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Items: 1 to 50 of 114


Cellular sensing of micron-scale curvature: a frontier in understanding the microenvironment.

Assoian RK, Bade ND, Cameron CV, Stebe KJ.

Open Biol. 2019 Oct 31;9(10):190155. doi: 10.1098/rsob.190155. Epub 2019 Oct 23.


MMP12 preferentially attenuates axial stiffening of aging arteries.

Brankovic S, Hawthorne EA, Yu X, Zhang Y, Assoian RK.

J Biomech Eng. 2019 Mar 27. doi: 10.1115/1.4043322. [Epub ahead of print]


Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson-Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite.

Del Campo L, Sánchez-López A, Salaices M, von Kleeck RA, Expósito E, González-Gómez C, Cussó L, Guzmán-Martínez G, Ruiz-Cabello J, Desco M, Assoian RK, Briones AM, Andrés V.

Aging Cell. 2019 Jun;18(3):e12936. doi: 10.1111/acel.12936. Epub 2019 Mar 18.


Cardiovascular protection in females linked to estrogen-dependent inhibition of arterial stiffening and macrophage MMP12.

Liu SL, Bajpai A, Hawthorne EA, Bae Y, Castagnino P, Monslow J, Puré E, Spiller KL, Assoian RK.

JCI Insight. 2019 Jan 10;4(1). pii: 122742. doi: 10.1172/jci.insight.122742. [Epub ahead of print]


Edges impose planar alignment in nematic monolayers by directing cell elongation and enhancing migration.

Bade ND, Kamien RD, Assoian RK, Stebe KJ.

Soft Matter. 2018 Sep 7;14(33):6867-6874. doi: 10.1039/c8sm00612a. Epub 2018 Aug 6.


Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration.

Bade ND, Xu T, Kamien RD, Assoian RK, Stebe KJ.

Biophys J. 2018 Mar 27;114(6):1467-1476. doi: 10.1016/j.bpj.2018.01.039.


Stiffness-dependent motility and proliferation uncoupled by deletion of CD44.

Razinia Z, Castagnino P, Xu T, Vázquez-Salgado A, Puré E, Assoian RK.

Sci Rep. 2017 Nov 28;7(1):16499. doi: 10.1038/s41598-017-16486-z.


Mining the Stiffness-Sensitive Transcriptome in Human Vascular Smooth Muscle Cells Identifies Long Noncoding RNA Stiffness Regulators.

Yu CK, Xu T, Assoian RK, Rader DJ.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):164-173. doi: 10.1161/ATVBAHA.117.310237. Epub 2017 Oct 19.


Curvature and Rho activation differentially control the alignment of cells and stress fibers.

Bade ND, Kamien RD, Assoian RK, Stebe KJ.

Sci Adv. 2017 Sep 6;3(9):e1700150. doi: 10.1126/sciadv.1700150. eCollection 2017 Sep.


Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, and N-cadherin balance in mural cell-endothelial cell-regulated barrier function.

Alimperti S, Mirabella T, Bajaj V, Polacheck W, Pirone DM, Duffield J, Eyckmans J, Assoian RK, Chen CS.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8758-8763. doi: 10.1073/pnas.1618333114. Epub 2017 Aug 1.


Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility.

Shutova MS, Asokan SB, Talwar S, Assoian RK, Bear JE, Svitkina TM.

J Cell Biol. 2017 Sep 4;216(9):2877-2889. doi: 10.1083/jcb.201705167. Epub 2017 Jul 12.


Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy.

Bae YH, Liu SL, Byfield FJ, Janmey PA, Assoian RK.

J Vis Exp. 2016 Oct 19;(116). doi: 10.3791/54630.


N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells.

Cosgrove BD, Mui KL, Driscoll TP, Caliari SR, Mehta KD, Assoian RK, Burdick JA, Mauck RL.

Nat Mater. 2016 Dec;15(12):1297-1306. doi: 10.1038/nmat4725. Epub 2016 Aug 15.


The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces.

Mui KL, Chen CS, Assoian RK.

J Cell Sci. 2016 Mar 15;129(6):1093-100. doi: 10.1242/jcs.183699. Epub 2016 Feb 26. Review.


Matrix metalloproteinase-12 is an essential mediator of acute and chronic arterial stiffening.

Liu SL, Bae YH, Yu C, Monslow J, Hawthorne EA, Castagnino P, Branchetti E, Ferrari G, Damrauer SM, Puré E, Assoian RK.

Sci Rep. 2015 Nov 26;5:17189. doi: 10.1038/srep17189.


Apolipoprotein E3 Inhibits Rho to Regulate the Mechanosensitive Expression of Cox2.

Hsu BY, Bae YH, Mui KL, Liu SL, Assoian RK.

PLoS One. 2015 Jun 11;10(6):e0128974. doi: 10.1371/journal.pone.0128974. eCollection 2015.


N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells.

Mui KL, Bae YH, Gao L, Liu SL, Xu T, Radice GL, Chen CS, Assoian RK.

Cell Rep. 2015 Mar 10;10(9):1477-1486. doi: 10.1016/j.celrep.2015.02.023. Epub 2015 Mar 5.


A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.

Bae YH, Mui KL, Hsu BY, Liu SL, Cretu A, Razinia Z, Xu T, Puré E, Assoian RK.

Sci Signal. 2014 Jun 17;7(330):ra57. doi: 10.1126/scisignal.2004838.


From tissue mechanics to transcription factors.

Janmey PA, Wells RG, Assoian RK, McCulloch CA.

Differentiation. 2013 Oct;86(3):112-20. doi: 10.1016/j.diff.2013.07.004. Epub 2013 Aug 20. Review.


Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.

Lopes J, Adiguzel E, Gu S, Liu SL, Hou G, Heximer S, Assoian RK, Bendeck MP.

Am J Pathol. 2013 Jun;182(6):2241-53. doi: 10.1016/j.ajpath.2013.02.011. Epub 2013 Apr 6.


miR-221/222 compensates for Skp2-mediated p27 degradation and is a primary target of cell cycle regulation by prostacyclin and cAMP.

Castagnino P, Kothapalli D, Hawthorne EA, Liu SL, Xu T, Rao S, Yung Y, Assoian RK.

PLoS One. 2013;8(2):e56140. doi: 10.1371/journal.pone.0056140. Epub 2013 Feb 7.


Apolipoprotein E-mediated cell cycle arrest linked to p27 and the Cox2-dependent repression of miR221/222.

Kothapalli D, Castagnino P, Rader DJ, Phillips MC, Lund-Katz S, Assoian RK.

Atherosclerosis. 2013 Mar;227(1):65-71. doi: 10.1016/j.atherosclerosis.2012.12.003. Epub 2012 Dec 19.


Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.

Yu Z, Ricciotti E, Miwa T, Liu S, Ihida-Stansbury K, Landesberg G, Jones PL, Scalia R, Song WC, Assoian RK, FitzGerald GA.

Circ Res. 2013 Feb 1;112(3):432-40. doi: 10.1161/CIRCRESAHA.112.300755. Epub 2012 Dec 18. Erratum in: Circ Res. 2016 Jul 22;119(3):e37.


Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening.

Kothapalli D, Liu SL, Bae YH, Monslow J, Xu T, Hawthorne EA, Byfield FJ, Castagnino P, Rao S, Rader DJ, Puré E, Phillips MC, Lund-Katz S, Janmey PA, Assoian RK.

Cell Rep. 2012 Nov 29;2(5):1259-71. doi: 10.1016/j.celrep.2012.09.018. Epub 2012 Oct 25.


Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.

Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA.

Circulation. 2011 Feb 15;123(6):631-9. doi: 10.1161/CIRCULATIONAHA.110.973685. Epub 2011 Jan 31.


Cell-type- and cell-cycle-specific anti-mitogenesis by cicaprost.

Castagnino P, Kothapalli D, Hawthorne EA, Xu T, Assoian RK.

Prostaglandins Other Lipid Mediat. 2010 Sep;93(1-2):20-4. doi: 10.1016/j.prostaglandins.2010.04.004. Epub 2010 May 10.


Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening.

Klein EA, Yin L, Kothapalli D, Castagnino P, Byfield FJ, Xu T, Levental I, Hawthorne E, Janmey PA, Assoian RK.

Curr Biol. 2009 Sep 29;19(18):1511-8. doi: 10.1016/j.cub.2009.07.069. Epub 2009 Sep 17.


The absence of caveolin-1 increases proliferation and anchorage- independent growth by a Rac-dependent, Erk-independent mechanism.

Cerezo A, Guadamillas MC, Goetz JG, Sánchez-Perales S, Klein E, Assoian RK, del Pozo MA.

Mol Cell Biol. 2009 Sep;29(18):5046-59. doi: 10.1128/MCB.00315-09. Epub 2009 Jul 20.


Rheostatic signaling by CD44 and hyaluronan.

Puré E, Assoian RK.

Cell Signal. 2009 May;21(5):651-5. doi: 10.1016/j.cellsig.2009.01.024. Epub 2009 Jan 13. Review.


Transcriptional regulation of the cyclin D1 gene at a glance.

Klein EA, Assoian RK.

J Cell Sci. 2008 Dec 1;121(Pt 23):3853-7. doi: 10.1242/jcs.039131. Review. No abstract available.


Differential activation of ERK and Rac mediates the proliferative and anti-proliferative effects of hyaluronan and CD44.

Kothapalli D, Flowers J, Xu T, Puré E, Assoian RK.

J Biol Chem. 2008 Nov 14;283(46):31823-9. doi: 10.1074/jbc.M802934200. Epub 2008 Sep 19.


Joint requirement for Rac and ERK activities underlies the mid-G1 phase induction of cyclin D1 and S phase entry in both epithelial and mesenchymal cells.

Klein EA, Campbell LE, Kothapalli D, Fournier AK, Assoian RK.

J Biol Chem. 2008 Nov 7;283(45):30911-8. doi: 10.1074/jbc.M804537200. Epub 2008 Aug 20.


Growth control by intracellular tension and extracellular stiffness.

Assoian RK, Klein EA.

Trends Cell Biol. 2008 Jul;18(7):347-52. doi: 10.1016/j.tcb.2008.05.002. Epub 2008 May 29. Review.


Fibroblast migration is mediated by CD44-dependent TGF beta activation.

Acharya PS, Majumdar S, Jacob M, Hayden J, Mrass P, Weninger W, Assoian RK, Puré E.

J Cell Sci. 2008 May 1;121(Pt 9):1393-402. doi: 10.1242/jcs.021683. Epub 2008 Apr 8.


ABCG2 expression and side population abundance regulated by a transforming growth factor beta-directed epithelial-mesenchymal transition.

Yin L, Castagnino P, Assoian RK.

Cancer Res. 2008 Feb 1;68(3):800-7. doi: 10.1158/0008-5472.CAN-07-2545.


Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion.

Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK.

J Cell Sci. 2008 Jan 15;121(Pt 2):226-33. doi: 10.1242/jcs.017012.


Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.

Yang C, Klein EA, Assoian RK, Kazanietz MG.

Biochem J. 2008 Feb 15;410(1):167-75.


A Skp2 autoinduction loop and restriction point control.

Yung Y, Walker JL, Roberts JM, Assoian RK.

J Cell Biol. 2007 Aug 27;178(5):741-7.


Cell adhesion, cellular tension, and cell cycle control.

Klein EA, Yung Y, Castagnino P, Kothapalli D, Assoian RK.

Methods Enzymol. 2007;426:155-75. Review.


NFkappaB-independent signaling to the cyclin D1 gene by Rac.

Klein EA, Yang C, Kazanietz MG, Assoian RK.

Cell Cycle. 2007 May 2;6(9):1115-21. Epub 2007 May 15.


ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targets.

Villanueva J, Yung Y, Walker JL, Assoian RK.

Mol Biol Cell. 2007 Apr;18(4):1457-63. Epub 2007 Feb 21.


Hyaluronan and CD44 antagonize mitogen-dependent cyclin D1 expression in mesenchymal cells.

Kothapalli D, Zhao L, Hawthorne EA, Cheng Y, Lee E, Puré E, Assoian RK.

J Cell Biol. 2007 Feb 12;176(4):535-44.


Post-transcriptional destabilization of p21cip1 by protein kinase C in fibroblasts.

Walker JL, Castagnino P, Chung BM, Kazanietz MG, Assoian RK.

J Biol Chem. 2006 Dec 15;281(50):38127-32. Epub 2006 Oct 16.


Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expression.

Roovers K, Klein EA, Castagnino P, Assoian RK.

Dev Cell. 2006 May;10(5):681. No abstract available.


Antimitogenic effects of prostacyclin on the G1 phase cyclin-dependent kinases.

Kothapalli D, Flores-Stewart SA, Assoian RK.

Prostaglandins Other Lipid Mediat. 2005 Dec;78(1-4):3-13. Epub 2005 May 31. Review.


Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression.

Walker JL, Assoian RK.

Cancer Metastasis Rev. 2005 Sep;24(3):383-93. Review.


Phorbol ester-induced G1 phase arrest selectively mediated by protein kinase Cdelta-dependent induction of p21.

Nakagawa M, Oliva JL, Kothapalli D, Fournier A, Assoian RK, Kazanietz MG.

J Biol Chem. 2005 Oct 7;280(40):33926-34. Epub 2005 Jul 28.

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