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Items: 1 to 50 of 297

1.

Perspectives in fluid biomarkers in neurodegeneration from the 2019 biomarkers in neurodegenerative diseases course-a joint PhD student course at University College London and University of Gothenburg.

Obrocki P, Khatun A, Ness D, Senkevich K, Hanrieder J, Capraro F, Mattsson N, Andreasson U, Portelius E, Ashton NJ, Blennow K, Schöll M, Paterson RW, Schott JM, Zetterberg H.

Alzheimers Res Ther. 2020 Feb 28;12(1):20. doi: 10.1186/s13195-020-00586-6. Review.

2.

Early Levallois core technology between Marine Isotope Stage 12 and 9 in Western Europe.

Moncel MH, Ashton N, Arzarello M, Fontana F, Lamotte A, Scott B, Muttillo B, Berruti G, Nenzioni G, Tuffreau A, Peretto C.

J Hum Evol. 2020 Feb;139:102735. doi: 10.1016/j.jhevol.2019.102735. Epub 2020 Feb 17.

PMID:
32078934
3.

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lléo A, Sala I, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Legido-Quigley C, Bertram L, Barkhof F, Zetterberg H, Morgan BP, Streffer J, Visser PJ, Lovestone S.

J Alzheimers Dis. 2020;74(1):213-225. doi: 10.3233/JAD-190434.

PMID:
31985466
4.

An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead.

Simrén J, Ashton NJ, Blennow K, Zetterberg H.

Curr Opin Neurobiol. 2019 Dec 12;61:29-39. doi: 10.1016/j.conb.2019.11.019. [Epub ahead of print] Review.

PMID:
31838254
5.

Salivary Biomarkers for Alzheimer's Disease and Related Disorders.

Ashton NJ, Ide M, Zetterberg H, Blennow K.

Neurol Ther. 2019 Dec;8(Suppl 2):83-94. doi: 10.1007/s40120-019-00168-1. Epub 2019 Dec 12. Review.

6.

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers.

Ashton NJ, Suárez-Calvet M, Heslegrave A, Hye A, Razquin C, Pastor P, Sanchez-Valle R, Molinuevo JL, Visser PJ, Blennow K, Hodges AK, Zetterberg H.

Alzheimers Res Ther. 2019 Nov 28;11(1):94. doi: 10.1186/s13195-019-0545-5.

7.

Propagation of Tau Pathology: Integrating Insights From Postmortem and In Vivo Studies.

Vogels T, Leuzy A, Cicognola C, Ashton NJ, Smolek T, Novak M, Blennow K, Zetterberg H, Hromadka T, Zilka N, Schöll M.

Biol Psychiatry. 2019 Oct 3. pii: S0006-3223(19)31744-5. doi: 10.1016/j.biopsych.2019.09.019. [Epub ahead of print] Review.

8.

Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals.

Benedet AL, Ashton NJ, Pascoal TA, Leuzy A, Mathotaarachchi S, Kang MS, Therriault J, Savard M, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Blennow K, Neto PR.

Alzheimers Dement (Amst). 2019 Sep 27;11:679-689. doi: 10.1016/j.dadm.2019.08.002. eCollection 2019 Dec.

9.

Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum.

Rajan MR, Sotak M, Barrenäs F, Shen T, Borkowski K, Ashton NJ, Biörserud C, Lindahl TL, Ramström S, Schöll M, Lindahl P, Fiehn O, Newman JW, Perkins R, Wallenius V, Lange S, Börgeson E.

Sci Rep. 2019 Oct 28;9(1):15385. doi: 10.1038/s41598-019-51673-0.

10.

Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer's disease.

Chatterjee P, Zetterberg H, Goozee K, Lim CK, Jacobs KR, Ashton NJ, Hye A, Pedrini S, Sohrabi HR, Shah T, Asih PR, Dave P, Shen K, Taddei K, Lovejoy DB, Guillemin GJ, Blennow K, Martins RN.

J Neuroinflammation. 2019 Oct 10;16(1):186. doi: 10.1186/s12974-019-1567-4.

11.

Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.

Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Buckley NJ, Kate MT, Scheltens P, Vandenberghe R, Gabel S, Meersmans K, Engelborghs S, De Roeck EE, Sleegers K, Frisoni GB, Blin O, Richardson JC, Bordet R, Molinuevo JL, Rami L, Wallin A, Kettunen P, Tsolaki M, Verhey F, Lleó A, Alcolea D, Popp J, Peyratout G, Martinez-Lage P, Tainta M, Johannsen P, Teunissen CE, Freund-Levi Y, Frölich L, Legido-Quigley C, Barkhof F, Blennow K, Zetterberg H, Baker S, Morgan BP, Streffer J, Visser PJ, Bertram L, Lovestone S, Nevado-Holgado AJ.

Alzheimers Dement. 2019 Nov;15(11):1478-1488. doi: 10.1016/j.jalz.2019.06.4951. Epub 2019 Sep 5.

12.

Simvastatin causes pulmonary artery relaxation by blocking smooth muscle ROCK and calcium channels: Evidence for an endothelium-independent mechanism.

Absi M, Eid BG, Ashton N, Hart G, Gurney AM.

PLoS One. 2019 Aug 1;14(8):e0220473. doi: 10.1371/journal.pone.0220473. eCollection 2019.

13.

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort.

Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A, Proitsi P, Nevado-Holgado A, Hye A, Bos I, Vos S, Vandenberghe R, Teunissen C, Ten Kate M, Scheltens P, Gabel S, Meersmans K, Blin O, Richardson J, De Roeck E, Sleegers K, Bordet R, Rami L, Kettunen P, Tsolaki M, Verhey F, Sala I, Lléo A, Peyratout G, Tainta M, Johannsen P, Freund-Levi Y, Frölich L, Dobricic V, Engelborghs S, Frisoni GB, Molinuevo JL, Wallin A, Popp J, Martinez-Lage P, Bertram L, Barkhof F, Ashton N, Blennow K, Zetterberg H, Streffer J, Visser PJ, Lovestone S, Legido-Quigley C.

Alzheimers Dement. 2019 Jun;15(6):817-827. doi: 10.1016/j.jalz.2019.03.004. Epub 2019 May 8.

14.

Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease.

Startin CM, Ashton NJ, Hamburg S, Hithersay R, Wiseman FK, Mok KY, Hardy J, Lleó A, Lovestone S, Parnetti L, Zetterberg H, Hye A; LonDownS Consortium, Strydom A.

Alzheimers Res Ther. 2019 Mar 21;11(1):26. doi: 10.1186/s13195-019-0477-0.

15.

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies.

Heurling K, Ashton NJ, Leuzy A, Zimmer ER, Blennow K, Zetterberg H, Eriksson J, Lubberink M, Schöll M.

Mol Cell Neurosci. 2019 Jun;97:34-42. doi: 10.1016/j.mcn.2019.02.001. Epub 2019 Feb 20. Review.

16.

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer's disease.

Ashton NJ, Nevado-Holgado AJ, Barber IS, Lynham S, Gupta V, Chatterjee P, Goozee K, Hone E, Pedrini S, Blennow K, Schöll M, Zetterberg H, Ellis KA, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Aarsland D, Powell J, Lovestone S, Martins R, Hye A.

Sci Adv. 2019 Feb 6;5(2):eaau7220. doi: 10.1126/sciadv.aau7220. eCollection 2019 Feb.

17.

In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating.

Ashton NN, Allyn G, Porter ST, Haussener TJ, Sebahar PR, Looper RE, Williams DL.

Acta Biomater. 2019 Jul 15;93:25-35. doi: 10.1016/j.actbio.2019.02.010. Epub 2019 Feb 12.

PMID:
30769135
18.

In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection.

Williams DL, Epperson RT, Ashton NN, Taylor NB, Kawaguchi B, Olsen RE, Haussener TJ, Sebahar PR, Allyn G, Looper RE.

Acta Biomater. 2019 Jul 15;93:36-49. doi: 10.1016/j.actbio.2019.01.055. Epub 2019 Jan 31.

PMID:
30710710
19.

Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration.

Ashton NJ, Leuzy A, Lim YM, Troakes C, Hortobágyi T, Höglund K, Aarsland D, Lovestone S, Schöll M, Blennow K, Zetterberg H, Hye A.

Acta Neuropathol Commun. 2019 Jan 9;7(1):5. doi: 10.1186/s40478-018-0649-3.

20.

Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [18F]-Flutemetamol PET Scan Result.

Westwood S, Baird AL, Hye A, Ashton NJ, Nevado-Holgado AJ, Anand SN, Liu B, Newby D, Bazenet C, Kiddle SJ, Ward M, Newton B, Desai K, Tan Hehir C, Zanette M, Galimberti D, Parnetti L, Lleó A, Baker S, Narayan VA, van der Flier WM, Scheltens P, Teunissen CE, Visser PJ, Lovestone S.

Front Aging Neurosci. 2018 Dec 11;10:409. doi: 10.3389/fnagi.2018.00409. eCollection 2018.

21.

Urotensin II in the development and progression of chronic kidney disease following ⅚ nephrectomy in the rat.

Eyre HJ, Speight T, Glazier JD, Smith DM, Ashton N.

Exp Physiol. 2019 Mar;104(3):421-433. doi: 10.1113/EP087366. Epub 2019 Jan 15.

22.

Biomarkers for tau pathology.

Schöll M, Maass A, Mattsson N, Ashton NJ, Blennow K, Zetterberg H, Jagust W.

Mol Cell Neurosci. 2019 Jun;97:18-33. doi: 10.1016/j.mcn.2018.12.001. Epub 2018 Dec 7. Review.

23.

The effect of Ramadan fasting during pregnancy on perinatal outcomes: a systematic review and meta-analysis.

Glazier JD, Hayes DJL, Hussain S, D'Souza SW, Whitcombe J, Heazell AEP, Ashton N.

BMC Pregnancy Childbirth. 2018 Oct 25;18(1):421. doi: 10.1186/s12884-018-2048-y.

24.

In vivo Detection of Alzheimer's Disease.

Leuzy A, Heurling K, Ashton NJ, Schöll M, Zimmer ER.

Yale J Biol Med. 2018 Sep 21;91(3):291-300. eCollection 2018 Sep. Review.

25.

Real-World Variability in the Prediction of Intracranial Aneurysm Wall Shear Stress: The 2015 International Aneurysm CFD Challenge.

Valen-Sendstad K, Bergersen AW, Shimogonya Y, Goubergrits L, Bruening J, Pallares J, Cito S, Piskin S, Pekkan K, Geers AJ, Larrabide I, Rapaka S, Mihalef V, Fu W, Qiao A, Jain K, Roller S, Mardal KA, Kamakoti R, Spirka T, Ashton N, Revell A, Aristokleous N, Houston JG, Tsuji M, Ishida F, Menon PG, Browne LD, Broderick S, Shojima M, Koizumi S, Barbour M, Aliseda A, Morales HG, Lefèvre T, Hodis S, Al-Smadi YM, Tran JS, Marsden AL, Vaippummadhom S, Einstein GA, Brown AG, Debus K, Niizuma K, Rashad S, Sugiyama SI, Owais Khan M, Updegrove AR, Shadden SC, Cornelissen BMW, Majoie CBLM, Berg P, Saalfield S, Kono K, Steinman DA.

Cardiovasc Eng Technol. 2018 Dec;9(4):544-564. doi: 10.1007/s13239-018-00374-2. Epub 2018 Sep 10.

26.

No association of salivary total tau concentration with Alzheimer's disease.

Ashton NJ, Ide M, Schöll M, Blennow K, Lovestone S, Hye A, Zetterberg H.

Neurobiol Aging. 2018 Oct;70:125-127. doi: 10.1016/j.neurobiolaging.2018.06.014. Epub 2018 Jun 20.

PMID:
30007161
27.

Aquatic caddisworm silk is solidified by environmental metal ions during the natural fiber-spinning process.

Ashton NN, Stewart RJ.

FASEB J. 2019 Jan;33(1):572-583. doi: 10.1096/fj.201801029R. Epub 2018 Jul 9.

PMID:
29985645
28.

Update on biomarkers for amyloid pathology in Alzheimer's disease.

Ashton NJ, Schöll M, Heurling K, Gkanatsiou E, Portelius E, Höglund K, Brinkmalm G, Hye A, Blennow K, Zetterberg H.

Biomark Med. 2018 Jul;12(7):799-812. doi: 10.2217/bmm-2017-0433. Epub 2018 Jun 15. Review.

PMID:
29902934
29.

Moss genetics and the way forward.

Ashton N.

PLoS Genet. 2018 May 10;14(5):e1007330. doi: 10.1371/journal.pgen.1007330. eCollection 2018 May. No abstract available. Erratum in: PLoS Genet. 2018 Jun 7;14(6):e1007446.

30.

FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis.

Ponnusamy A, Sinha S, Hyde GD, Borland SJ, Taylor RF, Pond E, Eyre HJ, Inkson CA, Gilmore A, Ashton N, Kalra PA, Canfield AE.

PLoS One. 2018 Apr 24;13(4):e0196232. doi: 10.1371/journal.pone.0196232. eCollection 2018.

31.
32.

A new model for fetal programming: maternal Ramadan-type fasting programs nephrogenesis.

Mohany M, Ashton N, Harrath AH, Nyengaard JR, Alomar SY, Alwasel S.

J Dev Orig Health Dis. 2018 Jun;9(3):287-298. doi: 10.1017/S204017441700109X. Epub 2018 Jan 10.

PMID:
29317010
33.

PpORS, an ancient type III polyketide synthase, is required for integrity of leaf cuticle and resistance to dehydration in the moss, Physcomitrella patens.

Li L, Aslam M, Rabbi F, Vanderwel MC, Ashton NW, Suh DY.

Planta. 2018 Feb;247(2):527-541. doi: 10.1007/s00425-017-2806-5. Epub 2017 Nov 8.

PMID:
29119267
34.

A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.

Touma C, Adams MN, Ashton NW, Mizzi M, El-Kamand S, Richard DJ, Cubeddu L, Gamsjaeger R.

Nucleic Acids Res. 2017 Aug 21;45(14):8609-8620. doi: 10.1093/nar/gkx526.

35.

Plasma REST: a novel candidate biomarker of Alzheimer's disease is modified by psychological intervention in an at-risk population.

Ashton NJ, Hye A, Leckey CA, Jones AR, Gardner A, Elliott C, Wetherell JL, Lenze EJ, Killick R, Marchant NL.

Transl Psychiatry. 2017 Jun 6;7(6):e1148. doi: 10.1038/tp.2017.113.

36.

hSSB1 associates with and promotes stability of the BLM helicase.

Croft LV, Ashton NW, Paquet N, Bolderson E, O'Byrne KJ, Richard DJ.

BMC Mol Biol. 2017 May 15;18(1):13. doi: 10.1186/s12867-017-0090-3.

37.

hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases.

Ashton NW, Paquet N, Shirran SL, Bolderson E, Kariawasam R, Touma C, Fallahbaghery A, Gamsjaeger R, Cubeddu L, Botting C, Pollock PM, O'Byrne KJ, Richard DJ.

DNA Repair (Amst). 2017 Jun;54:30-39. doi: 10.1016/j.dnarep.2017.03.006. Epub 2017 Apr 6.

38.

Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes.

Ashton NW, Loo D, Paquet N, O'Byrne KJ, Richard DJ.

BMC Mol Biol. 2016 Dec 9;17(1):24.

39.

A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution.

Touma C, Kariawasam R, Gimenez AX, Bernardo RE, Ashton NW, Adams MN, Paquet N, Croll TI, O'Byrne KJ, Richard DJ, Cubeddu L, Gamsjaeger R.

Nucleic Acids Res. 2016 Sep 19;44(16):7963-73. doi: 10.1093/nar/gkw617. Epub 2016 Jul 7.

40.

Connecting caddisworm silk structure and mechanical properties: combined infrared spectroscopy and mechanical analysis.

Ashton NN, Pan H, Stewart RJ.

Open Biol. 2016 Jun;6(6). pii: 160067. doi: 10.1098/rsob.160067.

41.

hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.

Paquet N, Adams MN, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Leong V, Beard S, Bolderson E, Botting CH, O'Byrne KJ, Richard DJ.

Sci Rep. 2016 Jun 8;6:27446. doi: 10.1038/srep27446.

42.

Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.

Westwood S, Leoni E, Hye A, Lynham S, Khondoker MR, Ashton NJ, Kiddle SJ, Baird AL, Sainz-Fuertes R, Leung R, Graf J, Hehir CT, Baker D, Cereda C, Bazenet C, Ward M, Thambisetty M, Lovestone S.

J Alzheimers Dis. 2016 Mar 29;52(2):561-72. doi: 10.3233/JAD-151155.

43.

Computational hemodynamics of abdominal aortic aneurysms: Three-dimensional ultrasound versus computed tomography.

Owen B, Lowe C, Ashton N, Mandal P, Rogers S, Wein W, McCollum C, Revell A.

Proc Inst Mech Eng H. 2016 Mar;230(3):201-10. doi: 10.1177/0954411915626742.

PMID:
26893226
44.

Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.

Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S, Chung R, Ward M, Rabinovici GD, Lovestone S, Breen G, Legido-Quigley C, Dobson RJ, Kiddle SJ; Alzheimer's Disease Neuroimaging Initiative.

Transl Psychiatry. 2016 Jan 26;6:e719. doi: 10.1038/tp.2015.205.

45.

PpASCL, the Physcomitrella patens Anther-Specific Chalcone Synthase-Like Enzyme Implicated in Sporopollenin Biosynthesis, Is Needed for Integrity of the Moss Spore Wall and Spore Viability.

Daku RM, Rabbi F, Buttigieg J, Coulson IM, Horne D, Martens G, Ashton NW, Suh DY.

PLoS One. 2016 Jan 11;11(1):e0146817. doi: 10.1371/journal.pone.0146817. eCollection 2016.

46.

Ancestral and more recently acquired syntenic relationships of MADS-box genes uncovered by the Physcomitrella patens pseudochromosomal genome assembly.

Barker EI, Ashton NW.

Plant Cell Rep. 2016 Mar;35(3):505-12. doi: 10.1007/s00299-015-1898-2. Epub 2015 Nov 14.

PMID:
26573679
47.

The Computational Fluid Dynamics Rupture Challenge 2013--Phase II: Variability of Hemodynamic Simulations in Two Intracranial Aneurysms.

Berg P, Roloff C, Beuing O, Voss S, Sugiyama S, Aristokleous N, Anayiotos AS, Ashton N, Revell A, Bressloff NW, Brown AG, Chung BJ, Cebral JR, Copelli G, Fu W, Qiao A, Geers AJ, Hodis S, Dragomir-Daescu D, Nordahl E, Bora Suzen Y, Owais Khan M, Valen-Sendstad K, Kono K, Menon PG, Albal PG, Mierka O, Münster R, Morales HG, Bonnefous O, Osman J, Goubergrits L, Pallares J, Cito S, Passalacqua A, Piskin S, Pekkan K, Ramalho S, Marques N, Sanchi S, Schumacher KR, Sturgeon J, Švihlová H, Hron J, Usera G, Mendina M, Xiang J, Meng H, Steinman DA, Janiga G.

J Biomech Eng. 2015 Dec;137(12):121008. doi: 10.1115/1.4031794.

PMID:
26473395
48.

Clinical Research Abstracts of the British Equine Veterinary Association Congress 2015.

Ashton NM, Doles J.

Equine Vet J. 2015 Sep;47 Suppl 48:17. doi: 10.1111/evj.12486_38.

PMID:
26376113
49.

hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.

Paquet N, Adams MN, Leong V, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess JT, Bolderson E, O'Byrne KJ, Richard DJ.

Nucleic Acids Res. 2015 Oct 15;43(18):8817-29. doi: 10.1093/nar/gkv790. Epub 2015 Aug 10.

50.

Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.

Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton NJ, Bazenet C, Killick R, Adnan J, Westman E, Nelson S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams SC, Lovestone S, Spector TD, Dobson RJ.

Transl Psychiatry. 2015 Jun 16;5:e584. doi: 10.1038/tp.2015.78.

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