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Items: 1 to 50 of 93

1.

Histone H1.5 binds over splice sites in chromatin and regulates alternative splicing.

Glaich O, Leader Y, Lev Maor G, Ast G.

Nucleic Acids Res. 2019 Jul 9;47(12):6145-6159. doi: 10.1093/nar/gkz338.

2.

Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients.

Yannai S, Zonszain J, Donyo M, Ast G.

PLoS One. 2019 Mar 19;14(3):e0211602. doi: 10.1371/journal.pone.0211602. eCollection 2019.

3.

Genetics of hearing loss in the Arab population of Northern Israel.

Danial-Farran N, Brownstein Z, Gulsuner S, Tammer L, Khayat M, Aleme O, Chervinsky E, Zoubi OA, Walsh T, Ast G, King MC, Avraham KB, Shalev SA.

Eur J Hum Genet. 2018 Dec;26(12):1840-1847. doi: 10.1038/s41431-018-0218-z. Epub 2018 Aug 23.

4.

The importance of DNA methylation of exons on alternative splicing.

Shayevitch R, Askayo D, Keydar I, Ast G.

RNA. 2018 Oct;24(10):1351-1362. doi: 10.1261/rna.064865.117. Epub 2018 Jul 12.

5.

Quantitative mass spectrometry analysis reveals a panel of nine proteins as diagnostic markers for colon adenocarcinomas.

Atak A, Khurana S, Gollapalli K, Reddy PJ, Levy R, Ben-Salmon S, Hollander D, Donyo M, Heit A, Hotz-Wagenblatt A, Biran H, Sharan R, Rane S, Shelar A, Ast G, Srivastava S.

Oncotarget. 2018 Feb 5;9(17):13530-13544. doi: 10.18632/oncotarget.24418. eCollection 2018 Mar 2.

6.

Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.

Naftelberg S, Ast G, Perlson E.

Neural Regen Res. 2017 Apr;12(4):534-537. doi: 10.4103/1673-5374.205082. Review.

7.

Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.

Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G.

PLoS Genet. 2016 Dec 20;12(12):e1006486. doi: 10.1371/journal.pgen.1006486. eCollection 2016 Dec.

8.

Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis.

Bochner R, Samuelov L, Sarig O, Li Q, Adase CA, Isakov O, Malchin N, Vodo D, Shayevitch R, Peled A, Yu BD, Fainberg G, Warshauer E, Adir N, Erez N, Gat A, Gottlieb Y, Rogers T, Pavlovsky M, Goldberg I, Shomron N, Sandilands A, Campbell LE, MacCallum S, McLean WHI, Ast G, Gallo RL, Uitto J, Sprecher E.

J Invest Dermatol. 2017 Feb;137(2):385-393. doi: 10.1016/j.jid.2016.07.043. Epub 2016 Oct 18.

9.

How Are Short Exons Flanked by Long Introns Defined and Committed to Splicing?

Hollander D, Naftelberg S, Lev-Maor G, Kornblihtt AR, Ast G.

Trends Genet. 2016 Oct;32(10):596-606. doi: 10.1016/j.tig.2016.07.003. Epub 2016 Aug 6. Review.

PMID:
27507607
10.

A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1.

Hollander D, Donyo M, Atias N, Mekahel K, Melamed Z, Yannai S, Lev-Maor G, Shilo A, Schwartz S, Barshack I, Sharan R, Ast G.

Genome Res. 2016 Apr;26(4):541-53. doi: 10.1101/gr.193169.115. Epub 2016 Feb 9.

11.

Phosphatidylserine enhances IKBKAP transcription by activating the MAPK/ERK signaling pathway.

Donyo M, Hollander D, Abramovitch Z, Naftelberg S, Ast G.

Hum Mol Genet. 2016 Apr 1;25(7):1307-17. doi: 10.1093/hmg/ddw011. Epub 2016 Jan 13.

PMID:
26769675
12.

Expanding the MYBPC1 phenotypic spectrum: a novel homozygous mutation causes arthrogryposis multiplex congenita.

Ekhilevitch N, Kurolap A, Oz-Levi D, Mory A, Hershkovitz T, Ast G, Mandel H, Baris HN.

Clin Genet. 2016 Jul;90(1):84-9. doi: 10.1111/cge.12707. Epub 2016 Jan 20.

PMID:
26661508
13.

Regulation of alternative splicing through coupling with transcription and chromatin structure.

Naftelberg S, Schor IE, Ast G, Kornblihtt AR.

Annu Rev Biochem. 2015;84:165-98. doi: 10.1146/annurev-biochem-060614-034242. Review.

PMID:
26034889
14.

SF3B1 association with chromatin determines splicing outcomes.

Kfir N, Lev-Maor G, Glaich O, Alajem A, Datta A, Sze SK, Meshorer E, Ast G.

Cell Rep. 2015 Apr 28;11(4):618-29. doi: 10.1016/j.celrep.2015.03.048. Epub 2015 Apr 16.

15.

The alternative role of DNA methylation in splicing regulation.

Lev Maor G, Yearim A, Ast G.

Trends Genet. 2015 May;31(5):274-80. doi: 10.1016/j.tig.2015.03.002. Epub 2015 Mar 30. Review.

PMID:
25837375
16.

HP1 is involved in regulating the global impact of DNA methylation on alternative splicing.

Yearim A, Gelfman S, Shayevitch R, Melcer S, Glaich O, Mallm JP, Nissim-Rafinia M, Cohen AH, Rippe K, Meshorer E, Ast G.

Cell Rep. 2015 Feb 24;10(7):1122-34. doi: 10.1016/j.celrep.2015.01.038. Epub 2015 Feb 19.

17.

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.

Fuchs G, Hollander D, Voichek Y, Ast G, Oren M.

Genome Res. 2014 Oct;24(10):1572-83. doi: 10.1101/gr.176487.114. Epub 2014 Jul 21.

18.

When epigenetics meets alternative splicing: the roles of DNA methylation and GC architecture.

Gelfman S, Ast G.

Epigenomics. 2013 Aug;5(4):351-3. doi: 10.2217/epi.13.32. No abstract available.

19.

Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions.

Melamed Z, Levy A, Ashwal-Fluss R, Lev-Maor G, Mekahel K, Atias N, Gilad S, Sharan R, Levy C, Kadener S, Ast G.

Mol Cell. 2013 Jun 27;50(6):869-81. doi: 10.1016/j.molcel.2013.05.007. Epub 2013 Jun 6.

20.

Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts.

Ramalho RF, Gelfman S, de Souza JE, Ast G, de Souza SJ, Meyer D.

J Mol Evol. 2013 Apr;76(4):228-39. doi: 10.1007/s00239-013-9555-2. Epub 2013 Mar 26.

PMID:
23529588
21.

Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model.

Bochner R, Ziv Y, Zeevi D, Donyo M, Abraham L, Ashery-Padan R, Ast G.

Hum Mol Genet. 2013 Jul 15;22(14):2785-94. doi: 10.1093/hmg/ddt126. Epub 2013 Mar 20.

PMID:
23515154
22.

DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure.

Gelfman S, Cohen N, Yearim A, Ast G.

Genome Res. 2013 May;23(5):789-99. doi: 10.1101/gr.143503.112. Epub 2013 Mar 15.

23.

Pre-mRNA splicing is a determinant of nucleosome organization.

Keren-Shaul H, Lev-Maor G, Ast G.

PLoS One. 2013;8(1):e53506. doi: 10.1371/journal.pone.0053506. Epub 2013 Jan 10.

24.

Differential GC content between exons and introns establishes distinct strategies of splice-site recognition.

Amit M, Donyo M, Hollander D, Goren A, Kim E, Gelfman S, Lev-Maor G, Burstein D, Schwartz S, Postolsky B, Pupko T, Ast G.

Cell Rep. 2012 May 31;1(5):543-56. doi: 10.1016/j.celrep.2012.03.013. Epub 2012 May 3.

25.

Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.

Gelfman S, Burstein D, Penn O, Savchenko A, Amit M, Schwartz S, Pupko T, Ast G.

Genome Res. 2012 Jan;22(1):35-50. doi: 10.1101/gr.119834.110. Epub 2011 Oct 5.

26.

Detection and removal of biases in the analysis of next-generation sequencing reads.

Schwartz S, Oren R, Ast G.

PLoS One. 2011 Jan 31;6(1):e16685. doi: 10.1371/journal.pone.0016685.

27.

IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia.

Cheishvili D, Maayan C, Cohen-Kupiec R, Lefler S, Weil M, Ast G, Razin A.

Hum Mol Genet. 2011 Apr 15;20(8):1585-94. doi: 10.1093/hmg/ddr036. Epub 2011 Jan 27.

PMID:
21273291
28.

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells.

Keren H, Donyo M, Zeevi D, Maayan C, Pupko T, Ast G.

PLoS One. 2010 Dec 29;5(12):e15884. doi: 10.1371/journal.pone.0015884.

29.

Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

Nat Struct Mol Biol. 2010 Sep;17(9):1114-23. doi: 10.1038/nsmb.1881. Epub 2010 Aug 15.

30.

Characteristics of transposable element exonization within human and mouse.

Sela N, Mersch B, Hotz-Wagenblatt A, Ast G.

PLoS One. 2010 Jun 1;5(6):e10907. doi: 10.1371/journal.pone.0010907.

31.

The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates.

Sela N, Kim E, Ast G.

Genome Biol. 2010;11(6):R59. doi: 10.1186/gb-2010-11-6-r59. Epub 2010 Jun 2.

32.

Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing.

Schwartz S, Ast G.

EMBO J. 2010 May 19;29(10):1629-36. doi: 10.1038/emboj.2010.71. Epub 2010 Apr 20.

33.

Alternative splicing and evolution: diversification, exon definition and function.

Keren H, Lev-Maor G, Ast G.

Nat Rev Genet. 2010 May;11(5):345-55. doi: 10.1038/nrg2776. Epub 2010 Apr 8. Review.

PMID:
20376054
34.

Overlapping splicing regulatory motifs--combinatorial effects on splicing.

Goren A, Kim E, Amit M, Vaknin K, Kfir N, Ram O, Ast G.

Nucleic Acids Res. 2010 Jun;38(10):3318-27. doi: 10.1093/nar/gkq005. Epub 2010 Jan 27.

35.

Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements.

Levy A, Schwartz S, Ast G.

Nucleic Acids Res. 2010 Mar;38(5):1515-30. doi: 10.1093/nar/gkp1134. Epub 2009 Dec 14.

36.

The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution.

Gal-Mark N, Schwartz S, Ram O, Eyras E, Ast G.

PLoS Genet. 2009 Nov;5(11):e1000717. doi: 10.1371/journal.pgen.1000717. Epub 2009 Nov 13.

37.

TEs or not TEs? That is the evolutionary question.

Vaknin K, Goren A, Ast G.

J Biol. 2009 Oct 23;8(9):83. doi: 10.1186/jbiol188.

38.

Chromatin organization marks exon-intron structure.

Schwartz S, Meshorer E, Ast G.

Nat Struct Mol Biol. 2009 Sep;16(9):990-5. doi: 10.1038/nsmb.1659.

PMID:
19684600
39.

SROOGLE: webserver for integrative, user-friendly visualization of splicing signals.

Schwartz S, Hall E, Ast G.

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W189-92. doi: 10.1093/nar/gkp320. Epub 2009 May 8.

40.

Alu exonization events reveal features required for precise recognition of exons by the splicing machinery.

Schwartz S, Gal-Mark N, Kfir N, Oren R, Kim E, Ast G.

PLoS Comput Biol. 2009 Mar;5(3):e1000300. doi: 10.1371/journal.pcbi.1000300. Epub 2009 Mar 6.

41.

Transduplication resulted in the incorporation of two protein-coding sequences into the turmoil-1 transposable element of C. elegans.

Sela N, Stern A, Makalowski W, Pupko T, Ast G.

Biol Direct. 2008 Oct 8;3:41. doi: 10.1186/1745-6150-3-41.

42.

Intronic Alus influence alternative splicing.

Lev-Maor G, Ram O, Kim E, Sela N, Goren A, Levanon EY, Ast G.

PLoS Genet. 2008 Sep 26;4(9):e1000204. doi: 10.1371/journal.pgen.1000204.

43.

Alternative splicing and disease.

Kim E, Goren A, Ast G.

RNA Biol. 2008 Jan-Mar;5(1):17-9. Epub 2008 Mar 22.

PMID:
18388487
44.

Multifactorial interplay controls the splicing profile of Alu-derived exons.

Ram O, Schwartz S, Ast G.

Mol Cell Biol. 2008 May;28(10):3513-25. doi: 10.1128/MCB.02279-07. Epub 2008 Mar 10.

45.

Alternative splicing of Alu exons--two arms are better than one.

Gal-Mark N, Schwartz S, Ast G.

Nucleic Acids Res. 2008 Apr;36(6):2012-23. doi: 10.1093/nar/gkn024. Epub 2008 Feb 14.

46.

Alternative approach to a heavy weight problem.

Goren A, Kim E, Amit M, Bochner R, Lev-Maor G, Ahituv N, Ast G.

Genome Res. 2008 Feb;18(2):214-20. Epub 2007 Dec 20.

47.

Alternative splicing: current perspectives.

Kim E, Goren A, Ast G.

Bioessays. 2008 Jan;30(1):38-47. Review.

PMID:
18081010
48.

Insights into the connection between cancer and alternative splicing.

Kim E, Goren A, Ast G.

Trends Genet. 2008 Jan;24(1):7-10. Epub 2007 Dec 3.

PMID:
18054115
49.

Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.

Amit M, Sela N, Keren H, Melamed Z, Muler I, Shomron N, Izraeli S, Ast G.

BMC Mol Biol. 2007 Nov 29;8:109.

50.

Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes.

Schwartz SH, Silva J, Burstein D, Pupko T, Eyras E, Ast G.

Genome Res. 2008 Jan;18(1):88-103. Epub 2007 Nov 21.

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