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Items: 1 to 50 of 98

1.

Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues.

Eraslan B, Wang D, Gusic M, Prokisch H, Hallström BM, Uhlén M, Asplund A, Pontén F, Wieland T, Hopf T, Hahne H, Kuster B, Gagneur J.

Mol Syst Biol. 2019 Feb 18;15(2):e8513. doi: 10.15252/msb.20188513.

2.

A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.

Wang D, Eraslan B, Wieland T, Hallström B, Hopf T, Zolg DP, Zecha J, Asplund A, Li LH, Meng C, Frejno M, Schmidt T, Schnatbaum K, Wilhelm M, Ponten F, Uhlen M, Gagneur J, Hahne H, Kuster B.

Mol Syst Biol. 2019 Feb 18;15(2):e8503. doi: 10.15252/msb.20188503.

3.

Corrigendum: Insufficient antibody validation challenges oestrogen receptor beta research.

Andersson S, Sundberg M, Pristovsek N, Ibrahim A, Jonsson P, Katona B, Clausson CM, Zieba A, Ramström M, Söderberg O, Williams C, Asplund A.

Nat Commun. 2017 Nov 29;8:16164. doi: 10.1038/ncomms16164.

4.

Comparative transcriptomics of hepatic differentiation of human pluripotent stem cells and adult human liver tissue.

Ghosheh N, Küppers-Munther B, Asplund A, Edsbagge J, Ulfenborg B, Andersson TB, Björquist P, Andersson CX, Carén H, Simonsson S, Sartipy P, Synnergren J.

Physiol Genomics. 2017 Aug 1;49(8):430-446. doi: 10.1152/physiolgenomics.00007.2017. Epub 2017 Jul 10.

5.

Insufficient antibody validation challenges oestrogen receptor beta research.

Andersson S, Sundberg M, Pristovsek N, Ibrahim A, Jonsson P, Katona B, Clausson CM, Zieba A, Ramström M, Söderberg O, Williams C, Asplund A.

Nat Commun. 2017 Jun 15;8:15840. doi: 10.1038/ncomms15840. Erratum in: Nat Commun. 2017 Nov 29;8:16164.

6.

A subcellular map of the human proteome.

Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.

Science. 2017 May 26;356(6340). pii: eaal3321. doi: 10.1126/science.aal3321. Epub 2017 May 11.

PMID:
28495876
7.

Let There Be Light!

Raykova D, Koos B, Asplund A, Gelléri M, Ivarsson Y, Danielson UH, Söderberg O.

Proteomes. 2016 Nov 29;4(4). pii: E36. doi: 10.3390/proteomes4040036. Review.

8.

Erratum to: Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 Jul;91(7):2711. doi: 10.1007/s00204-016-1895-4. No abstract available.

PMID:
27900403
9.

Maintenance of drug metabolism and transport functions in human precision-cut liver slices during prolonged incubation for 5 days.

Starokozhko V, Vatakuti S, Schievink B, Merema MT, Asplund A, Synnergren J, Aspegren A, Groothuis GMM.

Arch Toxicol. 2017 May;91(5):2079-2092. doi: 10.1007/s00204-016-1865-x. Epub 2016 Oct 7. Erratum in: Arch Toxicol. 2017 Jul;91(7):2711.

10.

A stromal cell population in the large intestine identified by tissue factor expression that is lost during colorectal cancer progression.

Eriksson O, Asplund A, Hegde G, Edqvist PH, Navani S, Pontén F, Siegbahn A.

Thromb Haemost. 2016 Nov 30;116(6):1050-1059. Epub 2016 Sep 22.

PMID:
27656710
11.

Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer.

Eriksson O, Thulin Å, Asplund A, Hegde G, Navani S, Siegbahn A.

BMC Cancer. 2016 May 31;16:341. doi: 10.1186/s12885-016-2375-1.

12.

A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues.

Lindskog C, Asplund A, Catrina A, Nielsen S, Rützler M.

J Histochem Cytochem. 2016 May;64(5):287-300. doi: 10.1369/0022155416641028. Epub 2016 Mar 29.

13.

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.

Ghosheh N, Olsson B, Edsbagge J, Küppers-Munther B, Van Giezen M, Asplund A, Andersson TB, Björquist P, Carén H, Simonsson S, Sartipy P, Synnergren J.

Stem Cells Int. 2016;2016:8648356. doi: 10.1155/2016/8648356. Epub 2016 Feb 1.

14.

Proteome- and Transcriptome-Driven Reconstruction of the Human Myocyte Metabolic Network and Its Use for Identification of Markers for Diabetes.

Väremo L, Scheele C, Broholm C, Mardinoglu A, Kampf C, Asplund A, Nookaew I, Uhlén M, Pedersen BK, Nielsen J.

Cell Rep. 2016 Feb 16;14(6):1567. doi: 10.1016/j.celrep.2016.01.054. Epub 2016 Feb 16. No abstract available.

15.

Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2016 Feb;64(2):525-526. doi: 10.1016/j.jhep.2015.11.003. Epub 2015 Dec 2. No abstract available.

16.

Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization.

Björnson E, Mukhopadhyay B, Asplund A, Pristovsek N, Cinar R, Romeo S, Uhlen M, Kunos G, Nielsen J, Mardinoglu A.

Cell Rep. 2015 Dec 1;13(9):2014-26. doi: 10.1016/j.celrep.2015.10.045. Epub 2015 Nov 19.

17.

The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.

Gustafsson Sheppard N, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, Tegnér J, Lundberg EK, Asplund A, Jain M, Nilsson R.

Sci Rep. 2015 Oct 13;5:15029. doi: 10.1038/srep15029.

18.

One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells.

Asplund A, Pradip A, van Giezen M, Aspegren A, Choukair H, Rehnström M, Jacobsson S, Ghosheh N, El Hajjam D, Holmgren S, Larsson S, Benecke J, Butron M, Wigander A, Noaksson K, Sartipy P, Björquist P, Edsbagge J, Küppers-Munther B.

Stem Cell Rev. 2016 Feb;12(1):90-104. doi: 10.1007/s12015-015-9621-9.

PMID:
26385115
19.

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Godoy P, Schmidt-Heck W, Natarajan K, Lucendo-Villarin B, Szkolnicka D, Asplund A, Björquist P, Widera A, Stöber R, Campos G, Hammad S, Sachinidis A, Chaudhari U, Damm G, Weiss TS, Nüssler A, Synnergren J, Edlund K, Küppers-Munther B, Hay DC, Hengstler JG.

J Hepatol. 2015 Oct;63(4):934-42. doi: 10.1016/j.jhep.2015.05.013. Epub 2015 May 25. Erratum in: J Hepatol. 2016 Feb;64(2):525-6. Erratum in: J Hepatol. 2016 Feb;64(2):525-526.

20.

Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes.

Väremo L, Scheele C, Broholm C, Mardinoglu A, Kampf C, Asplund A, Nookaew I, Uhlén M, Pedersen BK, Nielsen J.

Cell Rep. 2015 May 12;11(6):921-933. doi: 10.1016/j.celrep.2015.04.010. Epub 2015 Apr 30. Erratum in: Cell Rep. 2016 Feb 16;14(6):1567.

21.

Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling.

Ghaffari P, Mardinoglu A, Asplund A, Shoaie S, Kampf C, Uhlen M, Nielsen J.

Sci Rep. 2015 Feb 2;5:8183. doi: 10.1038/srep08183.

22.

Proteomics. Tissue-based map of the human proteome.

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.

Science. 2015 Jan 23;347(6220):1260419. doi: 10.1126/science.1260419.

23.

The transcriptomic and proteomic landscapes of bone marrow and secondary lymphoid tissues.

Andersson S, Nilsson K, Fagerberg L, Hallström BM, Sundström C, Danielsson A, Edlund K, Uhlen M, Asplund A.

PLoS One. 2014 Dec 26;9(12):e115911. doi: 10.1371/journal.pone.0115911. eCollection 2014.

24.

Diagnostics of primary immunodeficiency diseases: a sequencing capture approach.

Moens LN, Falk-Sörqvist E, Asplund AC, Bernatowska E, Smith CI, Nilsson M.

PLoS One. 2014 Dec 11;9(12):e114901. doi: 10.1371/journal.pone.0114901. eCollection 2014.

25.

Defining the human adipose tissue proteome to reveal metabolic alterations in obesity.

Mardinoglu A, Kampf C, Asplund A, Fagerberg L, Hallström BM, Edlund K, Blüher M, Pontén F, Uhlen M, Nielsen J.

J Proteome Res. 2014 Nov 7;13(11):5106-19. doi: 10.1021/pr500586e. Epub 2014 Sep 25.

PMID:
25219818
26.

Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53.

Sayin VI, Khan OM, Pehlivanoglu LE, Staffas A, Ibrahim MX, Asplund A, Agren P, Nilton A, Bergström G, Bergo MO, Borén J, Lindahl P.

Circ Res. 2014 Oct 10;115(9):781-9. doi: 10.1161/CIRCRESAHA.115.304992. Epub 2014 Sep 11.

PMID:
25212213
27.

The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer.

Hemdan T, Lindén M, Lind SB, Namuduri AV, Sjöstedt E, de Ståhl TD, Asplund A, Malmström PU, Segersten U.

Br J Cancer. 2014 Sep 9;111(6):1180-7. doi: 10.1038/bjc.2014.427. Epub 2014 Jul 29.

28.

Tyrosine phosphorylation profiling via in situ proximity ligation assay.

Elfineh L, Classon C, Asplund A, Pettersson U, Kamali-Moghaddam M, Lind SB.

BMC Cancer. 2014 Jun 13;14:435. doi: 10.1186/1471-2407-14-435.

29.

Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.

Sassi A, Lazaroski S, Wu G, Haslam SM, Fliegauf M, Mellouli F, Patiroglu T, Unal E, Ozdemir MA, Jouhadi Z, Khadir K, Ben-Khemis L, Ben-Ali M, Ben-Mustapha I, Borchani L, Pfeifer D, Jakob T, Khemiri M, Asplund AC, Gustafsson MO, Lundin KE, Falk-Sörqvist E, Moens LN, Gungor HE, Engelhardt KR, Dziadzio M, Stauss H, Fleckenstein B, Meier R, Prayitno K, Maul-Pavicic A, Schaffer S, Rakhmanov M, Henneke P, Kraus H, Eibel H, Kölsch U, Nadifi S, Nilsson M, Bejaoui M, Schäffer AA, Smith CI, Dell A, Barbouche MR, Grimbacher B.

J Allergy Clin Immunol. 2014 May;133(5):1410-9, 1419.e1-13. doi: 10.1016/j.jaci.2014.02.025. Epub 2014 Apr 1.

30.

Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.

Agren R, Mardinoglu A, Asplund A, Kampf C, Uhlen M, Nielsen J.

Mol Syst Biol. 2014 Mar 19;10:721. doi: 10.1002/msb.145122.

31.

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.

Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK.

Nat Commun. 2014;5:3128. doi: 10.1038/ncomms4128.

32.

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.

Mardinoglu A, Agren R, Kampf C, Asplund A, Uhlen M, Nielsen J.

Nat Commun. 2014;5:3083. doi: 10.1038/ncomms4083.

PMID:
24419221
33.

Antibody performance in western blot applications is context-dependent.

Algenäs C, Agaton C, Fagerberg L, Asplund A, Björling L, Björling E, Kampf C, Lundberg E, Nilsson P, Persson A, Wester K, Pontén F, Wernérus H, Uhlén M, Ottosson Takanen J, Hober S.

Biotechnol J. 2014 Mar;9(3):435-45. doi: 10.1002/biot.201300341. Epub 2014 Jan 29.

PMID:
24403002
34.

Evaluating real-time immunohistochemistry on multiple tissue samples, multiple targets and multiple antibody labeling methods.

Dubois L, Andersson K, Asplund A, Björkelund H.

BMC Res Notes. 2013 Dec 18;6:542. doi: 10.1186/1756-0500-6-542.

35.

Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.

Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sjöstedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, Uhlén M.

Mol Cell Proteomics. 2014 Feb;13(2):397-406. doi: 10.1074/mcp.M113.035600. Epub 2013 Dec 5.

36.

Antibodies biotinylated using a synthetic Z-domain from protein A provide stringent in situ protein detection.

Andersson S, Konrad A, Ashok N, Pontén F, Hober S, Asplund A.

J Histochem Cytochem. 2013 Nov;61(11):773-84. doi: 10.1369/0022155413502360. Epub 2013 Aug 6.

37.

Drug metabolizing enzyme and transporter protein profiles of hepatocytes derived from human embryonic and induced pluripotent stem cells.

Ulvestad M, Nordell P, Asplund A, Rehnström M, Jacobsson S, Holmgren G, Davidson L, Brolén G, Edsbagge J, Björquist P, Küppers-Munther B, Andersson TB.

Biochem Pharmacol. 2013 Sep 1;86(5):691-702. doi: 10.1016/j.bcp.2013.06.029. Epub 2013 Jul 12.

PMID:
23856292
38.

The continuing challenge of providing drug information services to diminish the knowledge--practice gap in medical practice.

Alván G, Andersson ML, Asplund AB, Böttiger Y, Elwin CE, Gustafsson LL, Öhman B, Törnqvist E.

Eur J Clin Pharmacol. 2013 May;69 Suppl 1:65-72. doi: 10.1007/s00228-013-1484-x. Epub 2013 May 3.

PMID:
23640190
39.

Socioeconomic characteristics, housing conditions and criminal offences among women with cervical neoplasia.

Billström E, Sundström-Poromaa I, Stålberg K, Asplund A, Hellberg D.

Acta Obstet Gynecol Scand. 2013 Aug;92(8):888-94. doi: 10.1111/aogs.12151. Epub 2013 May 10.

PMID:
23590762
40.

Integration of clinical data with a genome-scale metabolic model of the human adipocyte.

Mardinoglu A, Agren R, Kampf C, Asplund A, Nookaew I, Jacobson P, Walley AJ, Froguel P, Carlsson LM, Uhlen M, Nielsen J.

Mol Syst Biol. 2013;9:649. doi: 10.1038/msb.2013.5.

41.

Evaluation of real-time immunohistochemistry and interaction map as an alternative objective assessment of HER2 expression in human breast cancer tissue.

Gedda L, Björkelund H, Lebel L, Asplund A, Dubois L, Wester K, Penagos N, Malmqvist M, Andersson K.

Appl Immunohistochem Mol Morphol. 2013 Dec;21(6):497-505. doi: 10.1097/PAI.0b013e318281162d.

PMID:
23455178
42.

Contribution of antibody-based protein profiling to the human Chromosome-centric Proteome Project (C-HPP).

Fagerberg L, Oksvold P, Skogs M, Algenäs C, Lundberg E, Pontén F, Sivertsson A, Odeberg J, Klevebring D, Kampf C, Asplund A, Sjöstedt E, Al-Khalili Szigyarto C, Edqvist PH, Olsson I, Rydberg U, Hudson P, Ottosson Takanen J, Berling H, Björling L, Tegel H, Rockberg J, Nilsson P, Navani S, Jirström K, Mulder J, Schwenk JM, Zwahlen M, Hober S, Forsberg M, von Feilitzen K, Uhlén M.

J Proteome Res. 2013 Jun 7;12(6):2439-48. doi: 10.1021/pr300924j. Epub 2012 Dec 31.

PMID:
23276153
43.

A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas.

Kampf C, Bergman J, Oksvold P, Asplund A, Navani S, Wiking M, Lundberg E, Uhlén M, Ponten F.

BMC Med. 2012 Sep 12;10:103. doi: 10.1186/1741-7015-10-103.

44.

Antibodies for profiling the human proteome-The Human Protein Atlas as a resource for cancer research.

Asplund A, Edqvist PH, Schwenk JM, Pontén F.

Proteomics. 2012 Jul;12(13):2067-77. doi: 10.1002/pmic.201100504.

PMID:
22623277
45.

Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers.

Kiflemariam S, Andersson S, Asplund A, Pontén F, Sjöblom T.

PLoS One. 2012;7(3):e32927. doi: 10.1371/journal.pone.0032927. Epub 2012 Mar 8.

46.

Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia.

Samir R, Asplund A, Tot T, Pekar G, Hellberg D.

Contraception. 2012 Mar;85(3):288-93. doi: 10.1016/j.contraception.2011.09.001. Epub 2011 Oct 11.

PMID:
22067748
47.

The Human Protein Atlas as a proteomic resource for biomarker discovery.

Pontén F, Schwenk JM, Asplund A, Edqvist PH.

J Intern Med. 2011 Nov;270(5):428-46. doi: 10.1111/j.1365-2796.2011.02427.x. Epub 2011 Aug 3. Review.

48.

Large-scale protein profiling in human cell lines using antibody-based proteomics.

Fagerberg L, Strömberg S, El-Obeid A, Gry M, Nilsson K, Uhlen M, Ponten F, Asplund A.

J Proteome Res. 2011 Sep 2;10(9):4066-75. doi: 10.1021/pr200259v. Epub 2011 Jul 22.

PMID:
21726073
49.

SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas.

Magnusson K, de Wit M, Brennan DJ, Johnson LB, McGee SF, Lundberg E, Naicker K, Klinger R, Kampf C, Asplund A, Wester K, Gry M, Bjartell A, Gallagher WM, Rexhepaj E, Kilpinen S, Kallioniemi OP, Belt E, Goos J, Meijer G, Birgisson H, Glimelius B, Borrebaeck CA, Navani S, Uhlén M, O'Connor DP, Jirström K, Pontén F.

Am J Surg Pathol. 2011 Jul;35(7):937-48. doi: 10.1097/PAS.0b013e31821c3dae.

PMID:
21677534
50.

Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.

Lindström AK, Asplund A, Hellberg D.

Gynecol Oncol. 2011 Aug;122(2):372-6. doi: 10.1016/j.ygyno.2011.04.049. Epub 2011 May 31.

PMID:
21632100

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