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Items: 13


Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.

Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M.

Anesthesiology. 2010 Sep;113(3):600-9. doi: 10.1097/ALN.0b013e3181e89a77.


Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems.

Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M.

FASEB J. 2009 Aug;23(8):2735-40. doi: 10.1096/fj.09-129908. Epub 2009 Mar 30.


The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity.

Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M.

FASEB J. 2008 Dec;22(12):4109-16. doi: 10.1096/fj.08-113324. Epub 2008 Aug 15.


The connection between metal ion affinity and ligand affinity in integrin I domains.

Vorup-Jensen T, Waldron TT, Astrof N, Shimaoka M, Springer TA.

Biochim Biophys Acta. 2007 Sep;1774(9):1148-55. Epub 2007 Jul 12.


Importance of force linkage in mechanochemistry of adhesion receptors.

Astrof NS, Salas A, Shimaoka M, Chen J, Springer TA.

Biochemistry. 2006 Dec 19;45(50):15020-8.


AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.

Shimaoka M, Kim M, Cohen EH, Yang W, Astrof N, Peer D, Salas A, Ferrand A, Springer TA.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13991-6. Epub 2006 Sep 8.


Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

Jin M, Song G, Carman CV, Kim YS, Astrof NS, Shimaoka M, Wittrup DK, Springer TA.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5758-63. Epub 2006 Apr 4.


Multiple time scale backbone dynamics of homologous thermophilic and mesophilic ribonuclease HI enzymes.

Butterwick JA, Loria JP, Astrof NS, Kroenke CD, Cole R, Rance M, Palmer AG 3rd.

J Mol Biol. 2004 Jun 11;339(4):855-71.


Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.

Jaroniec CP, MacPhee CE, Astrof NS, Dobson CM, Griffin RG.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16748-53. Epub 2002 Dec 12.


Triple resonance solid state NMR experiments with reduced dimensionality evolution periods.

Astrof NS, Lyon CE, Griffin RG.

J Magn Reson. 2001 Oct;152(2):303-7.


Sensitivity-enhanced NMR of biological solids: dynamic nuclear polarization of Y21M fd bacteriophage and purple membrane.

Rosay M, Zeri AC, Astrof NS, Opella SJ, Herzfeld J, Griffin RG.

J Am Chem Soc. 2001 Feb 7;123(5):1010-1. No abstract available.


CO_H(N)CACB experiments for assigning backbone resonances in 13C/15N-labeled proteins.

Astrof N, Bracken C, Cavanagh J, Palmer AG 3rd.

J Biomol NMR. 1998 May;11(4):451-6.


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