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Syngeneic red blood cell-induced extracellular vesicles suppress delayed-type hypersensitivity to self-antigens in mice.

Nazimek K, Bustos-Morán E, Blas-Rus N, Nowak B, Ptak W, Askenase PW, Sánchez-Madrid F, Bryniarski K.

Clin Exp Allergy. 2019 Nov;49(11):1487-1499. doi: 10.1111/cea.13475. Epub 2019 Aug 26.


Delayed-Type Hypersensitivity Underlying Casein Allergy Is Suppressed by Extracellular Vesicles Carrying miRNA-150.

Wąsik M, Nazimek K, Nowak B, Askenase PW, Bryniarski K.

Nutrients. 2019 Apr 23;11(4). pii: E907. doi: 10.3390/nu11040907.


Antibody Light Chains Dictate the Specificity of Contact Hypersensitivity Effector Cell Suppression Mediated by Exosomes.

Nazimek K, Askenase PW, Bryniarski K.

Int J Mol Sci. 2018 Sep 7;19(9). pii: E2656. doi: 10.3390/ijms19092656.


Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord.

Lankford KL, Arroyo EJ, Nazimek K, Bryniarski K, Askenase PW, Kocsis JD.

PLoS One. 2018 Jan 2;13(1):e0190358. doi: 10.1371/journal.pone.0190358. eCollection 2018.


A novel community driven software for functional enrichment analysis of extracellular vesicles data.

Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, Maji S, Monteleone F, Øverbye A, Panaretakis T, Patel T, Peinado H, Pluchino S, Principe S, Ronquist G, Royo F, Sahoo S, Spinelli C, Stensballe A, Théry C, van Herwijnen MJC, Wauben M, Welton JL, Zhao K, Mathivanan S.

J Extracell Vesicles. 2017 May 26;6(1):1321455. doi: 10.1080/20013078.2017.1321455. eCollection 2017.


Corrigendum to "Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice" [Pharmacol. Rep. 66 (2014) 570-575].

Majewska-Szczepanik M, Yamamoto N, Askenase PW, Szczepanik M.

Pharmacol Rep. 2017 Jun;69(3):584. doi: 10.1016/j.pharep.2017.01.014. Epub 2017 Mar 29. No abstract available.


The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells.

Vuckovic S, Vandyke K, Rickards DA, McCauley Winter P, Brown SHJ, Mitchell TW, Liu J, Lu J, Askenase PW, Yuriev E, Capuano B, Ramsland PA, Hill GR, Zannettino ACW, Hutchinson AT.

Br J Haematol. 2017 May;177(3):423-440. doi: 10.1111/bjh.14561. Epub 2017 Feb 17.


Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity.

Nazimek K, Bryniarski K, Askenase PW.

Int Arch Allergy Immunol. 2016;171(1):1-26. Epub 2016 Nov 8. Review.


Epicutaneous immunization with ovalbumin and CpG induces TH1/TH17 cytokines, which regulate IgE and IgG2a production.

Majewska-Szczepanik M, Askenase PW, Lobo FM, Marcińska K, Wen L, Szczepanik M.

J Allergy Clin Immunol. 2016 Jul;138(1):262-273.e6. doi: 10.1016/j.jaci.2015.11.018. Epub 2016 Jan 22. Erratum in: J Allergy Clin Immunol. 2017 Feb;139(2):714.


A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.

Askenase PW, Bryniarski K, Paliwal V, Redegeld F, Groot Kormelink T, Kerfoot S, Hutchinson AT, van Loveren H, Campos R, Itakura A, Majewska-Szczepanik M, Yamamoto N, Nazimek K, Szczepanik M, Ptak W.

Ann N Y Acad Sci. 2015 Dec;1362:200-14. doi: 10.1111/nyas.12975. Review. Erratum in: Ann N Y Acad Sci. 2016 Jan;1363(1):176.


Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.

Yamamoto N, Kerfoot SM, Hutchinson AT, Dela Cruz CS, Nakazawa N, Szczepanik M, Majewska-Szczepanik M, Nazimek K, Ohana N, Bryniarski K, Mori T, Muramatsu M, Kanemitsu K, Askenase PW.

Immunology. 2016 Jan;147(1):97-113. doi: 10.1111/imm.12544. Erratum in: Immunology. 2017 Feb;150(2):236.


Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells.

Bryniarski K, Ptak W, Martin E, Nazimek K, Szczepanik M, Sanak M, Askenase PW.

PLoS One. 2015 Apr 29;10(4):e0122991. doi: 10.1371/journal.pone.0122991. eCollection 2015.


Macrophages play an essential role in antigen-specific immune suppression mediated by T CD8⁺ cell-derived exosomes.

Nazimek K, Ptak W, Nowak B, Ptak M, Askenase PW, Bryniarski K.

Immunology. 2015 Sep;146(1):23-32. doi: 10.1111/imm.12466. Epub 2015 Apr 27.


From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor.

Ptak W, Nazimek K, Askenase PW, Bryniarski K.

Arch Immunol Ther Exp (Warsz). 2015 Oct;63(5):345-56. doi: 10.1007/s00005-015-0331-4. Epub 2015 Feb 18. Review.


Diagnostic and therapeutic potentials of exosomes in CNS diseases.

Kawikova I, Askenase PW.

Brain Res. 2015 Aug 18;1617:63-71. doi: 10.1016/j.brainres.2014.09.070. Epub 2014 Oct 7. Review.


Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice.

Majewska-Szczepanik M, Yamamoto N, Askenase PW, Szczepanik M.

Pharmacol Rep. 2014 Aug;66(4):570-5. doi: 10.1016/j.pharep.2014.02.023. Epub 2014 Apr 26. Erratum in: Pharmacol Rep. 2017 Jun;69(3):584.


Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity.

Bryniarski K, Ptak W, Jayakumar A, Püllmann K, Caplan MJ, Chairoungdua A, Lu J, Adams BD, Sikora E, Nazimek K, Marquez S, Kleinstein SH, Sangwung P, Iwakiri Y, Delgato E, Redegeld F, Blokhuis BR, Wojcikowski J, Daniel AW, Groot Kormelink T, Askenase PW.

J Allergy Clin Immunol. 2013 Jul;132(1):170-81. doi: 10.1016/j.jaci.2013.04.048. Epub 2013 May 31.


Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-α, interferon-γ and interleukin-12.

Majewska-Szczepanik M, Paust S, von Andrian UH, Askenase PW, Szczepanik M.

Immunology. 2013 Sep;140(1):98-110. doi: 10.1111/imm.12120.


Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation.

Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-'t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S.

PLoS Biol. 2012;10(12):e1001450. doi: 10.1371/journal.pbio.1001450. Epub 2012 Dec 18.


Immunobiology of antigen-specific immunoglobulin free light chains in chronic inflammatory diseases.

Groot Kormelink T, Askenase PW, Redegeld FA.

Curr Pharm Des. 2012;18(16):2278-89. Review.


Stimulatory lipids accumulate in the mouse liver within 30 min of contact sensitization to facilitate the activation of Naïve iNKT cells in a CD1d-dependent fashion.

Dey N, Szczepanik M, Lau K, Majewska-Szczepanik M, Askenase PW.

Scand J Immunol. 2011 Jul;74(1):52-61. doi: 10.1111/j.1365-3083.2011.02540.x.


Participation of iNKT cells in the early and late components of Tc1-mediated DNFB contact sensitivity: cooperative role of γδ-T cells.

Askenase PW, Majewska-Szczepanik M, Kerfoot S, Szczepanik M.

Scand J Immunol. 2011 May;73(5):465-77. doi: 10.1111/j.1365-3083.2011.02522.x.


Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses.

Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH.

Nat Immunol. 2010 Dec;11(12):1127-35. doi: 10.1038/ni.1953. Epub 2010 Oct 24.


c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.

Pedra JH, Mattner J, Tao J, Kerfoot SM, Davis RJ, Flavell RA, Askenase PW, Yin Z, Fikrig E.

Infect Immun. 2008 Jan;76(1):308-16. Epub 2007 Nov 12.


Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity.

Campos RA, Szczepanik M, Lisbonne M, Itakura A, Leite-de-Moraes M, Askenase PW.

J Immunol. 2006 Sep 15;177(6):3686-94.


Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells.

Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K.

Int Arch Allergy Immunol. 2006;140 Suppl 1:8-16. Epub 2006 Jun 9.


Interleukin-4-dependent innate collaboration between iNKT cells and B-1 B cells controls adaptative contact sensitivity.

Campos RA, Szczepanik M, Itakura A, Lisbonne M, Dey N, Leite-de-Moraes MC, Askenase PW.

Immunology. 2006 Apr;117(4):536-47.


Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.

Sutterwala FS, Ogura Y, Szczepanik M, Lara-Tejero M, Lichtenberger GS, Grant EP, Bertin J, Coyle AJ, Galán JE, Askenase PW, Flavell RA.

Immunity. 2006 Mar;24(3):317-27.


An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity.

Itakura A, Szczepanik M, Campos RA, Paliwal V, Majewska M, Matsuda H, Takatsu K, Askenase PW.

J Immunol. 2005 Dec 1;175(11):7170-8.


TLR-dependent IL-4 production by invariant Valpha14+Jalpha18+ NKT cells to initiate contact sensitivity in vivo.

Askenase PW, Itakura A, Leite-de-Moraes MC, Lisbonne M, Roongapinun S, Goldstein DR, Szczepanik M.

J Immunol. 2005 Nov 15;175(10):6390-401.


Alpha-galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-gamma.

Hachem P, Lisbonne M, Michel ML, Diem S, Roongapinun S, Lefort J, Marchal G, Herbelin A, Askenase PW, Dy M, Leite-de-Moraes MC.

Eur J Immunol. 2005 Oct;35(10):2793-802.


Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma.

Kawikova I, Paliwal V, Szczepanik M, Itakura A, Fukui M, Campos RA, Geba GP, Homer RJ, Iliopoulou BP, Pober JS, Tsuji RF, Askenase PW.

Immunology. 2004 Oct;113(2):234-45.


Extravascular T-cell recruitment requires initiation begun by Valpha14+ NKT cells and B-1 B cells.

Askenase PW, Szczepanik M, Itakura A, Kiener C, Campos RA.

Trends Immunol. 2004 Aug;25(8):441-9. Review. No abstract available.


Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-gamma via CXCR3 chemokines.

Akahira-Azuma M, Szczepanik M, Tsuji RF, Campos RA, Itakura A, Mobini N, McNiff J, Kawikova I, Lu B, Gerard C, Pober JS, Askenase PW.

Immunology. 2004 Mar;111(3):306-17.


Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity.

Campos RA, Szczepanik M, Itakura A, Akahira-Azuma M, Sidobre S, Kronenberg M, Askenase PW.

J Exp Med. 2003 Dec 15;198(12):1785-96.


B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity.

Szczepanik M, Akahira-Azuma M, Bryniarski K, Tsuji RF, Kawikova I, Ptak W, Kiener C, Campos RA, Askenase PW.

J Immunol. 2003 Dec 1;171(11):6225-35.


Mast cells and the mediation of T-cell recruitment in arthritis.

Askenase PW.

N Engl J Med. 2003 Sep 25;349(13):1294. No abstract available.


Cutting edge: invariant V alpha 14 NKT cells are required for allergen-induced airway inflammation and hyperreactivity in an experimental asthma model.

Lisbonne M, Diem S, de Castro Keller A, Lefort J, Araujo LM, Hachem P, Fourneau JM, Sidobre S, Kronenberg M, Taniguchi M, Van Endert P, Dy M, Askenase P, Russo M, Vargaftig BB, Herbelin A, Leite-de-Moraes MC.

J Immunol. 2003 Aug 15;171(4):1637-41.


Proposing Th2 DTH relevant to asthma: cutaneous basophil hypersensitivity then and now.

Askenase PW.

Chem Immunol. 2000;78:112-23. Review. No abstract available.


B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity.

Tsuji RF, Szczepanik M, Kawikova I, Paliwal V, Campos RA, Itakura A, Akahira-Azuma M, Baumgarth N, Herzenberg LA, Askenase PW.

J Exp Med. 2002 Nov 18;196(10):1277-90.


Subunits of IgM reconstitute defective contact sensitivity in B-1 cell-deficient xid mice: kappa light chains recruit T cells independent of complement.

Paliwal V, Tsuji RF, Szczepanik M, Kawikova I, Campos RA, Kneilling M, Röcken M, Schuurman J, Redegeld FA, Nijkamp FP, Askenase PW.

J Immunol. 2002 Oct 15;169(8):4113-23.


Valvular heart disease in patients with hypocomplementemic urticarial vasculitis syndrome associated with Jaccoud's arthropathy.

Houser SL, Askenase PW, Palazzo E, Bloch KJ.

Cardiovasc Pathol. 2002 Jul-Aug;11(4):210-6. Review.


Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.

Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E.

Immunity. 2002 Jun;16(6):849-59.


CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation.

Thomas MJ, Noble A, Sawicka E, Askenase PW, Kemeny DM.

J Immunol. 2002 Jan 1;168(1):216-23.

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