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Items: 21


Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2.

Mihaila R, Ruhela D, Galinski B, Card A, Cancilla M, Shadel T, Kang J, Tep S, Wei J, Haas RM, Caldwell J, Flanagan WM, Kuklin N, Cherkaev E, Ason B.

Mol Ther Nucleic Acids. 2019 Jun 7;16:367-377. doi: 10.1016/j.omtn.2019.03.004. Epub 2019 Mar 23.


Stigmasterol accumulation causes cardiac injury and promotes mortality.

Tao C, Shkumatov AA, Alexander ST, Ason BL, Zhou M.

Commun Biol. 2019 Jan 16;2:20. doi: 10.1038/s42003-018-0245-x. eCollection 2019.


Ghanaians Might Be at Risk of Excess Dietary Intake of Potassium Based on Food Supply Data.

Yawson DO, Adu MO, Ason B, Armah FA, Boateng E, Quansah R.

J Nutr Metab. 2018 Oct 17;2018:5989307. doi: 10.1155/2018/5989307. eCollection 2018.


Ghanaians Might Be at Risk of Inadequate Dietary Intake of Potassium.

Yawson DO, Adu MO, Ason B, Armah FA, Boateng E, Quansah R.

J Nutr Metab. 2016;2016:3150498. doi: 10.1155/2016/3150498. Epub 2016 Dec 6. Retraction in: J Nutr Metab. 2017;2017:6195351.


Human Health Risk Assessment of Artisanal Miners Exposed to Toxic Chemicals in Water and Sediments in the Prestea Huni Valley District of Ghana.

Obiri S, Yeboah PO, Osae S, Adu-Kumi S, Cobbina SJ, Armah FA, Ason B, Antwi E, Quansah R.

Int J Environ Res Public Health. 2016 Jan 18;13(1). pii: E139. doi: 10.3390/ijerph13010139.


Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.

Henne KR, Ason B, Howard M, Wang W, Sun J, Higbee J, Tang J, Matsuda KC, Xu R, Zhou L, Chan JC, King C, Piper DE, Ketchem RR, Michaels ML, Jackson SM, Retter MW.

J Pharmacol Exp Ther. 2015 Apr;353(1):119-31. doi: 10.1124/jpet.114.221242. Epub 2015 Feb 4.


PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.

Ason B, van der Hoorn JW, Chan J, Lee E, Pieterman EJ, Nguyen KK, Di M, Shetterly S, Tang J, Yeh WC, Schwarz M, Jukema JW, Scott R, Wasserman SM, Princen HM, Jackson S.

J Lipid Res. 2014 Nov;55(11):2370-9. doi: 10.1194/jlr.M053207. Epub 2014 Sep 25.


Rescue of Mtp siRNA-induced hepatic steatosis by DGAT2 siRNA silencing.

Tep S, Mihaila R, Freeman A, Pickering V, Huynh F, Tadin-Strapps M, Stracks A, Hubbard B, Caldwell J, Flanagan WM, Kuklin NA, Ason B.

J Lipid Res. 2012 May;53(5):859-67. doi: 10.1194/jlr.M021063. Epub 2012 Feb 21. Erratum in: J Lipid Res. 2012 Nov;53(11):2484. Huyhn, Felicia [corrected to Huynh, Felicia].


ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ.

Lipids. 2011 Nov;46(11):991-1003. doi: 10.1007/s11745-011-3596-3. Epub 2011 Aug 9.


Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L.

J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26.


RNA-induced silencing complex-bound small interfering RNA is a determinant of RNA interference-mediated gene silencing in mice.

Wei J, Jones J, Kang J, Card A, Krimm M, Hancock P, Pei Y, Ason B, Payson E, Dubinina N, Cancilla M, Stroh M, Burchard J, Sachs AB, Hochman JH, Flanagan WM, Kuklin NA.

Mol Pharmacol. 2011 Jun;79(6):953-63. doi: 10.1124/mol.110.070409. Epub 2011 Mar 22.


siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.

Tadin-Strapps M, Peterson LB, Cumiskey AM, Rosa RL, Mendoza VH, Castro-Perez J, Puig O, Zhang L, Strapps WR, Yendluri S, Andrews L, Pickering V, Rice J, Luo L, Chen Z, Tep S, Ason B, Somers EP, Sachs AB, Bartz SR, Tian J, Chin J, Hubbard BK, Wong KK, Mitnaul LJ.

J Lipid Res. 2011 Jun;52(6):1084-97. doi: 10.1194/jlr.M012872. Epub 2011 Mar 11.


Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9.

Ason B, Tep S, Davis HR Jr, Xu Y, Tetzloff G, Galinski B, Soriano F, Dubinina N, Zhu L, Stefanni A, Wong KK, Tadin-Strapps M, Bartz SR, Hubbard B, Ranalletta M, Sachs AB, Flanagan WM, Strack A, Kuklin NA.

J Lipid Res. 2011 Apr;52(4):679-87. doi: 10.1194/jlr.M013664. Epub 2011 Jan 24.


Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination.

Dugas JC, Cuellar TL, Scholze A, Ason B, Ibrahim A, Emery B, Zamanian JL, Foo LC, McManus MT, Barres BA.

Neuron. 2010 Mar 11;65(5):597-611. doi: 10.1016/j.neuron.2010.01.027.


Differences in vertebrate microRNA expression.

Ason B, Darnell DK, Wittbrodt B, Berezikov E, Kloosterman WP, Wittbrodt J, Antin PB, Plasterk RH.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14385-9. Epub 2006 Sep 18.


Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors.

Ason B, Knauss DJ, Balke AM, Merkel G, Skalka AM, Reznikoff WS.

Antimicrob Agents Chemother. 2005 May;49(5):2035-43.


A high-throughput assay for Tn5 Tnp-induced DNA cleavage.

Ason B, Reznikoff WS.

Nucleic Acids Res. 2004 Jun 16;32(10):e83.


DNA sequence bias during Tn5 transposition.

Ason B, Reznikoff WS.

J Mol Biol. 2004 Jan 30;335(5):1213-25.


Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp.

Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB.

J Biol Chem. 2003 Mar 21;278(12):10033-40. Epub 2003 Jan 8.


Mutational analysis of the base flipping event found in Tn5 transposition.

Ason B, Reznikoff WS.

J Biol Chem. 2002 Mar 29;277(13):11284-91. Epub 2002 Jan 22.


A model for Escherichia coli DNA polymerase III holoenzyme assembly at primer/template ends. DNA triggers a change in binding specificity of the gamma complex clamp loader.

Ason B, Bertram JG, Hingorani MM, Beechem JM, O'Donnell M, Goodman MF, Bloom LB.

J Biol Chem. 2000 Jan 28;275(4):3006-15.

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