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Items: 1 to 50 of 77

1.

New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation.

Kim J, Chen B, Bru JL, Huynh E, Momen M, Aswad DW.

PLoS One. 2018 Jun 1;13(6):e0198266. doi: 10.1371/journal.pone.0198266. eCollection 2018.

2.

Polymorphic Variants of Human Protein l-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability: IMPLICATIONS FOR THE ETIOLOGY OF NEUROLOGICAL DISORDERS AND COGNITIVE AGING.

Juang C, Chen B, Bru JL, Nguyen K, Huynh E, Momen M, Kim J, Aswad DW.

J Biol Chem. 2017 Mar 3;292(9):3656-3665. doi: 10.1074/jbc.M116.765222. Epub 2017 Jan 18.

3.

Isoaspartylation appears to trigger small cell lung cancer-associated autoimmunity against neuronal protein ELAVL4.

Pulido MA, DerHartunian MK, Qin Z, Chung EM, Kang DS, Woodham AW, Tsou JA, Klooster R, Akbari O, Wang L, Kast WM, Liu SV, Verschuuren JJGM, Aswad DW, Laird-Offringa IA.

J Neuroimmunol. 2016 Oct 15;299:70-78. doi: 10.1016/j.jneuroim.2016.09.002. Epub 2016 Sep 3.

4.

The D-isoAsp-25 variant of histone H2B is highly enriched in active chromatin: potential role in the regulation of gene expression?

Qin Z, Zhu JX, Aswad DW.

Amino Acids. 2016 Feb;48(2):599-603. doi: 10.1007/s00726-015-2140-9. Epub 2015 Dec 14.

5.

Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging.

Qin Z, Dimitrijevic A, Aswad DW.

Neurobiol Aging. 2015 Feb;36(2):1029-36. doi: 10.1016/j.neurobiolaging.2014.10.036. Epub 2014 Nov 4.

6.

Isoaspartyl formation in creatine kinase B is associated with loss of enzymatic activity; implications for the linkage of isoaspartate accumulation and neurological dysfunction in the PIMT knockout mouse.

Dimitrijevic A, Qin Z, Aswad DW.

PLoS One. 2014 Jun 23;9(6):e100622. doi: 10.1371/journal.pone.0100622. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116556.

7.

Isoaspartyl protein damage and repair in mouse retina.

Qin Z, Yang J, Klassen HJ, Aswad DW.

Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1572-9. doi: 10.1167/iovs.13-13668.

8.

Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.

Qin Z, Kaufman RS, Khoury RN, Khoury MK, Aswad DW.

PLoS One. 2013 Nov 5;8(11):e80758. doi: 10.1371/journal.pone.0080758. eCollection 2013.

9.

Autoimmunity to isomerized histone H2B in systemic lupus erythematosus.

Doyle HA, Aswad DW, Mamula MJ.

Autoimmunity. 2013 Feb;46(1):6-13. doi: 10.3109/08916934.2012.710859. Epub 2012 Dec 3.

10.

Considerations in the identification of endogenous substrates for protein L-isoaspartyl methyltransferase: the case of synuclein.

Morrison GJ, Ganesan R, Qin Z, Aswad DW.

PLoS One. 2012;7(8):e43288. doi: 10.1371/journal.pone.0043288. Epub 2012 Aug 14.

11.

Acquisition of chemiluminescent signals from immunoblots with a digital single-lens reflex camera.

Khoury MK, Parker I, Aswad DW.

Anal Biochem. 2010 Feb 1;397(1):129-31. doi: 10.1016/j.ab.2009.09.041. Epub 2009 Sep 27.

12.

Formation, localization, and repair of L-isoaspartyl sites in histones H2A and H2B in nucleosomes from rat liver and chicken erythrocytes.

Carter WG, Aswad DW.

Biochemistry. 2008 Oct 7;47(40):10757-64. doi: 10.1021/bi8013467. Epub 2008 Sep 17.

PMID:
18795804
13.

Selective cleavage of isoaspartyl peptide bonds by hydroxylamine after methyltransferase priming.

Zhu JX, Aswad DW.

Anal Biochem. 2007 May 1;364(1):1-7. Epub 2007 Feb 22.

14.

Intracellular protein modification associated with altered T cell functions in autoimmunity.

Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ.

J Immunol. 2006 Oct 1;177(7):4541-9. Erratum in: J Immunol. 2006 Dec 15;177(12):8878.

15.

Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain.

Zhu JX, Doyle HA, Mamula MJ, Aswad DW.

J Biol Chem. 2006 Nov 3;281(44):33802-13. Epub 2006 Sep 7.

16.

Synapsin I is a major endogenous substrate for protein L-isoaspartyl methyltransferase in mammalian brain.

Reissner KJ, Paranandi MV, Luc TM, Doyle HA, Mamula MJ, Lowenson JD, Aswad DW.

J Biol Chem. 2006 Mar 31;281(13):8389-98. Epub 2006 Jan 27.

17.

Protein L-isoaspartyl methyltransferase catalyzes in vivo racemization of Aspartate-25 in mammalian histone H2B.

Young GW, Hoofring SA, Mamula MJ, Doyle HA, Bunick GJ, Hu Y, Aswad DW.

J Biol Chem. 2005 Jul 15;280(28):26094-8. Epub 2005 May 20.

18.

Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals?

Reissner KJ, Aswad DW.

Cell Mol Life Sci. 2003 Jul;60(7):1281-95. Review.

PMID:
12943218
19.

Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase.

Li H, Park S, Kilburn B, Jelinek MA, Henschen-Edman A, Aswad DW, Stallcup MR, Laird-Offringa IA.

J Biol Chem. 2002 Nov 22;277(47):44623-30. Epub 2002 Sep 16.

20.

Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.

Ma H, Baumann CT, Li H, Strahl BD, Rice R, Jelinek MA, Aswad DW, Allis CD, Hager GL, Stallcup MR.

Curr Biol. 2001 Dec 11;11(24):1981-5.

21.

Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme.

Young AL, Carter WG, Doyle HA, Mamula MJ, Aswad DW.

J Biol Chem. 2001 Oct 5;276(40):37161-5. Epub 2001 Jul 30.

22.

Methylation of histone H3 by coactivator-associated arginine methyltransferase 1.

Schurter BT, Koh SS, Chen D, Bunick GJ, Harp JM, Hanson BL, Henschen-Edman A, Mackay DR, Stallcup MR, Aswad DW.

Biochemistry. 2001 May 15;40(19):5747-56.

PMID:
11341840
23.

Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activation.

Stallcup MR, Chen D, Koh SS, Ma H, Lee YH, Li H, Schurter BT, Aswad DW.

Biochem Soc Trans. 2000;28(4):415-8.

PMID:
10961931
24.

Analysis of isoaspartate in peptides and proteins without the use of radioisotopes.

Schurter BT, Aswad DW.

Anal Biochem. 2000 Jul 1;282(2):227-31.

PMID:
10873277
25.

Isoaspartate in peptides and proteins: formation, significance, and analysis.

Aswad DW, Paranandi MV, Schurter BT.

J Pharm Biomed Anal. 2000 Jan;21(6):1129-36.

PMID:
10708396
26.

The effect of urea exposure on isoaspartyl content and protein L-isoaspartate methyltransferase activity in Drosophila melanogaster.

David CL, Pierce VA, Aswad DW, Gibbs AG.

Comp Biochem Physiol B Biochem Mol Biol. 1999 Dec;124(4):423-7.

PMID:
10665370
27.

Regulation of transcription by a protein methyltransferase.

Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR.

Science. 1999 Jun 25;284(5423):2174-7.

28.

Isoaspartate in ribosomal protein S11 of Escherichia coli.

David CL, Keener J, Aswad DW.

J Bacteriol. 1999 May;181(9):2872-7.

29.

Isoaspartate in chrondroitin sulfate proteoglycans of mammalian brain.

David CL, Orpiszewski J, Zhu XC, Reissner KJ, Aswad DW.

J Biol Chem. 1998 Nov 27;273(48):32063-70.

30.

Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability.

David CL, Szumlanski CL, DeVry CG, Park-Hah JO, Clarke S, Weinshilboum RM, Aswad DW.

Arch Biochem Biophys. 1997 Oct 15;346(2):277-86.

PMID:
9343375
33.

Molecular aging of tubulin: accumulation of isoaspartyl sites in vitro and in vivo.

Najbauer J, Orpiszewski J, Aswad DW.

Biochemistry. 1996 Apr 23;35(16):5183-90.

PMID:
8611502
34.

Spontaneous alterations in the covalent structure of synapsin I during in vitro aging.

Paranandi MV, Aswad DW.

Biochem Biophys Res Commun. 1995 Jul 17;212(2):442-8.

PMID:
7626058
35.

Cloning, expression, and purification of rat brain protein L-isoaspartyl methyltransferase.

David CL, Aswad DW.

Protein Expr Purif. 1995 Jun;6(3):312-8.

PMID:
7663167
36.

Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate.

Shahrokh Z, Eberlein G, Buckley D, Paranandi MV, Aswad DW, Stratton P, Mischak R, Wang YJ.

Pharm Res. 1994 Jul;11(7):936-44.

PMID:
7937552
37.

Deamidation and isoaspartate formation during in vitro aging of recombinant tissue plasminogen activator.

Paranandi MV, Guzzetta AW, Hancock WS, Aswad DW.

J Biol Chem. 1994 Jan 7;269(1):243-53.

38.

Identification of a 59-kDa Substrate for cAMP-Dependent Protein Kinase That Is Enriched in Rat Cerebellar Membranes.

Rich RC, Aswad DW.

Mol Cell Neurosci. 1993 Dec;4(6):562-70. doi: 10.1006/mcne.1993.1069.

PMID:
19912964
41.
43.

The type II isoform of bovine brain protein L-isoaspartyl methyltransferase has an endoplasmic reticulum retention signal (...RDEL) at its C-terminus.

Potter SM, Johnson BA, Henschen A, Aswad DW, Guzzetta AW.

Biochemistry. 1992 Jul 14;31(27):6339-47.

PMID:
1627573
44.

Analysis of stable protein methylation in cultured cells.

Najbauer J, Johnson BA, Aswad DW.

Arch Biochem Biophys. 1992 Feb 14;293(1):85-92.

PMID:
1731643
45.

Amplification and detection of substrates for protein carboxyl methyltransferases in PC12 cells.

Najbauer J, Johnson BA, Aswad DW.

Anal Biochem. 1991 Sep 2;197(2):412-20.

PMID:
1785697
46.
48.

Protein L-isoaspartyl methyltransferase in postmortem brains of aged humans.

Johnson BA, Shirokawa JM, Geddes JW, Choi BH, Kim RC, Aswad DW.

Neurobiol Aging. 1991 Jan-Feb;12(1):19-24.

PMID:
2002878

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