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Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77.

Mittelstadt PR, Taves MD, Ashwell JD.

J Immunol. 2019 Oct 15;203(8):2163-2170. doi: 10.4049/jimmunol.1900559. Epub 2019 Sep 16.


Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.

Taves MD, Mittelstadt PR, Presman DM, Hager GL, Ashwell JD.

Cell Rep. 2019 Mar 26;26(13):3629-3642.e4. doi: 10.1016/j.celrep.2019.02.108.


Getting MAD at MYC.

Giardino Torchia ML, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9821-9823. doi: 10.1073/pnas.1813867115. Epub 2018 Sep 10. No abstract available.


Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection.

Mittelstadt PR, Taves MD, Ashwell JD.

J Immunol. 2018 Mar 15;200(6):1988-1994. doi: 10.4049/jimmunol.1701328. Epub 2018 Feb 9.


Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.


Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.

Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD.

PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan.


Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.

Leigh ND, O'Neill RE, Du W, Chen C, Qiu J, Ashwell JD, McCarthy PL, Chen GL, Cao X.

J Immunol. 2017 Jul 1;199(1):336-347. doi: 10.4049/jimmunol.1502181. Epub 2017 May 26.


Recruitment of calcineurin to the TCR positively regulates T cell activation.

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD.

Nat Immunol. 2017 Feb;18(2):196-204. doi: 10.1038/ni.3640. Epub 2016 Dec 12.


Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes.

Kugler DG, Flomerfelt FA, Costa DL, Laky K, Kamenyeva O, Mittelstadt PR, Gress RE, Rosshart SP, Rehermann B, Ashwell JD, Sher A, Jankovic D.

J Exp Med. 2016 Dec 12;213(13):3041-3056. Epub 2016 Nov 14.


Correction: Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2.

Conze DB, Zhao Y, Ashwell JD.

PLoS Biol. 2016 Jun 23;14(6):e1002502. doi: 10.1371/journal.pbio.1002502. eCollection 2016 Jun.


The TBK1-binding domain of optineurin promotes type I interferon responses.

Meena NP, Zhu G, Mittelstadt PR, Giardino Torchia ML, Pourcelot M, Arnoult D, Ashwell JD, Munitic I.

FEBS Lett. 2016 May;590(10):1498-508. doi: 10.1002/1873-3468.12176. Epub 2016 May 4.


Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease.

Zilberman-Rudenko J, Shawver LM, Wessel AW, Luo Y, Pelletier M, Tsai WL, Lee Y, Vonortas S, Cheng L, Ashwell JD, Orange JS, Siegel RM, Hanson EP.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1612-7. doi: 10.1073/pnas.1518163113. Epub 2016 Jan 22.


Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR.

J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4.


Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.

Alam MS, Gaida MM, Bergmann F, Lasitschka F, Giese T, Giese NA, Hackert T, Hinz U, Hussain SP, Kozlov SV, Ashwell JD.

Nat Med. 2015 Nov;21(11):1337-43. doi: 10.1038/nm.3957. Epub 2015 Oct 19.


Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis.

Li CC, Munitic I, Mittelstadt PR, Castro E, Ashwell JD.

PLoS Biol. 2015 Oct 6;13(10):e1002269. doi: 10.1371/journal.pbio.1002269. eCollection 2015 Oct.


CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis.

Zhao Y, Ma CA, Wu L, Iwai K, Ashwell JD, Oltz EM, Ballard DW, Jain A.

J Biol Chem. 2015 Sep 4;290(36):22076-84. doi: 10.1074/jbc.M115.658096. Epub 2015 Jul 29.


c-IAP ubiquitin protein ligase activity is required for 4-1BB signaling and CD8(+) memory T-cell survival.

Giardino Torchia ML, Munitic I, Castro E, Herz J, McGavern DB, Ashwell JD.

Eur J Immunol. 2015 Sep;45(9):2672-82. doi: 10.1002/eji.201445342. Epub 2015 Jul 7.


Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming.

Li HH, Wang YW, Chen R, Zhou B, Ashwell JD, Fornace AJ Jr.

Int J Biol Sci. 2015 May 15;11(7):726-36. doi: 10.7150/ijbs.12009. eCollection 2015.


Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses.

Allam A, Swiecki M, Vermi W, Ashwell JD, Colonna M.

J Immunol. 2015 Feb 15;194(4):2033. doi: 10.4049/jimmunol.1490050. No abstract available.


Dual function of CD70 in viral infection: modulator of early cytokine responses and activator of adaptive responses.

Allam A, Swiecki M, Vermi W, Ashwell JD, Colonna M.

J Immunol. 2014 Jul 15;193(2):871-8. doi: 10.4049/jimmunol.1302429. Epub 2014 Jun 9. Erratum in: J Immunol. 2015 Feb 15;194(4):2033.


Counter-regulation of T cell effector function by differentially activated p38.

Alam MS, Gaida MM, Ogawa Y, Kolios AG, Lasitschka F, Ashwell JD.

J Exp Med. 2014 Jun 2;211(6):1257-70. doi: 10.1084/jem.20131917. Epub 2014 May 26.


Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.

Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.

PLoS Biol. 2014 Mar 18;12(3):e1001813. doi: 10.1371/journal.pbio.1001813. eCollection 2014 Mar.


Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.

Guo L, Zheng Z, Ai J, Howatt DA, Mittelstadt PR, Thacker S, Daugherty A, Ashwell JD, Remaley AT, Li XA.

Arterioscler Thromb Vasc Biol. 2014 May;34(5):966-75. doi: 10.1161/ATVBAHA.113.302484. Epub 2014 Mar 6.


Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells.

Munitic I, Giardino Torchia ML, Meena NP, Zhu G, Li CC, Ashwell JD.

J Immunol. 2013 Dec 15;191(12):6231-40. doi: 10.4049/jimmunol.1301696. Epub 2013 Nov 15.


A method for high purity sorting of rare cell subsets applied to TDC.

Kuka M, Ashwell JD.

J Immunol Methods. 2013 Dec 31;400-401:111-6. doi: 10.1016/j.jim.2013.10.002. Epub 2013 Oct 11.


CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection.

Kugler DG, Mittelstadt PR, Ashwell JD, Sher A, Jankovic D.

J Exp Med. 2013 Sep 23;210(10):1919-27. doi: 10.1084/jem.20122300. Epub 2013 Aug 26.


CD70 is downregulated by interaction with CD27.

Kuka M, Munitic I, Giardino Torchia ML, Ashwell JD.

J Immunol. 2013 Sep 1;191(5):2282-9. doi: 10.4049/jimmunol.1300868. Epub 2013 Aug 2.


c-IAP1 and c-IAP2 redundancy differs between T and B cells.

Giardino Torchia ML, Conze DB, Ashwell JD.

PLoS One. 2013 Jun 17;8(6):e66161. doi: 10.1371/journal.pone.0066161. Print 2013.


CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus.

Munitic I, Kuka M, Allam A, Scoville JP, Ashwell JD.

J Immunol. 2013 Feb 1;190(3):1169-79. doi: 10.4049/jimmunol.1202353. Epub 2012 Dec 26.


Balance between NF-κB p100 and p52 regulates T cell costimulation dependence.

Giardino Torchia ML, Conze DB, Jankovic D, Ashwell JD.

J Immunol. 2013 Jan 15;190(2):549-55. doi: 10.4049/jimmunol.1201697. Epub 2012 Dec 17.


Identification and characterization of polyclonal αβ-T cells with dendritic cell properties.

Kuka M, Munitic I, Ashwell JD.

Nat Commun. 2012;3:1223. doi: 10.1038/ncomms2223.


Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.

Shen Y, Giardino Torchia ML, Lawson GW, Karp CL, Ashwell JD, Mazmanian SK.

Cell Host Microbe. 2012 Oct 18;12(4):509-20. doi: 10.1016/j.chom.2012.08.004. Epub 2012 Sep 20.


Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.

Mittelstadt PR, Monteiro JP, Ashwell JD.

J Clin Invest. 2012 Jul;122(7):2384-94. doi: 10.1172/JCI63067. Epub 2012 Jun 1.


A20: more than one way to skin a cat.

Srinivasula SM, Ashwell JD.

Mol Cell. 2011 Nov 18;44(4):511-2. doi: 10.1016/j.molcel.2011.11.004.


Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.

Jirmanova L, Giardino Torchia ML, Sarma ND, Mittelstadt PR, Ashwell JD.

Blood. 2011 Sep 22;118(12):3280-9. doi: 10.1182/blood-2011-01-333039. Epub 2011 Jun 28.


Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

Conze DB, Zhao Y, Ashwell JD.

PLoS Biol. 2010 Oct 26;8(10):e1000518. doi: 10.1371/journal.pbio.1000518. Erratum in: PLoS Biol. 2016 Jun;14(6):e1002502.


T cell priming: let there be light.

Jirmanova L, Ashwell JD.

Cell Res. 2010 Jun;20(6):608-10. doi: 10.1038/cr.2010.72. Epub 2010 May 25. No abstract available.


The CD8+ memory T-cell state of readiness is actively maintained and reversible.

Allam A, Conze DB, Giardino Torchia ML, Munitic I, Yagita H, Sowell RT, Marzo AL, Ashwell JD.

Blood. 2009 Sep 3;114(10):2121-30. doi: 10.1182/blood-2009-05-220087. Epub 2009 Jul 17.


T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.

Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD.

J Biol Chem. 2009 Jun 5;284(23):15469-74. doi: 10.1074/jbc.M901004200. Epub 2009 Mar 25.


Structural basis for recognition of diubiquitins by NEMO.

Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H.

Mol Cell. 2009 Mar 13;33(5):602-15. doi: 10.1016/j.molcel.2009.01.012. Epub 2009 Jan 29.


Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.

Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD.

Blood. 2009 Mar 5;113(10):2229-37. doi: 10.1182/blood-2008-04-153304. Epub 2008 Nov 14.


TWEAKing death.

Ashwell JD.

J Cell Biol. 2008 Jul 14;182(1):15-7. doi: 10.1083/jcb.200806036. Epub 2008 Jul 7.


IAPs: what's in a name?

Srinivasula SM, Ashwell JD.

Mol Cell. 2008 Apr 25;30(2):123-35. doi: 10.1016/j.molcel.2008.03.008. Review.


Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.

Conze DB, Wu CJ, Thomas JA, Landstrom A, Ashwell JD.

Mol Cell Biol. 2008 May;28(10):3538-47. doi: 10.1128/MCB.02098-07. Epub 2008 Mar 17.


NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.

Wu CJ, Ashwell JD.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3023-8. doi: 10.1073/pnas.0712313105. Epub 2008 Feb 19.


Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.

Wagner S, Carpentier I, Rogov V, Kreike M, Ikeda F, Löhr F, Wu CJ, Ashwell JD, Dötsch V, Dikic I, Beyaert R.

Oncogene. 2008 Jun 12;27(26):3739-45. doi: 10.1038/sj.onc.1211042. Epub 2008 Jan 21.


Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.

Jirmanova L, Jankovic D, Fornace AJ Jr, Ashwell JD.

J Immunol. 2007 Apr 1;178(7):4153-8.


The many paths to p38 mitogen-activated protein kinase activation in the immune system.

Ashwell JD.

Nat Rev Immunol. 2006 Jul;6(7):532-40. Review.


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