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Items: 13


Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization.

Leung WH, Gay J, Martin U, Garrett TE, Horton HM, Certo MT, Blazar BR, Morgan RA, Gregory PD, Jarjour J, Astrakhan A.

JCI Insight. 2019 Apr 30;5. pii: 124430. doi: 10.1172/jci.insight.124430.


Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW.

Mol Ther Methods Clin Dev. 2018 Apr 5;9:347-357. doi: 10.1016/j.omtm.2018.04.002. eCollection 2018 Jun 15.


Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.

Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ.

Mol Ther Methods Clin Dev. 2017 Jan 10;4:192-203. doi: 10.1016/j.omtm.2016.12.008. eCollection 2017 Mar 17.


Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Romano Ibarra GS, Paul B, Sather BD, Younan PM, Sommer K, Kowalski JP, Hale M, Stoddard B, Jarjour J, Astrakhan A, Kiem HP, Rawlings DJ.

Mol Ther Nucleic Acids. 2016 Aug 23;5(8):e352. doi: 10.1038/mtna.2016.56.


Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ.

Sci Transl Med. 2015 Sep 30;7(307):307ra156. doi: 10.1126/scitranslmed.aac5530.


megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.

Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM.

Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26.


Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.

Astrakhan A, Sather BD, Ryu BY, Khim S, Singh S, Humblet-Baron S, Ochs HD, Miao CH, Rawlings DJ.

Blood. 2012 May 10;119(19):4395-407. doi: 10.1182/blood-2011-03-340711. Epub 2012 Mar 19.


Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.

Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ.

Mol Ther. 2011 Mar;19(3):515-25. doi: 10.1038/mt.2010.259. Epub 2010 Dec 7.


B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ.

Blood. 2010 Mar 18;115(11):2146-55. doi: 10.1182/blood-2009-09-241869. Epub 2010 Jan 21.


Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.

Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS.

Exp Hematol. 2009 Nov;37(11):1353-63. doi: 10.1016/j.exphem.2009.08.007. Epub 2009 Sep 3.


Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.

Astrakhan A, Ochs HD, Rawlings DJ.

J Immunol. 2009 Jun 15;182(12):7370-80. doi: 10.4049/jimmunol.0804256.


Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.

Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ.

Nat Immunol. 2007 May;8(5):522-31. Epub 2007 Apr 1. Erratum in: Nat Immunol. 2007 Jul;8(7):780.


Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.

Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ.

Blood. 2004 Sep 1;104(5):1281-90. Epub 2004 May 13.

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