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[Study of early events influencing the settlement of cancer cells in metastatic niches].

Marceaux C, Asselin-Labat ML.

Med Sci (Paris). 2020 Feb;36(2):109-112. doi: 10.1051/medsci/2020005. Epub 2020 Mar 4. French. No abstract available.


Cells tagged near an early spread of cancer.

Asselin-Labat ML.

Nature. 2019 Aug;572(7771):589-590. doi: 10.1038/d41586-019-02399-6. No abstract available.


Publisher Correction: Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer.

Merino D, Weber TS, Serrano A, Vaillant F, Liu K, Pal B, Di Stefano L, Schreuder J, Lin D, Chen Y, Asselin-Labat ML, Schumacher TN, Cameron D, Smyth GK, Papenfuss AT, Lindeman GJ, Visvader JE, Naik SH.

Nat Commun. 2019 Apr 24;10(1):1945. doi: 10.1038/s41467-019-09916-1.


Barcoding reveals complex clonal behavior in patient-derived xenografts of metastatic triple negative breast cancer.

Merino D, Weber TS, Serrano A, Vaillant F, Liu K, Pal B, Di Stefano L, Schreuder J, Lin D, Chen Y, Asselin-Labat ML, Schumacher TN, Cameron D, Smyth GK, Papenfuss AT, Lindeman GJ, Visvader JE, Naik SH.

Nat Commun. 2019 Feb 15;10(1):766. doi: 10.1038/s41467-019-08595-2. Erratum in: Nat Commun. 2019 Apr 24;10(1):1945.


Studying the immune landscape in lung cancer models: choosing the right experimental tools.

Weeden CE, Ah-Cann C, Asselin-Labat ML.

Transl Lung Cancer Res. 2018 Sep;7(Suppl 3):S248-S250. doi: 10.21037/tlcr.2018.09.05. No abstract available.


Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer.

Leong TL, Gayevskiy V, Steinfort DP, De Massy MR, Gonzalez-Rajal A, Marini KD, Stone E, Chin V, Havryk A, Plit M, Irving LB, Jennings BR, McCloy RA, Jayasekara WSN, Alamgeer M, Boolell V, Field A, Russell PA, Kumar B, Gough DJ, Szczepny A, Ganju V, Rossello FJ, Cain JE, Papenfuss AT, Asselin-Labat ML, Cowley MJ, Watkins DN.

Oncogene. 2019 Mar;38(10):1661-1675. doi: 10.1038/s41388-018-0536-1. Epub 2018 Oct 22.


Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs.

Kersbergen A, Best SA, Dworkin S, Ah-Cann C, de Vries ME, Asselin-Labat ML, Ritchie ME, Jane SM, Sutherland KD.

Dev Biol. 2018 Nov 1;443(1):1-9. doi: 10.1016/j.ydbio.2018.09.002. Epub 2018 Sep 5.


Transcriptional signature primes human oral mucosa for rapid wound healing.

Iglesias-Bartolome R, Uchiyama A, Molinolo AA, Abusleme L, Brooks SR, Callejas-Valera JL, Edwards D, Doci C, Asselin-Labat ML, Onaitis MW, Moutsopoulos NM, Gutkind JS, Morasso MI.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaap8798. doi: 10.1126/scitranslmed.aap8798.


FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium.

Best SA, Harapas CR, Kersbergen A, Rathi V, Asselin-Labat ML, Sutherland KD.

Oncogene. 2018 Nov;37(46):6096-6104. doi: 10.1038/s41388-018-0399-5. Epub 2018 Jul 10.


Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition.

Weeden CE, Ah-Cann C, Holik AZ, Pasquet J, Garnier JM, Merino D, Lessene G, Asselin-Labat ML.

Oncogene. 2018 Aug;37(32):4475-4488. doi: 10.1038/s41388-018-0268-2. Epub 2018 May 10.


Combining Cell Type-Restricted Adenoviral Targeting with Immunostaining and Flow Cytometry to Identify Cells-of-Origin of Lung Cancer.

Best SA, Kersbergen A, Asselin-Labat ML, Sutherland KD.

Methods Mol Biol. 2018;1725:15-29. doi: 10.1007/978-1-4939-7568-6_2.


Mechanisms of DNA damage repair in adult stem cells and implications for cancer formation.

Weeden CE, Asselin-Labat ML.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):89-101. doi: 10.1016/j.bbadis.2017.10.015. Epub 2017 Oct 14. Review.


High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.

Asselin-Labat ML, Rampersad R, Xu X, Ritchie ME, Michalski J, Huang L, Onaitis MW.

Radiat Res. 2017 Nov;188(5):562-570. doi: 10.1667/RR14794.1. Epub 2017 Sep 27.


Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma.

Weeden CE, Holik AZ, Young RJ, Ma SB, Garnier JM, Fox SB, Antippa P, Irving LB, Steinfort DP, Wright GM, Russell PA, Ritchie ME, Burns CJ, Solomon B, Asselin-Labat ML.

Mol Cancer Ther. 2017 Aug;16(8):1610-1622. doi: 10.1158/1535-7163.MCT-17-0174. Epub 2017 Jun 13.


Evaluating the Genomic Yield of a Single Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Lung Cancer: Meeting the Challenge of Doing More With Less.

Leong TL, Christie M, Kranz S, Pham K, Hsu A, Irving LB, Asselin-Labat ML, Steinfort DP.

Clin Lung Cancer. 2017 Nov;18(6):e467-e472. doi: 10.1016/j.cllc.2017.05.006. Epub 2017 May 10.


Glimma: interactive graphics for gene expression analysis.

Su S, Law CW, Ah-Cann C, Asselin-Labat ML, Blewitt ME, Ritchie ME.

Bioinformatics. 2017 Jul 1;33(13):2050-2052. doi: 10.1093/bioinformatics/btx094.


Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway.

Weeden CE, Chen Y, Ma SB, Hu Y, Ramm G, Sutherland KD, Smyth GK, Asselin-Labat ML.

PLoS Biol. 2017 Jan 26;15(1):e2000731. doi: 10.1371/journal.pbio.2000731. eCollection 2017 Jan.


Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability.

Ah-Cann C, Tailler M, Kueh AJ, Herold MJ, Opferman JT, Asselin-Labat ML, Bouillet P.

Cell Death Dis. 2016 Dec 1;7(12):e2490. doi: 10.1038/cddis.2016.391. No abstract available.


RNA-seq mixology: designing realistic control experiments to compare protocols and analysis methods.

Holik AZ, Law CW, Liu R, Wang Z, Wang W, Ahn J, Asselin-Labat ML, Smyth GK, Ritchie ME.

Nucleic Acids Res. 2017 Mar 17;45(5):e30. doi: 10.1093/nar/gkw1063.


Transcriptome and H3K27 tri-methylation profiling of Ezh2-deficient lung epithelium.

Holik AZ, Galvis LA, Lun AT, Ritchie ME, Asselin-Labat ML.

Genom Data. 2015 Jul 16;5:346-51. doi: 10.1016/j.gdata.2015.07.006. eCollection 2015 Sep.


The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.

Holik AZ, Filby CE, Pasquet J, Viitaniemi K, Ciciulla J, Sutherland KD, Asselin-Labat ML.

Respir Res. 2015 Jun 7;16:67. doi: 10.1186/s12931-015-0228-0.


Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses.

Liu R, Holik AZ, Su S, Jansz N, Chen K, Leong HS, Blewitt ME, Asselin-Labat ML, Smyth GK, Ritchie ME.

Nucleic Acids Res. 2015 Sep 3;43(15):e97. doi: 10.1093/nar/gkv412. Epub 2015 Apr 29.


Repression of Igf1 expression by Ezh2 prevents basal cell differentiation in the developing lung.

Galvis LA, Holik AZ, Short KM, Pasquet J, Lun AT, Blewitt ME, Smyth IM, Ritchie ME, Asselin-Labat ML.

Development. 2015 Apr 15;142(8):1458-69. doi: 10.1242/dev.122077. Epub 2015 Mar 19.


HSP90 inhibition suppresses lipopolysaccharide-induced lung inflammation in vivo.

Lilja A, Weeden CE, McArthur K, Nguyen T, Donald A, Wong ZX, Dousha L, Bozinovski S, Vlahos R, Burns CJ, Asselin-Labat ML, Anderson GP.

PLoS One. 2015 Jan 23;10(1):e0114975. doi: 10.1371/journal.pone.0114975. eCollection 2015.


FGFR1 inhibition in lung squamous cell carcinoma: questions and controversies.

Weeden CE, Solomon B, Asselin-Labat ML.

Cell Death Discov. 2015 Nov 23;1:15049. doi: 10.1038/cddiscovery.2015.49. eCollection 2015. Review.


Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2.

Merino D, Best SA, Asselin-Labat ML, Vaillant F, Pal B, Dickins RA, Anderson RL, Strasser A, Bouillet P, Lindeman GJ, Visvader JE.

Oncogene. 2015 Jul 23;34(30):3926-34. doi: 10.1038/onc.2014.313. Epub 2014 Sep 29.


TGF-β signaling in stromal cells acts upstream of FGF-10 to regulate epithelial stem cell growth in the adult lung.

McQualter JL, McCarty RC, Van der Velden J, O'Donoghue RJ, Asselin-Labat ML, Bozinovski S, Bertoncello I.

Stem Cell Res. 2013 Nov;11(3):1222-33. doi: 10.1016/j.scr.2013.08.007. Epub 2013 Aug 28.


Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.

Betterman KL, Paquet-Fifield S, Asselin-Labat ML, Visvader JE, Butler LM, Stacker SA, Achen MG, Harvey NL.

Am J Pathol. 2012 Dec;181(6):2225-38. doi: 10.1016/j.ajpath.2012.08.035. Epub 2012 Oct 11.


Adult lung stem cells and their contribution to lung tumourigenesis.

Asselin-Labat ML, Filby CE.

Open Biol. 2012 Aug;2(8):120094. doi: 10.1098/rsob.120094. Review.


Yersinia enterocolitica YopT and Clostridium difficile toxin B induce expression of GILZ in epithelial cells.

Köberle M, Göppel D, Grandl T, Gaentzsch P, Manncke B, Berchtold S, Müller S, Lüscher B, Asselin-Labat ML, Pallardy M, Sorg I, Langer S, Barth H, Zumbihl R, Autenrieth IB, Bohn E.

PLoS One. 2012;7(7):e40730. doi: 10.1371/journal.pone.0040730. Epub 2012 Jul 9.


Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.

Asselin-Labat ML, Sutherland KD, Vaillant F, Gyorki DE, Wu D, Holroyd S, Breslin K, Ward T, Shi W, Bath ML, Deb S, Fox SB, Smyth GK, Lindeman GJ, Visvader JE.

Mol Cell Biol. 2011 Nov;31(22):4609-22. doi: 10.1128/MCB.05766-11. Epub 2011 Sep 19.


Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells.

Naik E, O'Reilly LA, Asselin-Labat ML, Merino D, Lin A, Cook M, Coultas L, Bouillet P, Adams JM, Strasser A.

J Exp Med. 2011 Jul 4;208(7):1351-8. doi: 10.1084/jem.20100951. Epub 2011 Jun 6.


Mammary stem cells and their regulation by steroid hormones.

Asselin-Labat ML, Lindeman GJ, Visvader JE.

Expert Rev Endocrinol Metab. 2011 May;6(3):371-381. doi: 10.1586/eem.11.22.


Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit.

Smart CE, Wronski A, French JD, Edwards SL, Asselin-Labat ML, Waddell N, Peters K, Brewster BL, Brooks K, Simpson K, Manning N, Lakhani SR, Grimmond S, Lindeman GJ, Visvader JE, Brown MA.

Oncogene. 2011 Mar 31;30(13):1597-607. doi: 10.1038/onc.2010.538. Epub 2010 Dec 6.


ROAST: rotation gene set tests for complex microarray experiments.

Wu D, Lim E, Vaillant F, Asselin-Labat ML, Visvader JE, Smyth GK.

Bioinformatics. 2010 Sep 1;26(17):2176-82. doi: 10.1093/bioinformatics/btq401. Epub 2010 Jul 7.


Control of mammary stem cell function by steroid hormone signalling.

Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE.

Nature. 2010 Jun 10;465(7299):798-802. doi: 10.1038/nature09027. Epub 2010 Apr 11.


Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways.

Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE.

Breast Cancer Res. 2010;12(2):R21. doi: 10.1186/bcr2560. Epub 2010 Mar 26.


Glucocorticoid-induced leucine zipper (GILZ) promotes the nuclear exclusion of FOXO3 in a Crm1-dependent manner.

Latré de Laté P, Pépin A, Assaf-Vandecasteele H, Espinasse C, Nicolas V, Asselin-Labat ML, Bertoglio J, Pallardy M, Biola-Vidamment A.

J Biol Chem. 2010 Feb 19;285(8):5594-605. doi: 10.1074/jbc.M109.068346. Epub 2009 Dec 14.


Resident macrophages influence stem cell activity in the mammary gland.

Gyorki DE, Asselin-Labat ML, van Rooijen N, Lindeman GJ, Visvader JE.

Breast Cancer Res. 2009;11(4):R62. doi: 10.1186/bcr2353. Epub 2009 Aug 26.


Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

Lim E, Vaillant F, Wu D, Forrest NC, Pal B, Hart AH, Asselin-Labat ML, Gyorki DE, Ward T, Partanen A, Feleppa F, Huschtscha LI, Thorne HJ; kConFab, Fox SB, Yan M, French JD, Brown MA, Smyth GK, Visvader JE, Lindeman GJ.

Nat Med. 2009 Aug;15(8):907-13. doi: 10.1038/nm.2000. Epub 2009 Aug 2.


Delineating the epithelial hierarchy in the mouse mammary gland.

Asselin-Labat ML, Vaillant F, Shackleton M, Bouras T, Lindeman GJ, Visvader JE.

Cold Spring Harb Symp Quant Biol. 2008;73:469-78. doi: 10.1101/sqb.2008.73.020. Epub 2008 Nov 6. Review.


Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.

Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR, Lindeman GJ, Visvader JE.

Cell Stem Cell. 2008 Oct 9;3(4):429-41. doi: 10.1016/j.stem.2008.08.001.


The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.

Vaillant F, Asselin-Labat ML, Shackleton M, Forrest NC, Lindeman GJ, Visvader JE.

Cancer Res. 2008 Oct 1;68(19):7711-7. doi: 10.1158/0008-5472.CAN-08-1949.


The Ets transcription factor Elf5 specifies mammary alveolar cell fate.

Oakes SR, Naylor MJ, Asselin-Labat ML, Blazek KD, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE, Ormandy CJ.

Genes Dev. 2008 Mar 1;22(5):581-6. doi: 10.1101/gad.1614608.


[Mammary stem and progenitor cells: critical role of the transcription factor Gata-3].

Asselin-Labat ML.

Med Sci (Paris). 2007 Dec;23(12):1077-80. French. No abstract available.


The emerging picture of the mouse mammary stem cell.

Vaillant F, Asselin-Labat ML, Shackleton M, Lindeman GJ, Visvader JE.

Stem Cell Rev. 2007 Jun;3(2):114-23. Review.


Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation.

Asselin-Labat ML, Sutherland KD, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, Lindeman GJ, Visvader JE.

Nat Cell Biol. 2007 Feb;9(2):201-9. Epub 2006 Dec 24.


Steroid hormone receptor status of mouse mammary stem cells.

Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, Visvader JE, Lindeman GJ.

J Natl Cancer Inst. 2006 Jul 19;98(14):1011-4.


Dexamethasone and IL-10 stimulate glucocorticoid-induced leucine zipper synthesis by human mast cells.

Godot V, Garcia G, Capel F, Arock M, Durand-Gasselin I, Asselin-Labat ML, Emilie D, Humbert M.

Allergy. 2006 Jul;61(7):886-90.


Generation of a functional mammary gland from a single stem cell.

Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE.

Nature. 2006 Jan 5;439(7072):84-8.


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