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Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome.

Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE.

Neurobiol Dis. 2019 Oct 31;134:104616. doi: 10.1016/j.nbd.2019.104616. [Epub ahead of print]


Orexin-1 receptor signaling in ventral pallidum regulates motivation for the opioid remifentanil.

Mohammadkhani A, Fragale JE, Pantazis CB, Bowrey HE, James MH, Aston-Jones G.

J Neurosci. 2019 Oct 21. pii: 0255-19. doi: 10.1523/JNEUROSCI.0255-19.2019. [Epub ahead of print]


Persistent effects of the orexin-1 receptor antagonist SB-334867 on motivation for the fast acting opioid remifentanil.

Mohammadkhani A, James MH, Pantazis CB, Aston-Jones G.

Brain Res. 2019 Sep 14:146461. doi: 10.1016/j.brainres.2019.146461. [Epub ahead of print]


The number of lateral hypothalamus orexin/hypocretin neurons contributes to individual differences in cocaine demand.

Pantazis CB, James MH, Bentzley BS, Aston-Jones G.

Addict Biol. 2019 Jul 11:e12795. doi: 10.1111/adb.12795. [Epub ahead of print]


The role of orexin-1 receptor signaling in demand for the opioid fentanyl.

Fragale JE, Pantazis CB, James MH, Aston-Jones G.

Neuropsychopharmacology. 2019 Sep;44(10):1690-1697. doi: 10.1038/s41386-019-0420-x. Epub 2019 May 21.


The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.

Wiskerke J, James MH, Aston-Jones G.

Brain Res. 2019 Apr 16. pii: S0006-8993(19)30216-1. doi: 10.1016/j.brainres.2019.04.017. [Epub ahead of print]


Lateral septum inhibition reduces motivation for cocaine: Reversal by diazepam.

Pantazis CB, Aston-Jones G.

Addict Biol. 2019 Mar 21. doi: 10.1111/adb.12742. [Epub ahead of print]


DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting.

Cope ZA, Vazey EM, Floresco SB, Aston Jones GS.

Neurobiol Learn Mem. 2019 May;161:1-11. doi: 10.1016/j.nlm.2019.02.009. Epub 2019 Feb 22.


Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse.

Mahler SV, Brodnik ZD, Cox BM, Buchta WC, Bentzley BS, Quintanilla J, Cope ZA, Lin EC, Riedy MD, Scofield MD, Messinger J, Ruiz CM, Riegel AC, España RA, Aston-Jones G.

J Neurosci. 2019 Jan 16;39(3):503-518. doi: 10.1523/JNEUROSCI.0537-18.2018. Epub 2018 Nov 16.


Abnormal Locus Coeruleus Sleep Activity Alters Sleep Signatures of Memory Consolidation and Impairs Place Cell Stability and Spatial Memory.

Swift KM, Gross BA, Frazer MA, Bauer DS, Clark KJD, Vazey EM, Aston-Jones G, Li Y, Pickering AE, Sara SJ, Poe GR.

Curr Biol. 2018 Nov 19;28(22):3599-3609.e4. doi: 10.1016/j.cub.2018.09.054. Epub 2018 Nov 1.


Activation of lateral hypothalamic group III metabotropic glutamate receptors suppresses cocaine-seeking following abstinence and normalizes drug-associated increases in excitatory drive to orexin/hypocretin cells.

Yeoh JW, James MH, Adams CD, Bains JS, Sakurai T, Aston-Jones G, Graham BA, Dayas CV.

Neuropharmacology. 2019 Aug;154:22-33. doi: 10.1016/j.neuropharm.2018.09.033. Epub 2018 Sep 22.


Demand elasticity predicts addiction endophenotypes and the therapeutic efficacy of an orexin/hypocretin-1 receptor antagonist in rats.

James MH, Bowrey HE, Stopper CM, Aston-Jones G.

Eur J Neurosci. 2019 Aug;50(3):2602-2612. doi: 10.1111/ejn.14166. Epub 2018 Oct 14.


Phasic locus coeruleus activity regulates cortical encoding of salience information.

Vazey EM, Moorman DE, Aston-Jones G.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9439-E9448. doi: 10.1073/pnas.1803716115. Epub 2018 Sep 19.


Increased Number and Activity of a Lateral Subpopulation of Hypothalamic Orexin/Hypocretin Neurons Underlies the Expression of an Addicted State in Rats.

James MH, Stopper CM, Zimmer BA, Koll NE, Bowrey HE, Aston-Jones G.

Biol Psychiatry. 2019 Jun 1;85(11):925-935. doi: 10.1016/j.biopsych.2018.07.022. Epub 2018 Aug 7.


Activation of medial hypothalamic orexin neurons during a Go/No-Go task.

Freeman LR, Aston-Jones G.

Brain Res. 2018 Sep 1. pii: S0006-8993(18)30453-0. doi: 10.1016/j.brainres.2018.08.031. [Epub ahead of print]


Attenuated cocaine-seeking after oxytocin administration in male and female rats.

Kohtz AS, Lin B, Smith ME, Aston-Jones G.

Psychopharmacology (Berl). 2018 Jul;235(7):2051-2063. doi: 10.1007/s00213-018-4902-z. Epub 2018 Apr 18.


CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience.

Mahler SV, Aston-Jones G.

Neuropsychopharmacology. 2018 Apr;43(5):934-936. doi: 10.1038/npp.2017.299. Epub 2018 Feb 7. No abstract available.


Noradrenergic Regulation of Central Amygdala in Aversive Pavlovian-to-Instrumental Transfer.

Campese VD, Soroeta JM, Vazey EM, Aston-Jones G, LeDoux JE, Sears RM.

eNeuro. 2017 Oct 24;4(5). pii: ENEURO.0224-17.2017. doi: 10.1523/ENEURO.0224-17.2017. eCollection 2017 Sep-Oct.


Increased locus coeruleus tonic activity causes disengagement from a patch-foraging task.

Kane GA, Vazey EM, Wilson RC, Shenhav A, Daw ND, Aston-Jones G, Cohen JD.

Cogn Affect Behav Neurosci. 2017 Dec;17(6):1073-1083. doi: 10.3758/s13415-017-0531-y.


Dorsal Hippocampus Drives Context-Induced Cocaine Seeking via Inputs to Lateral Septum.

McGlinchey EM, Aston-Jones G.

Neuropsychopharmacology. 2018 Apr;43(5):987-1000. doi: 10.1038/npp.2017.144. Epub 2017 Jul 11.


New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway.

Bowrey HE, James MH, Aston-Jones G.

Depress Anxiety. 2017 Jul;34(7):588-595. doi: 10.1002/da.22635. Epub 2017 May 10. Review.


Dopamine terminals from the ventral tegmental area gate intrinsic inhibition in the prefrontal cortex.

Buchta WC, Mahler SV, Harlan B, Aston-Jones GS, Riegel AC.

Physiol Rep. 2017 Mar;5(6). pii: e13198. doi: 10.14814/phy2.13198.


Orexin/Hypocretin, Central Amygdala, and Escalation of Cocaine Intake.

James MH, Aston-Jones G.

Biol Psychiatry. 2017 Apr 1;81(7):552-553. doi: 10.1016/j.biopsych.2017.01.010. No abstract available.


Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.

Cox BM, Bentzley BS, Regen-Tuero H, See RE, Reichel CM, Aston-Jones G.

Biol Psychiatry. 2017 Jun 1;81(11):949-958. doi: 10.1016/j.biopsych.2016.11.011. Epub 2016 Dec 1.


A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

James MH, Mahler SV, Moorman DE, Aston-Jones G.

Curr Top Behav Neurosci. 2017;33:247-281. doi: 10.1007/7854_2016_57. Review.


Impact of gender on corticotropin-releasing factor and noradrenergic sensitivity in cocaine use disorder.

McRae-Clark AL, Cason AM, Kohtz AS, Moran Santa-Maria M, Aston-Jones G, Brady KT.

J Neurosci Res. 2017 Jan 2;95(1-2):320-327. doi: 10.1002/jnr.23860. Review.


Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.

Moorman DE, James MH, Kilroy EA, Aston-Jones G.

Brain Res. 2017 Jan 1;1654(Pt A):34-42. doi: 10.1016/j.brainres.2016.10.018. Epub 2016 Oct 19.


The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse.

James MH, Aston-Jones G.

Neuron. 2016 Oct 5;92(1):5-8. doi: 10.1016/j.neuron.2016.09.042.


Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking.

Augur IF, Wyckoff AR, Aston-Jones G, Kalivas PW, Peters J.

J Neurosci. 2016 Sep 28;36(39):10174-80. doi: 10.1523/JNEUROSCI.0773-16.2016. Epub 2016 Sep 28.


Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking.

McGlinchey EM, James MH, Mahler SV, Pantazis C, Aston-Jones G.

J Neurosci. 2016 Aug 17;36(33):8700-11. doi: 10.1523/JNEUROSCI.1291-15.2016.


Cocaine Seeking During Initial Abstinence Is Driven by Noradrenergic and Serotonergic Signaling in Hippocampus in a Sex-Dependent Manner.

Kohtz AS, Aston-Jones G.

Neuropsychopharmacology. 2017 Jan;42(2):408-418. doi: 10.1038/npp.2016.150. Epub 2016 Aug 12.


Role of Corticotropin Releasing Factor 1 Signaling in Cocaine Seeking during Early Extinction in Female and Male Rats.

Cason AM, Kohtz A, Aston-Jones G.

PLoS One. 2016 Jun 30;11(6):e0158577. doi: 10.1371/journal.pone.0158577. eCollection 2016.


Chronic methamphetamine self-administration alters cognitive flexibility in male rats.

Cox BM, Cope ZA, Parsegian A, Floresco SB, Aston-Jones G, See RE.

Psychopharmacology (Berl). 2016 Jun;233(12):2319-27. doi: 10.1007/s00213-016-4283-0. Epub 2016 Apr 2.


Locus coeruleus: From global projection system to adaptive regulation of behavior.

Aston-Jones G, Waterhouse B.

Brain Res. 2016 Aug 15;1645:75-8. doi: 10.1016/j.brainres.2016.03.001. Epub 2016 Mar 9. Review.


Inhibiting subthalamic nucleus decreases cocaine demand and relapse: therapeutic potential.

Bentzley BS, Aston-Jones G.

Addict Biol. 2017 Jul;22(4):946-957. doi: 10.1111/adb.12380. Epub 2016 Mar 3.


The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice.

Lopez MF, Moorman DE, Aston-Jones G, Becker HC.

Brain Res. 2016 Apr 1;1636:74-80. doi: 10.1016/j.brainres.2016.01.049. Epub 2016 Feb 4.


Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.

Moorman DE, James MH, Kilroy EA, Aston-Jones G.

Eur J Neurosci. 2016 Mar;43(5):710-20. doi: 10.1111/ejn.13170. Epub 2016 Feb 16.


Introduction to the special issue: "Role of corticostriatal circuits in addiction".

Aston-Jones G.

Brain Res. 2015 Dec 2;1628(Pt A):1. doi: 10.1016/j.brainres.2015.10.046. No abstract available.


Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil.

Porter-Stransky KA, Bentzley BS, Aston-Jones G.

Addict Biol. 2017 Mar;22(2):303-317. doi: 10.1111/adb.12323. Epub 2015 Nov 24.


Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal.

Kaufling J, Aston-Jones G.

J Neurosci. 2015 Jul 15;35(28):10290-303. doi: 10.1523/JNEUROSCI.0715-15.2015.


Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction.

Moorman DE, Aston-Jones G.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9472-7. doi: 10.1073/pnas.1507611112. Epub 2015 Jul 13.


Histologic validation of locus coeruleus MRI contrast in post-mortem tissue.

Keren NI, Taheri S, Vazey EM, Morgan PS, Granholm AC, Aston-Jones GS, Eckert MA.

Neuroimage. 2015 Jun;113:235-45. doi: 10.1016/j.neuroimage.2015.03.020. Epub 2015 Mar 17.


Orexin-1 receptor signaling increases motivation for cocaine-associated cues.

Bentzley BS, Aston-Jones G.

Eur J Neurosci. 2015 May;41(9):1149-56. doi: 10.1111/ejn.12866. Epub 2015 Mar 6.


Designer receptors enhance memory in a mouse model of Down syndrome.

Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC.

J Neurosci. 2015 Jan 28;35(4):1343-53. doi: 10.1523/JNEUROSCI.2658-14.2015.


Differential roles of medial prefrontal subregions in the regulation of drug seeking.

Moorman DE, James MH, McGlinchey EM, Aston-Jones G.

Brain Res. 2015 Dec 2;1628(Pt A):130-46. doi: 10.1016/j.brainres.2014.12.024. Epub 2014 Dec 18. Review.


Motivational activation: a unifying hypothesis of orexin/hypocretin function.

Mahler SV, Moorman DE, Smith RJ, James MH, Aston-Jones G.

Nat Neurosci. 2014 Oct;17(10):1298-303. doi: 10.1038/nn.3810. Epub 2014 Sep 25. Review.


Orbitofrontal cortical neurons encode expectation-driven initiation of reward-seeking.

Moorman DE, Aston-Jones G.

J Neurosci. 2014 Jul 30;34(31):10234-46. doi: 10.1523/JNEUROSCI.3216-13.2014.


Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat.

Bentzley BS, Jhou TC, Aston-Jones G.

Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11822-7. doi: 10.1073/pnas.1406324111. Epub 2014 Jul 28.


Role of orexin/hypocretin in conditioned sucrose-seeking in female rats.

Cason AM, Aston-Jones G.

Neuropharmacology. 2014 Nov;86:97-102. doi: 10.1016/j.neuropharm.2014.07.007. Epub 2014 Jul 15.

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