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Items: 24


Pathogenic tau does not drive activation of the unfolded protein response.

Pitera AP, Asuni AA, O'Connor V, Deinhardt K.

J Biol Chem. 2019 May 3. pii: jbc.RA119.008263. doi: 10.1074/jbc.RA119.008263. [Epub ahead of print]


Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau.

Rosenqvist N, Asuni AA, Andersson CR, Christensen S, Daechsel JA, Egebjerg J, Falsig J, Helboe L, Jul P, Kartberg F, Pedersen LØ, Sigurdsson EM, Sotty F, Skjødt K, Stavenhagen JB, Volbracht C, Pedersen JT.

Alzheimers Dement (N Y). 2018 Oct 14;4:521-534. doi: 10.1016/j.trci.2018.09.005. eCollection 2018.


Antibody Engineering for Optimized Immunotherapy in Alzheimer's Disease.

Sumner IL, Edwards RA, Asuni AA, Teeling JL.

Front Neurosci. 2018 Apr 23;12:254. doi: 10.3389/fnins.2018.00254. eCollection 2018. Review.


Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models.

Clement A, Mitchelmore C, Andersson DR, Asuni AA.

Neuroscience. 2017 Jun 23;354:101-109. doi: 10.1016/j.neuroscience.2017.04.030. Epub 2017 Apr 28.


Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo.

Asuni AA, Guridi M, Sanchez S, Sadowski MJ.

Neurochem Int. 2015 Nov;90:152-65. doi: 10.1016/j.neuint.2015.08.006. Epub 2015 Aug 8.


Effect of amyloid-β (Aβ) immunization on hyperphosphorylated tau: a potential role for glycogen synthase kinase (GSK)-3β.

Amin J, Paquet C, Baker A, Asuni AA, Love S, Holmes C, Hugon J, Nicoll JA, Boche D.

Neuropathol Appl Neurobiol. 2015 Jun;41(4):445-57. doi: 10.1111/nan.12205.


Reply: To PMID 24687915.

Asuni AA, Pankiewicz JE, Sadowski MJ.

Ann Neurol. 2014 Oct;76(4):630-1. doi: 10.1002/ana.24253. Epub 2014 Sep 5. No abstract available.


Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.

Pankiewicz JE, Guridi M, Kim J, Asuni AA, Sanchez S, Sullivan PM, Holtzman DM, Sadowski MJ.

Acta Neuropathol Commun. 2014 Jun 28;2:75. doi: 10.1186/s40478-014-0075-0.


Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model.

Asuni AA, Guridi M, Pankiewicz JE, Sanchez S, Sadowski MJ.

Ann Neurol. 2014 May;75(5):684-99. doi: 10.1002/ana.24149. Epub 2014 Apr 28.


Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration.

Asuni AA, Gray B, Bailey J, Skipp P, Perry VH, O'Connor V.

J Biol Chem. 2014 Feb 14;289(7):4532-45. doi: 10.1074/jbc.M113.502690. Epub 2013 Dec 23.


Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration.

Kuszczyk MA, Sanchez S, Pankiewicz J, Kim J, Duszczyk M, Guridi M, Asuni AA, Sullivan PM, Holtzman DM, Sadowski MJ.

Am J Pathol. 2013 May;182(5):1750-68. doi: 10.1016/j.ajpath.2013.01.034. Epub 2013 Mar 13.


Differential molecular chaperone response associated with various mouse adapted scrapie strains.

Asuni AA, Pankiewicz JE, Sadowski MJ.

Neurosci Lett. 2013 Mar 22;538:26-31. doi: 10.1016/j.neulet.2013.01.027. Epub 2013 Jan 28.


Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease.

Asuni AA, Perry VH, O'Connor V.

Biochem Soc Trans. 2010 Apr;38(2):545-51. doi: 10.1042/BST0380545. Review.


Alpha-synuclein deficiency in the C57BL/6JOlaHsd strain does not modify disease progression in the ME7-model of prion disease.

Asuni AA, Hilton K, Siskova Z, Lunnon K, Reynolds R, Perry VH, O'Connor V.

Neuroscience. 2010 Feb 3;165(3):662-74. doi: 10.1016/j.neuroscience.2009.10.047. Epub 2009 Oct 30.


Unaltered SNARE complex formation in an in vivo model of prion disease.

Asuni AA, Cunningham C, Vigneswaran P, Perry VH, O'Connor V.

Brain Res. 2008 Oct 3;1233:1-7. doi: 10.1016/j.brainres.2008.07.083. Epub 2008 Jul 30.


Biochemical evidence for the differential association of metabotropic glutamate receptors within synaptic complexes.

Asuni AA, Lidwell K, O'Connor V.

Neurosci Lett. 2008 Oct 17;444(1):27-30. doi: 10.1016/j.neulet.2008.08.009. Epub 2008 Aug 8.


GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

Asuni AA, Hooper C, Reynolds CH, Lovestone S, Anderton BH, Killick R.

Eur J Neurosci. 2006 Dec;24(12):3387-92.


Vaccination of Alzheimer's model mice with Abeta derivative in alum adjuvant reduces Abeta burden without microhemorrhages.

Asuni AA, Boutajangout A, Scholtzova H, Knudsen E, Li YS, Quartermain D, Frangione B, Wisniewski T, Sigurdsson EM.

Eur J Neurosci. 2006 Nov;24(9):2530-42.


Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons.

Saha AR, Hill J, Utton MA, Asuni AA, Ackerley S, Grierson AJ, Miller CC, Davies AM, Buchman VL, Anderton BH, Hanger DP.

J Cell Sci. 2004 Mar 1;117(Pt 7):1017-24.


GSK-3beta inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila.

Mudher A, Shepherd D, Newman TA, Mildren P, Jukes JP, Squire A, Mears A, Drummond JA, Berg S, MacKay D, Asuni AA, Bhat R, Lovestone S.

Mol Psychiatry. 2004 May;9(5):522-30. Erratum in: Mol Psychiatry. 2004 Aug;9(8):812.


Efficient gene delivery to primary neuron cultures using a synthetic peptide vector system.

Collins L, Asuni AA, Anderton BH, Fabre JW.

J Neurosci Methods. 2003 May 30;125(1-2):113-20.


The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.

Utton MA, Connell J, Asuni AA, van Slegtenhorst M, Hutton M, de Silva R, Lees AJ, Miller CC, Anderton BH.

J Neurosci. 2002 Aug 1;22(15):6394-400.


Presenilin 1 independently regulates beta-catenin stability and transcriptional activity.

Killick R, Pollard CC, Asuni AA, Mudher AK, Richardson JC, Rupniak HT, Sheppard PW, Varndell IM, Brion JP, Levey AI, Levy OA, Vestling M, Cowburn R, Lovestone S, Anderton BH.

J Biol Chem. 2001 Dec 21;276(51):48554-61. Epub 2001 Oct 17.

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