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Items: 32


Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer's disease: a preclinical study in rTg4510 mice.

Foster JB, Lashley R, Zhao F, Wang X, Kung N, Askwith CC, Lin L, Shultis MW, Hodgetts KJ, Lin CG.

Alzheimers Res Ther. 2019 Aug 23;11(1):75. doi: 10.1186/s13195-019-0530-z.


Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes.

Foster JB, Zhao F, Wang X, Xu Z, Lin K, Askwith CC, Hodgetts KJ, Lin CG.

Neuroscience. 2018 Sep 15;388:224-238. doi: 10.1016/j.neuroscience.2018.07.028. Epub 2018 Jul 27.


Dissipation of transmembrane potassium gradient is the main cause of cerebral ischemia-induced depolarization in astrocytes and neurons.

Du Y, Wang W, Lutton AD, Kiyoshi CM, Ma B, Taylor AT, Olesik JW, McTigue DM, Askwith CC, Zhou M.

Exp Neurol. 2018 May;303:1-11. doi: 10.1016/j.expneurol.2018.01.019. Epub 2018 Feb 3.


Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism.

Ferraiuolo L, Meyer K, Sherwood TW, Vick J, Likhite S, Frakes A, Miranda CJ, Braun L, Heath PR, Pineda R, Beattie CE, Shaw PJ, Askwith CC, McTigue D, Kaspar BK.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6496-E6505. Epub 2016 Sep 29.


ASICs and neuropeptides.

Vick JS, Askwith CC.

Neuropharmacology. 2015 Jul;94:36-41. doi: 10.1016/j.neuropharm.2014.12.012. Epub 2015 Jan 12. Review.


Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons.

Koemeter-Cox AI, Sherwood TW, Green JA, Steiner RA, Berbari NF, Yoder BK, Kauffman AS, Monsma PC, Brown A, Askwith CC, Mykytyn K.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10335-40. doi: 10.1073/pnas.1403286111. Epub 2014 Jun 30.


Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation.

Frey EN, Pavlovicz RE, Wegman CJ, Li C, Askwith CC.

PLoS One. 2013 Aug 14;8(8):e71733. doi: 10.1371/journal.pone.0071733. eCollection 2013.


Structure and activity of the acid-sensing ion channels.

Sherwood TW, Frey EN, Askwith CC.

Am J Physiol Cell Physiol. 2012 Oct 1;303(7):C699-710. doi: 10.1152/ajpcell.00188.2012. Epub 2012 Jul 25. Review.


Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death.

Sherwood TW, Lee KG, Gormley MG, Askwith CC.

J Neurosci. 2011 Jun 29;31(26):9723-34. doi: 10.1523/JNEUROSCI.1665-11.2011.


Dopamine receptor 1 localizes to neuronal cilia in a dynamic process that requires the Bardet-Biedl syndrome proteins.

Domire JS, Green JA, Lee KG, Johnson AD, Askwith CC, Mykytyn K.

Cell Mol Life Sci. 2011 Sep;68(17):2951-60. doi: 10.1007/s00018-010-0603-4. Epub 2010 Dec 9.


Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant.

Hoagland EN, Sherwood TW, Lee KG, Walker CJ, Askwith CC.

J Biol Chem. 2010 Dec 31;285(53):41852-62. doi: 10.1074/jbc.M110.171330. Epub 2010 Oct 29.


Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.

Sherwood TW, Askwith CC.

J Neurosci. 2009 Nov 11;29(45):14371-80. doi: 10.1523/JNEUROSCI.2186-09.2009.


Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.

Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4242-6. doi: 10.1073/pnas.0711027105. Epub 2008 Mar 11.


Identification of ciliary localization sequences within the third intracellular loop of G protein-coupled receptors.

Berbari NF, Johnson AD, Lewis JS, Askwith CC, Mykytyn K.

Mol Biol Cell. 2008 Apr;19(4):1540-7. doi: 10.1091/mbc.E07-09-0942. Epub 2008 Feb 6.


Presynaptic release probability is increased in hippocampal neurons from ASIC1 knockout mice.

Cho JH, Askwith CC.

J Neurophysiol. 2008 Feb;99(2):426-41. Epub 2007 Dec 19.


Endogenous arginine-phenylalanine-amide-related peptides alter steady-state desensitization of ASIC1a.

Sherwood TW, Askwith CC.

J Biol Chem. 2008 Jan 25;283(4):1818-30. Epub 2007 Nov 5.


Potentiation of acid-sensing ion channels by sulfhydryl compounds.

Cho JH, Askwith CC.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2161-74. Epub 2007 Mar 28.


Hippocampal neurons possess primary cilia in culture.

Berbari NF, Bishop GA, Askwith CC, Lewis JS, Mykytyn K.

J Neurosci Res. 2007 Apr;85(5):1095-100.


Ultrasound-mediated gene transfer into neuronal cells.

Fischer AJ, Stanke JJ, Omar G, Askwith CC, Burry RW.

J Biotechnol. 2006 Apr 20;122(4):393-411. Epub 2005 Nov 22.


Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.

Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3621-6. Epub 2004 Feb 26.


Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neurons.

Askwith CC, Wemmie JA, Price MP, Rokhlina T, Welsh MJ.

J Biol Chem. 2004 Apr 30;279(18):18296-305. Epub 2004 Feb 11.


Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.

Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr, Welsh MJ.

J Neurosci. 2003 Jul 2;23(13):5496-502.


ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons.

Xie J, Price MP, Wemmie JA, Askwith CC, Welsh MJ.

J Neurophysiol. 2003 May;89(5):2459-65. Epub 2003 Jan 22.


cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1.

Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2029-34. Epub 2003 Feb 10.


The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH Jr, Welsh MJ.

Neuron. 2002 Apr 25;34(3):463-77.


DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature.

Askwith CC, Benson CJ, Welsh MJ, Snyder PM.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):6459-63. Epub 2001 May 15.


Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels.

Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, Welsh MJ.

Neuron. 2000 Apr;26(1):133-41.


Chloride is an allosteric effector of copper assembly for the yeast multicopper oxidase Fet3p: an unexpected role for intracellular chloride channels.

Davis-Kaplan SR, Askwith CC, Bengtzen AC, Radisky D, Kaplan J.

Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13641-5.


Site-directed mutagenesis of the yeast multicopper oxidase Fet3p.

Askwith CC, Kaplan J.

J Biol Chem. 1998 Aug 28;273(35):22415-9.


Molecular biology of iron acquisition in Saccharomyces cerevisiae.

Askwith CC, de Silva D, Kaplan J.

Mol Microbiol. 1996 Apr;20(1):27-34. Review.


Molecular mechanisms of iron uptake in eukaryotes.

de Silva DM, Askwith CC, Kaplan J.

Physiol Rev. 1996 Jan;76(1):31-47. Review.


The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase.

De Silva DM, Askwith CC, Eide D, Kaplan J.

J Biol Chem. 1995 Jan 20;270(3):1098-101.

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