):3161. doi: 10.1038/s41598-017-03552-9.

29.

The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.

Tan A, Atack JM, Jennings MP, Seib KL.

Front Immunol. 2016 Dec 12;7:586. doi: 10.3389/fimmu.2016.00586. eCollection 2016. Review.

30.

ModA2 Phasevarion Switching in Nontypeable Haemophilus influenzae Increases the Severity of Experimental Otitis Media.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz LO.

J Infect Dis. 2016 Sep 1;214(5):817-24. doi: 10.1093/infdis/jiw243. Epub 2016 Jun 10.

31.

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

Gaekens T, Guillaume M, Borghys H, De Zwart LL, de Vries R, Embrechts RC, Vermeulen A, Megens AA, Leysen JE, Herdewijn P, Annaert PP, Atack JR.

J Control Release. 2016 Jun 28;232:196-202. doi: 10.1016/j.jconrel.2016.04.029. Epub 2016 Apr 21.

PMID:
27107723
32.

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW.

Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20.

33.

The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits.

VanWagoner TM, Atack JM, Nelson KL, Smith HK, Fox KL, Jennings MP, Stull TL, Smith AL.

Microb Pathog. 2016 Mar;92:60-67. doi: 10.1016/j.micpath.2015.12.006. Epub 2015 Dec 21.

34.

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Brockman KL, Clark TA, Boitano M, Power PM, Jen FE, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP.

Nat Commun. 2015 Jul 28;6:7828. doi: 10.1038/ncomms8828.

35.

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor.

Spurny R, Debaveye S, Farinha A, Veys K, Vos AM, Gossas T, Atack J, Bertrand S, Bertrand D, Danielson UH, Tresadern G, Ulens C.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2543-52. doi: 10.1073/pnas.1418289112. Epub 2015 Apr 27.

36.

Selection and Counterselection of Hia Expression Reveals a Key Role for Phase-Variable Expression of Hia in Infection Caused by Nontypeable Haemophilus influenzae.

Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP.

J Infect Dis. 2015 Aug 15;212(4):645-53. doi: 10.1093/infdis/jiv103. Epub 2015 Feb 23.

37.

A random six-phase switch regulates pneumococcal virulence via global epigenetic changes.

Manso AS, Chai MH, Atack JM, Furi L, De Ste Croix M, Haigh R, Trappetti C, Ogunniyi AD, Shewell LK, Boitano M, Clark TA, Korlach J, Blades M, Mirkes E, Gorban AN, Paton JC, Jennings MP, Oggioni MR.

Nat Commun. 2014 Sep 30;5:5055. doi: 10.1038/ncomms6055.

38.

JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease.

Atack JR, Shook BC, Rassnick S, Jackson PF, Rhodes K, Drinkenburg WH, Ahnaou A, Te Riele P, Langlois X, Hrupka B, De Haes P, Hendrickx H, Aerts N, Hens K, Wellens A, Vermeire J, Megens AA.

ACS Chem Neurosci. 2014 Oct 15;5(10):1005-19. doi: 10.1021/cn5001606. Epub 2014 Sep 24.

PMID:
25203719
39.

A role for lactate dehydrogenases in the survival of Neisseria gonorrhoeae in human polymorphonuclear leukocytes and cervical epithelial cells.

Atack JM, Ibranovic I, Ong CL, Djoko KY, Chen NH, Vanden Hoven R, Jennings MP, Edwards JL, McEwan AG.

J Infect Dis. 2014 Oct 15;210(8):1311-8. doi: 10.1093/infdis/jiu230. Epub 2014 Apr 15.

40.

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S, Atack JR.

Anal Biochem. 2014 Jun 1;454:17-22. doi: 10.1016/j.ab.2014.03.004. Epub 2014 Mar 14.

41.

Selection for phase variation of LOS biosynthetic genes frequently occurs in progression of non-typeable Haemophilus influenzae infection from the nasopharynx to the middle ear of human patients.

Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP.

PLoS One. 2014 Feb 28;9(2):e90505. doi: 10.1371/journal.pone.0090505. eCollection 2014.

42.

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.

Lavreysen H, Langlois X, Ahnaou A, Drinkenburg W, te Riele P, Biesmans I, Van der Linden I, Peeters L, Megens A, Wintmolders C, Cid JM, Trabanco AA, Andrés JI, Dautzenberg FM, Lütjens R, Macdonald G, Atack JR.

J Pharmacol Exp Ther. 2013 Sep;346(3):514-27. doi: 10.1124/jpet.113.204990. Epub 2013 Jun 13.

PMID:
23766542
43.

Distinct physiological roles for the two L-asparaginase isozymes of Escherichia coli.

Srikhanta YN, Atack JM, Beacham IR, Jennings MP.

Biochem Biophys Res Commun. 2013 Jul 5;436(3):362-5. doi: 10.1016/j.bbrc.2013.05.066. Epub 2013 May 31.

PMID:
23726917
44.

Characterization of an ntrX mutant of Neisseria gonorrhoeae reveals a response regulator that controls expression of respiratory enzymes in oxidase-positive proteobacteria.

Atack JM, Srikhanta YN, Djoko KY, Welch JP, Hasri NH, Steichen CT, Vanden Hoven RN, Grimmond SM, Othman DS, Kappler U, Apicella MA, Jennings MP, Edwards JL, McEwan AG.

J Bacteriol. 2013 Jun;195(11):2632-41. doi: 10.1128/JB.02062-12. Epub 2013 Apr 5.

45.

Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys.

Shinday NM, Sawyer EK, Fischer BD, Platt DM, Licata SC, Atack JR, Dawson GR, Reynolds DS, Rowlett JK.

Neuropsychopharmacology. 2013 May;38(6):1006-14. doi: 10.1038/npp.2012.265. Epub 2012 Dec 27.

46.

The wonders of flap endonucleases: structure, function, mechanism and regulation.

Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B.

Subcell Biochem. 2012;62:301-26. doi: 10.1007/978-94-007-4572-8_16. Review.

47.

Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases.

Beddows A, Patel N, Finger LD, Atack JM, Williams DM, Grasby JA.

Chem Commun (Camb). 2012 Sep 14;48(71):8895-7. doi: 10.1039/c2cc33400c. Epub 2012 Jul 31.

PMID:
22850542
48.

GABA(A) Receptor Subtypes: Novel Targets for Novel Medicines.

Mirza NR, Atack J, Wafford K.

Adv Pharmacol Sci. 2012;2012:529861. doi: 10.1155/2012/529861. Epub 2012 Apr 18. No abstract available.

49.

Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia.

Langlois X, Megens A, Lavreysen H, Atack J, Cik M, te Riele P, Peeters L, Wouters R, Vermeire J, Hendrickx H, Macdonald G, De Bruyn M.

J Pharmacol Exp Ther. 2012 Jul;342(1):91-105. doi: 10.1124/jpet.111.190702. Epub 2012 Apr 6.

PMID:
22490380
50.

Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA.

Nucleic Acids Res. 2012 May;40(10):4507-19. doi: 10.1093/nar/gks051. Epub 2012 Feb 8.

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