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Items: 1 to 50 of 58

1.

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Jishage M, Yu X, Shi Y, Ganesan SJ, Chen WY, Sali A, Chait BT, Asturias FJ, Roeder RG.

Nat Struct Mol Biol. 2018 Sep;25(9):859-867. doi: 10.1038/s41594-018-0118-5. Epub 2018 Sep 6.

2.

Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses.

Yu X, Veesler D, Campbell MG, Barry ME, Asturias FJ, Barry MA, Reddy VS.

Sci Adv. 2017 May 10;3(5):e1602670. doi: 10.1126/sciadv.1602670. eCollection 2017 May.

3.

Mediator structure and rearrangements required for holoenzyme formation.

Tsai KL, Yu X, Gopalan S, Chao TC, Zhang Y, Florens L, Washburn MP, Murakami K, Conaway RC, Conaway JW, Asturias FJ.

Nature. 2017 Apr 13;544(7649):196-201. doi: 10.1038/nature21393. Epub 2017 Mar 1.

PMID:
28241144
4.

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme.

Sato S, Tomomori-Sato C, Tsai KL, Yu X, Sardiu M, Saraf A, Washburn MP, Florens L, Asturias FJ, Conaway RC, Conaway JW.

J Biol Chem. 2016 Dec 23;291(52):26886-26898. doi: 10.1074/jbc.M116.756098. Epub 2016 Nov 7.

5.

Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.

Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL.

Biochemistry. 2016 Jan 19;55(2):373-81. doi: 10.1021/acs.biochem.5b01207. Epub 2016 Jan 4.

6.

Structure of an RNA polymerase II preinitiation complex.

Murakami K, Tsai KL, Kalisman N, Bushnell DA, Asturias FJ, Kornberg RD.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13543-8. doi: 10.1073/pnas.1518255112. Epub 2015 Oct 19.

7.

Structure of a designed protein cage that self-assembles into a highly porous cube.

Lai YT, Reading E, Hura GL, Tsai KL, Laganowsky A, Asturias FJ, Tainer JA, Robinson CV, Yeates TO.

Nat Chem. 2014 Dec;6(12):1065-71. doi: 10.1038/nchem.2107. Epub 2014 Nov 10.

8.

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex.

Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ.

Cell. 2014 Jul 17;158(2):463. doi: 10.1016/j.cell.2014.06.036. Epub 2014 Jul 17. No abstract available.

9.

Subunit architecture and functional modular rearrangements of the transcriptional mediator complex.

Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ.

Cell. 2014 Jun 5;157(6):1430-44. doi: 10.1016/j.cell.2014.05.015. Epub 2014 May 29. Erratum in: Cell. 2014 Jul 17;158(2):463.

10.

Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.

Lai YT, Tsai KL, Sawaya MR, Asturias FJ, Yeates TO.

J Am Chem Soc. 2013 May 22;135(20):7738-43. doi: 10.1021/ja402277f. Epub 2013 May 8.

11.

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction.

Tsai KL, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, Asturias FJ.

Nat Struct Mol Biol. 2013 May;20(5):611-9. doi: 10.1038/nsmb.2549. Epub 2013 Apr 7.

12.

Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase.

Minnihan EC, Ando N, Brignole EJ, Olshansky L, Chittuluru J, Asturias FJ, Drennan CL, Nocera DG, Stubbe J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3835-40. doi: 10.1073/pnas.1220691110. Epub 2013 Feb 19.

13.

Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers.

Aye Y, Brignole EJ, Long MJ, Chittuluru J, Drennan CL, Asturias FJ, Stubbe J.

Chem Biol. 2012 Jul 27;19(7):799-805. doi: 10.1016/j.chembiol.2012.05.015.

14.

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Zimanyi CM, Ando N, Brignole EJ, Asturias FJ, Stubbe J, Drennan CL.

Structure. 2012 Aug 8;20(8):1374-83. doi: 10.1016/j.str.2012.05.009. Epub 2012 Jun 21.

15.

Interaction of the mediator head module with RNA polymerase II.

Cai G, Chaban YL, Imasaki T, Kovacs JA, Calero G, Penczek PA, Takagi Y, Asturias FJ.

Structure. 2012 May 9;20(5):899-910. doi: 10.1016/j.str.2012.02.023.

16.

Iterative stable alignment and clustering of 2D transmission electron microscope images.

Yang Z, Fang J, Chittuluru J, Asturias FJ, Penczek PA.

Structure. 2012 Feb 8;20(2):237-47. doi: 10.1016/j.str.2011.12.007.

17.

Subunit architecture of general transcription factor TFIIH.

Gibbons BJ, Brignole EJ, Azubel M, Murakami K, Voss NR, Bushnell DA, Asturias FJ, Kornberg RD.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1949-54. doi: 10.1073/pnas.1105266109. Epub 2012 Jan 20.

18.

Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase.

Ando N, Brignole EJ, Zimanyi CM, Funk MA, Yokoyama K, Asturias FJ, Stubbe J, Drennan CL.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21046-51. doi: 10.1073/pnas.1112715108. Epub 2011 Dec 12.

19.

A soluble α-synuclein construct forms a dynamic tetramer.

Wang W, Perovic I, Chittuluru J, Kaganovich A, Nguyen LT, Liao J, Auclair JR, Johnson D, Landeru A, Simorellis AK, Ju S, Cookson MR, Asturias FJ, Agar JN, Webb BN, Kang C, Ringe D, Petsko GA, Pochapsky TC, Hoang QQ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17797-802. doi: 10.1073/pnas.1113260108. Epub 2011 Oct 17.

20.

Structure and nucleosome interaction of the yeast NuA4 and Piccolo-NuA4 histone acetyltransferase complexes.

Chittuluru JR, Chaban Y, Monnet-Saksouk J, Carrozza MJ, Sapountzi V, Selleck W, Huang J, Utley RT, Cramet M, Allard S, Cai G, Workman JL, Fried MG, Tan S, Côté J, Asturias FJ.

Nat Struct Mol Biol. 2011 Oct 9;18(11):1196-203. doi: 10.1038/nsmb.2128.

21.

Architecture of the Mediator head module.

Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y.

Nature. 2011 Jul 3;475(7355):240-3. doi: 10.1038/nature10162.

22.

A TFIIH-associated mediator head is a basal factor of small nuclear spliced leader RNA gene transcription in early-diverged trypanosomes.

Lee JH, Cai G, Panigrahi AK, Dunham-Ems S, Nguyen TN, Radolf JD, Asturias FJ, Günzl A.

Mol Cell Biol. 2010 Dec;30(23):5502-13. doi: 10.1128/MCB.00966-10. Epub 2010 Sep 27.

23.

Complete structural model of Escherichia coli RNA polymerase from a hybrid approach.

Opalka N, Brown J, Lane WJ, Twist KA, Landick R, Asturias FJ, Darst SA.

PLoS Biol. 2010 Sep 14;8(9). pii: e1000483. doi: 10.1371/journal.pbio.1000483.

24.

Mediator head module structure and functional interactions.

Cai G, Imasaki T, Yamada K, Cardelli F, Takagi Y, Asturias FJ.

Nat Struct Mol Biol. 2010 Mar;17(3):273-9. doi: 10.1038/nsmb.1757. Epub 2010 Feb 14.

25.

TFIID: a closer look highlights its complexity.

Asturias FJ.

Structure. 2009 Nov 11;17(11):1423-4. doi: 10.1016/j.str.2009.10.004. No abstract available.

26.

Mediator structural conservation and implications for the regulation mechanism.

Cai G, Imasaki T, Takagi Y, Asturias FJ.

Structure. 2009 Apr 15;17(4):559-67. doi: 10.1016/j.str.2009.01.016.

27.

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs.

Shaikh TR, Gao H, Baxter WT, Asturias FJ, Boisset N, Leith A, Frank J.

Nat Protoc. 2008;3(12):1941-74. doi: 10.1038/nprot.2008.156.

28.

Conformational flexibility of metazoan fatty acid synthase enables catalysis.

Brignole EJ, Smith S, Asturias FJ.

Nat Struct Mol Biol. 2009 Feb;16(2):190-7. doi: 10.1038/nsmb.1532. Epub 2009 Jan 18.

29.

Structure of a RSC-nucleosome complex and insights into chromatin remodeling.

Chaban Y, Ezeokonkwo C, Chung WH, Zhang F, Kornberg RD, Maier-Davis B, Lorch Y, Asturias FJ.

Nat Struct Mol Biol. 2008 Dec;15(12):1272-7. doi: 10.1038/nsmb.1524. Epub 2008 Nov 23.

30.

Malleable machines take shape in eukaryotic transcriptional regulation.

Fuxreiter M, Tompa P, Simon I, Uversky VN, Hansen JC, Asturias FJ.

Nat Chem Biol. 2008 Dec;4(12):728-37. doi: 10.1038/nchembio.127. Review.

31.

Mammalian fatty acid synthase: X-ray structure of a molecular assembly line.

Asturias FJ.

ACS Chem Biol. 2006 Apr 25;1(3):135-8.

PMID:
17163658
32.

The parallelization of SPIDER on distributed-memory computers using MPI.

Yang C, Penczek PA, Leith A, Asturias FJ, Ng EG, Glaeser RM, Frank J.

J Struct Biol. 2007 Jan;157(1):240-9. Epub 2006 Jun 8.

PMID:
16859923
33.

Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.

Asturias FJ, Cheung IK, Sabouri N, Chilkova O, Wepplo D, Johansson E.

Nat Struct Mol Biol. 2006 Jan;13(1):35-43. Epub 2005 Dec 20.

PMID:
16369485
34.

Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Takagi Y, Chadick JZ, Davis JA, Asturias FJ.

J Biol Chem. 2005 Sep 2;280(35):31200-7. Epub 2005 Jul 6.

35.

Structure of eukaryotic Mediator complexes.

Chadick JZ, Asturias FJ.

Trends Biochem Sci. 2005 May;30(5):264-71. Review.

PMID:
15896745
36.

Structure and molecular organization of mammalian fatty acid synthase.

Asturias FJ, Chadick JZ, Cheung IK, Stark H, Witkowski A, Joshi AK, Smith S.

Nat Struct Mol Biol. 2005 Mar;12(3):225-32. Epub 2005 Feb 13.

PMID:
15711565
37.

Head-to-head coiled arrangement of the subunits of the animal fatty acid synthase.

Witkowski A, Ghosal A, Joshi AK, Witkowska HE, Asturias FJ, Smith S.

Chem Biol. 2004 Dec;11(12):1667-76.

38.

Another piece in the transcription initiation puzzle.

Asturias FJ.

Nat Struct Mol Biol. 2004 Nov;11(11):1031-3. No abstract available.

PMID:
15523475
39.

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD.

Mol Cell. 2004 Jun 4;14(5):553-7. No abstract available.

40.

RNA polymerase II structure, and organization of the preinitiation complex.

Asturias FJ.

Curr Opin Struct Biol. 2004 Apr;14(2):121-9. Review.

PMID:
15093825
41.

Electron microscopic analysis of the RSC chromatin remodeling complex.

Asturias FJ, Ezeokonkwo C, Kornberg RD, Lorch Y.

Methods Enzymol. 2004;376:48-62. Review. No abstract available.

PMID:
14975298
42.

RNA polymerase II/TFIIF structure and conserved organization of the initiation complex.

Chung WH, Craighead JL, Chang WH, Ezeokonkwo C, Bareket-Samish A, Kornberg RD, Asturias FJ.

Mol Cell. 2003 Oct;12(4):1003-13.

43.

RNA polymerase II at initiation.

Asturias FJ, Craighead JL.

Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6893-5. Epub 2003 Jun 2. No abstract available.

44.

Structural analysis of the RSC chromatin-remodeling complex.

Asturias FJ, Chung WH, Kornberg RD, Lorch Y.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13477-80. Epub 2002 Oct 4.

45.
46.

Structural organization of yeast and mammalian mediator complexes.

Dotson MR, Yuan CX, Roeder RG, Myers LC, Gustafsson CM, Jiang YW, Li Y, Kornberg RD, Asturias FJ.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14307-10.

47.

Protein crystallization on lipid layers and structure determination of the RNA polymerase II transcription initiation complex.

Asturias FJ, Kornberg RD.

J Biol Chem. 1999 Mar 12;274(11):6813-6. Review. No abstract available.

48.

Conserved structures of mediator and RNA polymerase II holoenzyme.

Asturias FJ, Jiang YW, Myers LC, Gustafsson CM, Kornberg RD.

Science. 1999 Feb 12;283(5404):985-7.

49.

Electron crystallography of yeast RNA polymerase II preserved in vitreous ice.

Asturias FJ, Chang W, Li Y, Kornberg RD.

Ultramicroscopy. 1998 Jan;70(3):133-43.

PMID:
9499590
50.

Two conformations of RNA polymerase II revealed by electron crystallography.

Asturias FJ, Meredith GD, Poglitsch CL, Kornberg RD.

J Mol Biol. 1997 Oct 3;272(4):536-40.

PMID:
9325110

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