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Items: 24


A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites.

McCormick B, Craig HE, Chu JY, Carlin LM, Canel M, Wollweber F, Toivakka M, Michael M, Astier AL, Norton L, Lilja J, Felton JM, Sasaki T, Ivaska J, Hers I, Dransfield I, Rossi AG, Vermeren S.

J Immunol. 2019 Sep 15;203(6):1579-1588. doi: 10.4049/jimmunol.1900443. Epub 2019 Aug 19.


The anthelmintic drug praziquantel promotes human Tr1 differentiation.

Eyoh E, McCallum P, Killick J, Amanfo S, Mutapi F, Astier AL.

Immunol Cell Biol. 2019 May;97(5):512-518. doi: 10.1111/imcb.12229. Epub 2019 Jan 30.


TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells.

Ni Choileain S, Hay J, Thomas J, Williams A, Vermeren MM, Benezech C, Gomez-Salazar M, Hugues OR, Vermeren S, Howie SEM, Dransfield I, Astier AL.

Sci Signal. 2017 Oct 24;10(502). pii: eaah6163. doi: 10.1126/scisignal.aah6163.


HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T, Wear M, Hoving D, Filbey KJ, Hewitson JP, Henderson H, Gonzàlez-Cìscar A, Errington C, Vermeren S, Astier AL, Wallace WA, Schwarze J, Ivens AC, Maizels RM, McSorley HJ.

Immunity. 2017 Oct 17;47(4):739-751.e5. doi: 10.1016/j.immuni.2017.09.015.


Complement as a regulator of adaptive immunity.

Killick J, Morisse G, Sieger D, Astier AL.

Semin Immunopathol. 2018 Jan;40(1):37-48. doi: 10.1007/s00281-017-0644-y. Epub 2017 Aug 25. Review.


Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential.

Yu C, Fitzpatrick A, Cong D, Yao C, Yoo J, Turnbull A, Schwarze J, Norval M, Howie SEM, Weller RB, Astier AL.

J Allergy Clin Immunol. 2017 Nov;140(5):1441-1444.e6. doi: 10.1016/j.jaci.2017.05.023. Epub 2017 Jun 7. No abstract available.


Editorial: T cell regulation by the environment.

Hafler DA, Astier AL.

Front Immunol. 2015 May 13;6:229. doi: 10.3389/fimmu.2015.00229. eCollection 2015. No abstract available.


Monocyte:T-cell interaction regulates human T-cell activation through a CD28/CD46 crosstalk.

Charron L, Doctrinal A, Ni Choileain S, Astier AL.

Immunol Cell Biol. 2015 Oct;93(9):796-803. doi: 10.1038/icb.2015.42. Epub 2015 Mar 19.


Recombinant Ad35 adenoviral proteins as potent modulators of human T cell activation.

Hay J, Carter D, Lieber A, Astier AL.

Immunology. 2014 Sep 22. doi: 10.1111/imm.12391. [Epub ahead of print]


Calcitriol modulates the CD46 pathway in T cells.

Kickler K, Ni Choileain S, Williams A, Richards A, Astier AL.

PLoS One. 2012;7(10):e48486. doi: 10.1371/journal.pone.0048486. Epub 2012 Oct 29.


Prostaglandin E2 affects T cell responses through modulation of CD46 expression.

Kickler K, Maltby K, Ni Choileain S, Stephen J, Wright S, Hafler DA, Jabbour HN, Astier AL.

J Immunol. 2012 Jun 1;188(11):5303-10. doi: 10.4049/jimmunol.1103090. Epub 2012 Apr 27.


CD46 processing: a means of expression.

Ni Choileain S, Astier AL.

Immunobiology. 2012 Feb;217(2):169-75. doi: 10.1016/j.imbio.2011.06.003. Epub 2011 Jul 13. Review.


The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation.

Ni Choileain S, Weyand NJ, Neumann C, Thomas J, So M, Astier AL.

PLoS One. 2011 Jan 19;6(1):e16287. doi: 10.1371/journal.pone.0016287.


CD46 plasticity and its inflammatory bias in multiple sclerosis.

Ni Choileain S, Astier AL.

Arch Immunol Ther Exp (Warsz). 2011 Feb;59(1):49-59. doi: 10.1007/s00005-010-0109-7. Epub 2011 Jan 26. Review.


RNA interference screen in primary human T cells reveals FLT3 as a modulator of IL-10 levels.

Astier AL, Beriou G, Eisenhaure TM, Anderton SM, Hafler DA, Hacohen N.

J Immunol. 2010 Jan 15;184(2):685-93. doi: 10.4049/jimmunol.0902443. Epub 2009 Dec 16.


Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.

Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL.

J Neuroimmunol. 2008 Mar;195(1-2):140-5. doi: 10.1016/j.jneuroim.2008.01.002. Epub 2008 Apr 10.


T-cell regulation by CD46 and its relevance in multiple sclerosis.

Astier AL.

Immunology. 2008 Jun;124(2):149-54. doi: 10.1111/j.1365-2567.2008.02821.x. Epub 2008 Apr 2. Review.


Abnormal Tr1 differentiation in multiple sclerosis.

Astier AL, Hafler DA.

J Neuroimmunol. 2007 Nov;191(1-2):70-8. Epub 2007 Oct 22.


Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis.

Astier AL, Meiffren G, Freeman S, Hafler DA.

J Clin Invest. 2006 Dec;116(12):3252-7. Epub 2006 Nov 9.


Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation.

Astier AL, Svoboda M, Hinds E, De Beaumont R, Munoz O, Freedman AS.

Leukemia. 2004 Apr;18(4):873-5. No abstract available.


Temporal gene expression profile of human precursor B leukemia cells induced by adhesion receptor: identification of pathways regulating B-cell survival.

Astier AL, Xu R, Svoboda M, Hinds E, Munoz O, de Beaumont R, Crean CD, Gabig T, Freedman AS.

Blood. 2003 Feb 1;101(3):1118-27. Epub 2002 Sep 19.


Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation.

Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF, Horvat B.

Nat Immunol. 2002 Jul;3(7):659-66. Epub 2002 Jun 10.


CD46/CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase.

Zaffran Y, Destaing O, Roux A, Ory S, Nheu T, Jurdic P, Rabourdin-Combe C, Astier AL.

J Immunol. 2001 Dec 15;167(12):6780-5.

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